Article
Neurosciences
Shane M. O'Neil, Emma E. Hans, Starr Jiang, Lynde M. Wangler, Jonathan P. Godbout
Summary: The study found that aged mice's hippocampal microglia had an amplified and prolonged neuroinflammatory response to peripheral LPS challenge. Furthermore, astrocytes in the aged hippocampus showed immunosenescence, with deficits in IL-10R signaling and cholesterol biosynthesis.
Review
Endocrinology & Metabolism
Xiaoli Liao, Miao Chen, Yamin Li
Summary: The present study aimed to review evidence from postmortem brain and PET studies on the role of glia induced neuroinflammation in the pathogenesis of ASD. The findings from postmortem studies showed increased microglial number and density, as well as increased GFAP protein and mRNA expression in ASD subjects. However, the outcomes of PET studies were inconsistent, with one reporting increased TSPO expression and two reporting decreased TSPO expression in ASD subjects.
FRONTIERS IN NEUROENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yukari Suda, Toshihisa Nakashima, Hiroaki Matsumoto, Daisuke Sato, Satoshi Nagano, Haruka Mikata, Sara Yoshida, Kenichi Tanaka, Yusuke Hamada, Naoko Kuzumaki, Minoru Narita
Summary: The study found that aging in the hypothalamus contributes to increased anxiety, impaired motor coordination, and reduced muscle strength in mice. Aging leads to the production of PD-1-enriched exhausted microglia and neuroinflammatory A1-like reactive astrocytes in the hypothalamus.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Sai Shi, Tianzhen Chen, Min Zhao
Summary: This article reviews the interaction between neurons and glial cells in METH-induced neuroinflammation. Neuroinflammation plays a crucial role in the brain dysfunction caused by METH abuse, and abnormal communication between neurons and glia can lead to adverse behavioral consequences.
NEUROCHEMICAL RESEARCH
(2022)
Review
Immunology
Ruicheng Yang, Bo Yang, Wei Liu, Chen Tan, Huanchun Chen, Xiangru Wang
Summary: Neuroinflammation is implicated in various CNS disorders, and the activation of astrocytes and microglia plays a crucial role in defense mechanisms. However, their activation can trigger neuroinflammation, exacerbating or inducing CNS injury. Non-coding RNAs are highly expressed in astrocytes and microglia and may be mediators of neuroinflammation.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Biochemistry & Molecular Biology
Roberta J. Ward, David T. Dexter, Robert R. Crichton
Summary: Disturbance of brain homeostasis leads to inflammation and cell death. Inflammation and iron metabolism interact, leading to iron deposition in brain cells. Reactive oxygen and nitrogen species play a role in inflammation and iron metabolism. Mechanisms to regulate iron homeostasis are important, and therapeutic approaches include N-acetyl cysteine, anti-inflammatory compounds, and iron chelation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Zsuzsanna Barad, Joana Augusto, Aine M. Kelly
Summary: Optimal performance of the central nervous system depends on communication between different cell types. Ageing is associated with CNS disequilibrium, but endurance exercise can have a positive impact on neuroimmune communications. Regular aerobic exercise provides an adaptive advantage against perturbations to homeostasis.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Review
Biochemistry & Molecular Biology
Ignazio Antignano, Yingxiao Liu, Nina Offermann, Melania Capasso
Summary: This review discusses the latest research on aging microglia, comparing findings in rodent models and human subjects. Understanding the phenotype of aging microglia is crucial for designing better preventive and therapeutic strategies.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Julia Sala-Jarque, Elisa Garcia-Lara, Paula Carreras-Dominguez, Chunfang Zhou, Neus Rabaneda-Lombarte, Carme Sola, Jose M. Vidal-Taboada, Adam Feiler, Ninnie Abrahamsson, Elena N. Kozlova, Josep Saura
Summary: This study analyzed the responses of two types of brain cells, astrocytes and microglia, to mesoporous silica particles (MSPs), and found that MSPs can be effectively internalized into microglial cells without affecting cell viability or morphology, but significantly increase extracellular levels of proinflammatory mediators when used in combination with lipopolysaccharide. These results suggest that MSPs could be a novel tool for specific drug delivery to microglial cells.
Review
Immunology
Yu Chen, Fu Peng, Ziwei Xing, Junren Chen, Cheng Peng, Dan Li
Summary: Neuroinflammation is an immune response in the central nervous system that is involved in various brain diseases. Flavonoids can alleviate neuroinflammation by inhibiting inflammatory mediators, promoting anti-inflammatory factors, and modulating glial cell polarization. They have therapeutic potential for brain disorders associated with neuroinflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Neurosciences
Octavio Garcia, Lisi Flores-Aguilar
Summary: Down syndrome is caused by the triplication of human chromosome 21, leading to intellectual disability. Individuals with DS may develop clinical symptoms associated with Alzheimer's disease in middle adulthood.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Cell Biology
Nadia D'Ambrosi, Martina Milani, Savina Apolloni
Summary: S100A4, a member of the S100 protein family, plays diverse roles in different cellular contexts; while it has been primarily associated with tumorigenesis and metastasis, it also plays a key role in promoting inflammation in various organs; in the nervous system, S100A4 contributes to neurogenesis, cellular motility, and inflammatory responses.
