Article
Multidisciplinary Sciences
BeumJin Park, Seok-Jae Heo, Yong Joon Lee, Mi-Kyoung Seo, Jiyun Hong, Eui-Cheol Shin, Inkyung Jung, Sangwoo Kim
Summary: CD8(+) T cells can recognize and kill early tumor cells, with the efficiency influenced by the coverage of HLA-I tumor antigens. Tumors with HLA-I homozygosity show earlier onset. The association may depend on the tumor type and driver mutation specificity. Testing on an independent dataset confirmed the acceleration of tumor onset in a specific type of tumor with HLA-I heterozygosity.
Article
Biochemistry & Molecular Biology
Xiao Lu, Alice Prodger, Jingwei Sim, Colin E. Evans
Summary: Cancer patients have a higher risk of thrombosis compared to individuals without cancer. Thrombosis can also be a diagnostic predictor of cancer, but the mechanisms by which thrombosis promotes tumor propagation are not fully understood. This study investigates the role of hypoxia-inducible factors (HIF) in myeloid cells in thrombosis-induced tumorigenesis. The results show that HIF1-alpha and HIF2-alpha levels are increased in myeloid cells of murine thrombi. Additionally, thrombosis increases HIF1-alpha and HIF2-alpha levels in murine lungs, promoting tumor development. In vitro studies also demonstrate that hypoxia upregulates tumorigenic factors in the secretome of neutrophils and macrophages, leading to lung cancer cell proliferation and migration in a myeloid-HIF-dependent manner. These findings highlight the importance of thrombotic insult and myeloid HIFs in mediating tumorigenic success.
Article
Biology
Jong S. Park, Austin M. Gabel, Polina Kassir, Lois Kang, Prableen K. Chowdhary, Afia Osei-Ntansah, Neil D. Tran, Soujanya Viswanathan, Bryanna Canales, Pengfei Ding, Young-Sam Lee, Rachel Brewster
Summary: Lack of oxygen can be detrimental to cell function and survival, and this study demonstrates the role of the ndrg1a gene in hypoxia adaptation in zebrafish embryos. ndrg1a is involved in degrading ATPase, which helps maintain cellular energy homeostasis.
Article
Obstetrics & Gynecology
Akemi Nishigaki, Hiroaki Tsubokura, Mitsuaki Ishida, Yoshiko Hashimoto, Aya Yoshida, Yoji Hisamatsu, Tomoko Tsuzuki-Nakao, Hiromi Murata, Hidetaka Okada
Summary: The expression and role of NDRG1 in the human ovary remain unclear. This study found that NDRG1 is expressed in luteinized granulosa cells and its concentration is positively correlated with VEGF and progesterone concentrations. Hypoxic stress significantly increases the expression of NDRG1 and VEGF, and this overexpression can be suppressed by echinomycin. Additionally, transfection with NDRG1 siRNA significantly inhibits progesterone release.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2022)
Article
Cell Biology
Dexin Shen, Zhao Deng, Wei Liu, Fenfang Zhou, Yayun Fang, Danni Shan, Gang Wang, Kaiyu Qian, Mengxue Yu, Yi Zhang, Lingao Ju, Yu Xiao, Xinghuan Wang
Summary: Melatonin, a natural hormone, has shown potential anticancer effects in various human cancers. In our study, we found that melatonin could inhibit glycolysis and identified ENO1 as a downstream effector and potential biomarker of bladder cancer. We also demonstrated that enhanced glycolysis and gemcitabine resistance could be induced by exogenous pyruvate, and melatonin or ENO1 silencing could enhance the cytotoxic effect of gemcitabine on bladder cancer cells. Furthermore, we discovered that PPAR gamma acted as an upstream regulator of ENO1.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Miguel Angel Merlos Rodrigo, Hana Michalkova, Vladislav Strmiska, Berta Casar, Piero Crespo, Vivian de los Rios, J. Ignacio Casal, Yazan Haddad, Roman Guran, Tomas Eckschlager, Petra Pokorna, Zbynek Heger, Vojtech Adam
Summary: This study revealed that up-regulation of metallothionein-3 (hMT3) in neuroblastoma cells was associated with increased cisplatin resistance, indicating a potential cause for tumor relapse. Multiple biological pathways related to apoptosis, transport, proteasome, and cellular stress were implicated in cisplatin resistance in hMT3-overexpressing neuroblastoma cells.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Jorge Duarte-Gutierrez, Alma B. Peregrino-Uriarte, Silvia Gomez-Jimenez, Veronica Mata-Haro, Gloria Yepiz-Plascencia
Summary: The study investigated the impact of silencing HIF-1 on MT expression and apoptosis in Litopenaeus vannamei under different oxygen conditions. Results showed differential regulation of MT expression and apoptosis by HIF-1 in various tissues during normoxia, hypoxia, and reoxygenation.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yaoyi Xiong, Lingao Ju, Lushun Yuan, Liang Chen, Gang Wang, Huimin Xu, Tianchen Peng, Yongwen Luo, Yu Xiao, Xinghuan Wang
Summary: This study identified an oncogene KNSTRN that promotes tumorigenesis and gemcitabine resistance by activating AKT phosphorylation. KNSTRN interacts with PTEN and AKT at the cell membrane, facilitating AKT movement to PIP3 for activation. The findings suggest that KNSTRN may serve as a potential therapeutic target for bladder cancer.
Article
Biochemistry & Molecular Biology
Yong Xi, Yaxing Shen, Donglei Wu, Jingtao Zhang, Chengbin Lin, Lijie Wang, Chaoqun Yu, Bentong Yu, Weiyu Shen
Summary: This study found that circBCAR3 is highly expressed in esophageal cancer and it can promote the tumorigenesis of esophageal cancer by interacting with miR-27a-3p to upregulate TNPO1. The splicing factor QKI was identified as a positive regulator of circBCAR3 and hypoxia upregulates E2F7 to transcriptionally activate QKI.
Article
Oncology
Shiuh-Rong Ho, Yu-Cheng Lee, Michael M. Ittmann, Fang-Tsyr Lin, Keith Syson Chan, Weei-Chin Lin
Summary: The study reveals the tumor suppressor activity of RNF144A in vivo upon carcinogenic insult. Loss of RNF144A promotes the expression of DNA-PKcs, BMI1 and PD-L1, likely contributing to the carcinogen-induced bladder tumorigenesis.
Article
Multidisciplinary Sciences
Jae Heon Kim, Hee Jo Yang, Sung Sik Choi, Seung U. Kim, Hong J. Lee, Yun Seob Song
Summary: Transplanting hMSCs into the bladder wall can increase micro-vessel formation, decrease collagen deposition and detrusor muscle apoptosis, and improve underactive bladder. Overexpression of HGF in hMSCs further enhances these effects.
Article
Multidisciplinary Sciences
Shinsuke Oda, Masayoshi Fujisawa, Li Chunning, Toshihiro Ito, Takahiro Yamaguchi, Teizo Yoshimura, Akihiro Matsukawa
Summary: Aberrant activation of the Ras/Raf/ERK-MAPK pathway is involved in cancer progression, but the negative regulation by Spred2 may counter this progression in non-invasive bladder carcinoma. The loss of Spred2 regulation is associated with increased ERK activation and Ki67 index in more malignant cancers. Spred2 appears to be a key regulator in the progression of non-invasive bladder carcinoma.
Review
Immunology
Maoyu Wang, Zhensheng Zhang, Zhizhou Li, Yasheng Zhu, Chuanliang Xu
Summary: With the increasing incidence of bladder cancer, there has been a focus on understanding its mechanism and developing new treatment strategies. The introduction of immune checkpoint inhibitor-based immunotherapy has shown great promise in treating advanced bladder cancer and improving patients' survival. The ubiquitin-proteasome system, which plays a crucial role in various biological processes, has been found to be involved in bladder cancer. This review summarizes the recent progress in understanding the role of E3 ubiquitin ligases and deubiquitinases in bladder cancer tumorigenesis and highlights their implications for bladder cancer immunotherapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Fajuan Cheng, Bin Zheng, Shubin Si, Jianwei Wang, Guiting Zhao, Zhongshun Yao, Zhihong Niu, Wei He
Summary: Bladder cancer (BCa) is the most common malignancy of the urinary system. CircRNAs, a subtype of non-coding RNAs, play a crucial role in physiological and developmental processes. Dysregulated circRNAs associated with BCa contribute to abnormalities in biological, genetic, and epigenetic information.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medical Laboratory Technology
Yu-Jing Sun, Ai-Wei Li, Yun-Cong Zhang, Ju-Hua Dai, Xi Zhu
Summary: The study revealed a significant correlation between urine NDRG1 and NMP22 levels with the diagnosis of bladder cancer, and the combination of these two biomarkers showed a higher ROC value for diagnosis of BC.
CLINICAL LABORATORY
(2021)
Article
Biochemistry & Molecular Biology
Chen-Pang Hou, Ke-Hung Tsui, Kang-Shuo Chang, Hsin-Ching Sung, Shu-Yuan Hsu, Yu-Hsiang Lin, Pei-Shan Yang, Chien-Lun Chen, Tsui-Hsia Feng, Horng-Heng Juang
Summary: In this study, the anti-cancer effect of CAPE on bladder carcinoma cells was investigated. The results showed that CAPE suppressed cell proliferation and invasion through the upregulation of GDF15.
BIOMEDICAL JOURNAL
(2022)
Article
Medicine, General & Internal
Po-You Chen, Shao-Ming Chen, Horng-Heng Juang, Chen-Pang Hou, Yu-Hsiang Lin, Pei-Shan Yang, Chien-Lun Chen, Phei-Lang Chang, Kuo-Yen Lin, Ke-Hung Tsui
Summary: The study found a correlation between prostate-specific antigen velocity (PSAV) and the surgical outcome of thulium laser enucleation of the prostate (ThuLEP), with a cutoff value of -0.52 ng/ml for PSAV to guide postoperative follow-up treatment at 3 months after benign prostatic hyperplasia (BPH) surgery.
