Article
Chemistry, Applied
Jinfeng Chen, Yanli Cui, Shenggui Zhang, Yunxiang Ma, Fumin Yang
Summary: This study investigated the effects of pectin and thiolated pectin alone and in combination with Na2HPO4 on the performance of gluten. The results showed that thiolated pectin and Na2HPO4 significantly improved the strength, viscoelasticity, and stability of gluten.
Article
Polymer Science
Gilberto S. N. Bezerra, Tielidy A. de M. de Lima, Declan M. Colbert, Joseph Geever, Luke Geever
Summary: This study aimed to demonstrate the feasibility of using hot-melt extrusion to develop extended-release formulations of Fenbendazole dispersed in PEO/PCL blend-based matrices. The results showed that the drug converted to its amorphous state after thermal treatment, and the release rate of the drug could be controlled by adjusting the content of PCL in the blend.
Article
Food Science & Technology
Eden Shlush, Maya Davidovich-Pinhas
Summary: Ethyl-cellulose was used for thermal fabrication of bioplastic materials, and plasticizers were added to improve thermal and mechanical properties, resulting in stronger and more flexible films. These films are suitable for packaging fresh produce.
FOOD PACKAGING AND SHELF LIFE
(2023)
Article
Biochemistry & Molecular Biology
Eun-Ji Go, Byeong-Ryeol Ryu, Su-Ji Ryu, Hyun-Bok Kim, Hyun-Tai Lee, Jin-Woo Kwon, Jong-Suep Baek, Jung-Dae Lim
Summary: Hot-melt extrusion processing of mulberry samples led to the production of colloidal dispersions, improving water solubility and stability of anthocyanins with prolonged release.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Kinga Biedrzycka, Agnieszka Marcinkowska
Summary: In this study, the hot melt extrusion method was used to obtain an amorphous dispersion of an active pharmaceutical ingredient (API) that is sparingly soluble in water. The extrusion conditions included a screw rotation speed of 250 rpm, temperature above 100°C, and two mixing zones. The use of Eudragit EPO as a polymer matrix and ibuprofen as an API was investigated. The addition of the plasticizer Compritol 888 ATO improved processing parameters and modified the release profile of ibuprofen. The obtained solid dispersions showed good stability and released about 40% to 63% of the API within 180 minutes.
Article
Instruments & Instrumentation
Rhayssa de Oliveira Nonato, Anna Paula Krawczyk-Santos, Gleidson Cardoso, Ana Carolina Kogawa, Karina Ricommini, Adley Antonini Neves de Lima, Luana Heimfarth, Lucindo Jose Quintans-Junior, Marcilio Cunha-Filho, Stephania Fleury Taveira, Ricardo Neves Marreto
Summary: This study investigated the use of hot-melt extrusion (HME) processing for molecular encapsulation of a multi-component natural product, ginger oleoresin (OR), with cyclodextrins. The results showed that HME complexes exhibited better solubility, dissolution, and anti-inflammatory activity compared to solvent-based complexes. These findings suggest that HME can be a useful method for encapsulating complex natural products containing volatile and thermolabile substances.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Yun-Chu Chen, Dana E. Moseson, Coralie A. Richard, Monica R. Swinney, Sarena D. Horava, Kaoutar Abbou Oucherif, Amy L. Cox, Eric D. Hawkins, Yongzhe Li, Daniel F. DeNeve, Joshua Lomeo, Aiden Zhu, L. Tiffany Lyle, Eric J. Munson, Lynne S. Taylor, Kinam Park, Yoon Yeo
Summary: In this study, a polymeric implant that can sustain release meloxicam was developed for effective resolution of regional subacute inflammation and prevention of biofouling formation. The choice of polymer platform is crucial to continuous release of meloxicam, and the drug release rate can be controlled by the amount of drug loaded in the polymer matrices.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Khater AL-Japairai, Samah Hamed Almurisi, Syed Mahmood, Thiagarajan Madheswaran, Bappaditya Chatterjee, Prasanthi Sri, Nadiatul Azra Binti Ahmad Mazlan, Turki Al Hagbani, Fawaz Alheibshy
Summary: Oral administration of drugs is preferred for being non-invasive, easy to administer, and easy to store. However, the poor solubility of drugs in oral formulations limits their effectiveness and commercial value. Amorphous solid dispersion (ASD), a method that changes the molecular structure of drugs to improve solubility, is being used with the emerging hot melt extrusion (HME) method in the pharmaceutical industry. Despite solving solubility issues, ASD also poses a risk of crystallization, requiring optimization in formulation, polymers, and HME manufacturing processes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Yaser Mansuroglu, Jennifer Dressman
Summary: Hot-melt extrusion is widely used in the pharmaceutical industry to increase the solubility of poorly soluble drugs. This study investigated the release of flurbiprofen from sustained-release hot-melt extrudates with different Eudragit polymers. The choice of polymer and particle size reduction by milling were found to be key factors influencing the release profile, while drug loading and hydrodynamics had minimal impact. Hot-melt extrusion allows for tailored drug release through particle size and polymer selection, with robustness under various hydrodynamic conditions.
Article
Pharmacology & Pharmacy
Jiawei Han, Mengyuan Tang, Yang Yang, Wen Sun, Zhimin Yue, Yunran Zhang, Yijun Zhu, Xiaoqian Liu, Jue Wang
Summary: This review discusses the use of solid dispersion systems as an effective formulation strategy to enhance the performance of poorly water-soluble drugs. It provides a comprehensive understanding of SD classification and highlights the most popular amorphous solid dispersions. Furthermore, it proposes a systematic design strategy for satisfactory ASDs and explores the application of hot melt extrusion as a continuous manufacturing technique.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Polymer Science
Guangming Yan, Zhi Cao, Declan Devine, Manfred Penning, Noel M. Gately
Summary: The study explored various types of shellac and found no chemical difference between them, but identified variations in extrudable temperature ranges and rheological properties. Due to its shear-thinning behaviors, shellac can be extruded at lower temperatures, providing necessary data for processing conditions in hot melt extrusion applications for shellac materials.
Article
Medicine, Research & Experimental
Stephen A. Thompson, Daniel A. Jr Jr Davis, Chaeho Moon, Robert O. I. I. I. I. I. I. Williams
Summary: Maximizing the drug loading of pH-dependent APIs in amorphous solid dispersions (ASDs) produced by hot-melt extrusion (HME) can reduce pill burden without compromising dissolution performance. By incorporating bases to modify pH during HME, the drug loading (w/w) of telmisartan in ASDs was significantly increased from 5% to 50%. The stability of the polymer Soluplus when extruded with a strong base was also examined.
MOLECULAR PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Victoire de Margerie, Christopher McConville, Suha M. Dadou, Shu Li, Pascal Boulet, Lionel Aranda, Andrew Walker, Valentyn Mohylyuk, David S. Jones, Brian Murray, Gavin P. Andrews
Summary: During pandemics and global crises, drug shortages become critical due to increased demand, shortages in personnel, and lockdown restrictions. This study investigates the scale-up of a continuous process using hot melt extrusion with Hydroxychloroquine Sulphate as the model drug, demonstrating improved robustness with a pilot-scale vertical extruder compared to a lab-scale horizontal extruder. The vertical extruder reduces variation in crystallinity and release profile, allowing for efficient production with minimum waste of raw materials.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Food Science & Technology
Yan-Lei Li, Qi-Jun Ruan, Jin-Mei Wang, Xiao-Quan Yang
Summary: Hot-melt extrusion (HME) technology was used to enhance the water dispersibility of phytosterol using glycerol, lecithin, and gum arabic. The HME products showed improved water dispersibility and storage stability, with the P:L:G:A extrudate performing particularly well. These improvements were attributed to reduced crystallinity of phytosterol and the stabilizing effect of reaction products induced by HME.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2021)
Article
Pharmacology & Pharmacy
Da In Jeong, Sungyun Kim, Ja Seong Koo, Song Yi Lee, Minju Kim, Kwang Yeol Kim, Md Obyedul Kalam Azad, Mrinmoy Karmakar, Seongnam Chu, Byung-Jo Chae, Wie-Soo Kang, Hyun-Jong Cho
Summary: The study developed manganese sulfate-dispersed nanoparticles using a hot-melt extrusion system for chemodynamic therapy of colorectal cancer. The distribution of manganese sulfate in the extrudate and its interaction with pharmaceutical additives were analyzed. The nanoparticles showed high efficiency in generating hydroxyl radicals and inducing apoptosis in cancer cells, making them a promising treatment option.
Article
Pharmacology & Pharmacy
Youssra Moustafa Gadelkareem Mohamdeen, Atabak Ghanizadeh Tabriz, Mohammad Tighsazzadeh, Uttom Nandi, Roxanne Khalaj, Ioannis Andreadis, Joshua S. Boateng, Dennis Douroumis
Summary: This study introduces 3D printing technology for the design and fabrication of drug-eluting contact lenses for the treatment of glaucoma. By using hot melt extrusion and fusion deposition modeling, printable filaments loaded with timolol maleate were successfully produced. The study demonstrates the feasibility of using 3D printing to manufacture contact lenses with controlled drug release.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Instruments & Instrumentation
Mushfiq Akanda, Giulia Getti, Dennis Douroumis
Summary: Nanostructure lipid carriers (NLCs) were developed for the delivery of curmumin (CRN) for the treatment of prostate cancer. NLCs showed promising performance in drug delivery and cancer treatment.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Laura Andrade Junqueira, Atabak Ghanizadeh Tabriz, Francisco Jose Raposo, Luana Rocha Carobini, Urias Pardocimo Vaz, Marcos Antonio Fernandes Brandao, Dennis Douroumis, Nadia Rezende Barbosa Raposo
Summary: The study utilized Fused Deposition Modelling (FDM) and inkjet printing technologies to fabricate polyvinyl alcohol tablets and dispense minoxidil ethanolic solutions, demonstrating the potential for rapid development of personalized dosage forms.
Review
Pharmacology & Pharmacy
Atabak Ghanizadeh Tabriz, Dennis Douroumis
Summary: Advances in additive manufacturing have led to innovative strategies in the healthcare sector, particularly in the treatment and healing of chronic wounds. The incorporation of novel biomaterials and cell-laden bioinks combined with drugs has paved the way for effective wound treatment and management. The advantages of printing technologies include the combination of bioactive molecules and cells with polymers, fabrication of complex scaffold designs, accelerated healing times, and personalized wound dressings.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Atabak Ghanizadeh Tabriz, Md Sadeque Mithu, Milan D. Antonijevic, Lilian Vilain, Youri Derrar, Clara Grau, Anais Morales, Orestis L. Katsamenis, Dennis Douroumis
Summary: 3D printed LEGO (R)-like tablets were fabricated to deliver different drug substances by altering the modular units and filament composition. By combining immediate release and pH dependent compartments, we customized the release kinetics of melatonin and caffeine for the treatment of sleep disorders. The design of LEGO (R)-like compartments achieved immediate release of melatonin and controlled release of caffeine with variable lag times.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Michael I. Okereke, Roxanne Khalaj, Atabak Ghanizadeh Tabriz, Uttom Nandi, Nick Scoutaris, Dennis Douroumis
Summary: This study used computational modeling to investigate and predict the behavior of 3D printed stents. Racetrack-cell and diamond-cell shaped stents were printed using Fusion Deposition Modeling (FDM) with bioresorbable polymers. The study revealed that racetrack designs are marginally better than the diamond stent designs.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Laura Andrade Junqueira, Atabak Ghanizadeh Tabriz, Fiona Rousseau, Nadia Rezende Barbosa Raposo, Marcos Antonio Fernandes Branda, Dennis Douroumis
Summary: This study combines Fused Deposition Modelling (FDM) and jet dispensing to print polyvinyl alcohol (PVA) tablets and customize the drug dissolution rates by dispensing polymer inks loaded with rosuvastatin calcium (RSV). The drop on demand approach is used to dispense RSV-loaded inks of methacrylate (EUDRAGIT EPO), vinylpyrrolidone-vinyl acetate copolymer (Kollidon VA64), and ethylcellulose (Aqualon) in FDM printed tablets with 5 and 15 mg of active dose respectively. Physicochemical characterization confirms the molecular dispersion of RSV in the deposited inks. Different dissolution rates are achieved based on polymer solubility and drug loading. This study sets a paradigm for printing personalized dosage forms through the development of suitable inks.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Atabak Ghanizadeh Tabriz, Hannah Kuofie, James Scoble, Sam Boulton, Dennis Douroumis
Summary: Three-dimensional printing, particularly selective laser sintering (SLS), has revolutionized pharmaceutical manufacturing by allowing personalized dosage forms with improved clinical outcomes. SLS has the technological features to overcome manufacturing challenges and introduce new supply chain models, paving the way for decentralization and customization of medicines.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Dennis Douroumis, Atabak Ghanizadeh Tabriz, Ho-Wah Hui, Nathan Boersen, Sandra Roberts, John Jones
Summary: In recent years, 3D printing technologies have been gaining interest in the development of personalized medicinal products. The printing of drug products allows for customization in dose, shape/design, and flavor, potentially improving acceptability in pediatric populations. This study successfully designed and developed flavored chewable dosage forms of ibuprofen using microextrusion for processing powdered blends. The optimized processing parameters resulted in high-quality tablets with various designs and a glossy appearance. The physicochemical characterization revealed the dispersion of ibuprofen in the polymer matrix and the formation of hydrogen bonding. Taste masking and aroma evaluation were excellent when strawberry and orange flavors were used. Dissolution studies showed rapid dissolution rates of ibuprofen in acidic media. Microextrusion is an effective 3D printing technology for generating patient-specific dosage forms for children at the point of care.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Dunja Silic, Biserka Cetina-Cizcmek, Steven A. Ross, Andrew Hurt, Milan Antonijevic, Dennis Douroumis
Summary: In this study, extruded fluoxetine HCl-succinic acid ionic cocrystals were successfully synthesized using different screw configurations. These cocrystals manufactured by HME showed complete transformation of the drug-coformer pair with high purity, improved intrinsic dissolution rates, and long-term storage stability compared to their counterparts produced by solvent evaporation.
CRYSTAL GROWTH & DESIGN
(2023)
Review
Pharmacology & Pharmacy
Mushfiq Akanda, Sadeque Hossain Mithu, Dennis Douroumis
Summary: Solid lipid nanoparticles (SLN) are at the forefront of nanotechnology, with potential applications in drug delivery and research. They offer controlled and site-specific drug delivery, making them a popular choice over other colloidal carriers. This review discusses the production techniques, drug incorporation, and release mechanisms of SLN. The route of administration and in vivo fate of SLNs are also explored, along with their potential in anti-cancer drug delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Joshua Siaw Boateng, Forough Hafezi, Atabak Ghanizadeh Tabriz, Dennis Douroumis
Summary: This study developed and analyzed 3D printed polymer-based film dressings composed of chitosan crosslinked with genipin or chitosan combined with collagen, both loaded with epidermal growth factor (EGF). The films exhibited biocompatibility and displayed significant swelling and mucoadhesion properties. The release of EGF from the films was observed to be sustained over a 72-hour period. Overall, these findings demonstrate the potential of chitosan-based 3D printed films as effective dressings for chronic wounds.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Laura Andrade Junqueira, Francisco Jose Raposo, Geraldo Sergio Farinazzo Vitral, Atabak Ghanizadeh Tabriz, Dennis Douroumis, Nadia Rezende Barbosa Raposo, Marcos Antonio Fernandes Brandao
Summary: This study investigated the perception of women and gynecologists regarding personalized vaginal rings (VRs) fabricated through 3D printing. The findings showed that most women were comfortable with certain 3D-printed VR designs, and both traditional and innovative designs were well accepted. However, women had varying preferences when evaluating the actual geometry. Gynecologists favored traditional and flat circle designs when prescribing VRs.
Article
Pharmacology & Pharmacy
Atabak Ghanizadeh Tabriz, Quentin Gonot-Munck, Arnaud Baudoux, Vivek Garg, Richard Farnish, Orestis L. Katsamenis, Ho-Wah Hui, Nathan Boersen, Sandra Roberts, John Jones, Dennis Douroumis
Summary: This study employed selective laser sintering technology to manufacture personalized dosage forms of carvedilol with different strengths. By tuning the laser intensity parameter, the printability and tablet quality were improved, and the drug release rate was impacted. The results demonstrated that SLS is a suitable technology for developing personalized medicines.
Review
Engineering, Multidisciplinary
Md Jasim Uddin, Jasmin Hassan, Dennis Douroumis
Summary: This review discusses the advancements and applications of inkjet printing technologies in the pharmaceutical and biomedical sector, highlighting the versatility of thermal inkjet printing and the potential for manufacturing personalized medications. It also provides a comprehensive analysis of the principles, advantages, and limitations of inkjet printing technologies.
Article
Pharmacology & Pharmacy
Xueliang Xiu, Shichao Ma, Zhiyong Li, Zhipeng Li, Xuemei Li, Yangtao Ruan, Dezhao Li, Jianwei Wang, Fengsen Ma
Summary: Liposomes are promising delivery vehicles for drugs and vaccines. The use of microfluidic chips for liposome preparation is an effective method. However, traditional liposome preparation technologies hinder their industrial production and clinical application. This study presents a novel three-dimensional integrated microfluidic device for continuous liposome preparation and purification, which shows potential for industrial production of nano-pharmaceutical applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2024)
