Article
Chemistry, Multidisciplinary
Naoya Kawakami, Hiroki Sato, Naohiro Terasaka, Kunio Matsumoto, Hiroaki Suga
Summary: The researchers have developed a ubiquitin-based protein ligand multimer, called U-bodies, as a surrogate agonist for the MET receptor. These U-body constructs have high binding affinity, thermal stability, and proteolytic stability. By assembling them into dimeric, tetrameric, and octameric structures, potent MET activation and cell proliferation-promoting activities are achieved.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Eva Prasnikar, Andrej Perdih, Jure Borisek
Summary: NK cells exert their cytolytic function against tumors and virally infected cells through interactions with specific ligands on target cells, which involve complex molecular events and signal transduction mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
David Tomaz, Pedro Matos Pereira, Nadia Guerra, Julian Dyson, Keith Gould, Ricardo Henriques
Summary: NK cell inhibition and activation rely on the nanoscale colocalization of their receptors. NKG2D and Ly49A integrate signals at the immune synapse based on their relative positioning, which is affected by the size of NK cell ligand-receptor pairs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Pere Monge, Kaja Borup Lovschall, Ane Bretschneider Sogaard, Raoul Walther, Thaddeus W. Golbek, Lars Schmuser, Tobias Weidner, Alexander N. Zelikin
Summary: A fully synthetic, chemical apoptosis-inducing receptor (AIR) molecule has been designed to be anchored into the lipid bilayer of cells and release a highly potent toxin in response to incoming biological input. The synthetic receptor has four elements and can be installed into cells with minimal handling, remaining dormant until external activation triggers the release of the toxin. Activation of the receptor in 3D cell culture remains accessible for at least 5 days, outperforming other state of the art receptor designs.
Article
Multidisciplinary Sciences
Ruiju Wang, Ruixuan Wang, Mengmeng Liu, Weiwei Yuan, Zhiying Zhao, Xiaoqian Liu, Yameng Peng, Xiaorui Yang, Yu Sun, Wenqiang Tang
Summary: BZR1, a key transcription factor in the brassinosteroid signaling pathway, is tightly regulated by phosphorylation and subcellular localization; it can be rapidly recruited from the cytoplasm to the nucleus by BR treatment, and its protein abundance is regulated by two distinct turnover mechanisms.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Allergy
Francesca Levi-Schaffer, Bernhard F. Gibbs, Jenny Hallgren, Carlo Pucillo, Frank Redegeld, Frank Siebenhaar, Joana Vitte, Soraya Mezouar, Moiese Michel, Pier Giorgio Puzzovio, Marcus Maurer
Summary: With the advancement of research technologies and methodologies, there has been an increased understanding of the origin, development, function, and interactions of human mast cells. The potential contribution of mast cells to disease has led to the development of novel therapeutic approaches.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Momoko Akiyama, Ryosuke Ueki, Masataka Yanagawa, Mitsuhiro Abe, Michio Hiroshima, Yasushi Sako, Shinsuke Sando
Summary: In this study, a synthetic receptor agonist was designed using a DNA aptamer as a building block to fine-tune agonism. The developed synthetic partial agonist can regulate therapeutically relevant cellular activities by eliciting finely-tuned receptor signaling.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Engineering, Biomedical
Rocco Latorre, Paulina D. Ramirez-Garcia, Alan Hegron, James L. Grace, Jeffri S. Retamal, Priyank Shenoy, Mai Tran, Luigi Aurelio, Bernard Flynn, Daniel P. Poole, Rafael Klein-Cloud, Dane D. Jensen, Thomas P. Davis, Brian L. Schmidt, John F. Quinn, Michael R. Whittaker, Nicholas A. Veldhuis, Nigel W. Bunnett
Summary: Stable star polymer nanostars that release antagonists continuously for 24 hours provide effective and long-lasting relief from chronic pain by disrupting endosomal signaling.
