Article
Biochemistry & Molecular Biology
Laura Stein, Nora Brunner, Salah Amasheh
Summary: The epithelial barrier plays a crucial role in gastrointestinal function by preventing the passage of solutes. This study investigates the interaction between claudin-4 and claudin-18.2, two tight junction proteins in the gastric epithelium, and suggests that this interaction is dependent on both mechanical force and pH. The findings highlight the importance of tight junction integrity for proper gastrointestinal function.
Article
Pharmacology & Pharmacy
Helena Hader, Nina A. Hering, Joerg-Dieter Schulzke, Roland Buecker, Rita Rosenthal
Summary: The study demonstrates the antagonizing effects of myrrh against IL-13-induced barrier impairment in a human intestinal cell model. This suggests the potential use of myrrh as a treatment option for inflammatory bowel disease.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Food Science & Technology
Marta Justyna Koziel, Maksymilian Ziaja, Agnieszka Wanda Piastowska-Ciesielska
Summary: The intestinal barrier acts as the main defense against substances entering the body, ensuring balance in the organism; Mycotoxins, toxic fungi metabolites, may disrupt homeostasis by affecting the intestinal barrier; Claudins, proteins involved in tight junction formation between epithelial cells, play a significant role in responding to mycotoxin-induced cytotoxicity.
Article
Biochemistry & Molecular Biology
Linda Droessler, Valeria Cornelius, Alexander G. Markov, Salah Amasheh
Summary: The study demonstrates the detrimental effects of TNFα on non-transformed intestinal epithelial cells, leading to barrier dysfunction. This is achieved through modulation of tight junction proteins and TNF receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Linda Droessler, Valeria Cornelius, Elisa Boehm, Laura Stein, Nora Brunner, Salah Amasheh
Summary: TNF affects the barrier function of follicle-associated epithelium of porcine Peyer's patches, but has no effects on villus epithelium. These findings reveal the differences in epithelial barrier function between the two structures and the importance of Peyer's patches as a primary mucosal immune defense.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Atul K. Srivastava, Bharat Somireddy Venkata, Yan Y. Sweat, Heather R. Rizzo, Lea Jean-Francois, Li Zuo, Kathleen W. Kurgan, Patrick Moore, Nitesh Shashikanth, Izabela Smok, Joseph R. Sachleben, Jerrold R. Turner, Stephen C. Meredith
Summary: This study investigates the effects of S408 phosphorylation on occludin protein structure and demonstrates its role in regulating intercellular junction function through interactions with other components.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Mitsunobu Ueda, Hidetomo Kobayashi, Soshi Seike, Eizo Takahashi, Keinosuke Okamoto, Hiroyasu Yamanaka
Summary: Aeromonas sobria, a Gram-negative pathogen causing food-borne illness, opportunistically leads to severe extraintestinal diseases in immunocompromised patients and the elderly. It can disrupt the barrier function of the intestinal epithelium by destroying tight junctions, potentially aiding the invasion of pathogens into deep sites in the human body.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Food Science & Technology
Lucas Heils, Martina Schneemann, Ralf Gerhard, Joerg-Dieter Schulzke, Roland Buecker
Summary: The study investigated the impact of Clostridioides difficile binary toxin (CDT) on the intestinal epithelial barrier and found that sublethal concentrations of CDT induced barrier dysfunction with increased permeability and redistribution of tight junction proteins. This suggests that CDT may contribute to diarrhea by compromising the intestinal barrier function.
Article
Endocrinology & Metabolism
Lars Winkler, Rosel Blasig, Olga Breitkreuz-Korff, Philipp Berndt, Sophie Dithmer, Hans C. Helms, Dmytro Puchkov, Kavi Devraj, Mehmet Kaya, Zhihai Qin, Stefan Liebner, Hartwig Wolburg, Anuska Andjelkovic, Andre Rex, Ingolf E. Blasig, Reiner F. Haseloff
Summary: The study shows that Cldn3 and occludin play a protective role in the stroke by maintaining the integrity of TJ and BBB, but also contribute to the development of edema and infarction.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Gastroenterology & Hepatology
Jia-Chen E. Hu, Franziska Weiss, Christian Bojarski, Federica Branchi, Joerg-Dieter Schulzke, Michael Fromm, Susanne M. Krug
Summary: In remission of UC, tricellulin expression level and intestinal barrier functions were restored to normal after being impaired in active UC. This indicates a re-sealing of the impaired tricellular paracellular pathway and reduced uptake of antigens back to normal rates in remission of UC.
BMC GASTROENTEROLOGY
(2021)
Article
Engineering, Biomedical
Elisa Boehm, Linda Droessler, Salah Amasheh
Summary: CBD, as a component of Cannabis-based biomaterials, has a strengthening effect on the cellular barrier under inflammatory conditions and mitigates the disruption of paracellular permeability and sealing proteins. These findings demonstrate the potential of CBD in therapeutic approaches against inflammatory pathogenesis.
MATERIALS TODAY BIO
(2023)
Article
Biochemistry & Molecular Biology
Viviana Scalavino, Emanuele Piccinno, Antonio Lacalamita, Angela Tafaro, Raffaele Armentano, Gianluigi Giannelli, Grazia Serino
Summary: This study identified 18 dysregulated miRNAs in intestinal epithelial cells from the ulcerative colitis (UC) mice model. MiR-195-5p, one of the down-regulated miRNAs, was found to be involved in impaired barrier function. The study demonstrated that miR-195-5p can regulate tight junctions by decreasing CLDN2 levels and subsequently affecting CLDN1 expression.
Article
Multidisciplinary Sciences
Ilke De Boeck, Stijn Wittouck, Katleen Martens, Irina Spacova, Eline Cauwenberghs, Camille Nina Allonsius, Jennifer Joerissen, Sander Wuyts, Wannes Van Beeck, Jelle Dillen, Peter A. Bron, Brecht Steelant, Peter W. Hellings, Olivier M. Vanderveken, Sarah Lebeer
Summary: The study found Dolosigranulum pigrum to be a species clearly associated with nasal health, mainly present in the human nasal cavity. The strain exhibits antimicrobial activity, decreases inflammation, and protects nasal barrier function, showing potential as a topical live biotherapeutic product.
Article
Chemistry, Multidisciplinary
Sofie Van Den Broucke, Jeroen A. J. Vanoirbeek, Rita Derua, Peter H. M. Hoet, Manosij Ghosh
Summary: This study investigated the impact of environmental and occupational irritants on the airway epithelial barrier using an in vitro coculture model. The findings suggest that graphene nanoparticles have a negative effect on the epithelial barrier, possibly due to slight alterations in tight junction organization.
Article
Food Science & Technology
Sefat E. Khuda, Ann V. Nguyen, Girdhari M. Sharma, Mohammad S. Alam, Kannan V. Balan, Kristina M. Williams
Summary: This study found that polysorbate-80 may enhance the absorption of allergens in a size-dependent manner by modulating paracellular permeability.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Physiology
A. G. Markov, E. L. Falchuk, N. M. Kruglova, J. Radloff, S. Amasheh
Review
Biochemistry & Molecular Biology
Alexander G. Markov, Joerg R. Aschenbach, Salah Amasheh
Article
Gastroenterology & Hepatology
Ulrike Lodemann, Salah Amasheh, Judith Radloff, Martina Kern, Astrid Bethe, Lothar H. Wieler, Robert Pieper, Juergen Zentek, Joerg R. Aschenbach
DIGESTIVE DISEASES AND SCIENCES
(2017)
Article
Immunology
Lukasz Grzeskowiak, Beatriz Martinez-Vallespin, Temesgen H. Dadi, Judith Radloff, Salah Amasheh, Femke-Anouska Heinsen, Andre Franke, Knut Reinert, Wilfried Vahjen, Juergen Zentek, Robert Pieper
JOURNAL OF INFECTIOUS DISEASES
(2018)
Article
Physiology
Judith Radloff, Evgeny L. Falchuk, Alexander G. Markov, Salah Amasheh
FRONTIERS IN PHYSIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Linda Droessler, Valeria Cornelius, Alexander G. Markov, Salah Amasheh
Summary: The study demonstrates the detrimental effects of TNFα on non-transformed intestinal epithelial cells, leading to barrier dysfunction. This is achieved through modulation of tight junction proteins and TNF receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Alexandra A. Livanova, Arina A. Fedorova, Alexander Zavirsky, Anastasia E. Bikmurzina, Igor I. Krivoi, Alexander G. Markov
Summary: Ionizing radiation causes significant changes in the transport and barrier functions of the intestine, with the most pronounced effects observed at 72 hours after a 10 Gy exposure in the rat jejunum. This experimental time point may be the most suitable for future studies involving rat jejunum as a model.
PHYSIOLOGICAL REPORTS
(2021)
Article
Pathology
Vsevolod A. Zinserling, Natalia Yu Semenova, Anastasia E. Bikmurzina, Natalia M. Kruglova, Oksana V. Rybalchenko, Alexander G. Markov
Summary: This study conducted immunohistochemistry analysis on 1200 deceased cases, finding that COVID-19 can cause cytoproliferative changes and multi-organ damage. Severe patients die from specific viral pneumonia, microcirculatory bed alterations, and vascular disorders associated with endothelial damage.
Meeting Abstract
Endocrinology & Metabolism
Judith Radloff, Maximilian Pagitz, Olena Andrukhova, Rainer Oberbauer, Iwan Burgener, Reinhold Erben
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Meeting Abstract
Endocrinology & Metabolism
Judith Radloff, Nejla Latic, Ulrike Pfeiffenberger, Claudia Bergow, Reinhold Erben
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Meeting Abstract
Endocrinology & Metabolism
Olena Andrukhova, Nejla Latic, Judith Radloff, Svetlana Slavic, Lukas Endler, Sathish Murali, Jessica Bayer, Ute Zeitz, Ulrike Pfeiffenberger, Simone Tangermann, Sabine Lagger, Julia Wilflingseder, Lukas Kenner, Birgit Strobl, Reinhold Erben, Christoph Kornauth, Rainer Oberbauer, Dario Alessi
JOURNAL OF BONE AND MINERAL RESEARCH
(2019)
Article
Multidisciplinary Sciences
Judith Radloff, Silke S. Zakrzewski, Robert Pieper, Alexander G. Markov, Salah Amasheh
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2017)
Meeting Abstract
Physiology
J. Radloff, S. S. Zakrzewski, E. L. Falchuk, A. G. Markov, S. Amasheh