Review
Oncology
Inge Oudaert, Arne Van der Vreken, Anke Maes, Elke De Bruyne, Kim De Veirman, Karin Vanderkerken, Eline Menu
Summary: This article discusses the metabolic adaptations of Multiple Myeloma (MM) cells in a hypoxic environment and how targeted treatments can block tumor progression.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Oxana Lungu, Denise Toscani, Jessica Burroughs-Garcia, Nicola Giuliani
Summary: The study of osteoblast metabolism has attracted increasing attention recently due to its high energy demand during bone remodeling. In addition to glucose, recent data show that amino acid and fatty acid metabolism plays an important role in providing fuel for osteoblast functioning. Glutamine has been identified as a crucial amino acid for osteoblast differentiation and activity. This review focuses on the metabolic pathways involved in the fate and functions of osteoblasts, particularly in multiple myeloma (MM) bone disease where the presence of malignant plasma cells disrupts osteoblast formation and activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yike Wan, Mengping Chen, Xin Li, Lu Zhong, Fei Xiao, Jia Liu, Jing Xiang, Jinxing Jiang, Xiaotong Chen, Junling Liu, Hua Li, Bin Li, Honghui Huang, Jian Hou
Summary: Single-cell RNA sequencing was used to compare gene expression profiles in T cells in bone marrow and peripheral blood of MM patients and healthy donors. The study revealed increased expression of senescence and exhaustion-related markers in cytotoxic T cells in MM. Pathway enrichment analyses showed downregulated amino acid metabolism, upregulated unfolded protein response pathways, and dysregulation of glutamine uptake in MM cytotoxic T cells.
Article
Oncology
Appalaraju Jaggupilli, Stanley Ly, Khoa Nguyen, Vivek Anand, Bin Yuan, Fouad El-Dana, Yuanqing Yan, Zoe Arvanitis, Danthasinghe Waduge Badrajee Piyarathna, Nagireddy Putluri, Helen Piwnica-Worms, Henry Charles Manning, Michael Andreeff, V. Lokesh Battula
Summary: This study demonstrates that metabolic stress induces the GD2(+) BCSC phenotype in triple-negative breast cancer (TNBC) and highlights the role of glutamine in this phenotype. Inhibiting glutamine transporters can reduce BCSC characteristics in TNBC cells, suggesting a potential complementary approach to conventional chemotherapy.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Xianlei Cai, Chao Liang, Miaozun Zhang, Yuan Xu, Yihui Weng, Xueying Li, Weiming Yu
Summary: N6-methyladenosine (m6A) modification plays a significant role in the metabolic reprogramming of digestive system malignancies.
Review
Oncology
Vincenzo Raimondi, Denise Toscani, Valentina Marchica, Jessica Burroughs-Garcia, Paola Storti, Nicola Giuliani
Summary: Multiple myeloma (MM) is a hematological malignancy characterized by the accumulation of malignant plasma cells (PCs) in the bone marrow (BM). The complex interaction between the BM microenvironment and MM cells has a significant impact on bone remodeling. MM cells exhibit metabolic alterations, including enhanced glycolysis and glutamine addiction, which can affect the differentiation process of bone cells. Understanding these metabolic changes may lead to the development of new therapeutic approaches and diagnostic tools for MM patients.
FRONTIERS IN ONCOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Xuemei Yao, Wei Li, De Fang, Chuyu Xiao, Xiao Wu, Menghuan Li, Zhong Luo
Summary: Ferroptosis is a new form of cell death characterized by iron-dependent accumulation of lethal lipid peroxides, with tumor cells activating adaptive metabolic responses to inhibit it; targeting tumor energy metabolism may disrupt redox homeostasis and induce ferroptosis for potential therapeutic strategies.
Article
Multidisciplinary Sciences
Benedikt Feuerecker, Philipp Biechl, Christof Seidl, Frank Bruchertseifer, Alfred Morgenstern, Markus Schwaiger, Wolfgang Eisenreich
Summary: This study utilized Bi-213-anti-EGFR-MAb to treat bladder and glioma cancer cells, revealing an early treatment response in bladder cancer cells but not in glioma cells.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Monika K. Prelowska, Dawid Mehlich, M. Talha Ugurlu, Hanna Kedzierska, Aleksandra Cwiek, Artur Kosnik, Klaudia Kaminska, Anna A. Marusiak, Dominika Nowis
Summary: The combination of ASCT2 inhibitor and proteasome inhibitor enhances cytotoxic activity through inducing apoptosis and modulating autophagy.
