Article
Chemistry, Multidisciplinary
Yi-Ran Yao, Ya-Jun Jin, Xin Jia, Yang Yang
Summary: The porous nano-sized metal-organic framework, with proper surface modification, enhances drug loading capability and introduces biocompatibility, biodegradability, and targeting functions in nano-drug delivery systems. The obtained nanoMOF nanoparticle is stable in physiological fluids and can effectively load chemotherapeutic drugs for controlled release in tumor tissues.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Cell Biology
Sisi Yang, Chengwei Cai, Huanqiu Wang, Xueqing Ma, Anwen Shao, Jifang Sheng, Chengbo Yu
Summary: Hepatocellular carcinoma (HCC) is a common malignant tumor worldwide, and traditional antitumor drugs have limitations. The application of nanotechnology plays a significant role in improving drug delivery and selective accumulation.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Engineering, Biomedical
Wenyu Chen, Huixin He, Pengfei Jiao, Lefei Han, Jianchun Li, Xiu Wang, Xuliang Guo
Summary: A triple-responsive metal-organic framework is designed to release photosensitizers under low oxygen, reactive oxygen species, and low pH conditions, enhancing the efficacy of photodynamic therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Laura Ha, Kyung Min Choi, Dong-Pyo Kim
Summary: The study addressed the issues in cell-mediated drug delivery systems by utilizing Janus structure, MOF nanoparticles, and tannic acid. The developed MOF-coated Janus cells successfully eliminated three-dimensional tumor spheroids, showcasing potential applications in drug delivery.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Pharmacology & Pharmacy
Ya-Nan Li, Xiaoju Shi, Dandan Sun, Shulan Han, Yifang Zou, Lingzhi Wang, Leilei Yang, Yutong Li, Ying Shi, Jianfeng Guo, Caitriona M. O'Driscoll
Summary: In this study, the potential of melarsoprol (MEL) for hepatocellular carcinoma (HCC) therapy was investigated for the first time using in vitro and in vivo experimental approaches. A folate-targeted polyethylene glycol-modified amphiphilic cyclodextrin nanoparticle was developed for safe, efficient and specific delivery of MEL. The targeted nanoformulation achieved cell-specific uptake, cytotoxicity, apoptosis and migration inhibition in HCC cells, and significantly prolonged the survival of mice with orthotopic tumor without causing toxicity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Linlin Li, Yifang Zou, Lingzhi Wang, Leilei Yang, Yutong Li, Anqi Liao, Zheng Chen, Zhuo Yu, Jianfeng Guo, Shulan Han
Summary: This study confirmed the potential of scutellarin for inducing immunogenic cell death in hepatocellular carcinoma cells. To enable its in vivo application, a targeted nanocarrier was developed. The nanocarrier effectively delivered scutellarin to the tumor site and reversed the immune suppressive tumor microenvironment, resulting in improved therapeutic efficacy and increased survival in a mouse model of hepatocellular carcinoma, without causing toxicity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Menghan Wang, Xing Ma, Guoyu Wang, Yanan Song, Miao Zhang, Zhongchao Mai, Borong Zhou, Ying Ye, Wei Xia
Summary: This study found that UBR5 acts as an oncogene in HCC tissues and its expression can be inhibited by ECH. By delivering ECH to HepG2 cells through a nanoparticle-based drug delivery system, the sensitivity of HCC cells to ECH can be improved, promoting cell apoptosis and inhibiting glycolysis. In vivo experiments confirmed that this delivery system enhances the antitumor effects of ECH on HCC cells.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Nanoscience & Nanotechnology
Lingwei Liu, Jialang Zhuang, Jizhou Tan, Ting Liu, Wenzhe Fan, Yuanqing Zhang, Jiaping Li
Summary: Transcatheter arterial chemoembolization (TACE) is the preferred treatment for intermediate hepatocellular carcinoma (HCC). However, there are still challenges in effectively targeting cancer cells without damage to normal liver cells. Researchers have developed multifunctional nanoparticles using a simple solvothermal method, which can achieve both photothermal effects and low pH-triggered drug release. The results demonstrate that these nanoparticles have high efficacy and biocompatibility for HCC treatment.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Abhinav P. Acharya, Kutay B. Sezginel, Hannah P. Gideon, Ashlee C. Greene, Harrison D. Lawson, Sahil Inamdar, Ying Tang, Amy J. Fraser, Kush V. Patel, Chong Liu, Nathaniel L. Rosi, Stephen Y. Chan, JoAnne L. Flynn, Christopher E. Wilmer, Steven R. Little
Summary: This study proposes a new drug delivery system that utilizes a customized MOF material for simultaneous delivery of multiple drugs. Experimental results demonstrate the biological stability of the delivery system and its ability to effectively reduce bacterial and viral growth.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Physical
Mohammad Reza Saeb, Navid Rabiee, Masoud Mozafari, Ebrahim Mostafavi
Summary: Metal-organic frameworks (MOFs), especially nanoscale MOFs (NMOFs), show exceptional tailorable properties and high potential for carrying anticancer drugs. Compared to other delivery systems, NMOFs are more flexible, have higher biodegradability potential, and can be easily functionalized.
Review
Chemistry, Inorganic & Nuclear
Shadpour Mallakpour, Elham Nikkhoo, Chaudhery Mustansar Hussain
Summary: Metal-organic frameworks (MOFs) have gained attention for their adjustable pore sizes, large surface area, and various functionalities, making them suitable for applications in energy storage, CO2 adsorption, catalysis, drug storage, and release.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Materials Science, Biomaterials
Dalia Ramos, Javier Aguila-Rosas, Carlos T. Quirino-Barreda, Alfonso Santiago-Tellez, Hugo A. Lara-Garcia, Ariel Guzman, Ilich A. Ibarra, Enrique Lima
Summary: Linezolid (LNZ), a new-generation synthetic molecule, is being explored for antibacterial treatment, with research focusing on its release within MOFs (MOF-74(Zn) and MOF-74(Cu)) as a potential antimicrobial system for combating antimicrobial resistance.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Materials Science, Biomaterials
Isabel Abanades Lazaro, Jose M. Rodrigo-Munoz, Beatriz Sastre, Maria Romero Angel, Carlos Marti-Gastaldo, Victoria del Pozo
Summary: Ti-Ca heterometallic MOF MUV-10 shows good dispersibility in phosphate buffer and low phosphate-induced degradation compared to other MOF systems. It exhibits no cytotoxicity towards immune system cells and no immune response, making it an attractive candidate for biomedical applications and showing its safe use in other fields.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Physical
Xiaoyue Qi, Qizhe Chen, Ziyong Chang, Yulin Deng
Summary: By using a pH-sensitive zeolitic imidazolate framework (ZIF)-8, we developed a simple method to increase the porosity of metal-organic frameworks (MOFs) and achieve customized and controllable pore size. Bioetching in an acidic microenvironment during biocatalysis produced stable large mesopores suitable for enzyme loading with retained activity.
Article
Materials Science, Multidisciplinary
Xiao Fu, Yulin Zhang, Gaorui Zhang, Xingang Li, Shilei Ni, Jiwei Cui
Summary: This study reports the synthesis of targeted nanoparticles encapsulated with multiple therapeutics for catalyzing cascade reactions in tumor microenvironments, providing a promising approach for combinational therapy.
APPLIED MATERIALS TODAY
(2022)
Article
Chemistry, Applied
Weiwen Wang, Lu Zhang, Tianping Wang, Zhen Zhang, Xiangnan Wang, Chong Cheng, Xikui Liu
Summary: Covalent organic frameworks (COFs) are promising supports for electrocatalysis due to their good crystallinity, ordered pores, and structural diversity. However, their poor conductivity hinders their practical application. This study presents a novel synthesis strategy to enhance the electrical conductivity of a triphenylamine-based COF by in-situ deposition of palladium nanoparticles, resulting in improved catalytic activity for oxygen reduction.
JOURNAL OF ENERGY CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Lijian Cao, Ziyan Feng, Ruiqian Guo, Qinyu Tian, Weiwen Wang, Xiao Rong, Mi Zhou, Chong Cheng, Tian Ma, Dawei Deng
Summary: Designing an ideal platform that can convert H2O2 in the tumor microenvironment into ROS and O-2 for efficient chem-/sono-/photo-multimodal tumor therapies.
MATERIALS HORIZONS
(2023)
Review
Chemistry, Multidisciplinary
Ning Lv, Qian Li, Huang Zhu, Shengdong Mu, Xianglin Luo, Xiancheng Ren, Xikui Liu, Shuang Li, Chong Cheng, Tian Ma
Summary: Metal-porphyrins or metal-phthalocyanines-based organic frameworks (POFs) have unique structures and properties that make them promising materials for electrocatalysis. This comprehensive review summarizes the synthesis methods, catalytic activity modulation principles, and electrocatalytic behaviors of 2D/3D POFs. It also discusses the challenges and applications of POFs in electrocatalytic energy conversion systems. The review provides guidance for future experimental and theoretical progress in this field.
Article
Chemistry, Multidisciplinary
Xin Fan, Yang Gao, Fan Yang, Jian Liang Low, Lei Wang, Beate Paulus, Yi Wang, Andrej Trampuz, Chong Cheng, Rainer Haag
Summary: A bionanocatalyst Au@CuBCats containing dual-enzyme mimetics is synthesized to control glucose concentration and bacteria in diabetic ulcers, which demonstrates excellent antibacterial therapeutic efficacy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Minjia Yuan, Qian Li, Yang Gao, Chao He, Mohsen Adli, Changzhu Wu, Hongju Zhou, Xianglin Luo, Lang Ma, Chong Cheng
Summary: This review comprehensively summarizes the recent progress and future trends in the engineering of tunable structured metal oxides for biocatalytic therapeutics. It discusses the fundamental activities, evaluations, and mechanisms of metal oxide-based biocatalysts, as well as the design methods and achievements of different types of nanostructured and biofunctionalized metal oxides. It also highlights the strategies for modulating the catalytic centers of metal oxides for efficient reactive oxygen species (ROS)-catalysis and provides an overview of their applications in various therapeutic areas.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Huang Zhu, Jiuhong Deng, Minjia Yuan, Xiao Rong, Xi Xiang, Fangxue Du, Xianglin Luo, Chong Cheng, Li Qiu
Summary: In this study, a novel semiconducting titanate-supported Ru clusterzyme (RuNC/BTO) was successfully created for ultrasound-amplified biocatalytic tumor nanotherapies. The biocatalyst consists of Ru nanoclusters tightly stabilized on BaTiO3, and exhibits peroxidase-like and halogenperoxidase-like activities that can produce abundant O-2(-) radicals. Moreover, the RuNC/BTO also has catalase-like activity to decompose H2O2 for relieving tumor hypoxia and amplifying ROS level via ultrasound irradiation. Comprehensive cellular and animal experiments have validated the superior tumor cell-killing effects and suppression abilities of this multi-modal strategy.
Article
Chemistry, Multidisciplinary
Min Liao, Fan Chen, Lin Chen, Zihe Wu, Jianbo Huang, Houqing Pang, Chong Cheng, Zhe Wu, Lang Ma, Qiang Lu
Summary: In this work, a Mn-coordinated polyphthalocyanine sonocavitation agent (Mn-SCA) is identified for non-thermal sonocavitation and sonodynamic therapy in liver cancer ablation. The enzymatic properties of Mn-SCA are utilized to lower the cavitation threshold and catalytically generate oxygen, which assists cavitation formation and relieves hypoxia in the tumor microenvironment. Under pHIFU irradiation, high reactive oxygen species (ROS) production can be achieved, demonstrating the merits of this method in liver cancer ablation.
Review
Electrochemistry
Wenjie Shao, Rui Yan, Mi Zhou, Lang Ma, Christina Roth, Tian Ma, Sujiao Cao, Chong Cheng, Bo Yin, Shuang Li
Summary: In this review, the design and optimization methods of nanostructured carbon-based electrodes for advanced Zn-air batteries are comprehensively summarized. By tailoring the structure of carbon-based materials and oxygen catalytic centers, the performance of oxygen electrodes can be improved. Furthermore, recent progress in engineering flexible and high-power Zn-air batteries is briefly outlined, and the challenges and future perspectives on the rational design of nanostructured carbon-based oxygen electrodes are discussed.
