Article
Chemistry, Applied
Eurico Lima, Andreia G. Barroso, Octavio Ferreira, Renato E. Boto, Jose R. Fernandes, Paulo Almeida, Samuel M. Silvestre, Adriana O. Santos, Lucinda V. Reis
Summary: The introduction of amines into squaraine dyes improved their aqueous solubility, absorption at higher wavelengths, and interaction with biological targets. The synthesis of N-ethyl chain benz[e]indole-based amino-squaraine dyes with increasing amine complexity was conducted to investigate the impact of small modifications on their photobiological activity. Amino and hydroxyethylamino-bearing dyes exhibited promising results in silico and cytotoxicity assays, with strong binding to human serum albumin protein and high rates of photocytotoxicity and tumor selectivity. Further studies showed that these dyes are linked to mitochondria, have low genotoxicity, and induce cell cycle arrest in the G2/M phase.
Article
Chemistry, Physical
Wenbo Wu, Leilei Shi, Yukun Duan, Shidang Xu, Xihui Gao, Xinyuan Zhu, Bin Liu
Summary: A highly efficient metabolizable type-II photosensitizer with aggregation-induced emission characteristics was developed in this study, demonstrating good anti-tumor PDT efficiency in mouse models. Importantly, the photosensitizer can be gradually oxidized by endogenous hypochlorite after PDT and subsequently excreted through urine within 24 hours of administration.
CHEMISTRY OF MATERIALS
(2021)
Review
Chemistry, Inorganic & Nuclear
Manjunatha Ankathatti Munegowda, Angelica Manalac, Madrigal Weersink, Sherri A. McFarland, Lothar Lilge
Summary: Ruthenium(II)-based coordination complexes have great potential as photosensitizers for photodynamic therapy. The modular architectures of these complexes allow for tuning of various properties such as cellular uptake, subcellular targeting, solubility, and light absorption. Many studies focus on systematic variation of ligands to investigate their impact on photophysical and photobiological performance. However, comparisons between Ru(II)-based PSs and other generations of PSs are scarce. Nonetheless, quantitative models based on PDT dose metrics are available for qualitative comparisons. This review summarizes the relevant studies on Ru(II)-containing PSs and their potential efficacy.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Chemistry, Inorganic & Nuclear
Manjunatha Ankathatti Munegowda, Angelica Manalac, Madrigal Weersink, Sherri A. McFarland, Lothar Lilge
Summary: Ruthenium(II)-based coordination complexes are promising photosensitizers for photodynamic therapy with potential in oncology and antimicrobial fields. These complexes can be tuned for different photophysical properties and studies comparing their efficacy to other PSs are limited but possible using PDT dose metrics.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Biotechnology & Applied Microbiology
Jie Luo, Zhijun Miao, Xinglong Huang, Yifan Yang, Ming Liu, Gang Shen, Tao Yang
Summary: By encapsulating the photosensitizer Chlorin e6 (Ce6) into human serum albumin nanoparticles, the tumor accumulation and therapeutic effect of photodynamic therapy (PDT) against bladder cancer models were enhanced.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Polymer Science
Dong-Jin Lim
Summary: Methylene blue (MB) has been utilized in the textile industry and for pharmacological purposes. It has gained attention for its potential as a safe photosensitizer in photodynamic therapy (PDT), showing both anticancer and antibacterial activity. Challenges in creating MB-embedded nanoparticles or microparticles may affect the clinical efficacy of PDT.
Review
Nanoscience & Nanotechnology
Jianhua Zou, Ling Li, Zhen Yang, Xiaoyuan Chen
Summary: Phototherapy combined with immunotherapy enhances the immunostimulating response and has synergistic effects for cancer treatment. Photoimmunotherapy (PIT) is a potential win-win strategy to prevent tumor metastases and recurrence by inducing immunogenic cell death (ICD).
