Article
Chemistry, Multidisciplinary
Ayesha M. Patel, E. Neil G. Marsh
Summary: The study demonstrates that viperin activates a component of the protein ubiquitination machinery, enhancing TRAF6's ubiquitin transfer activity and increasing important polyubiquitinated forms, suggesting a potential role as an agonist of immune signaling pathways.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Fisheries
Jian Zhang, Xiangyi Sun, Xuepeng Li, Shuning Zhang, Xiudan Xu, Jixing Feng
Summary: Many viruses hijack the host's ubiquitin-proteasome system (UPS) for successful infection. This study identified and characterized a protein called SmE2D2 in turbot, which interacts with the RBIV-C1 virus. The results show that SmE2D2 is an E2 ubiquitin-conjugating enzyme that is used by RBIV-C1 to promote efficient replication.
Review
Biochemistry & Molecular Biology
Natsuki Osaka, Yoshihisa Hirota, Doshun Ito, Yoshiki Ikeda, Ryo Kamata, Yuki Fujii, Venkat R. Chirasani, Sharon L. Campbell, Koh Takeuchi, Toshiya Senda, Atsuo T. Sasaki
Summary: The article provides an overview of post-translational modifications in the RAS G4 and G5 motifs, highlighting their role in RAS activation and potential applications in cancer therapy.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Plant Sciences
Pengcheng Wang, Kai Guo, Qian Su, Jinwu Deng, Xianlong Zhang, Lili Tu
Summary: The E2 enzyme GhUBC2L modulates histone monoubiquitination synergistically with E3 ligase GhUbox8 to control organ size in cotton by affecting the expression of genes related to cell cycle and organ development.
Review
Oncology
Ana Gonzalez-Garcia, Antonio Garrido, Ana C. Carrera
Summary: Genetic alterations in the PI3-kinase/PTEN pathway are common in cancer cells. Current efforts to treat PTEN-dependent tumors mainly focus on PI3-kinase inhibition, but modulating PTEN post-translational modifications could provide alternative therapeutic strategies.
Review
Cell Biology
Xiu Yin, Qingbin Liu, Fen Liu, Xinchen Tian, Tinghao Yan, Jie Han, Shulong Jiang
Summary: This review summarizes the role of ubiquitination in tumorigenesis and related signaling pathways, aiming to provide a reference for future exploration of ubiquitination and potential targets for cancer therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chenxi Ouyang, Guang Lu, Weifeng He, Boon-Huat Bay, Han-Ming Shen
Summary: The study reveals two forms of post-translational modifications of SIRT1 and their reciprocal effects. The post-translational modifications of SIRT1 play a crucial role in determining cell fate in response to DNA damage.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Immunology
Ting Zhong, Kang Lei, Xiaoxi Lin, Zhiguo Xie, Shuoming Luo, Zhiguang Zhou, Bin Zhao, Xia Li
Summary: Protein ubiquitination, an important form of posttranslational modification, plays a crucial role in regulating T cell development and differentiation. Recent research has shown that the ubiquitination system is involved in the regulation of thymocyte developmental programs. This review summarizes the molecular mechanisms and cellular pathways associated with thymocyte ubiquitination, providing insights into cell fate determination and potential therapeutic strategies for autoimmune diseases and cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Eric Schulze-Niemand, Michael Naumann
Summary: The COP9 signalosome (CSN) is a universal regulator of Cullin-RING ubiquitin ligases (CRLs) that control cellular processes by degrading signaling proteins. The CSN, with its eight-subunit architecture, inactivates CRLs by removing a small ubiquitin-like modifier called Nedd8. Recent findings on the versatile regulation of CSN-CRL complexes are presented in this review.
TRENDS IN BIOCHEMICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Yanxiang Meng, Jarrod J. Sandow, Peter E. Czabotar, James M. Murphy
Summary: This article discusses the role of phosphorylation, ubiquitylation, GlcNAcylation, proteolytic cleavage, and disulfide bonding in regulating necroptotic signaling, with a focus on RIPK1, RIPK3, and MLKL. Understanding of these post-translational modifications can be valuable in efforts to therapeutically modulate necroptosis.
