Widely Applicable AIE Chemosensor for On-Site Fast Detection of Drugs Based on the POSS-Core Dendrimer with the Controlled Self-Assembly Mechanism

A novel fluorescence chemosensor that can quickly on-site detect synthetic drugs and undergo prescreening is first reported. An eight tetraphenylethene (TPE)-modified polyhedral oligomeric silsesquioxane (POSS) dendrimer is designed and synthesized as an aggregation induced emission (AIE) chemosensor, which exhibits great enhancement of unique monomer emission in pure tetrahydrofuran (THF) and ME emission in THF/water, thanks to forming different self-assembly morphologies. In addition, POSS-TPE can sensitively detect methamphetamine and ketamine even in artificial saliva by noncovalent interaction forces. It has great potential to be a new widely applicable ME chemosensor for aromatic molecules.