Skin Sensitization Testing—What’s Next?

Is a combination of assays really needed for non-animal prediction of skin sensitization potential? Performance of the GARD™ (Genomic Allergen Rapid Detection) assay in comparison with OECD guideline assays alone and in combination

(2018) David W. Roberts   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Prediction of skin sensitization potency using machine learning approaches

(2017) Qingda Zang et al.   JOURNAL OF APPLIED TOXICOLOGY

Skin Sensitization: Challenging the Conventional Thinking—A Case Against 2 Out of 3 as Integrated Testing Strategy

(2017) Henrik Johansson et al.   TOXICOLOGICAL SCIENCES

Multivariate models for prediction of human skin sensitization hazard

(2016) Judy Strickland et al.   JOURNAL OF APPLIED TOXICOLOGY

Consensus of classification trees for skin sensitisation hazard prediction

(2016) D. Asturiol et al.   TOXICOLOGY IN VITRO

SENS-IS, a 3D reconstituted epidermis based model for quantifying chemical sensitization potency: Reproducibility and predictivity results from an inter-laboratory study

(2016) Françoise Cottrez et al.   TOXICOLOGY IN VITRO

The GARD assay expanded – Potency assessment of skin sensitizing chemicals

(2016) K.S. Zeller et al.   TOXICOLOGY LETTERS

Machine Learning in Medicine

(2015) R. C. Deo   CIRCULATION

Machine learning applications in genetics and genomics

(2015) Maxwell W. Libbrecht et al.   NATURE REVIEWS GENETICS

Prediction of Chemical Respiratory Sensitizers Using GARD, a Novel In Vitro Assay Based on a Genomic Biomarker Signature

(2015) Andy Forreryd et al.   PLoS One

Anin vitromethod for detecting chemical sensitization using human reconstructed skin models and its applicability to cosmetic, pharmaceutical, and medical device safety testing

(2012) James M. McKim et al.   Cutaneous and Ocular Toxicology

The GARD assay for assessment of chemical skin sensitizers

(2012) Henrik Johansson et al.   TOXICOLOGY IN VITRO

A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests

(2011) Henrik Johansson et al.   BMC GENOMICS

Functionality and specificity of gene markers for skin sensitization in dendritic cells

(2011) Nathalie Lambrechts et al.   TOXICOLOGY LETTERS

The relationship between CD86/CD54 expression and THP-1 cell viability in an in vitro skin sensitization test – human cell line activation test (h-CLAT)

(2008) Hitoshi Sakaguchi et al.   CELL BIOLOGY AND TOXICOLOGY