CELL DEATH AND DIFFERENTIATION
(2021)
Review
Biochemistry & Molecular Biology
Shuangze Han, Ruike Wang, Yangnan Zhang, Xiaoying Li, Yu Gan, Feng Gao, Pengfei Rong, Wei Wang, Wei Li
Summary: This review summarizes the regulatory role of ubiquitination in tumor metastasis, particularly focusing on the important roles of E3 ubiquitin ligases and deubiquitinases, and discusses the relationship between ubiquitination components and tumor progression.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Yun Li, Hong Yang, Tianhan He, Liang Zhang, Chao Liu
Summary: Cav1.2 plays a crucial role in neurodegenerative diseases, but the regulation of its activity remains incompletely understood. The repurposing of DHP drugs may offer potential therapeutic strategies, but further research is needed.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Xingde Wang, Xingzhi Xu, Zhifeng Wang
Summary: In this review, the authors summarize the known information about the UFM1 enzymatic cascade and its biological functions, discuss the identified substrates, and explore the pathological role of UFMylation in human disease.
Review
Biochemistry & Molecular Biology
Lynsay Blake, Martin J. Cann
Summary: Carbon dioxide plays a crucial role in various life processes, regulating cellular reactions, transport, maintenance, and behavior. Protein carbamate modification, mediated by carbon dioxide, is a mechanism that may alter protein function and participate in sensing and signaling.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Cell Biology
Yi Xiong, Chao Yu, Qianting Zhang
Summary: This review discusses the functions of ubiquitin proteasome system (UPS) components in mammalian spermatogenesis, including the composition of proteasome isoforms at each stage, the specificity and associated degradation events of each isoform, E3 ubiquitin ligases mediating protein ubiquitination, and the deubiquitinases involved in spermatogenesis and male fertility. Exploring the UPS machineries in spermatogenesis provides insights into protein dynamics during male germ cell production and sheds light on the etiology and pathogenesis of human male infertility.
Article
Biochemistry & Molecular Biology
Sonja Lorenz, Patricia Deng, Oliver Hantschel, Giulio Superti-Furga, John Kuriyan
BIOCHEMICAL JOURNAL
(2015)
Article
Biology
Bodo Sander, Wenshan Xu, Martin Eilers, Nikita Popov, Sonja Lorenz
Review
Biochemistry & Molecular Biology
Sonja Lorenz
BIOLOGICAL CHEMISTRY
(2018)
Review
Biology
Sonja Lorenz, Aaron J. Cantor, Michael Rape, John Kuriyan
Article
Biochemistry & Molecular Biology
Katherine E. Wickliffe, Sonja Lorenz, David E. Wemmer, John Kuriyan, Michael Rape
Review
Biochemistry & Molecular Biology
Dan Chen, Matthias Gehringer, Sonja Lorenz
Article
Multidisciplinary Sciences
Sonja Lorenz, Moitrayee Bhattacharyya, Christian Feiler, Michael Rape, John Kuriyan
Article
Biochemistry & Molecular Biology
Sonja Lorenz, Ioannis Vakonakis, Edward D. Lowe, Lain D. Campbell, Martin E. M. Noble, Maria K. Hoellerer
Article
Biochemistry & Molecular Biology
Lena K. Ries, Anna K. L. Liess, Christian G. Feiler, Donald E. Spratt, Edward D. Lowe, Sonja Lorenz
Article
Multidisciplinary Sciences
Natascha Rill, Ann Mukhortava, Sonja Lorenz, Ingrid Tessmer
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
News Item
Biochemistry & Molecular Biology
Sonja Lorenz, Katrin Rittinger
NATURE CHEMICAL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Anna K. L. Liess, Alena Kucerova, Kristian Schweimer, Doerte Schlesinger, Olexandr Dybkov, Henning Urlaub, Joerg Mansfeld, Sonja Lorenz
Article
Biochemistry & Molecular Biology
Rahul M. Nair, Ayshwarya Seenivasan, Bing Liu, Dan Chen, Edward D. Lowe, Sonja Lorenz
Summary: This study demonstrates the use of an activity-based probe, ubiquitin-propargylamine, for reconstituting and analyzing the interactions between ubiquitin and certain HECT ligases. The crystal structure reveals a catalytically critical conformation of the C-terminal tail of the ligase for ubiquitin transfer. Additionally, the probe shows selectivity among HECT domains, suggesting potential for developing specific inhibitors and reporters of HECT ligase activities.
ACS CHEMICAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
M Sumper, S Lorenz, E Brunner
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2003)