20-Hydroxy- and 20-carboxy-leukotriene (LT) B4 downregulate LTB4 -mediated responses of human neutrophils and eosinophils

The Endocannabinoid Metabolite Prostaglandin E2(PGE2)-Glycerol Inhibits Human Neutrophil Functions: Involvement of Its Hydrolysis into PGE2and EP Receptors

(2017) Caroline Turcotte et al.   JOURNAL OF IMMUNOLOGY

Leukotriene B₄ Metabolism and p70S6 Kinase 1 Inhibitors: PF-4708671 but Not LY2584702 Inhibits CYP4F3A and the ω-Oxidation of Leukotriene B₄ In Vitro and In Cellulo

(2017) Anne-Sophie Archambault et al.   PLoS One

Recent advances in clinical development of leukotriene B4 pathway drugs

(2017) L. Bhatt et al.   SEMINARS IN IMMUNOLOGY

Neutrophil Resolvin E1 Receptor Expression and Function in Type 2 Diabetes

(2016) Marcelo O. Freire et al.   JOURNAL OF IMMUNOLOGY

On the cellular metabolism of the click chemistry probe 19-alkyne arachidonic acid

(2016) Philippe Pierre Robichaud et al.   JOURNAL OF LIPID RESEARCH

Correlation between CCL26 production by human bronchial epithelial cells and airway eosinophils: Involvement in patients with severe eosinophilic asthma

(2015) Marie-Chantal Larose et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Leukotriene B4 Enhances NOD2-Dependent Innate Response against Influenza Virus Infection

(2015) Manon Le Bel et al.   PLoS One

CYP4F18-Deficient Neutrophils Exhibit Increased Chemotaxis to Complement Component C5a

(2015) Rachel Vaivoda et al.   Journal of Immunology Research

Altered leukotriene B4 metabolism in CYP4F18-deficient mice does not impact inflammation following renal ischemia

(2014) Valeria Winslow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mechanisms of human eosinophil migration induced by the combination of IL-5 and the endocannabinoid 2-arachidonoyl-glycerol

(2014) Marie-Chantal Larose et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A randomized double blind, placebo controlled phase 2 trial of BIIL 284 BS (an LTB4 receptor antagonist) for the treatment of lung disease in children and adults with cystic fibrosis

(2014) M.W. Konstan et al.   Journal of Cystic Fibrosis

Diverse novel functions of neutrophils in immunity, inflammation, and beyond

(2013) Attila Mócsai   JOURNAL OF EXPERIMENTAL MEDICINE

Leukotriene B4, an Endogenous Stimulator of the Innate Immune Response against Pathogens

(2013) Manon Le Bel et al.   Journal of Innate Immunity

Randomized, Double-Blind, Phase II Trial Comparing Gemcitabine-Cisplatin plus the LTB4 Antagonist LY293111 versus Gemcitabine-Cisplatin plus Placebo in First-Line Non–Small-Cell Lung Cancer

(2013) Pasi A. Jänne et al.   Journal of Thoracic Oncology

Metabolomic profiling of regulatory lipid mediators in sputum from adult cystic fibrosis patients

(2012) Jun Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Intrapulmonary Administration of Leukotriene B4 Augments Neutrophil Accumulation and Responses in the Lung to Klebsiella Infection in CXCL1 Knockout Mice

(2012) S. Batra et al.   JOURNAL OF IMMUNOLOGY

2-Arachidonoyl-glycerol- and arachidonic acid-stimulated neutrophils release antimicrobial effectors against E. coli, S. aureus, HSV-1, and RSV

(2012) F. Chouinard et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Endocannabinoid 2-Arachidonoyl-Glycerol Activates Human Neutrophils: Critical Role of Its Hydrolysis and De Novo Leukotriene B4 Biosynthesis

(2011) F. Chouinard et al.   JOURNAL OF IMMUNOLOGY

LTB4 increases nasal neutrophil activity and conditions neutrophils to exert antiviral effects

(2011) Henrik Widegren et al.   RESPIRATORY MEDICINE

Intrapulmonary Administration of Leukotriene B4 Enhances Pulmonary Host Defense against Pneumococcal Pneumonia

(2010) P. Mancuso et al.   INFECTION AND IMMUNITY

Resolvin D1 binds human phagocytes with evidence for proresolving receptors

(2010) S. Krishnamoorthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Randomized Double-Blind Phase II Trial Comparing Gemcitabine Plus LY293111 Versus Gemcitabine Plus Placebo in Advanced Adenocarcinoma of the Pancreas

(2009) Muhammad Wasif Saif et al.   CANCER JOURNAL

Leukotriene B4-loaded microspheres: a new therapeutic strategy to modulate cell activation

(2008) Roberto Nicolete et al.   BMC IMMUNOLOGY

Effect of the oral leukotriene B4 receptor antagonist LTB019 on inflammatory sputum markers in patients with chronic obstructive pulmonary disease

(2007) L. Grönke et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS