Loss of ARHGEF1 causes a human primary antibody deficiency

Mutations in the adaptor-binding domain and associated linker region of p110δ cause Activated PI3K-δ Syndrome 1 (APDS1)

(2017) Lucie Heurtier et al.   HAEMATOLOGICA

Leukocyte RhoA exchange factor Arhgef1 mediates vascular inflammation and atherosclerosis

(2017) Maria Luigia Carbone et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease

(2017) Walter H. A. Kahr et al.   Nature Communications

Mutations in the adaptor-binding domain and associated linker region of p110δ cause Activated PI3K-δ Syndrome 1 (APDS1)

(2017) Lucie Heurtier et al.   HAEMATOLOGICA

X-linked primary immunodeficiency associated with hemizygous mutations in the moesin ( MSN ) gene

(2016) Chantal Lagresle-Peyrou et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics

(2016) Elisabeth Salzer et al.   NATURE IMMUNOLOGY

The G protein–coupled receptor P2RY8 and follicular dendritic cells promote germinal center confinement of B cells, whereas S1PR3 can contribute to their dissemination

(2015) Jagan R. Muppidi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections

(2015) Kerry Dobbs et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immune deficiency–related enteropathy-lymphocytopenia-alopecia syndrome results from tetratricopeptide repeat domain 7A deficiency

(2014) Roxane Lemoine et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

An update on the biology of sphingosine 1-phosphate receptors

(2014) Victoria A. Blaho et al.   JOURNAL OF LIPID RESEARCH

Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma

(2014) Jagan R. Muppidi et al.   NATURE

DOCK8 Immune Deficiency as a Model for Primary Cytoskeletal Dysfunction

(2013) Sean A. McGhee et al.   DISEASE MARKERS

Proper desensitization of CXCR4 is required for lymphocyte development and peripheral compartmentalization in mice

(2012) K. Balabanian et al.   BLOOD

The phenotype of human STK4 deficiency

(2012) H. Abdollahpour et al.   BLOOD

Activation of p115-RhoGEF Requires Direct Association of Gα13and the Dbl Homology Domain

(2012) Zhe Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections

(2012) Amandine Crequer et al.   JOURNAL OF CLINICAL INVESTIGATION

A novel primary human immunodeficiency due to deficiency in the WASP-interacting protein WIP

(2012) Gaetana Lanzi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Icy: an open bioimage informatics platform for extended reproducible research

(2012) Fabrice de Chaumont et al.   NATURE METHODS

MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival

(2011) N. T. Nehme et al.   BLOOD

Mechanistic Insights into Specificity, Activity, and Regulatory Elements of the Regulator of G-protein Signaling (RGS)-containing Rho-specific Guanine Nucleotide Exchange Factors (GEFs) p115, PDZ-RhoGEF (PRG), and Leukemia-associated RhoGEF (LARG)

(2011) Mamta Jaiswal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement

(2011) Jesse A Green et al.   NATURE IMMUNOLOGY

The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure

(2010) Christophe Guilluy et al.   NATURE MEDICINE

The actin regulator coronin 1A is mutant in a thymic egress–deficient mouse strain and in a patient with severe combined immunodeficiency

(2008) Lawrence R Shiow et al.   NATURE IMMUNOLOGY