The Potential Beneficial Effects of Resveratrol on Cardiovascular Complications in Marfan Syndrome Patients–Insights from Rodent-Based Animal Studies

Therapies for Thoracic Aortic Aneurysms and Acute Aortic Dissections

(2019) Dianna M. Milewicz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Decreased mitochondrial respiration in aneurysmal aortas of Fibulin-4 mutant mice is linked to PGC1A regulation

(2018) I van der Pluijm et al.   CARDIOVASCULAR RESEARCH

Effect of resveratrol on blood pressure: A systematic review and meta-analysis of randomized, controlled, clinical trials

(2018) Federica Fogacci et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Redox stress in Marfan syndrome: Dissecting the role of the NADPH oxidase NOX4 in aortic aneurysm

(2018) Francesc Jiménez-Altayó et al.   FREE RADICAL BIOLOGY AND MEDICINE

A heart for fibrillin: spatial arrangement in adult wild-type murine myocardial tissue

(2018) Felke Steijns et al.   HISTOCHEMISTRY AND CELL BIOLOGY

VESS07. Metformin Prescription Status and Abdominal Aortic Aneurysm Disease Progression in the U.S. Veteran Patient Population

(2018) Nathan K. Itoga et al.   JOURNAL OF VASCULAR SURGERY

Losartan Versus Atenolol for Prevention of Aortic Dilation in Patients With Marfan Syndrome

(2018) Gisela Teixido-Tura et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Evaluation of Flow-Mediated Vasodilation in the Brachial Artery Correlates With Endothelial Dysfunction Evaluated by Nitric Oxide Synthase Metabolites in Marfan Syndrome Patients

(2018) Oscar Lomelí et al.   Frontiers in Physiology

Comparison of biomechanical properties in ascending aortic aneurysms of patients with congenital bicuspid aortic valve and Marfan syndrome

(2018) Junfeng Yan et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR pathway

(2018) Jun Song et al.   Frontiers of Medicine

Mild aerobic exercise blocks elastin fiber fragmentation and aortic dilatation in a mouse model of Marfan syndrome associated aortic aneurysm

(2017) Christine Gibson et al.   JOURNAL OF APPLIED PHYSIOLOGY

Aortic microcalcification is associated with elastin fragmentation in Marfan syndrome

(2017) Shaynah Wanga et al.   JOURNAL OF PATHOLOGY

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome

(2017) Jorge Oller et al.   NATURE MEDICINE

Cardiovascular Benefits of Moderate Exercise Training in Marfan Syndrome: Insights From an Animal Model

(2017) Aleksandra Mas‐Stachurska et al.   Journal of the American Heart Association

Premature aortic smooth muscle cell differentiation contributes to matrix dysregulation in Marfan Syndrome

(2017) Matthew Dale et al.   PLoS One

Cardiac remodeling in the mouse model of Marfan syndrome develops into two distinctive phenotypes

(2016) Hyun-Jin Tae et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Resveratrol Inhibits Aortic Root Dilatation in the Fbn1C1039G/+Marfan Mouse ModelHighlights

(2016) Stijntje Hibender et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Altered Smooth Muscle Cell Force Generation as a Driver of Thoracic Aortic Aneurysms and DissectionsHighlights

(2016) Dianna M. Milewicz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Effects of exercise training and resveratrol on vascular health in aging

(2016) Lasse Gliemann et al.   FREE RADICAL BIOLOGY AND MEDICINE

Resveratrol-induced autophagy promotes survival and attenuates doxorubicin-induced cardiotoxicity

(2016) Jun Gu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Beneficial action of resveratrol: How and why?

(2016) Gustavo Tomas Diaz-Gerevini et al.   NUTRITION

Participation of oleic acid in the formation of the aortic aneurysm in Marfan syndrome patients

(2016) María Elena Soto et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Resveratrol and Cardiovascular Diseases

(2016) Dominique Bonnefont-Rousselot   Nutrients

Doxycycline for Stabilization of Abdominal Aortic Aneurysms

(2016) C. Arnoud Meijer et al.   ANNALS OF INTERNAL MEDICINE

Therapeutic potential of resveratrol in heart failure

(2015) Miranda M. Sung et al.   Annals of the New York Academy of Sciences

Local MicroRNA Modulation Using a Novel Anti-miR-21–Eluting Stent Effectively Prevents Experimental In-Stent RestenosisSignificance

(2015) Dong Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Vascular Smooth Muscle Cell Phenotypic Changes in Patients With Marfan SyndromeSignificance

(2015) Eva Crosas-Molist et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

SIRT1 Suppresses Doxorubicin-Induced Cardiotoxicity by Regulating the Oxidative Stress and p38MAPK Pathways

(2015) Yang Ruan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Histopathology of aortic complications in bicuspid aortic valve versus Marfan syndrome: relevance for therapy?

(2015) Nimrat Grewal et al.   HEART AND VESSELS

Resveratrol protects against doxorubicin-induced cardiotoxicity in aged hearts through the SIRT1-USP7 axis

(2015) Thomas K. Sin et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Risk for Type B Aortic Dissection in Marfan Syndrome

(2015) Alexander W. den Hartog et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Intrinsic cardiomyopathy in Marfan syndrome: results from in-vivo and ex-vivo studies of the Fbn1 C1039G/+ model and longitudinal findings in humans

(2015) Laurence Campens et al.   PEDIATRIC RESEARCH

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research

(2015) Norman Moullan et al.   Cell Reports

A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome

(2015) Jefferson J Doyle et al.   eLife

Aortopathy in Marfan syndrome: an update

(2014) Federico Romaniello et al.   CARDIOVASCULAR PATHOLOGY

Role of miR-195 in Aortic Aneurysmal Disease

(2014) Anna Zampetaki et al.   CIRCULATION RESEARCH

Abnormal muscle mechanosignaling triggers cardiomyopathy in mice with Marfan syndrome

(2014) Jason R. Cook et al.   JOURNAL OF CLINICAL INVESTIGATION

Analysis of Oxidative Stress Enzymes and Structural and Functional Proteins on Human Aortic Tissue from Different Aortopathies

(2014) María Elena Soto et al.   Oxidative Medicine and Cellular Longevity

No Beneficial Effect of General and Specific Anti-Inflammatory Therapies on Aortic Dilatation in Marfan Mice

(2014) Romy Franken et al.   PLoS One

Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway

(2013) Ming-liang Chen et al.   Autophagy

SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: Implications for vascular aging

(2013) María José Zarzuelo et al.   BIOCHEMICAL PHARMACOLOGY

Resveratrol prevents hypertension and cardiac hypertrophy in hypertensive rats and mice

(2013) Vernon W. Dolinsky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Resveratrol Protects HUVECs from Oxidized-LDL Induced Oxidative Damage by Autophagy Upregulation via the AMPK/SIRT1 Pathway

(2013) Hualei Guo et al.   CARDIOVASCULAR DRUGS AND THERAPY

Losartan reduces aortic dilatation rate in adults with Marfan syndrome: a randomized controlled trial

(2013) M. Groenink et al.   EUROPEAN HEART JOURNAL

Mechanosensitive microRNAs—role in endothelial responses to shear stress and redox state

(2013) Traci Marin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Relation between genotype and left-ventricular dilatation in patients with Marfan syndrome

(2013) Jan J.J. Aalberts et al.   GENE

Impairment of flow-mediated dilation correlates with aortic dilation in patients with Marfan syndrome

(2013) Munenori Takata et al.   HEART AND VESSELS

Circulating transforming growth factor-β as a prognostic biomarker in Marfan syndrome

(2013) Romy Franken et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Resveratrol Attenuates Doxorubicin-Induced Cardiomyocyte Apoptosis in Lymphoma Nude Mice by Heme Oxygenase-1 Induction

(2012) Jun Gu et al.   Cardiovascular Toxicology

MMP-2 Regulates Erk1/2 Phosphorylation and Aortic Dilatation in Marfan Syndrome

(2012) Wanfen Xiong et al.   CIRCULATION RESEARCH

Current and future pharmacological treatment strategies with regard to aortic disease in Marfan syndrome

(2012) Alexander W Hartog et al.   EXPERT OPINION ON PHARMACOTHERAPY

Inflammation Aggravates Disease Severity in Marfan Syndrome Patients

(2012) Teodora Radonic et al.   PLoS One

MicroRNA-21 Blocks Abdominal Aortic Aneurysm Development and Nicotine-Augmented Expansion

(2012) L. Maegdefessel et al.   Science Translational Medicine

Elastin in Large Artery Stiffness and Hypertension

(2012) Jessica E. Wagenseil et al.   Journal of Cardiovascular Translational Research

Resveratrol prevents the development of abdominal aortic aneurysm through attenuation of inflammation, oxidative stress, and neovascularization

(2011) Hidehiro Kaneko et al.   ATHEROSCLEROSIS

Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through SIRT1-mediated deacetylation of p53

(2011) C. Zhang et al.   CARDIOVASCULAR RESEARCH

Modulation of Anthracycline-Induced Cardiotoxicity by Aerobic Exercise in Breast Cancer

(2011) Jessica M. Scott et al.   CIRCULATION

MicroRNA-29 in Aortic Dilation: Implications for Aneurysm Formation

(2011) Reinier A. Boon et al.   CIRCULATION RESEARCH

miR-29b Participates in Early Aneurysm Development in Marfan Syndrome

(2011) Denis R. Merk et al.   CIRCULATION RESEARCH

Resveratrol Counteracts Systemic and Local Inflammation Involved in Early Abdominal Aortic Aneurysm Development

(2011) Daniela Palmieri et al.   JOURNAL OF SURGICAL RESEARCH

Assessing adriamycin-induced early cardiotoxicity by estimating left ventricular ejection fraction using technetium-99m multiple-gated acquisition scan and echocardiography

(2011) Nosheen Fatima et al.   NUCLEAR MEDICINE COMMUNICATIONS

Noncanonical TGF  Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice

(2011) T. M. Holm et al.   SCIENCE

MiR-21 is induced in endothelial cells by shear stress and modulates apoptosis and eNOS activity

(2010) Martina Weber et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cardiovascular manifestations in men and women carrying a FBN1 mutation

(2010) Delphine Détaint et al.   EUROPEAN HEART JOURNAL

The revised Ghent nosology for the Marfan syndrome

(2010) B. L. Loeys et al.   JOURNAL OF MEDICAL GENETICS

Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype

(2009) J. Gracia-Sancho et al.   CARDIOVASCULAR RESEARCH

Distinct defects in collagen microarchitecture underlie vessel-wall failure in advanced abdominal aneurysms and aneurysms in Marfan syndrome

(2009) J. H. N. Lindeman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vasomotor dysfunction in the thoracic aorta of Marfan syndrome is associated with accumulation of oxidative stress

(2009) H.H. Clarice Yang et al.   VASCULAR PHARMACOLOGY

Endothelial dysfunction and compromised eNOS/Akt signaling in the thoracic aorta during the progression of Marfan syndrome

(2007) A W Y Chung et al.   BRITISH JOURNAL OF PHARMACOLOGY