FRONTIERS IN MEDICINE
(2022)
Article
Health Care Sciences & Services
Yu-Ting Chen, Chen-Pang Hou, Horng-Heng Juang, Yu-Hsiang Lin, Pei-Shan Yang, Phei-Lang Chang, Chien-lun Chen, Shu-Chuan Weng, Ke-Hung Tsui
Summary: This study compared patient outcomes between ThuLEP and B-TUEP techniques in treating BPH patients. Results showed that patients in the ThuLEP group experienced less postoperative pain, while the B-TUEP group had a higher rate of complications. However, there were no significant differences between the two groups in terms of uroflowmetry parameters and IPSS scores.
THERAPEUTICS AND CLINICAL RISK MANAGEMENT
(2022)
Article
Medicine, General & Internal
Shu-Han Tsao, Chien-Ho Wang, Horng-Heng Juang, Yu-Hsiang Lin, Pei-Shan Yang, Phei-Lang Chang, Chien-Lun Chen, Chen-Pang Hou
Summary: This study reviewed 86 patients with XGP and found that both the midline transperitoneal and the flank retroperitoneal approach for nephrectomy produced similar surgical outcomes, with differences observed in surgical time and postoperative recovery time.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Hsin-Ching Sung, Kang-Shuo Chang, Syue-Ting Chen, Shu-Yuan Hsu, Yu-Hsiang Lin, Chen-Pang Hou, Tsui-Hsia Feng, Ke-Hung Tsui, Horng-Heng Juang
Summary: This study evaluated the mechanisms and functions of metallothionein 2A (MT2A) in bladder cancer cells. Results showed that MT2A overexpression reduced endogenous ROS levels and inhibited ROS induced by H2O2. Treatment with caffeic acid phenethyl ester (CAPE) induced MT2A and heme oxygenase-1 (HO-1) expressions, and this effect was dependent on MT2A in bladder carcinoma cells. Knockdown of MT2A increased invasion and cell growth, while ectopic overexpression of MT2A had the opposite effect. RT-qPCR analysis revealed higher levels of MT2A mRNA in normal bladder tissues compared to bladder cancer tissues.
Article
Biochemistry & Molecular Biology
Chen-Pang Hou, Ke-Hung Tsui, Syue-Ting Chen, Kang-Shuo Chang, Hsin-Ching Sung, Shu-Yuan Hsu, Yu-Hsiang Lin, Tsui-Hsia Feng, Horng-Heng Juang
Summary: GDF15 is a TGF beta-like cytokine that regulates target gene expression. TGF beta downregulates the expression of GDF15 through the activation of Smad signaling pathways. CAPE acts as an antagonist to block the effect of TGF beta on GDF15 expression.
Article
Medicine, General & Internal
Shu-Chuan Weng, Shu-Han Tsao, Han-Yu Tsai, Horng-Heng Juang, Yu-Hsiang Lin, Phei-Lang Chang, Chien-Lun Chen, Chen-Pang Hou
Summary: Bleeding during endoscopic prostate surgery is often overlooked, but we proposed a simple method to assess its severity. Our research revealed that using the thulium laser, patients over 80 years old, and those with a preoperative Qmax of more than 10 cc/s experienced less bleeding. The severity of bleeding affected the treatment outcomes, with patients experiencing less severe bleeding having easier tissue enucleation and better postoperative outcomes.
Article
Medicine, General & Internal
Yu-Ju Yeh, Shu-Chuan Weng, Yu-Hsiang Lin, Chien-Lun Chen, Shu-Han Tsao, Han-Yu Tsai, Horng-Heng Juang, Phei-Lang Chang, Chen-Pang Hou
Summary: This study evaluated and compared the surgical outcomes of retrograde intrarenal surgery (RIRS) lithotripsy versus robot-assisted laparoscopic pyelolithotomy (RAPL) in community patients with renal pelvic stones larger than 2 cm. The result showed that RIRS had superior outcomes in terms of operative time, length of postoperative hospital stay, surgical wound pain, and medical expenditures, while RAPL had a higher stone clearance rate. Both procedures were equally safe.
MEDICINA-LITHUANIA
(2023)
Article
Urology & Nephrology
Yu-Hsiang Lin, Shin-Yuan Chang, Shu-Han Tsao, Chen-Pang Hou, Chien-Lun Chen, Wen-Chou Lin, Ke-Hung Tsui, Horng-Heng Juang
Summary: This study describes the surgical technique of anterior fibromuscular stroma (AFS)-preserved endoscopic enucleation of the prostate (EEP) for benign prostate obstruction (BOO). The technique can prevent postoperative incontinence and achieves similar surgical outcomes as other methods.
WORLD JOURNAL OF UROLOGY
(2023)
Letter
Oncology
Yu-Hsiang Lin, Horng-Heng Juang
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Letter
Urology & Nephrology
Yu-Hsiang Lin, Ke-Hung Tsui, Horng-Heng Juang
INVESTIGATIVE AND CLINICAL UROLOGY
(2023)