Article
Cardiac & Cardiovascular Systems
Subin Jang, Elise F. Palzer, Kyle D. Rudser, Claudia K. Fox, Robert P. Hebbel, Donald R. Dengel, Liming Milbauer, Aaron S. Kelly, Justin R. Ryder
Summary: Levels of microparticles, EMPs, and activated EMPs were positively associated with adiposity and poor subclinical CVD risk in a pediatric population.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Nutrition & Dietetics
Chih-Kuo Lee, Charlene Wu, Chien-Yu Lin, Po-Chin Huang, Fung-Chang Sung, Ta-Chen Su
Summary: The study found that higher urinary lead and cadmium concentrations are strongly associated with endothelium-platelet microparticles in the adolescent and young adult population, which could help explain, in part, the mechanism through which heavy metal exposure results in cardiotoxicity.
Review
Biochemistry & Molecular Biology
Xiaoshuai Li, Qiushi Wang
Summary: Extracellular microparticles serve as a means of cell-to-cell communication and can facilitate information exchanges between nearby or distant cells. Platelets, derived from megakaryocytes, play a crucial role in hemostasis, inflammation regulation, and vascular integrity maintenance. Upon activation, platelets can perform these functions by secreting platelet-derived microparticles containing lipids, proteins, nucleic acids, and organelles. Circulating platelet levels differ in various autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, antiphospholipid antibody syndrome, and Sjogren's syndrome. This review paper discusses the latest research findings in platelet-derived microparticles, including their potential role in the pathogenesis, as markers, and for monitoring disease treatment progress and prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Bernadett Szilagyi, Zsolt Fejes, Agnes Rusznyak, Ferenc Fenyvesi, Marianna Pocsi, Sandor Halmi, Zoltan Griger, Satya P. Kunapuli, Janos Kappelmayer, Bela Nagy
Summary: The study revealed that activated platelets transfer miR-223 to endothelial cells via microparticles during sepsis, leading to a decrease in ICAM-1 expression. This protective mechanism may help regulate excessive sepsis-induced vascular inflammation.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Polymer Science
Jordan Thomas Lovegrove, Radhika Raveendran, Patrick Spicer, Stephan Foerster, Christopher J. Garvey, Martina H. Stenzel
Summary: Margination refers to the movement of particles towards the endothelial wall within blood vessels. This study focused on 2D platelet particles as a potential drug delivery system and quantified their margination propensity. The results showed that 2D platelet particles exhibited increased margination compared to spherical particles, with higher margination observed at higher shear rates.
Article
Biochemistry & Molecular Biology
Abu Saleh Md Moin, Manjula Nandakumar, Ahmed Al-Qaissi, Thozhukat Sathyapalan, Stephen L. Atkin, Alexandra E. Butler
Summary: This study investigated several proteins indicative of acute ischemic stroke due to large vessel occlusion in patients with type 2 diabetes, finding that certain proteins were elevated in these patients, potentially indicating a higher risk of ischemic stroke.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Rheumatology
Chunyan Cheng, Elisa Bison, Elena Pontara, Maria Grazia Cattini, Marta Tonello, Gentian Denas, Vittorio Pengo
Summary: This study investigated microparticles (MPs) in patients with antiphospholipid antibodies (aPL) and found that the levels of total MPs and endothelial microparticles (EMPs) were significantly higher in triple positive patients compared to single positive patients, and were correlated with IgG antibody titers. Additionally, platelet microparticles (PMPs) were found to be the lowest in triple positive patients and inversely correlated with IgG antibody titers.
Review
Cell Biology
Shuo Feng, Jia Wei Chen, Xin Yi Shu, Muladili Aihemaiti, Jin Wei Quan, Lin Lu, Rui Yan Zhang, Chen Die Yang, Xiao Qun Wang
Summary: Hemodynamic shear stress (SS) regulates vascular homeostasis and injury through the release of endothelial microparticles (EMP), affecting physiological function of endothelial cells, inflammatory response, vascular permeability, and the coagulation system.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Ehsan Gharib, Vanessa Veilleux, Luc H. Boudreau, Nicolas Pichaud, Gilles A. Robichaud
Summary: Inflammation and platelets promote cancer malignancy. Platelet-derived microparticles (PMPs) induce metabolic plasticity and disease progression in chronic lymphocytic leukemia (CLL). PMPs enhance CLL tumor growth and invasiveness through mitochondrial internalization and OXPHOS stimulation, as well as increase resistance to chemotherapy drugs.
