The multiple faces of CD5

Protein Kinase CK2 Controls the Fate between Th17 Cell and Regulatory T Cell Differentiation

(2017) Sara A. Gibson et al.   JOURNAL OF IMMUNOLOGY

Human Blood CD1c+Dendritic Cells Encompass CD5highand CD5lowSubsets That Differ Significantly in Phenotype, Gene Expression, and Functions

(2017) Xiangyun Yin et al.   JOURNAL OF IMMUNOLOGY

Naïve helper T cells with high CD5 expression have increased calcium signaling

(2017) Claudia M. Tellez Freitas et al.   PLoS One

A distinct subset of plasmacytoid dendritic cells induces activation and differentiation of B and T lymphocytes

(2017) Hong Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunomodulatory effects of soluble CD5 on experimental tumor models

(2017) Inês T. Simões et al.   Oncotarget

Impact of the functional CD5 polymorphism A471V on the response of chronic lymphocytic leukaemia to conventional chemotherapy regimens

(2016) Julio Delgado et al.   BRITISH JOURNAL OF HAEMATOLOGY

CD5 Binds to Interleukin-6 and Induces a Feed-Forward Loop with the Transcription Factor STAT3 in B Cells to Promote Cancer

(2016) Chunyan Zhang et al.   IMMUNITY

Inherited functional variants of the lymphocyte receptor CD5 influence melanoma survival

(2016) Miriam Potrony et al.   INTERNATIONAL JOURNAL OF CANCER

CD5-mediated inhibition of TCR signaling proceeds normally in the absence of SHP-1

(2016) BAOXIA DONG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Co‐recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR‐induced ubiquitylation

(2016) Guillaume Voisinne et al.   Molecular Systems Biology

CD5-CK2 Signaling Modulates Erk Activation and Thymocyte Survival

(2016) Carlos A. Mier-Aguilar et al.   PLoS One

Protein kinase CK2 governs the molecular decision between encephalitogenic TH17 cell and Tregcell development

(2016) Alexander Ulges et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional requirement of tyrosine residue 429 within CD5 cytoplasmic domain for regulation of T cell activation and survival

(2015) Carlos A. Mier-Aguilar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CD5 Instructs Extrathymic Regulatory T Cell Development in Response to Self and Tolerizing Antigens

(2015) Jacob G. Henderson et al.   IMMUNITY

The TCR's sensitivity to self peptide–MHC dictates the ability of naive CD8+ T cells to respond to foreign antigens

(2014) Ross B Fulton et al.   NATURE IMMUNOLOGY

Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC

(2014) Stephen P Persaud et al.   NATURE IMMUNOLOGY

Transgenic Expression of Soluble Human CD5 Enhances Experimentally-Induced Autoimmune and Anti-Tumoral Immune Responses

(2014) Rafael Fenutría et al.   PLoS One

Analysis of Ancestral and Functionally Relevant CD5 Variants in Systemic Lupus Erythematosus Patients

(2014) Maria Carmen Cenit et al.   PLoS One

The carboxy-terminal region of CD5 is required for c-CBL mediated TCR signaling downmodulation in thymocytes

(2013) Nelly S. Roa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CD5 enhances Th17-cell differentiation by regulating IFN-γ response and RORγt localization

(2013) Donald J. McGuire et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD5-Dependent CK2 Activation Pathway Regulates Threshold for T Cell Anergy

(2012) C. M. Sestero et al.   JOURNAL OF IMMUNOLOGY

Hepatitis C Virus Infection of Human T Lymphocytes Is Mediated by CD5

(2012) M. A. Sarhan et al.   JOURNAL OF VIROLOGY

Distinct CD4+ helper T cells involved in primary and secondary responses to infection

(2012) K. S. Weber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Historical Overview of Immunological Tolerance

(2012) R. H. Schwartz   Cold Spring Harbor Perspectives in Biology

PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation by Regulating Gfi1 Expression and Nuclear Translocation of RORγ

(2012) Yutaka Kurebayashi et al.   Cell Reports

CD5 costimulation induces stable Th17 development by promoting IL-23R expression and sustained STAT3 activation

(2011) J. de Wit et al.   BLOOD

The immunomodulatory properties of the CD5 lymphocyte receptor in health and disease

(2011) Gloria Soldevila et al.   CURRENT OPINION IN IMMUNOLOGY

A New Pathway of CD5 Glycoprotein-mediated T Cell Inhibition Dependent on Inhibitory Phosphorylation of Fyn Kinase

(2011) Martina Bamberger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rescue of Tumor-Infiltrating Lymphocytes from Activation-Induced Cell Death Enhances the Antitumor CTL Response in CD5-Deficient Mice

(2011) M. Tabbekh et al.   JOURNAL OF IMMUNOLOGY

Lyn-mediated SHP-1 recruitment to CD5 contributes to resistance to apoptosis of B-cell chronic lymphocytic leukemia cells

(2011) E Tibaldi et al.   LEUKEMIA

Increased antigen responsiveness of naive CD8 T cells exposed to IL-7 and IL-21 is associated with decreased CD5 expression

(2010) Julien Gagnon et al.   IMMUNOLOGY AND CELL BIOLOGY

A Conserved Enhancer Element Differentially Regulates Developmental Expression of CD5 in B and T Cells

(2010) R. Berland et al.   JOURNAL OF IMMUNOLOGY

A Ligand for CD5 Is CD5

(2010) M. H. Brown et al.   JOURNAL OF IMMUNOLOGY

Increased numbers of thymic and peripheral CD4+ CD25+Foxp3+ cells in the absence of CD5 signaling

(2009) Diana Ordoñez-Rueda et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mechanisms maintaining peripheral tolerance

(2009) Daniel L Mueller   NATURE IMMUNOLOGY

The CD5 ectodomain interacts with conserved fungal cell wall components and protects from zymosan-induced septic shock-like syndrome

(2009) J. Vera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD5 plays an inhibitory role in the suppressive function of murine CD4+ CD25+ Treg cells

(2008) Trivikram Dasu et al.   IMMUNOLOGY LETTERS

Differential Regulation of STAT Family Members by Glycogen Synthase Kinase-3

(2008) Eléonore Beurel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

(2008) S. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology