Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands

The absence of class III β-tubulin is predictive of a favorable response to nab -paclitaxel and gemcitabine in patients with unresectable pancreatic ductal adenocarcinoma

(2018) Akihisa Kato et al.   HUMAN PATHOLOGY

Bipolar androgen therapy in men with metastatic castration-resistant prostate cancer after progression on enzalutamide: an open-label, phase 2, multicohort study

(2018) Benjamin A Teply et al.   LANCET ONCOLOGY

Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

(2018) Peter Schmid et al.   NEW ENGLAND JOURNAL OF MEDICINE

Modification of C-seco taxoids through ring tethering and substituent replacement leading to effective agents against tumor drug resistance mediated by βIII-Tubulin and P-glycoprotein (P-gp) overexpressions

(2017) Yong Tang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration

(2017) Jessica Field et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Insights into the Distinct Mechanisms of Action of Taxane and Non-Taxane Microtubule Stabilizers from Cryo-EM Structures

(2017) Elizabeth H. Kellogg et al.   JOURNAL OF MOLECULAR BIOLOGY

Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites

(2017) Jessica J. Field et al.   JOURNAL OF NATURAL PRODUCTS

Mechanism of microtubule stabilization by taccalonolide AJ

(2017) Yuxi Wang et al.   Nature Communications

Pironetin Binds Covalently to αCys316 and Perturbs a Major Loop and Helix of α-Tubulin to Inhibit Microtubule Formation

(2016) Andrea E. Prota et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanism of super-assembly of respiratory complexes III and IV

(2016) Sara Cogliati et al.   NATURE

Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule

(2016) Jianhong Yang et al.   Nature Communications

Overexpression of Class III β-tubulin, Sox2, and nuclear Survivin is predictive of taxane resistance in patients with stage III ovarian epithelial cancer

(2015) Jintong Du et al.   BMC CANCER

Effect of CH-35, a novel anti-tumor colchicine analogue, on breast cancer cells overexpressing the βIII isotype of tubulin

(2015) Lee-Chuan C. Yeh et al.   INVESTIGATIONAL NEW DRUGS

Designing and Testing of Novel Taxanes to Probe the Highly Complex Mechanisms by Which Taxanes Bind to Microtubules and Cause Cytotoxicity to Cancer Cells

(2015) Marc St. George et al.   PLoS One

Structural Basis of Microtubule Stabilization by Laulimalide and Peloruside A

(2014) Andrea E. Prota et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances

(2014) Ruth Matesanz et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antibody–drug conjugates—A new wave of cancer drugs

(2014) Hervé Bouchard et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization

(2014) Andrea E. Prota et al.   JOURNAL OF MOLECULAR BIOLOGY

A semisynthetic taxane Yg-3-46a effectively evades P-glycoprotein and β-III tubulin mediated tumor drug resistance in vitro

(2013) Pei Cai et al.   CANCER LETTERS

Taccalonolide Binding to Tubulin Imparts Microtubule Stability and Potent In Vivo Activity

(2013) A. L. Risinger et al.   CANCER RESEARCH

Structural basis of tubulin tyrosination by tubulin tyrosine ligase

(2013) Andrea E. Prota et al.   JOURNAL OF CELL BIOLOGY

Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents

(2013) A. E. Prota et al.   SCIENCE

Zampanolide, a Potent New Microtubule-Stabilizing Agent, Covalently Reacts with the Taxane Luminal Site in Tubulin α,β-Heterodimers and Microtubules

(2012) Jessica J. Field et al.   CHEMISTRY & BIOLOGY

Insights into the Interaction of Discodermolide and Docetaxel with Tubulin. Mapping the Binding Sites of Microtubule-Stabilizing Agents by Using an Integrated NMR and Computational Approach

(2011) Angeles Canales et al.   ACS Chemical Biology

Cyclostreptin Derivatives Specifically Target Cellular Tubulin and Further Map the Paclitaxel Site

(2011) Enrique Calvo et al.   BIOCHEMISTRY

Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules

(2011) J. Alberto Marco et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Determinants That Govern Microtubule Assembly from the Atomic Structure of GTP-Tubulin

(2011) Agata Nawrotek et al.   JOURNAL OF MOLECULAR BIOLOGY

Specific β-Tubulin Isotypes Can Functionally Enhance or Diminish Epothilone B Sensitivity in Non-Small Cell Lung Cancer Cells

(2011) Pei Pei Gan et al.   PLoS One

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

βIII-Tubulin Is a Multifunctional Protein Involved in Drug Sensitivity and Tumorigenesis in Non–Small Cell Lung Cancer

(2010) Joshua A. McCarroll et al.   CANCER RESEARCH

Tubulin targets in the pathobiology and therapy of glioblastoma multiforme. I. class III β-tubulin

(2009) Christos D. Katsetos et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Taccalonolides: Microtubule Stabilizers That Circumvent Clinically Relevant Taxane Resistance Mechanisms

(2008) April L. Risinger et al.   CANCER RESEARCH

Proteomic characterization of cytoskeletal and mitochondrial class III  -tubulin

(2008) L. Cicchillitti et al.   MOLECULAR CANCER THERAPEUTICS

The roles of cys124 and ser239 in the functional properties of human βIII tubulin

(2008) Patrick A. Joe et al.   CELL MOTILITY AND THE CYTOSKELETON

Hypoxia induces class III beta-tubulin gene expression by HIF-1α binding to its 3' flanking region

(2007) Giuseppina Raspaglio et al.   GENE