FRONTIERS IN IMMUNOLOGY
(2023)
Letter
Medicine, General & Internal
Jiahui Yang, Zhengjun Bao, Guoyu Hu, Xiaopeng Luo, Zhen Zhao
Summary: The aim of this study was to investigate the role of genetic variation and DNA methylation of PEAR1 rs12041331 in high on-treatment platelet reactivity (HPR) and recurrent ischemic stroke (RIS). Genotype, methylation, and mRNA of PEAR1 rs12041331 were detected in patients with cerebral ischemia, and the effect of PEAR1 rs12041331 on HPR and RIS was analyzed. The major G allele of PEAR1 rs12041331 was associated with hypermethylation, which was correlated with HPR but not with RIS. The study suggests that PEAR1 rs12041331 genetic polymorphism and DNA methylation may be among the genetic factors affecting HPR, and further research is needed to investigate the correlation between PEAR1 and RIS.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Lazzaro di Biase, Adriano Bonura, Pasquale Maria Pecoraro, Simona Paola Carbone, Vincenzo Di Lazzaro
Summary: Stroke, a complex and heterogeneous disease, poses challenges for early diagnosis and treatment due to the lack of specific diagnostic biomarkers. This review identifies four promising biomarkers for early diagnosis, differentiation between ischemic and hemorrhagic stroke, and prediction of hemorrhagic transformation. Integration of these biomarkers could significantly improve stroke patients' detection and treatment. However, further research and validation are needed to demonstrate their clinical utility in routine stroke treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Karolina Gawrys, Aleksandra Turek-Jakubowska, Jakub Gawrys, Maciej Jakubowski, Janusz Debski, Ewa Szahidewicz-Krupska, Malgorzata Trocha, Arkadiusz Derkacz, Adrian Doroszko
Summary: The aim of this dynamic LC-MS proteomic study in human platelets was to identify potential protein candidates for biomarkers of acute ischemic stroke (AIS), assess their changes during the acute phase of stroke, and define new drug targets. The study found differences in platelet proteins between AIS patients and healthy controls, and identified Thymidine Phosphorylase 4 (TYMP-4) as a promising drug target for the management or prevention of ischemic stroke.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Daniel Cacic, Hakon Reikvam, Oddmund Nordgard, Peter Meyer, Tor Hervig
Summary: The study demonstrates that platelet microparticles can alter the behavior and activity of THP-1 cells, contributing to the development of acute myelogenous leukemia and resistance to chemotherapy. This finding highlights the potential role of platelet microparticles as a target for treatment in leukemia cases.
Review
Biochemistry & Molecular Biology
Sebastian Andone, Zoltan Bajko, Anca Motataianu, Oana Mosora, Rodica Balasa
Summary: Atherosclerosis is the main cause of stroke, and biomarkers play an important role in the diagnosis, prognosis, and treatment of stroke. Biomarkers have predictive capabilities for short-term and long-term prognosis for stroke patients, as well as influence over acute phase treatment, especially for risk stratification in patients who have not yet suffered a stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Chiara Gardin, Letizia Ferroni, Sara Leo, Elena Tremoli, Barbara Zavan
Summary: This review summarizes the role of platelet-derived exosomes in intercellular communication in the pathogenesis of atherosclerosis, as well as their potential as biomarkers for AS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Shahenda S. Abdelsalam, Mazhar Pasha, Heba El-Gamal, Maram Hasan, Mohamed A. Elrayess, Asad Zeidan, Hesham M. Korashy, Abdelali Agouni
Summary: Inhibiting PTP1B can prevent ER stress-induced endothelial dysfunction and impaired angiogenesis. PTP1B blockade reduced ER stress-induced apoptosis and cell cycle arrest, possibly through decreased expression levels of caspase-12 and PARP1.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Multidisciplinary Sciences
Myriam Jaam, Zachariah Nazar, Daniel C. Rainkie, Diana Alsayed Hassan, Farhat Naz Hussain, Salah Eldin Kassab, Abdelali Agouni
Summary: This study retrospectively investigated assessments implemented during the rapid transition to remote learning using the Assessment Design Decision Framework (ADDF). Three major themes were identified: the impact of sudden transition on assessment design and plan, changing assessment environment, and faculty-student interactions related to assessment including feedback. The use of ADDF can improve the validity and credibility of assessments, and this study validates its use in circumstances requiring rapid transition.
