Article
Public, Environmental & Occupational Health
Farhad Ali Khattak, Taj Ali Khan, Mubashir Hussain, Shahid Niaz Khan, N. Ullah, Basheer Rehman, Muhammad Qasim, Aziz Ur Rehman Safi, Muhammad Ishfaq, Saima Afaq
Summary: The study found that females are more likely to suffer from recurrent leishmaniasis, and older adults are more prone compared to adolescents. Patients receiving intradermal injections for treatment were less likely to experience recurrence.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Article
Chemistry, Multidisciplinary
Muhammad Tahir Khan, Sajid Ali, Anwar Sheed Khan, Noor Muhammad, Faiza Khalil, Muhammad Ishfaq, Muhammad Irfan, Abdullah G. Al-Sehemi, Shabbir Muhammad, Arif Malik, Taj Ali Khan, Dong Qing Wei
Summary: Genome sequencing of SARS-CoV-2 strains in Pakistan revealed unique characteristics compared to neighboring countries and specific mutations that may impact viral transmission, epidemiology, and disease severity. Computational modeling showed that these mutations could have a stabilizing effect on the viral protein structure. Understanding local strains is important for better pathogenicity, immunogenicity, and epidemiology research.
Article
Infectious Diseases
Wasia Ullah, Tsai-Ying Yen, Sadaf Niaz, Nasreen Nasreen, Yu-Feng Tsai, Roger Ivan Rodriguez-Vivas, Adil Khan, Kun-Hsien Tsai
Summary: This study analyzed clinico-epidemiological data of 3188 cutaneous leishmaniasis (CL) patients in Khyber Pakhtunkhwa, Pakistan, using regression analysis and GIS technology, and estimated the risk of epidemics. The results revealed that males and individuals younger than 20 were more prone to infection, with most patients presenting a single lesion and the face being the most affected part. The study provided valuable information for the development of intervention strategies for future CL epidemics.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Parasitology
Ismail Zeb, Naveeda Akhter Qureshi, Nargis Shaheen, Mazhar Iqbal Zafar, Abid Ali, Aneeqa Hamid, Syed Aizaz Ali Shah, Asma Ashraf
Summary: This study utilized GIS to analyze the transmission of CL in Upper and Lower Dir Districts of Pakistan, identifying high-risk areas primarily in low altitude central regions such as Balambat and Khal, especially affecting children younger than 20 years old.
Article
Public, Environmental & Occupational Health
Farhana Badar, Muhammad Sohaib, Shahid Mahmood, Omar Rasheed Chughtai, Faisal Sultan, Muhammed Aasim Yusuf
Summary: This study presents population-based cancer statistics for Khyber Pakhtunkhwa (KP), Pakistan. The study collected records of new cancer cases among residents of KP and analyzed the incidence rates by age group and sex, identifying the common types of cancer in different populations.
Article
Zoology
Romaan Hayat Khattak, Zhensheng Liu, Liwei Teng
Summary: The study provides important information on wild ungulate species, breeding practices, and challenges in captive breeding in Khyber Pakhtunkhwa Province of Pakistan.
PAKISTAN JOURNAL OF ZOOLOGY
(2021)
Article
Environmental Sciences
Ashfaq Ahmad Shah, Zaiwu Gong, Nasir Abbas Khan, Imran Khan, Muhammad Ali, Syed Asif Ali Naqvi
Summary: This paper analyzes the livelihood diversification strategies in managing catastrophic risks among rural farm households in Pakistan, finding that 50% of the respondents adopted off-farm livelihood diversification strategies, while 40.5% adopted on-farm livelihood diversification strategies. Logistic regression analysis shows that attributes such as socioeconomic and demographic characteristics, institutional factors, and risk perception significantly influenced households' choices in livelihood diversification.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Green & Sustainable Science & Technology
Sajjad Ali, Liu Ying, Adnan Nazir, Abdullah, Muhammad Ishaq, Tariq Shah, Xinyue Ye, Aasir Ilyas, Azam Tariq
Summary: Climate change has severe impacts on Pakistan's agriculture sector, with smallholder farmers in KPK province adapting by using strategies such as irrigation, non-farm activities, and early planting. However, barriers like lack of funds and seed availability hinder their adaptation efforts. More awareness, timely information, extension services, and investment facilities are needed to support farmers in coping with climate change in the long term.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Multidisciplinary Sciences
Anwar Sheed Khan, Jody E. Phelan, Muhammad Tahir Khan, Sajid Ali, Muhammad Qasim, Gary Napier, Susana Campino, Sajjad Ahmad, Otavio Marques Cabral, Shulin Zhang, Hazir Rahman, Dong-Qing Wei, Taane G. Clark, Taj Ali Khan
Summary: This study conducted genetic analysis on isolates from a high TB endemic province in Pakistan, identifying mutations associated with multidrug-resistant TB. Additionally, internal resistance diversity and heteroresistance were observed, suggesting a complexity that may be linked to high transmission dynamics.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Ghani Rahman, Atta-ur Rahman, Sami Ullah, Muhammad Dawood, Muhammad Farhan Ul Moazzam, Byung Gul Lee
Summary: This study analyzed spatio-temporal fluctuations in rainfall in Khyber Pakhtunkhwa, Pakistan to evaluate drought and wet spell patterns, identifying a decreasing trend in rainfall in some areas, while others experienced an increasing trend. The study used the SPEI and SR tests to assess drought and wet spells, providing valuable insight for water resource planning and management.
Article
Social Issues
Nawab Khan, Ram L. Ray, Shemei Zhang, Evans Osabuohien, Muhammad Ihtisham
Summary: This study examines the impact of mobile phone and internet technology usage (MPITU) on the income and sales channel selection of rural wheat growers. The findings suggest that a higher level of MPITU has a positive effect on agricultural income. It is recommended to provide MPITU training services to farmers to enhance agricultural productivity and household income.
TECHNOLOGY IN SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Khan Alam, Nadeem Ahmad, Imran Ahmad, Muhammad Nafees
Summary: This study investigated the phytochemical screening and pharmacological activities of the crude extract of leaves and stem of R. afghanicum. The results showed that the extract exhibited anti-inflammatory, antibacterial, phytotoxic, and cytotoxic activities. These findings support the traditional use of this plant for treating digestive, analgesic, and inflammatory ailments.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Public, Environmental & Occupational Health
Khurshaid Khan, Nazma Habib Khan, Farhat Anwar, Ihtisham Ullah, Noor Badshah, Irfan Irfan, Khalid Iqbal, Ibrar Shah, Shah Tariq Aziz, Muhammad Shahid Naseem Khan, Safeer Ullah Shah
Summary: The study aimed to investigate sand fly species composition, breeding sites ecology, seasonal abundance, and spatial distribution in Malakand, Pakistan, as well as evaluate risk factors associated with cutaneous leishmaniasis. The results showed that age, knowledge of leishmaniasis, living in a middle and upper class, preachers visiting villages, and assumption that Afghan refugees are more prone to CL were significant risk factors. The majority of CL patients had lesions on the face and hands, with the highest influx of patients in February and March.
ZOONOSES AND PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Sadaf Niaz, Abdur Raqeeb, Adil Khan, Nasreen, Sohail Amir, Ling Zhu, Sachin Kumar
Summary: The study found significant differences in the prevalence of brucellosis based on age and geographical locations in Malakand District, Khyber Pakhtunkhwa, Pakistan. The infection rate was higher from January to April.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Humera Qureshi, Muhammad Imran Khan, Suk Joo Bae, Sohail Akhtar, Aamer Ali Khattak, Ayesha Haider, Alisha Nisar
Summary: Dengue virus (DENV) has caused 12 major outbreaks in Pakistan, resulting in 286,262 cases of morbidity and 1108 deaths. The most affected province is Khyber Pakhtunkhwa (KP). A cross-sectional study was conducted in the Haripur district of KP to determine the average prevalence of DENV and its causing factors. The study found that males are at a higher risk of DENV infection and individuals aged 16-30 are the most affected. The proper monitoring and assessment of DENV are essential for prevention and control.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Editorial Material
Immunology
Colin J. Sutherland
JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Biochemical Research Methods
David J. Clark, Catherine M. Moore, Marc Flanagan, Katrien Van Bocxlaer, Evangelia-Theophano Piperaki, Vanessa Yardley, Simon L. Croft, John Tyson, Sam P. Whitehouse, Jonathan O'Halloran, Sanjeev Krishna, Henry M. Staines
Article
Microbiology
Jose Francis, Karen I. Barnes, Lesley Workman, Tamara Kredo, Lasse S. Vestergaard, Richard M. Hoglund, Pauline Byakika-Kibwika, Mohammed Lamorde, Stephen I. Walimbwa, Ifeyinwa Chijioke-Nwauche, Colin J. Sutherland, Concepta Merry, Kimberley K. Scarsi, Nyagonde Nyagonde, Martha M. Lemnge, Saye H. Khoo, Ib C. Bygbjerg, Sunil Parikh, Francesca T. Aweeka, Joel Tarning, Paolo Denti
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Article
Microbiology
Ryan C. Henrici, Rachel L. Edwards, Martin Zoltner, Donelly A. van Schalkwyk, Melissa N. Hart, Franziska Mohring, Robert W. Moon, Stephanie D. Nofal, Avnish Patel, Christian Flueck, David A. Baker, Audrey R. Odom John, Mark C. Field, Colin J. Sutherland
Article
Genetics & Heredity
Ernest Diez Benavente, Monica Campos, Jody Phelan, Debbie Nolder, Jamille G. Dombrowski, Claudio R. F. Marinho, Kanlaya Sriprawat, Aimee R. Taylor, James Watson, Cally Roper, Francois Nosten, Colin J. Sutherland, Susana Campino, Taane G. Clark
Article
Microbiology
Inke N. D. Lubis, Hendri Wijaya, Munar Lubis, Chairuddin P. Lubis, Khalid B. Beshir, Colin J. Sutherland
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Article
Microbiology
Donelly A. van Schalkwyk, Michael K. Riscoe, Sovitj Pou, Rolf W. Winter, Aaron Nilsen, Maelle Duffey, Robert W. Moon, Colin J. Sutherland
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Review
Microbiology
Colin J. Sutherland, Ryan C. Henrici, Katerina Artavanis-Tsakonas
Summary: Studies on the susceptibility of Plasmodium falciparum to artemisinin antimalarial drugs have shown a complex picture of partial resistance related to various genetic loci. Detailed research on specific proteins has led to the proposal of a dual-component model that explains the mechanisms of drug tolerance, suggesting ways to prolong the useful life of current combination therapies.
FEMS MICROBIOLOGY REVIEWS
(2021)
Article
Public, Environmental & Occupational Health
Ifeyinwa Chijioke-Nwauche, Mary C. Oguike, Chijioke A. Nwauche, Khalid B. Beshir, Colin J. Sutherland
Summary: The study found evidence of continued chloroquine use among HIV-positive individuals, and selection for the pfmdr1 86N gene after artemether-lumefantrine treatment may pose a threat to antimalarial efficacy in the study area; the complexity of pfdhps haplotypes emphasizes the need for careful monitoring of anti-folate susceptibility in Nigeria.
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
(2021)
Editorial Material
Biology
Colin Sutherland, Didier Menard
Summary: A tool that analyzes the genome of parasites in the blood of malaria patients can assist policymakers in making informed decisions on how to address the increase in drug-resistant infections.
Article
Microbiology
Franziska Mohring, Donelly A. van Schalkwyk, Ryan C. Henrici, Benjamin Blasco, Didier Leroy, Colin J. Sutherland, Robert W. Moon
Summary: Several unrelated antimalarial compounds targeting PfATP4 have lower efficacy against other malaria parasite species infecting humans. By replacing the ATP4 genes in P. knowlesi with orthologues from different species, researchers found significant differences in susceptibility to ATP4 inhibitors among the parasites. This study highlights the importance of developing antimalarials that can effectively target all human malaria parasite species.
Article
Infectious Diseases
Adeola Y. Olukosi, Olusola Ajibaye, Omowunmi Omoniwa, Olusola Oresanya, Aina O. Oluwagbemiga, Chinazo Ujuju, Michael Ekholuenetale, Kolawole Maxwell, Colin J. Sutherland, James K. Tibenderana, Khalid B. Beshir
Summary: A rapid surveillance study was conducted in Ebonyi and Osun states in Nigeria to assess the suitability of sulfadoxine/pyrimethamine (SP) as perennial malaria chemoprevention (PMC). The study revealed that both states are suitable for SP-PMC implementation, and it has been implemented in Osun since 2022. Continuous monitoring of the 540E mutation is necessary to ensure the effectiveness of SP chemoprevention in Nigeria.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Tianyang Liu, Fiona Shilliday, Alexander D. Cook, Mohammad Zeeshan, Declan Brady, Rita Tewari, Colin J. Sutherland, Anthony J. Roberts, Carolyn A. Moores
Summary: In this study, the authors investigated the role of Plasmodium kinesin-8B in microtubule motility and depolymerization. They found that kinesin-8B is essential for the formation of male gametes and parasite transmission. The study provides important insights into the molecular mechanisms underlying malaria transmission.
NATURE COMMUNICATIONS
(2022)
Correction
Multidisciplinary Sciences
Tianyang Liu, Fiona Shilliday, Alexander D. Cook, Mohammad Zeeshan, Declan Brady, Rita Tewari, Colin J. Sutherland, Anthony J. Roberts, Carolyn A. Moores
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Arfan Ul Bari, Syed Umair Ahmed Najmi
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2020)