Article
Oncology
Andrew O. Yam, Jacqueline Bailey, Francis Lin, Arnolda Jakovija, Scott E. Youlten, Claudio Counoupas, Matthias Gunzer, Tobias Bald, Trent M. Woodruff, James A. Triccas, Leonard D. Goldstein, David Gallego-Ortega, Shane T. Grey, Tatyana Chtanova
Summary: Intratumoral injection of microbial bioparticles stimulates neutrophil antitumor functions, leading to remodeling of tumor tissue, repression of tumor growth, and enhancement of checkpoint inhibitor therapy. This indicates the potential of microbial therapy in the treatment of solid cancers.
Article
Chemistry, Multidisciplinary
Hui Chen, Wanyu Xu, Hui Shi, Yan Qiao, Xiaoxiao He, Jing Zheng, Shaohong Zhou, Xiaohai Yang, Kemin Wang, Jianbo Liu
Summary: In this study, an artificial transmembrane signal transduction system using DNA-based artificial membrane receptors is described. Through low pH-mediated formation of the i-motif and dimerization of the receptors, fluorescence resonance energy transfer and G-quadruplex/hemin-mediated fluorescence amplification are activated within giant unilamellar vesicles. The study also establishes an intercellular signal communication model using coacervate microdroplets, which activate the dimerization of artificial receptors and subsequent fluorescence production or polymerization in giant unilamellar vesicles.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Oncology
Qingqing Dai, Quratul Ain, Michael Rooney, Fei Song, Alexander Zipprich
Summary: IQGAPs are a class of proteins that regulate cellular activities by controlling cytoskeletal remodeling and cellular signal transduction. In hepatocellular carcinoma, IQGAP1 and 3 are upregulated and considered oncogenes, while IQGAP2 is downregulated and acts as a tumor suppressor. This review provides a detailed overview of the structure, expression, and role of IQGAPs in liver diseases and hepatocellular carcinoma, serving as a reference for further research.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemical Research Methods
Can Huang, Fengguang Guo, Han Wang, Jasmine Olivares, James Iii Dalton, Olga Belyanina, Alice R. Wattam, Clark A. Cucinell, Allan W. Dickerman, Qing-Ming Qin, Arum Han, Paul de Figueiredo
Summary: This study presents a microfluidic system called SEER that automates the selection of bacteria with enhanced intracellular survival within host cells, important for endosymbiosis. Using this system, the researchers found that Escherichia coli evolved a 55-fold enhancement in intracellular survival due to a single-point mutation in the CpxR gene regulator. This study establishes SEER as a valuable tool for studying the evolution of endosymbiosis and highlights the significance of CpxR in this process.
Article
Biochemistry & Molecular Biology
Vadim M. Gumerov, Luke E. Ulrich, Igor B. Zhulin
Summary: This study introduces a new version of the MiST database, MiST 4.0, which includes over 10,000 metagenome-assembled genomes (MAGs) and provides detailed protein representation and BioSample information. A new interface has been developed to allow users to seamlessly switch between genomes and MAGs.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Medicine, Research & Experimental
Rafaela Schober, Bianca Brandus, Thessa Laeremans, Gilles Iserentant, Camille Rolin, Geraldine Dessilly, Jacques Zimmer, Michel Moutschen, Joeri L. Aerts, Xavier Dervillez, Carole Seguin-Devaux
Summary: The study investigated the potency of NaMiX, a natural killer activating multimeric immunotherapeutic complex, in killing HIV-1 infected cells. NaMiX significantly enhanced the cytolytic activity of NK and CD8+ T cells against tumor cells and HIV-1 infected cells, and also improved the activation, cytotoxicity, IFN-γ production, and CXCR5 expression of NK cells. It is a promising approach for supporting HIV-1 cure strategies.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Xin Zhuo, Yue Wu, Xiujuan Fu, Xiaoyu Liang, Yuxin Xiang, Jianbin Li, Canquan Mao, Yuhong Jiang
Summary: Inflammatory diseases are increasing globally, and COVID-19 also exhibits hyperinflammatory responses. Protease-activated receptors (PARs) are popular drug targets involved in regulating inflammatory responses in multiple systems. PARs activation has both anti-inflammatory and pro-inflammatory effects depending on the context of inflammation. Recent findings suggest that PARs also participate in COVID-19-related inflammatory cytokine release.