Article
Pharmacology & Pharmacy
Ola El Atab, Crystal M. Ghantous, Nabil El-Zein, Rima Farhat, Abdelali Agouni, Hesham M. Korashy, Laiche Djouhri, Layla Kamareddine, Kazem Zibara, Asad Zeidan
Summary: This study investigates the molecular mechanisms involved in hyperglycemia-induced vascular remodeling, with a focus on the role of APN and leptin. It found that hyperglycemia increases APN synthesis but decreases APN receptor expression, and upregulates leptin expression in vascular smooth muscle cells. These changes lead to increased oxidative stress and alterations in actin cytoskeleton dynamics, facilitating vascular remodeling.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Laura Soriano-Romani, Fayaz A. Mir, Niharika Singh, Ian Chin, Ali Hafezi-Moghadam, Sharmila Masli
Summary: This study investigates the role of thrombospondin (TSP)-1 in regulating leukocyte recruitment and VCAM-1 expression in mouse models of uveitis. The results show that TSP-1 deficiency can reduce retinal leukocyte adhesion in LPS-mediated acute uveitis, while TSP-1-derived CD47-binding peptide can reduce the clinical disease course and retinal leukocyte adhesion in chronic uveitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Safeer Ahmad, Muhammad Zeeshan Ali, Muhammad Muzammal, Fayaz Ahmad Mir, Muzammil Ahmad Khan
Summary: This article introduces the definition, classification, and research progress of inherited abnormalities of the human appendicular skeleton. Common diseases such as polydactyly, syndactyly, brachydactyly, split-hand-foot malformation, and clubfoot disorders are highlighted, and the number of genes identified to be associated with these diseases is summarized. The molecular genetic data presented in this article is of great significance to scientists studying rare skeletal disorders, as well as in genetic counseling and molecular diagnosis.
MOLECULAR GENETICS AND GENOMICS
(2022)
Article
Endocrinology & Metabolism
Fayaz Ahmad Mir, Raghvendra Mall, Ahmad Iskandarani, Ehsan Ullah, Tareq A. Samra, Farhan Cyprian, Aijaz Parray, Meis Alkasem, Ibrahem Abdalhakam, Faisal Farooq, Abdul-Badi Abou-Samra
Summary: This study aimed to evaluate the relationship between circulating miRNAs and clinical features in obese individuals. The results showed that there are certain miRNAs associated with metabolic syndrome in obese individuals, which may have a pathophysiologic role and can serve as markers for obese individuals predisposed to various metabolic diseases like diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fayaz Ahmad Mir, Ehsan Ullah, Raghvendra Mall, Ahmad Iskandarani, Tareq A. Samra, Farhan Cyprian, Aijaz Parray, Meis Alkasem, Ibrahem Abdalhakam, Faisal Farooq, Abdul-Badi Abou-Samra
Summary: This study found differential expression of serum metabolites and pathways between Arabic subjects with obesity and metabolic syndrome compared to subjects with obesity only. Lipids, including sphingomyelin, were significantly decreased in the group with metabolic syndrome. Non-lipid metabolites, such as quinolinate, kynurenine, and tryptophan, were also decreased in the group with metabolic syndrome. Metabolites and pathways associated with chronic inflammation were found to be dysregulated in subjects with metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hend Al-Jaber, Nura A. Mohamed, Vijay K. Govindharajan, Samir Taha, Jomon John, Sharique Halim, Maha Alser, Shamma Al-Muraikhy, Najeha Rizwana Anwardeen, Abdelali Agouni, Abdelbary Elhissi, Hamda A. Al-Naemi, Layla Al-Mansoori, Mohamed A. Elrayess
Summary: Inhibition of GATA3 promotes adipogenesis and enhances insulin signaling, offering potential therapeutic benefits for correcting impaired adipogenesis, promoting healthy fat distribution, improving insulin sensitivity, and lowering the risk of T2D.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Shamma AlMuraikhy, Najeha Anwardeen, Aisha Naeem, Maha Sellami, Alexander Domling, Abdelali Agouni, Mohamed A. Elrayess