ELECTROCHEMICAL ENERGY REVIEWS
(2023)
Review
Chemistry, Multidisciplinary
Ziyan Feng, Xi Xiang, Jianbo Huang, Liyun Wang, Bihui Zhu, Hongju Zhou, Houqing Pang, Chong Cheng, Lang Ma, Li Qiu
Summary: Sonodynamic therapy (SDT) uses ultrasound and sonosensitizers to generate reactive oxygen species (ROS) that induce cell death. The latest advancements in intelligent sonocatalytic nanoagents (SCNs) have facilitated the design and construction of versatile SCNs for various energy conversion-based therapies. These SCNs have shown promising potential for a wide range of biomedical applications.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Physical
Weiwen Wang, Lu Zhang, Chen Gao, Huang Zhu, Xing Yang, Chong Cheng, Xikui Liu, Shuang Li
Summary: In this study, a stable Mo-based catalyst was fabricated by pyrolysis of Mo, Ni adsorbed two-dimensional covalent organic framework (COF). The derived catalyst, Mo2C-MoNi4@NC, showed excellent HER activity and remarkable stability due to the protective effect of the nitrogen-doped graphene shell layer.
APPLIED SURFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Minjia Yuan, Qian Li, Zihe Wu, Huang Zhu, Yang Gao, Mi Zhou, Xianglin Luo, Mao Wang, Chong Cheng
Summary: This study engineered a unique CeO2 support as nanoglue to anchor Ru single-atom sites (CeO2-Ru) for sensitive and robust H2O2-related biocatalytic diagnosis. The CeO2-Ru exhibited outstanding catalytic activity and selectivity to H2O2, demonstrating its potential for colorimetric detection of L-cysteine, glucose, and uric acid. This work offers a new pathway for creating single-atom noble metal biocatalysts and has promising applications in biotherapeutics and biocatalysis.
Review
Chemistry, Multidisciplinary
Zhenyu Xing, Jiusi Guo, Zihe Wu, Chao He, Liyun Wang, Mingru Bai, Xikui Liu, Bihui Zhu, Qiuyue Guan, Chong Cheng
Summary: Bacterial infection is a global health problem, and the rise of antibiotic resistance and biofilm formation has made it difficult to combat bacteria. Therefore, the development of antimicrobial nanomaterials is crucial for finding alternative treatments.
Meeting Abstract
Transplantation
Shanshan Chen, Qian Li, Chong Cheng, Baihai Su
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Materials Science, Multidisciplinary
Menghao Cheng, Zhenyu Xing, Rui Yan, Zhenyang Zhao, Tian Ma, Mi Zhou, Xikui Liu, Shuang Li, Chong Cheng
Summary: This study fabricated an oxygen-modulated metal nitride cluster (C-MoNx-O) as an electrocatalyst for lithium-sulfur batteries, which showed a high discharge capacity of 875 mAh g(-1) at 0.5 C and a low capacity decay rate of 0.10% after 280 cycles. The C-MoNx-O electrocatalyst effectively immobilized and catalyzed the solid-solid conversion of Li2S2-Li2S, promoting reaction kinetics and eliminating the shuttle effect. This research provides innovative structures and reversible solid-solid conversions to overcome the sluggish redox chemistry of polysulfides.
Article
Chemistry, Multidisciplinary
Chenxi Zhang, Rui Yan, Mingru Bai, Yimin Sun, Xianglong Han, Chong Cheng, Ling Ye
Summary: This study presents a Pt-clusters-equipped antioxidase-like biocatalyst with superior catalytic abilities for stem cell protection and periodontitis treatment. The biocatalyst demonstrates exceptional ROS-scavenging activities and effectively protects stem cell survival and adhesion in high ROS levels microenvironment. It also reduces the inflammatory response and protects against bone loss in the treatment of mouse periodontitis.
