Article
Environmental Sciences
Ronan Adler Tavella, Caroline Lopes Feijo Fernandes, Lucia Emanueli Schimith, Lisiane Martins Volcao, Marina dos Santos, Flavio Manoel Rodrigues da Silva Junior
Summary: Socioeconomic and demographic factors, lifestyle, and cultural characteristics may have an important impact on genetic damage. This study analyzed the association between a set of factors and genetic damage by studying populations in southern Brazil. The results showed that age had a weak association with genetic damage, while factors such as skin color, occupational exposure, drug use, exposure to radiation, and the cultural habit of consuming chimarrao were found to be associated with genetic damage. Yerba mate consumption was identified as a confounding factor in cytogenetic studies in the southern region of South America.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Carla M. Ribeiro-Silva, Ana Faustino-Rocha, Rui M. Gil da Costa, Rui Medeiros, Maria J. Pires, Isabel Gaivao, Adelina Gama, Maria J. Neuparth, Joana Barbosa, Francisco Peixoto, Fernao D. Magalhaes, Margarida M. S. M. Bastos, Paula A. Oliveira
Summary: This study investigated the toxic effects of eugenol and pulegone on laboratory animals for the first time, showing that these compounds can induce behavioral changes, body weight loss, and even mortality in certain doses.
Article
Environmental Sciences
Jorid B. Sorli, Alexander C. o. Jensen, Alicja Mortensen, Jozef Szarek, Eleni Chatzigianelli, Claudia A. T. Gutierrez, Nicklas R. Jacobsen, Sarah S. Poulsen, Iosif Hafez, Charis Loizides, George Biskos, Karin S. Hougaard, Ulla Vogel, Niels Hadrup
Summary: This study evaluated the pulmonary toxicity of tungsten by exposing male mice to tungsten particles and found increased genotoxicity at certain exposure levels. However, no adverse effects were observed on body weight, inflammation, or organ pathology. The study suggests that tungsten exhibits non-dose dependent genotoxicity without inflammation.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Environmental Sciences
Serena Galati, Giovanni DalCorso, Antonella Furini, Rosaria Fragni, Chiara Maccari, Paola Mozzoni, Gianluigi Giannelli, Annamaria Buschini, Giovanna Visioli
Summary: This study assessed the DNA damage caused by cadmium in the hyperaccumulator Noccaea caerulescens and the non-accumulator Arabidopsis thaliana. The results showed that Noccaea caerulescens had less DNA damage compared to Arabidopsis thaliana under cadmium treatment. Furthermore, Noccaea caerulescens exhibited increased CpG DNA methylation and MET1 gene expression, suggesting epigenetic modifications to preserve genome integrity and enhance cadmium tolerance.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Williams Nascimento de Siqueira, Elvis Joacir de Franca, Dewson Rocha Pereira, Maira de Vasconcelos Lima, Hianna Arely Milca Fagundes Silva, Jose Luis Ferreira Sa, Hallysson Douglas Andrade de Araujo, Ana Maria Mendonca de Albuquerque Melo
Summary: The study investigated the genotoxic and cytotoxic effects of domestic sewage sludge on the mollusk Biomphalaria glabrata. The results showed deleterious effects on mollusk cells, confirming genotoxicity and cytotoxicity caused by domestic sewage sludge. The mollusk B. glabrata can be a cost-effective alternative for biomonitoring freshwater environments.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Celeste Ruiz de Arcaute, Milagros R. Laborde, Sonia Soloneski, Marcelo L. Larramendy
Summary: The lethal and sublethal effects of IMI on Cnesterodon decemmaculatus were evaluated through acute exposure to environmentally relevant concentrations. The study found that the LC50 96 h value of IMI was 35.59 mg/L. Additionally, sublethal concentrations of IMI caused genetic damage, increased catalase activity, and decreased total protein content in the fish.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Agricultural Engineering
Jeferson Adriano e Silva Assuncao, Diego da Silva Marcelino, Jessica Regina Sales Felisberto, Elsie Fraklin Guimaraes, George de Azevedo Queiroz, Ygor Jesse Ramos, Davyson de Lima Moreira
Summary: This study aimed to assess the post-harvest impact of UV-C irradiation on the metabolic profile of essential oils (EOs) from fresh leaves of Piper aduncum cultivated in Southeastern Brazil. The results showed that UV-C radiation can alter the relative percentage of specific chemical constituents, with a significant increase in the relative percentage of the compound dillapiole. This study suggests that UV-C irradiation may be a promising technique for enriching the dillapiole content in the essential oil of P. aduncum.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Environmental Sciences
Paulina Abrica-Gonzalez, Sandra Gomez-Arroyo, Aron Jazcilevich-Diamant, Antonio Sotelo-Lopez, Ana Rosa Flores-Marquez, Josefina Cortes-Eslava
Summary: Nanoparticles are causing concerns due to their potential toxicity when incorporated into consumer products and industrial applications. The automotive industry, in particular, is emitting a large number of nanoparticles into the atmosphere through the use of novel materials. Taraxacum officinale was used as a bioindicator to assess the effects of ZnO and CuO nanoparticles on growth rate, chlorophyll content, and DNA damage. The study demonstrated the feasibility of using Taraxacum officinale as a bioindicator for atmospheric nanoparticles toxicity, and the high sensitivity of the comet assay for evaluating DNA damage.
