Targeting Complement Pathways During Cold Ischemia and Reperfusion Prevents Delayed Graft Function

Thrombin may modulate dendritic cell activation in kidney transplant recipients with delayed graft function

(2015) Paola Pontrelli et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Complement-dependent NADPH oxidase enzyme activation in renal ischemia/reperfusion injury

(2014) S. Simone et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Novel Targeted Inhibitor of the Alternative Pathway of Complement and Its Therapeutic Application in Ischemia/Reperfusion Injury

(2014) Y. Huang et al.   JOURNAL OF IMMUNOLOGY

Summary of FDA Workshop on Ischemia Reperfusion Injury in Kidney Transplantation

(2013) M. Cavaillé-Coll et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Blocking Properdin, the Alternative Pathway, and Anaphylatoxin Receptors Ameliorates Renal Ischemia-Reperfusion Injury in Decay-Accelerating Factor and CD59 Double-Knockout Mice

(2013) T. Miwa et al.   JOURNAL OF IMMUNOLOGY

Thrombin generates previously unidentified C5 products that support the terminal complement activation pathway

(2012) M. J. Krisinger et al.   BLOOD

The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment

(2012) A. M. Risitano et al.   BLOOD

Solution Structure of TT30, a Novel Complement Therapeutic Agent, Provides Insight into Its Joint Binding to Complement C3b and C3d

(2012) Keying Li et al.   JOURNAL OF MOLECULAR BIOLOGY

Delayed Graft Function in the Kidney Transplant

(2011) A. Siedlecki et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseases

(2011) M. Fridkis-Hareli et al.   BLOOD

Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury

(2011) Brandon Renner et al.   KIDNEY INTERNATIONAL

Lectin complement pathway gene profile of the donor and recipient does not influence graft outcome after kidney transplantation

(2011) Jeffrey Damman et al.   MOLECULAR IMMUNOLOGY

Targeting complement activation in brain-dead donors improves renal function after transplantation

(2011) Jeffrey Damman et al.   TRANSPLANT IMMUNOLOGY

Therapeutic Targeting of Classical and Lectin Pathways of Complement Protects from Ischemia-Reperfusion-Induced Renal Damage

(2010) Giuseppe Castellano et al.   AMERICAN JOURNAL OF PATHOLOGY

A Risk Prediction Model for Delayed Graft Function in the Current Era of Deceased Donor Renal Transplantation

(2010) W. D. Irish et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Anti-thrombin Therapy During Warm Ischemia and Cold Preservation Prevents Chronic Kidney Graft Fibrosis in a DCD Model

(2009) F. Favreau et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Interactions of Ficolin and Mannose-Binding Lectin with Fibrinogen/Fibrin Augment the Lectin Complement Pathway

(2009) Yuichi Endo et al.   Journal of Innate Immunity

Direct Thrombin Inhibitor Prevents Delayed Graft Function in a Porcine Model of Renal Transplantation

(2009) Sebastien Giraud et al.   TRANSPLANTATION

Pharmacological targeting of C5a receptors during organ preservation improves kidney graft survival

(2008) A. G. Lewis et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Marked variation in the definition and diagnosis of delayed graft function: a systematic review

(2008) S. G. Yarlagadda et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION