Dementia spectrum disorders: lessons learnt from decades with PET research

Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F-18]-T807

(2018) David T. Chien et al.   JOURNAL OF ALZHEIMERS DISEASE

Hypertension is associated with worse cognitive function and hippocampal hypometabolism in Alzheimer's disease

(2017) I. Moonga et al.   EUROPEAN JOURNAL OF NEUROLOGY

cGMP production of the radiopharmaceutical [18 F]MK-6240 for PET imaging of human neurofibrillary tangles

(2017) Thomas Lee Collier et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Cognitive decline in Parkinson disease

(2017) Dag Aarsland et al.   Nature Reviews Neurology

Frontotemporal Dementia

(2017) Nicholas T. Olney et al.   NEUROLOGIC CLINICS

Frontotemporal dementia with the V337M MAPT mutation

(2017) Salvatore Spina et al.   NEUROLOGY

18 F-AV-1451 binds to motor-related subcortical gray and white matter in corticobasal syndrome

(2017) Hanna Cho et al.   NEUROLOGY

In vivo retention of 18 F-AV-1451 in corticobasal syndrome

(2017) Ruben Smith et al.   NEUROLOGY

[18F]AV-1451 tau-PET uptake does correlate with quantitatively measured 4R-tau burden in autopsy-confirmed corticobasal degeneration

(2016) Keith A. Josephs et al.   ACTA NEUROPATHOLOGICA

Multimodal evaluation demonstrates in vivo 18F-AV-1451 uptake in autopsy-confirmed corticobasal degeneration

(2016) Corey T. McMillan et al.   ACTA NEUROPATHOLOGICA

Characterization of tau positron emission tomography tracer [ 18 F]AV-1451 binding to postmortem tissue in Alzheimer's disease, primary tauopathies, and other dementias

(2016) Kerstin Sander et al.   Alzheimers & Dementia

AV-1451 tau and β-amyloid positron emission tomography imaging in dementia with Lewy bodies

(2016) Kejal Kantarci et al.   ANNALS OF NEUROLOGY

Regional profiles of the candidate tau PET ligand18F-AV-1451 recapitulate key features of Braak histopathological stages

(2016) Adam J. Schwarz et al.   BRAIN

Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease

(2016) Rik Ossenkoppele et al.   BRAIN

A systematic review of lessons learned from PET molecular imaging research in atypical parkinsonism

(2016) Flavia Niccolini et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Cholinergic imaging in dementia spectrum disorders

(2016) Roman Roy et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Discovery of 6-(Fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs)

(2016) Abbas M. Walji et al.   JOURNAL OF MEDICINAL CHEMISTRY

11 C-ER176, a Radioligand for 18-kDa Translocator Protein, Has Adequate Sensitivity to Robustly Image All Three Affinity Genotypes in Human Brain

(2016) Masamichi Ikawa et al.   JOURNAL OF NUCLEAR MEDICINE

Flutriciclamide (18F-GE180) PET: First-in-Human PET Study of Novel Third-Generation In Vivo Marker of Human Translocator Protein

(2016) Z. Fan et al.   JOURNAL OF NUCLEAR MEDICINE

Tracer Kinetic Analysis of (S)-18F-THK5117 as a PET Tracer for Assessing Tau Pathology

(2016) M. Jonasson et al.   JOURNAL OF NUCLEAR MEDICINE

Preclinical Characterization of 18F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles

(2016) E. D. Hostetler et al.   JOURNAL OF NUCLEAR MEDICINE

[18F]AV-1451 tau positron emission tomography in progressive supranuclear palsy

(2016) Jennifer L. Whitwell et al.   MOVEMENT DISORDERS

Tau PET in Alzheimer disease and mild cognitive impairment

(2016) Hanna Cho et al.   NEUROLOGY

In vivo visualization of tau deposits in corticobasal syndrome by 18 F-THK5351 PET

(2016) Akio Kikuchi et al.   NEUROLOGY

Imaging synaptic density in the living human brain

(2016) Sjoerd J. Finnema et al.   Science Translational Medicine

Tau Positron Emission Tomographic Imaging in the Lewy Body Diseases

(2016) Stephen N. Gomperts et al.   JAMA Neurology

Drug Development in Alzheimer’s Disease: The Contribution of PET and SPECT

(2016) Lieven D. Declercq et al.   Frontiers in Pharmacology

[18F]AV-1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation

(2016) W. Richard Bevan Jones et al.   Annals of Clinical and Translational Neurology

An autoradiographic evaluation of AV-1451 Tau PET in dementia

(2016) Val J. Lowe et al.   Acta Neuropathologica Communications

Tau PET with [ 18 F]AV1451 in non-alzheimer's disease neurodegenerative syndromes