WATER AIR AND SOIL POLLUTION
(2023)
Article
Environmental Sciences
Jelena Radovanovic, Biljana Antonijevic, Stoimir Kolarevic, Sanja Milutinovic-Smiljanic, Jelena Mandic, Branka Vukovic-Gacic, Zorica Bulat, Marijana Curcic, Margareta Kracun-Kolarevic, Karolina Sunjog, Jovana Kostic-Vukovic, Jovana Jovanovic Maric, Evica Antonijevic-Miljakovic, Danijela Dukic-Cosic, Aleksandra Buha Djordjevic, Dragana Javorac, Katarina Baralic, Zoran Mandinic
Summary: The study revealed that sodium fluoride (NaF) at high doses had toxic effects on blood, liver, spleen, and brain cells of rats, but selenium supplementation reduced DNA damage in liver and spleen cells. However, a similar protective effect was not observed in brain cells.
Article
Pharmacology & Pharmacy
Tianlong Liu, Yao Zhang, Jing Liu, Junwen Peng, Xin Jia, Yunfeng Xiao, Lanbing Zheng, Yu Dong
Summary: The study found that Jaranol was relatively safe in mice when administered orally in both acute and sub-acute toxicity tests, but caused changes in body weight and biochemical parameters. More chronic toxicity studies are recommended to ensure its safety for human use.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Armelle T. Mbaveng, Brice E. N. Wamba, Gabin T. M. Bitchagno, Simplice Beaudelaire Tankeo, Ilhami Celik, Brice C. K. Atontsa, Antoine H. Nkuete Lonfouo, Victor Kuete, Thomas Efferth
Summary: Piper capense is a medicinal spice with potential cytotoxic effects against various cancer cell lines, especially compound 2 and PCFb, which induce apoptosis in cancer cells. These findings suggest that Piper capense could be explored further for developing new drugs to combat malignancies.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Andre M. Marques, Alexandre Siqueira da Rocha Queiroz, Elsie F. Guimaraes, Ana Carolina Mafud, Paulo de Sousa Carvalho, Yvonne Primerano Mascarenhas, Thais da Silva Barenco, Pamella Dourila N. Souza, David William Provance, Jose Hamilton M. do Nascimento, Cristiano G. Ponte, Maria Auxiliadora C. Kaplan, Davyson de Lima Moreira, Maria Raquel Figueiredo
Summary: Piper species, especially Piper tectoniifolium Kunth, are potential natural sources of the bioactive compound (-)-grandisin. A new method for identifying (-)-grandisin was developed, and the molecule was found to have a vasorelaxant effect. These findings suggest that P. tectoniifolium has the potential to be a renewable source of grandisin and a template for the development of new drugs.
Article
Food Science & Technology
Julen Sanz-Serrano, Ariane Vettorazzi, Damian Muruzabal, Amaya Azqueta, Adela Lopez de Cerain
Summary: This article provides a complete in vitro genotoxicity assessment of three nutrients widely used in the European market, demonstrating that they did not show genotoxicity in any of the conditions tested. This study contributes to the limited evidence available and complements EFSA recommendations for in vitro genotoxicity testing of nutrients.
Article
Environmental Sciences
Nicholas Silvestre de Souza Trigueiro, Bruno Bastos Gonsalves, Felipe Cirqueira Dias, Emilia Celma de Oliveira Lima, Thiago Lopes Rocha, Simone Maria Teixeira Saboia-Morais
Summary: The co-exposure of iron oxide nanoparticles and glyphosate-based herbicide induced genotoxicity and mutagenicity in freshwater fish, with effects becoming more pronounced over time.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Plant Sciences
Ygor Jesse Ramos, Jessica Sales Felisberto, Joao Gabriel Gouvea-Silva, Ulisses Carvalho de Souza, Claudete da Costa-Oliveira, George Azevedo de Queiroz, Elsie Franklin Guimaraes, Nicholas John Sadgrove, Davyson de Lima Moreira
Summary: This study tested the hypothesis that clonal chemical heritability is crucial for the conservation of chemical uniformity in controlled monoclonal cultivation of Piper essential oils. The results showed that while clonal heritability is important for chemical homology, significant chemical plasticity can occur when cultivated from wild specimens.
Article
Biochemical Research Methods
Ingrid V. Farias, Clarissa Krieger Amorin, Milena Guimaraes dos Santos, Carmem Lucia dos Santos Machado, Favero Reisdorfer Paula, Louis P. Sandjo, Angela Malheiros, Christiane Meyre-Silva, Tania Mari Belle Bresolin
PHYTOCHEMICAL ANALYSIS
(2020)
Article
Immunology
Roberta Nunes, Milena Fronza Broering, Renata De Faveri, Fernanda Capitanio Goldoni, Luisa Nathalia Bolda Mariano, Pamela Cecilia Muller Mafessoli, Franco Delle Monache, Valdir Cechinel Filho, Rivaldo Niero, Jose Roberto Santin, Nara Lins Meira Quintao
Summary: The methanol extract of Garcinia humilis leaves shows significant anti-inflammatory effects by reducing neutrophil migration and important chemical mediator release. This reinforces its traditional use as a medicinal plant for treating inflammatory illnesses.
INFLAMMOPHARMACOLOGY
(2021)
Article
Plant Sciences
Saravanan Shanmugam, Parimelazhagan Thangaraj, Bruno dos Santos Lima, Gabriela G. G. Trindade, Narendra Narain, Ana Mara de Oliveira e Silva, Jose Roberto Santin, Milena Fronza Broering, Mairim Russo Serafini, Lucindo Jose Quintans-Junior, Adrian Antunes de Souza Araujo
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Plant Sciences
Aline De Faveri, Renata De Faveri, Milena Fronza Broering, Izabel Terranova Bousfield, Marina Jagielski Goss, Samuel Paulo Muller, Raquel Oliveira Pereira, Ana Mara de Oliveira e Silva, Isabel Daufenback Machado, Nara Lins Meira Quintao, Jose Roberto Santin
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Plant Sciences
Jade Andre de Souza, Yasmin Beatrisse Klein Patel, Heloise Adeli Grockoski, Roberta Nunes, Silvia Aparecida Ramos, Maria Veronica Davila Pastor, Luis Carlos Stoeberl, Adriana Campos, Valdir Cechinel Filho, Jose Roberto Santin, Nara Lins Meira Quintao
Summary: The study demonstrated the anti-inflammatory activity of Synadenium grantii extract by reducing leukocyte influx and inflammatory cytokine levels. The toxicological analysis showed no significant acute or subacute toxicity when administered to mice orally.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Food Science & Technology
Deise Tramontin, Santiago Esmiro Cadena-Carrera, Jamil Assreuy, Roberta Nunes, Jose Roberto Santin, Ariovaldo Bolzan, Marintho Quadri
Summary: Jackfruit seeds are a valuable source of bioactive compounds such as triterpenes and sterols, with potential anti-inflammatory and cytotoxic properties. This study evaluated the extraction of these compounds using high- and low-pressure techniques, with supercritical CO2 showing promising results. In vitro tests indicated no cytotoxicity in L929 cells at certain concentrations, and some extracts exhibited anti-inflammatory properties in RAW 264.7 cells, suggesting potential applications in pharmaceutical and food industries.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2021)
Article
Immunology
Larissa Benvenutti, Roberta Nunes, Ivonilce Venturi, Silvia Aparecida Ramos, Milena Fronza Broering, Fernanda Capitanio Goldoni, Sarah Eskelsen Pavan, Maria Veronica Davila Pastor, Angela Malheiros, Nara Lins Meira Quintao, Elizabeth Soares Fernandes, Jose Roberto Santin
Summary: The study demonstrated that the fruit extract of S. diploconos has anti-inflammatory and wound healing activities by modulating neutrophil migration and macrophage-dependent efferocytosis of apoptotic cells. It also showed potential as a healing agent without toxic or genotoxic effects.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Immunology
Marina de Paula-Silva, Gustavo Henrique Oliveira da Rocha, Milena Fronza Broering, Maria Luiza Queiroz, Silvana Sandri, Rodrigo Azevedo Loiola, Sonia Maria Oliani, Andrea Vieira, Mauro Perretti, Sandra Helena Poliselli Farsky
Summary: Non-responsiveness to anti-TNF-alpha therapies is common in inflammatory bowel disease patients, highlighting the importance of finding biomarkers associated with therapeutic efficacy. Levels of colonic formyl peptide receptor 1 and annexin A1 are correlated with histological recovery in Crohn's disease patients under remission. Infliximab may induce annexin A1 expression and secretion in activated intestinal leukocytes, potentially stimulating epithelial formyl peptide receptors and promoting wound healing in inflammatory bowel disease patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Jose Roberto Santin, Larissa Benvenutti, Milena Fronza Broering, Roberta Nunes, Fernanda Capitanio Goldoni, Yasmin Beatrisse Klein Patel, Jade Andre de Souza, Mainara Adriane Tesser Kopp, Priscila de Souza, Rita de Cassia Vilhena da Silva, Maria Veronica Davila Pastor, Angelita Boldieri de Souza, Leticia Debatin Testoni, Angelica Garcia Couto, Tania Mari Belle Bresolin, Nara Lins Meira Quintao
Summary: The study showed that the extract from Sambucus nigra flowers has anti-inflammatory and relaxant effects, reducing neutrophil migration and levels of inflammatory mediators, promoting efferocytosis and resolution of acute inflammation. It also has antinociceptive effects and relaxation effect on smooth muscle tissues of both vascular and non-vascular rat, supporting its traditional medicinal use.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Applied
Angelita B. de Souza, Leticia D. Testoni, Thayna B. Pereira, Nara L. M. Quintao, Jose R. Santin, Tania M. B. Bresolin, Angelica G. Couto
Summary: In this study, spray dried microparticles of elderberry flowers were developed using optimized drying conditions and formulation, which improved their stability and ease of application.
NATURAL PRODUCT RESEARCH
(2022)
Article
Immunology
Nara Lins Meira Quintao, Jaqueline Pavesi Reis, Larissa Benvenutti, Roberta Nunes, Fernanda Capitanio Goldoni, Manuela Somensi Cozer, Priscila de Souza, Rita de Cassia Melo Vilhena de Andrade Fonseca da Silva, Jessica Melato, Carlos Rafael Vaz, Juliana Cristina Pereira Whitaker, Flavia Werner Jesuino, Mariana Couto Costa, Maria Veronica Davila Pastor, Angela Malheiros, Christiane Meyre-Silva, Jose Roberto Santin
Summary: P. malacophyllum may have potential in alleviating symptoms of primary dysmenorrhoea by reducing pain, inflammation, and uterine spasms. The isolated compounds and extracts were found to decrease abdominal writhing, neutrophil chemotaxis, and inflammatory mediator release, while attenuating neutrophil and mast cell infiltration in the uterus of mice with primary dysmenorrhoea.
INFLAMMOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marina de Paula-Silva, Milena Fronza Broering, Pablo Scharf, Gustavo Henrique Oliveira da Rocha, Sandra Farsky, Adriana Lino-dos-Santos-Franco
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2020)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)