Genetic polymorphisms of histone methyltransferase SETD2 predicts prognosis and chemotherapy response in Chinese acute myeloid leukemia patients

Setd2 deficiency impairs hematopoietic stem cell self-renewal and causes malignant transformation

(2018) Yuan-Liang Zhang et al.   CELL RESEARCH

Association of genetic polymorphisms in genes involved in Ara-C and dNTP metabolism pathway with chemosensitivity and prognosis of adult acute myeloid leukemia (AML)

(2018) Ke-Wei Zhu et al.   Journal of Translational Medicine

Influence of UGT1A1 polymorphisms on the outcome of acute myeloid leukemia patients treated with cytarabine-base regimens

(2018) Peng Chen et al.   Journal of Translational Medicine

Acquired SETD2 mutation and impaired CREB1 activation confer cisplatin resistance in metastatic non-small cell lung cancer

(2018) In-Kyu Kim et al.   ONCOGENE

SETD2 and histone H3 lysine 36 methylation deficiency in advanced systemic mastocytosis

(2017) G Martinelli et al.   LEUKEMIA

Intragenic DNA methylation prevents spurious transcription initiation

(2017) Francesco Neri et al.   NATURE

Set2 methyltransferase facilitates cell cycle progression by maintaining transcriptional fidelity

(2017) Raghuvar Dronamraju et al.   NUCLEIC ACIDS RESEARCH

Cabozantinib is selectively cytotoxic in acute myeloid leukemia cells with FLT3-internal tandem duplication (FLT3-ITD)

(2016) Jeng-Wei Lu et al.   CANCER LETTERS

Dual Chromatin and Cytoskeletal Remodeling by SETD2

(2016) In Young Park et al.   CELL

Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia

(2016) H Parker et al.   LEUKEMIA

Long non-coding RNA GAS5 polymorphism predicts a poor prognosis of acute myeloid leukemia in Chinese patients via affecting hematopoietic reconstitution

(2016) Han Yan et al.   LEUKEMIA & LYMPHOMA

Genomic Classification and Prognosis in Acute Myeloid Leukemia

(2016) Elli Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Association betweenDCK35708 T>C variation and clinical outcomes of acute myeloid leukemia in South Chinese patients

(2016) Dao-Yu Zhang et al.   PHARMACOGENOMICS

Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation

(2015) Sophia X. Pfister et al.   CANCER CELL

Incidence and outcomes for adults diagnosed with acute myeloid leukemia in the north of England: a real world study

(2015) Andrew Kenneth McGregor et al.   LEUKEMIA & LYMPHOMA

Wilms Tumor 1 rs16754 predicts favorable clinical outcomes for acute myeloid leukemia patients in South Chinese population

(2015) Dao-Yu Zhang et al.   LEUKEMIA RESEARCH

Decreased Expression of SETD2 Predicts Unfavorable Prognosis in Patients With Nonmetastatic Clear-Cell Renal Cell Carcinoma

(2015) Weisi Liu et al.   MEDICINE

Identification of functional cooperative mutations of SETD2 in human acute leukemia

(2014) Xiaofan Zhu et al.   NATURE GENETICS

Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks

(2014) François Aymard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Evidences for mutations in the histone modifying gene SETD2 as critical drivers in leukemia development

(2014) QianFei Wang et al.   Science China-Life Sciences

Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia

(2014) Brenton G. Mar et al.   Nature Communications

SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint

(2014) Sílvia Carvalho et al.   eLife

Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas

(2013) Adam M. Fontebasso et al.   ACTA NEUROPATHOLOGICA

Decoding the Histone Code: Role of H3K36me3 in Mismatch Repair and Implications for Cancer Susceptibility and Therapy

(2013) G.-M. Li   CANCER RESEARCH

The Histone Mark H3K36me3 Regulates Human DNA Mismatch Repair through Its Interaction with MutSα

(2013) Feng Li et al.   CELL

Acute myeloid leukaemia in adults

(2013) Felicetto Ferrara et al.   LANCET

Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia

(2012) A. F. T. Ribeiro et al.   BLOOD

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

(2012) Jinghui Zhang et al.   NATURE

Understanding the language of Lys36 methylation at histone H3

(2012) Eric J. Wagner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics

(2011) W.-C. Chou et al.   BLOOD

Histone Methyltransferase Gene SETD2 Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma

(2010) Gerben Duns et al.   CANCER RESEARCH

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

(2010) Gillian L. Dalgliesh et al.   NATURE

Improved patient survival for acute myeloid leukemia: a population-based study of 9729 patients diagnosed in Sweden between 1973 and 2005

(2008) A. R. Derolf et al.   BLOOD