(2015) Gil D. Rabinovici et al.   Alzheimers & Dementia

Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue

(2015) Marta Marquié et al.   ANNALS OF NEUROLOGY

Tau positron emission tomographic imaging in aging and early Alzheimer disease

(2015) Keith A. Johnson et al.   ANNALS OF NEUROLOGY

Regional brain hypometabolism is unrelated to regional amyloid plaque burden

(2015) Andre Altmann et al.   BRAIN

Longitudinal influence of microglial activation and amyloid on neuronal function in Alzheimer’s disease

(2015) Zhen Fan et al.   BRAIN

[18F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer’s disease

(2015) Ryuichi Harada et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Cholinesterase Inhibitors for Lewy Body Disorders: A Meta-Analysis

(2015) Shinji Matsunaga et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Prevalence of Amyloid PET Positivity in Dementia Syndromes

(2015) Rik Ossenkoppele et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia

(2015) Willemijn J. Jansen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Mapping neuroinflammation in frontotemporal dementia with molecular PET imaging

(2015) Jing Zhang   Journal of Neuroinflammation

Recent imaging advances in neurology

(2015) Lorenzo Rocchi et al.   JOURNAL OF NEUROLOGY

18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease

(2015) R. Harada et al.   JOURNAL OF NUCLEAR MEDICINE

Multimodal imaging in Alzheimer's disease: validity and usefulness for early detection

(2015) Stefan Teipel et al.   LANCET NEUROLOGY

PET Radioligands Reveal the Basis of Dementia in Parkinson's Disease and Dementia with Lewy Bodies

(2015) Stephen N. Gomperts et al.   Neurodegenerative Diseases

Primary age-related tauopathy (PART): a common pathology associated with human aging

(2014) John F. Crary et al.   ACTA NEUROPATHOLOGICA

A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease

(2014) Eric Karran et al.   ANNALS OF NEUROLOGY

Regional glucose metabolic reduction in dementia with Lewy bodies is independent of amyloid deposition

(2014) Kazunari Ishii et al.   ANNALS OF NUCLEAR MEDICINE

Non-invasive assessment of Alzheimer’s disease neurofibrillary pathology using 18F-THK5105 PET

(2014) Nobuyuki Okamura et al.   BRAIN

In vivo evaluation of a novel tau imaging tracer for Alzheimer’s disease

(2014) Victor L. Villemagne et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Modulation of inflammation in transgenic models of Alzheimer’s disease

(2014) Amy M Birch et al.   Journal of Neuroinflammation

Evaluation of 11C-BU99008, a PET Ligand for the Imidazoline2 Binding Sites in Rhesus Brain

(2014) C. A. Parker et al.   JOURNAL OF NUCLEAR MEDICINE

In Vivo Imaging of Human Cholinergic Nerve Terminals with (-)-5-18F-Fluoroethoxybenzovesamicol: Biodistribution, Dosimetry, and Tracer Kinetic Analyses

(2014) M. Petrou et al.   JOURNAL OF NUCLEAR MEDICINE

Florbetapir F 18 amyloid PET and 36-month cognitive decline:a prospective multicenter study

(2014) P M Doraiswamy et al.   MOLECULAR PSYCHIATRY

Neuroimaging in Parkinson disease: from research setting to clinical practice

(2014) Marios Politis   Nature Reviews Neurology

18F-fluorodeoxyglucose positron emission tomography, aging, and apolipoprotein E genotype in cognitively normal persons

(2014) David S. Knopman et al.   NEUROBIOLOGY OF AGING

Association of hypometabolism and amyloid levels in aging, normal subjects

(2014) V. J. Lowe et al.   NEUROLOGY

[18F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease

(2013) Chun-Fang Xia et al.   Alzheimers & Dementia

Alterations in α4β2 nicotinic receptors in cognitive decline in Alzheimer’s aetiopathology

(2013) Hiroyuki Okada et al.   BRAIN

Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer’s disease

(2013) Yen Ying Lim et al.   BRAIN

In vivo radioligand binding to translocator protein correlates with severity of Alzheimer’s disease

(2013) William C. Kreisl et al.   BRAIN

Automated analysis of FDG PET as a tool for single-subject probabilistic prediction and detection of Alzheimer’s disease dementia

(2013) Javier Arbizu et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

TDP-43 frontotemporal lobar degeneration and autoimmune disease

(2013) Z. A. Miller et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease

(2013) Sruti Rayaprolu et al.   Molecular Neurodegeneration

Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

(2013) Masahiro Maruyama et al.   NEURON

Patterns of microglial cell activation in frontotemporal lobar degeneration

(2013) Suzannah B. Lant et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Microglia, Amyloid and Glucose Metabolism in Parkinson’s Disease with and without Dementia

(2013) Paul Edison et al.   NEUROPSYCHOPHARMACOLOGY

Neuropathology of dementia in a large cohort of patients with Parkinson's disease

(2013) Judit Horvath et al.   PARKINSONISM & RELATED DISORDERS

Binding of the Radioligand SIL23 to α-Synuclein Fibrils in Parkinson Disease Brain Tissue Establishes Feasibility and Screening Approaches for Developing a Parkinson Disease Imaging Agent

(2013) Devika P. Bagchi et al.   PLoS One

Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease

(2013) T. L. S. Benzinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Fully automated synthesis of PET TSPO radioligands [11C]DAA1106 and [18F]FEDAA1106

(2012) Min Wang et al.   APPLIED RADIATION AND ISOTOPES

Diagnostic accuracy of 18F-FDG and 11C-PIB-PET for prediction of short-term conversion to Alzheimer’s disease in subjects with mild cognitive impairment

(2012) S. Zhang et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Positron emission tomography imaging in neurological disorders

(2012) Marios Politis et al.   JOURNAL OF NEUROLOGY

Imaging Imidazoline-I2 Binding Sites in Porcine Brain Using 11C-BU99008

(2012) S. Kealey et al.   JOURNAL OF NUCLEAR MEDICINE

Clinical Validation of 18F-AZD4694, an Amyloid- -Specific PET Radioligand

(2012) Z. Cselenyi et al.   JOURNAL OF NUCLEAR MEDICINE

Brain amyloid and cognition in Lewy body diseases

(2012) Stephen N. Gomperts et al.   MOVEMENT DISORDERS

β-amyloid in lewy body disease is related to Alzheimer's disease-like atrophy

(2012) Hitoshi Shimada et al.   MOVEMENT DISORDERS

Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia

(2012) R. Ossenkoppele et al.   NEUROLOGY

Thalamic cholinergic innervation is spared in Alzheimer disease compared to parkinsonian disorders

(2012) Vikas Kotagal et al.   NEUROSCIENCE LETTERS

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

In vitro characterization of [18F]-florbetaben, an Aβ imaging radiotracer

(2012) Michelle T. Fodero-Tavoletti et al.   NUCLEAR MEDICINE AND BIOLOGY

In vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson's disease

(2012) S. Iannaccone et al.   PARKINSONISM & RELATED DISORDERS

Progressive Supranuclear Palsy: In Vivo SPECT Imaging of Presynaptic Vesicular Acetylcholine Transporter with [123I]-Iodobenzovesamicol

(2012) Joachim Mazère et al.   RADIOLOGY

Evaluation and initial in vitro and ex vivo characterization of the potential positron emission tomography ligand, BU99008 (2-(4,5-Dihydro-1H-imidazol-2-yl)-1- methyl-1H-indole), for the imidazoline2 binding site

(2012) Robin J. Tyacke et al.   SYNAPSE

Imaging of microglia in patients with neurodegenerative disorders

(2012) Marios Politis   Frontiers in Pharmacology

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease

(2011) M. T. Fodero-Tavoletti et al.   BRAIN

A visual [18F]FDG-PET rating scale for the differential diagnosis of frontotemporal lobar degeneration

(2011) Stefan Poljansky et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Multimodality imaging characteristics of dementia with Lewy bodies

(2011) Kejal Kantarci et al.   NEUROBIOLOGY OF AGING

18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: A phase 2 trial

(2010) Rik Vandenberghe et al.   ANNALS OF NEUROLOGY

Hypometabolism in Alzheimer-Affected Brain Regions in Cognitively Healthy Latino Individuals Carrying the Apolipoprotein E ε4 Allele

(2010) Jessica B. S. Langbaum et al.   ARCHIVES OF NEUROLOGY

Increased metabolic vulnerability in early-onset Alzheimer’s disease is not related to amyloid burden

(2010) Gil D. Rabinovici et al.   BRAIN

Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer's disease

(2010) C. R. Jack et al.   BRAIN

Cholinergic imaging in corticobasal syndrome, progressive supranuclear palsy and frontotemporal dementia

(2010) Shigeki Hirano et al.   BRAIN

Frontotemporal Lobar Degeneration

(2010) Gil D. Rabinovici et al.   CNS DRUGS

Synapse loss in dementias

(2010) Ryan Clare et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Imaging amyloid in Parkinson's disease dementia and dementia with Lewy bodies with positron emission tomography

(2010) David J. Brooks   MOVEMENT DISORDERS

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Cognition, glucose metabolism and amyloid burden in Alzheimer's disease