Summary: This study aimed to analyze the metabolic profiles of young non-obese individuals and compare the effects of physical activity on insulin-sensitive and insulin-resistant groups. The results showed that physical activity had a positive impact on the health status of insulin-resistant individuals.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Ghulam Jeelani Pir, Aijaz Parray, Raheem Ayadathil, Sajitha Pananchikkal, Fayaz Ahmad Mir, Islam Muhammad, Ahmed Abubakar, Nueman Amir, Sohail Hussain, Khawaja H. Haroon, Ahmad Muhammad, Yahya Imam, Satya Narayana Patro, Naveed Akhtar, Aymen Zakaria, Saadat Kamran
Summary: The histological structure of thrombi plays a crucial role in the outcome of vascular recanalization therapy for AIS patients. This study investigated the composition and structure of thrombi in AIS patients, revealing that they were predominantly platelet-rich and contained complex platelet-rich areas associated with activated neutrophils and NETs. The NETs-containing areas showed strong reactivity to Willebrand factor, platelets, and HMGB1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Aijaz Parray, Naveed Akhtar, Ghulam Jeelani Pir, Sajitha Pananchikkal, Raheem Ayadathil, Fayaz Ahmad Mir, Reny Francis, Ahmed Own, Ashfaq Shuaib
Summary: This study found that the level of RGMa mRNA is increased in patients with acute stroke, and this increase is observed in patients with both lacunar and cortical stroke. The increase in RGMa mRNA level is related to the severity of stroke and gradually increases over the first 5 days after stroke onset.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Muhammad Ammar Zahid, Shahenda Salaheldin Abdelsalam, Hicham Raiq, Aijaz Parray, Hesham Mohamed Korashy, Asad Zeidan, Mohamed A. Elrayess, Abdelali Agouni
Summary: A timely and adequate response to stress is crucial for maintaining cell function, and disruptions in defense mechanisms against stress can lead to various pathologies. Aging and cardiovascular diseases can reduce the effectiveness of these defense mechanisms. Sestrin2 (SESN2) is a stress-inducible protein that can protect cells by increasing antioxidants, temporarily halting stressful reactions, and promoting autophagy. Maintaining sufficient levels/activity of SESN2 may prevent cardiovascular aging and disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Fayaz Ahmad Mir, Raghvendra Mall, Ehsan Ullah, Ahmad Iskandarani, Farhan Cyprian, Tareq A. A. Samra, Meis Alkasem, Ibrahem Abdalhakam, Faisal Farooq, Shahrad Taheri, Abdul-Badi Abou-Samra
Summary: This study analyzed a cohort of 39 obese participants, comparing 21 with metabolic syndrome to 18 without metabolic complications. Through analyzing human microRNAs, metabolites, and transcripts, several differentially expressed genes, metabolites, and microRNAs were identified in obese subjects with metabolic syndrome. Integrative analysis revealed 8 dysregulated metabolic pathways in obesity with metabolic complications.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Shamma Almuraikhy, Najeha Anwardeen, Asmma Doudin, Maha Sellami, Alexander Domling, Abdelali Agouni, Asmaa A. Althani, Mohamed A. Elrayess
Summary: This study investigated the metabolic pathways involved in the protective effects of moderate physical activity in non-obese and healthy individuals. The results showed increased activation of antioxidative stress pathways in active participants, as well as significant associations between glutathione metabolites and certain clinical traits.
Article
Biochemistry & Molecular Biology
Shamma Almuraikhy, Najeha Anwardeen, Asmma Doudin, Maha Sellami, Alexander Domling, Abdelali Agouni, Asmaa A. Al Thani, Mohamed A. Elrayess
Summary: Healthy non-obese insulin resistant individuals have a higher risk of metabolic syndrome. Physical activity can lower insulin resistance, but the metabolic pathways involved are still unknown. This study analyzed data from 305 non-obese participants and found that active insulin resistant individuals showed differences in fatty acid metabolism, while sedentary insulin resistant individuals showed changes in glucose metabolism. These findings have important implications for the prevention and treatment of metabolic syndrome. Rating: 8 out of 10.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