Article
Chemistry, Medicinal
Ravindra R. Cheruku, Steven G. Turowski, Farukh A. Durrani, Walter A. Tabaczynski, Joseph Cacaccio, Joseph R. Missert, Leslie Curtin, Sandra Sexton, Ronald Alberico, Craig M. Hendler, Joseph A. Spernyak, Zachary Grossman, Ravindra K. Pandey
Summary: In this study, a tumor-avid chlorophyll a derivative, HPPH, currently undergoing clinical trials, was conjugated with Gd(III)tetraxetan (DOTA) moieties to create a conjugate with potential for both tumor imaging and photodynamic therapy (PDT). The conjugate showed tumor specificity and low organ toxicity in mice, indicating its potential as a cancer imaging and treatment agent.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Alex Vasilev, Roba Sofi, Stuart J. Smith, Ruman Rahman, Anja G. Teschemacher, Sergey Kasparov
Summary: One of the most challenging problems in treating glioblastoma (GBM) is its highly infiltrative nature. Researchers have found that using tetramethylrhodamine methyl ester (TMRM) as a photosensitizer in combination with photodynamic therapy (PDT) can target GBM cells, inducing mitochondrial damage and cell death, making it a potential direction for clinical translation.
Review
Pharmacology & Pharmacy
Marcin Olek, Agnieszka Machorowska-Pieniazek, Wojciech Stos, Janusz Kalukin, Dorota Bartusik-Aebisher, David Aebisher, Grzegorz Cieslar, Aleksandra Kawczyk-Krupka
Summary: Treatment of malocclusions with fixed orthodontic appliances can hinder oral hygiene, leading to enamel demineralization and periodontal diseases. In addition to traditional methods, new approaches like photodynamic therapy are being explored for reducing plaque around brackets.
Review
Biochemistry & Molecular Biology
Shujin Lin, Chun Liu, Xiao Han, Haowei Zhong, Cui Cheng
Summary: Photodynamic therapy (PDT) is a promising treatment method due to its efficiency and accuracy, with viral nanoparticles (VNPs) showing great potential as delivery vehicles for PDT. VNPs have favorable properties and are being explored for applications in tumor cell treatment and antimicrobial therapy, with future prospects focusing on developing novel viral nanocarriers or improving existing viral vectors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Elzbieta Ostasnka, David Aebisher, Dorota Bartusik-Aebisher
Summary: Photodynamic Therapy (PDT) is a well-known alternative cancer treatment that relies on light activation of a photosensitizer in the presence of oxygen to induce cytotoxic effects in cancer cells. Proper light delivery and the selection of an appropriate photosensitizer are crucial for the effectiveness of PDT in treating cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Sam Benson, Fabio de Moliner, Antonio Fernandez, Erkin Kuru, Nicholas L. Asiimwe, Jun-Seok Lee, Lloyd Hamilton, Dirk Sieger, Isabel R. Bravo, Abigail M. Elliot, Yi Feng, Marc Vendrell
Summary: The authors have developed a new family of photosensitizers that target pathogenic cells and retain metabolite function, enabling precise cell ablation through photodynamic therapy. By mimicking metabolic indicators of disease onset and progression, these photoactivatable probes can selectively kill pathogenic cells with high precision, offering a safer therapeutic approach that reduces potential side effects.
NATURE COMMUNICATIONS
(2021)
Article
Spectroscopy
Vinicius N. da Rocha, Mateus H. Kohler, Khayth Nagata, Paulo C. Piquini
Summary: In this study, we examine the structural, electronic, and spectroscopic properties of corrole macrocycles bound to different polycyclic aromatic groups in various environments using Density Functional Theory (DFT) calculations. We also investigate the binding of these functionalized corrole molecules with biomolecules through molecular docking. The results demonstrate the potential of functionalized corrole macrocycles as effective photosensitizers for photodynamic therapy (PDT).
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Physical
Mohd Sajid Ali, Jayaraman Muthukumaran, Monika Jain, Teresa Santos-Silva, Hamad A. Al-Lohedan, Noura Saad Al-Shuail
Summary: The study investigated the binding of the cephalosporin-class drug cefoperazone with bovine serum albumin using spectroscopic techniques and in silico methods. The importance of correcting for the inner filter effect in this type of study was emphasized, and the binding mechanism was found to involve hydrogen bonding and hydrophobic forces with almost 1:1 static binding between BSA and CFP. Molecular docking and molecular dynamics simulation suggested the presence of a putative binding site between BSA domains 1 and 3, which could be a target for future research related to BSA-drug binding.
JOURNAL OF MOLECULAR LIQUIDS
(2021)