Article
Oncology
Hatice Satilmis, Emma Verheye, Philip Vlummens, Inge Oudaert, Niels Vandewalle, Rong Fan, Jennifer M. Knight, Nathan De Beule, Gamze Ates, Ann Massie, Jerome Moreaux, Anke Maes, Elke De Bruyne, Karin Vanderkerken, Eline Menu, Erica K. Sloan, Kim De Veirman
Summary: This study investigates the potential therapeutic effects of beta-blockers, specifically targeting the beta(2)-adrenergic receptor, in multiple myeloma treatment. The blockade of beta(2)-adrenergic receptors reduces cell viability, induces apoptosis and autophagy, and modulates cancer cell metabolism. Combining beta(2)AR blockade with other drugs enhances apoptosis in multiple myeloma cells.
JOURNAL OF PATHOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jones Gyamfi, Jinyoung Kim, Junjeong Choi
Summary: Cancer is not only a genetic disease but also a result of metabolic dysregulation. Metabolic alterations in cancer cells, including key changes in glucose, glutamine, and fatty acid metabolism, are more common among different subtypes and types of cancer. Recognizing cancer as a metabolic disorder can reveal important diagnostic and treatment markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Madeline P. Sheeley, Violet A. Kiesel, Chaylen Andolino, Nadia A. Lanman, Shawn S. Donkin, Stephen D. Hursting, Michael K. Wendt, Dorothy Teegarden
Summary: Metabolic reprogramming plays a key role in cancer progression and metastasis. In this study, the researchers investigated the effects of the bioactive metabolite of vitamin D, 1,25(OH)(2)D, on cell survival in ECM-detached conditions. They found that pretreatment with 1,25(OH)(2)D reduced cell viability in detached conditions and altered glutamine metabolism. Further analysis revealed that 1,25(OH)(2)D suppressed the expression and activity of pyruvate carboxylase (PC), a key enzyme involved in cancer cell anchorage independence. These results suggest that 1,25(OH)(2)D may suppress cancer progression by inhibiting PC and preventing anchorage independence.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Biochemical Research Methods
Brandon Faubert, Alpaslan Tasdogan, Sean J. Morrison, Thomas P. Mathews, Ralph J. DeBerardinis
Summary: This protocol assesses metabolism in intact tumors by using stable isotope-labeled nutrients delivered through bolus injection and continuous infusion in mice and humans. The study focuses on metabolic adaptations of cancer cells to meet energetic demands imposed by dysregulated growth. The methods involve introducing labeled nutrients into the circulation prior to surgical resection and analyzing isotope labeling patterns in metabolic intermediates.
Article
Cell Biology
Wei Xu, Chirag H. Patel, Liang Zhao, Im-Hong Sun, Min-Hee Oh, Im-Meng Sun, Rachel S. Helms, Jiayu Wen, Jonathan D. Powell
Summary: GOT1 plays a crucial role in CD8+ T cell effector differentiation and function by maintaining redox balance and promoting purine nucleotide biosynthesis, glycolytic programming, and cytotoxic function, possibly through posttranslational regulation of HIF protein. Conversely, genetic deletion of GOT1 promotes the generation of memory CD8+ T cells.
Article
Oncology
Tomas Jelinek, Renata Bezdekova, David Zihala, Tereza Sevcikova, Anjana Anilkumar Sithara, Lenka Pospisilova, Sabina Sevcikova, Petra Polackova, Martin Stork, Zdenka Knechtova, Ondrej Venglar, Veronika Kapustova, Tereza Popkova, Ludmila Muronova, Zuzana Chyra, Matous Hrdinka, Michal Simicek, Juan-Jose Garces, Noemi Puig, Maria-Teresa Cedena, Artur Jurczyszyn, Jorge J. Castillo, Miroslav Penka, Jakub Radocha, Maria Victoria Mateos, Jesus F. San-Miguel, Bruno Paiva, Ludek Pour, Lucie Rihova, Roman Hajek
Summary: This study reveals that >= 2% circulating plasma cells (CTCs) can serve as a biomarker of hidden primary plasma cell leukemia (PCL) and supports the use of flow cytometry to assess CTC levels during the diagnostic workup of multiple myeloma (MM).
JOURNAL OF CLINICAL ONCOLOGY
(2023)