Article
Immunology
Abdel A. M. Shaheen, Ranjani Somayaji, Robert Myers, Christopher H. Mody
INTERNATIONAL JOURNAL OF STD & AIDS
(2018)
Article
Microbiology
Esther K. S. Lee, Mark R. Gillrie, Lu Li, Jason W. Arnason, Jung Hwan Kim, Liane Babes, Yuefei Lou, Amir Sanati-Nezhad, Stephen K. Kyei, Margaret M. Kelly, Christopher H. Mody, May Ho, Bryan G. Yipp
CELL HOST & MICROBE
(2018)
Article
Multidisciplinary Sciences
Shu Shun Li, Henry Ogbomo, Michael K. Mansour, Richard F. Xiang, Lian Szabo, Fay Munro, Priyanka Mukherjee, Roy A. Mariuzza, Matthias Amrein, Jatin M. Vyas, Stephen M. Robbins, Christopher H. Mody
NATURE COMMUNICATIONS
(2018)
Article
Respiratory System
Sachin R. Pendharkar, Maria B. Ospina, Danielle A. Southern, Naushad Hirani, Jim Graham, Peter Faris, Mohit Bhutani, Richard Leigh, Christopher H. Mody, Michael K. Stickland
BMC PULMONARY MEDICINE
(2018)
Article
Immunology
Richard F. Xiang, ShuShun Li, Henry Ogbomo, Danuta Stack, Christopher H. Mody
JOURNAL OF IMMUNOLOGY
(2018)
Article
Cell Biology
Henry Ogbomo, Martina Timm-McCann, Tavish Barnes, Richard F. Xiang, Khusraw Jamil, Anutosh Ganguly, Danuta Stack, Shaunna M. Huston, Shu Shun Li, Pina Colarusso, Christopher H. Mody
Article
Multidisciplinary Sciences
T. E. Woo, R. Lim, A. A. Heirali, N. Acosta, H. R. Rabin, C. H. Mody, R. Somayaji, M. G. Surette, C. D. Sibley, D. G. Storey, M. D. Parkins
SCIENTIFIC REPORTS
(2019)
Article
Microbiology
Khusraw Jamil, Maria J. Polyak, David D. Feehan, Philip Surmanowicz, Danuta Stack, Shu Shun Li, Henry Ogbomo, Michal Olszewski, Anutosh Ganguly, Christopher H. Mody
Review
Microbiology
Adley C. H. Mok, Christopher H. Mody, Shu Shun Li
Summary: This review explores mechanisms of fungal host defense by the immune system, highlighting both similarities and differences in granule morphology, content, release process, etc. among different immune cells, aiming to facilitate further research in this area.
Review
Primary Health Care
Alan Kaplan, Pierre Arsenault, Brian Aw, Vivien Brown, George Fox, Ron Grossman, Taj Jadavji, Craig Laferriere, Suzanne Levitz, Mark Loeb, Andrew McIvor, Christopher H. Mody, Yannick Poulin, Marla Shapiro, Dominique Tessier, Francois Theoret, Karl Weiss, John Yaremko, George Zhanel
CANADIAN FAMILY PHYSICIAN
(2019)
Article
Immunology
Shu Shun Li, Marwah Saleh, Richard F. Xiang, Henry Ogbomo, Danuta Stack, Shaunna H. Huston, Christopher H. Mody
INTERNATIONAL IMMUNOLOGY
(2019)
Article
Respiratory System
Taylor E. Woo, Rachel Lim, Michael G. Surette, Barbara Waddell, Joel C. Bowron, Ranjani Somayaji, Jessica Duong, Christopher H. Mody, Harvey R. Rabin, Douglas G. Storey, Michael D. Parkins
Article
Respiratory System
Kate Skolnik, Shaunna Huston, Christopher H. Mody
CLINICS IN CHEST MEDICINE
(2017)
Article
Cardiac & Cardiovascular Systems
David R. Stather, Alain Tremblay, Elaine Dumoulin, Paul MacEachern, Alex Chee, Christopher Hergott, Jacob Gelberg, Gary A. Gelfand, Paul Burrowes, John H. MacGregor, Christopher H. Mody
ANNALS OF THORACIC SURGERY
(2017)