(2010) Ansgar J. Furst et al.   NEUROBIOLOGY OF AGING

Cerebral cortical and subcortical cholinergic deficits in parkinsonian syndromes

(2010) S. Gilman et al.   NEUROLOGY

Distribution of cerebral amyloid deposition and its relevance to clinical phenotype in Lewy body dementia

(2010) Hiroshige Fujishiro et al.   NEUROSCIENCE LETTERS

In vivo detection of neuropathologic changes in presymptomatic MAPT mutation carriers: A PET and MRI study

(2010) Michie Miyoshi et al.   PARKINSONISM & RELATED DISORDERS

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

The neuropathology of probable Alzheimer disease and mild cognitive impairment

(2009) Julie A. Schneider et al.   ANNALS OF NEUROLOGY

Mild Cognitive Impairment

(2009) Ronald C. Petersen et al.   ARCHIVES OF NEUROLOGY

Carbon 11–Labeled Pittsburgh Compound B and Carbon 11–Labeled (R)-PK11195 Positron Emission Tomographic Imaging in Alzheimer Disease

(2009) Clayton A. Wiley et al.   ARCHIVES OF NEUROLOGY

In vitro characterisation of BF227 binding to α-synuclein/Lewy bodies

(2009) Michelle T. Fodero-Tavoletti et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Basal Cerebral Metabolism May Modulate the Cognitive Effects of A  in Mild Cognitive Impairment: An Example of Brain Reserve

(2009) A. D. Cohen et al.   JOURNAL OF NEUROSCIENCE

123I-5-IA-85380 SPECT Imaging of Nicotinic Receptors in Alzheimer Disease and Mild Cognitive Impairment

(2009) E. M. Mitsis et al.   JOURNAL OF NUCLEAR MEDICINE

Comparative Evaluation of the Translocator Protein Radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a Rat Model of Acute Neuroinflammation

(2009) F. Chauveau et al.   JOURNAL OF NUCLEAR MEDICINE

Development of radioligands with optimized imaging properties for quantification of nicotinic acetylcholine receptors by positron emission tomography

(2009) Andrew G. Horti et al.   LIFE SCIENCES

Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI

(2009) Susan M. Landau et al.   NEUROBIOLOGY OF AGING

Microglial activation and amyloid deposition in mild cognitive impairment: A PET study

(2009) A. Okello et al.   NEUROLOGY

Mapping of brain acetylcholinesterase alterations in Lewy body disease by PET

(2009) H. Shimada et al.   NEUROLOGY

Fluorodeoxyglucose–Positron-Emission Tomography, Single-Photon Emission Tomography, and Structural MR Imaging for Prediction of Rapid Conversion to Alzheimer Disease in Patients with Mild Cognitive Impairment: A Meta-Analysis

(2008) Y. Yuan et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Frequent Amyloid Deposition Without Significant Cognitive Impairment Among the Elderly

(2008) Howard Jay Aizenstein et al.   ARCHIVES OF NEUROLOGY

Increased Binding of Peripheral Benzodiazepine Receptor in Alzheimer's Disease Measured by Positron Emission Tomography with [11C]DAA1106

(2008) Fumihiko Yasuno et al.   BIOLOGICAL PSYCHIATRY

Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease

(2008) Milos D. Ikonomovic et al.   BRAIN

Dementia in Parkinsonʼs disease

(2008) Dag Aarsland et al.   CURRENT OPINION IN NEUROLOGY

Acetylcholine receptors in dementia and mild cognitive impairment

(2008) Osama Sabri et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer’s disease

(2008) Yi Li et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

In vitro high affinity α-synuclein binding sites for the amyloid imaging agent PIB are not matched by binding to Lewy bodies in postmortem human brain

(2008) Liang Ye et al.   JOURNAL OF NEUROCHEMISTRY

Current and future uses of neuroimaging for cognitively impaired patients

(2008) Gary W Small et al.   LANCET NEUROLOGY

5-123I-A-85380 binding to the α4β2-nicotinic receptor in mild cognitive impairment

(2008) Emma Terrière et al.   NEUROBIOLOGY OF AGING

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

(2008) Paul Edison et al.   NEUROBIOLOGY OF DISEASE

Imaging amyloid deposition in Lewy body diseases

(2008) S. N. Gomperts et al.   NEUROLOGY

PET imaging of the in vivo brain acetylcholinesterase activity and nicotine binding in galantamine-treated patients with AD

(2007) A. Kadir et al.   NEUROBIOLOGY OF AGING

[11C]PIB binding in Parkinson's disease dementia

(2007) Walter Maetzler et al.   NEUROIMAGE

Imaging of amyloid plaques and cerebral glucose metabolism in semantic dementia and Alzheimer’s disease

(2007) Alexander Drzezga et al.   NEUROIMAGE