Review
Biochemistry & Molecular Biology
Ying Chen, John Man Tak Chu, Raymond Chuen Chung Chang, Gordon Tin Chun Wong
Summary: The complement system plays a crucial role in the central nervous system beyond immunity, impacting neurodevelopment and neurodegenerative diseases. Proper activation of the complement system is essential for maintaining normal brain function, but overactivation or dysregulation may lead to synaptic dysfunction and excessive pro-inflammatory responses. Targeting complement factors shows therapeutic potential for neurodegenerative conditions.
Article
Food Science & Technology
Yanjun Liu, Panpan Li, Yuanfa Liu, Tianyu Jiang, Jie Xu, Changhu Xue
Summary: The study demonstrates that plasmenylethanolamine (PlsEtn) attenuates neuroinflammation and neuronal loss by promoting microglial autophagy. This finding may contribute to the prevention and treatment of Alzheimer's disease.
Review
Immunology
Deepali Singh
Summary: Neuroinflammation is caused by the misfiring of immune cells in the central nervous system and can have both positive and negative effects on neurodevelopment and post-injury tissue. Chronic or uncontrolled inflammatory responses may lead to neurodegenerative diseases, while abnormal activation of glial cells can mediate neuroinflammation.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Neurosciences
Jaekwang Kim, Hyejin Yoon, Takahiro Horie, Jack M. Burchett, Jessica L. Restivo, Noemi Rotllan, Cristina M. Ramirez, Philip B. Verghese, Masafumi Ihara, Hyang-Sook Hoe, Christine Esau, Carlos Fernandez-Hernando, David M. Holtzman, John R. Cirrito, Koh Ono, Jungsu Kim
JOURNAL OF NEUROSCIENCE
(2015)
Article
Cell Biology
Jinkuk Choi, Jie Gao, Jaekwang Kim, Cynthia Hong, Jungsu Kim, Peter Tontonoz
SCIENCE TRANSLATIONAL MEDICINE
(2015)
Article
Biochemistry & Molecular Biology
Jaekwang Kim, Hyejin Yoon, Dah-eun Chung, Jennifer L. Brown, Krystal C. Belmonte, Jungsu Kim
JOURNAL OF NEUROCHEMISTRY
(2016)
Article
Neurosciences
Jaekwang Kim, Fabienne C. Fiesel, Krystal C. Belmonte, Roman Hudec, Wang-Xia Wang, Chaeyoung Kim, Peter T. Nelson, Wolfdieter Springer, Jungsu Kim
MOLECULAR NEURODEGENERATION
(2016)
Article
Chemistry, Inorganic & Nuclear
Anuj K. Sharma, Jaekwang Kim, John T. Prior, Nicholas J. Hawco, Nigam P. Rath, Jungsu Kim, Liviu M. Mirica
INORGANIC CHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
Kiyoung Kim, Song-Hee Kim, Jaekwang Kim, Heuijong Kim, Jeongbin Yim
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Biochemistry & Molecular Biology
Anuj K. Sharma, Stephanie T. Pavlova, Jaekwang Kim, Jungsu Kim, Liviu M. Mirica
Review
Biochemistry & Molecular Biology
Jaekwang Kim, Hyejin Yoon, Jacob Basak, Jungsu Kim
MOLECULES AND CELLS
(2014)
Article
Cell Biology
Shinrye Lee, Yu-Mi Jeon, Sun Joo Cha, Seyeon Kim, Younghwi Kwon, Myungjin Jo, You-Na Jang, Seongsoo Lee, Jaekwang Kim, Sang Ryong Kim, Kea Joo Lee, Sung Bae Lee, Kiyoung Kim, Hyung-Jun Kim
Article
Geriatrics & Gerontology
Ha-Young Kang, Hyung-Jun Kim, Kiyoung Kim, Seung-Il Oh, Sunggyu Yoon, Jaekwang Kim, Sangwoo Park, Yeongmi Cheon, Song Her, Mihye Lee, Bingwei Lu, Seongsoo Lee
NEUROBIOLOGY OF AGING
(2020)
Article
Neurosciences
Md. Razaul Karim, Elly E. Liao, Jaekwang Kim, Joyce Meints, Hector Martell Martinez, Olga Pletnikova, Juan C. Troncoso, Michael K. Lee
MOLECULAR NEURODEGENERATION
(2020)
Article
Biochemical Research Methods
Jinhee Park, Hyerin Kim, Jaekwang Kim, Mookyung Cheon
PLOS COMPUTATIONAL BIOLOGY
(2020)
Article
Chemistry, Physical
Minkyo Jung, Hyosun Choi, Jaekwang Kim, Ji Young Mun
Article
Neurosciences
Gongbo Li, Chaeyoung Kim, Jaekwang Kim, Hyejin Yoon, Huadong Zhou, Jungsu Kim
JOURNAL OF ALZHEIMERS DISEASE
(2015)