How to increase our belief in discovered statistical interactions via large-scale association studies?

Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease

(2018) Elena S. Gusareva et al.   NEUROBIOLOGY OF AGING

Properties of global- and local-ancestry adjustments in genetic association tests in admixed populations

(2017) Eden R. Martin et al.   GENETIC EPIDEMIOLOGY

Genotypic Context and Epistasis in Individuals and Populations

(2016) Timothy B. Sackton et al.   CELL

The statistical properties of gene-set analysis

(2016) Christiaan A. de Leeuw et al.   NATURE REVIEWS GENETICS

A fast and powerfulW-test for pairwise epistasis testing

(2016) Maggie Haitian Wang et al.   NUCLEIC ACIDS RESEARCH

Detecting gene-gene interactions using a permutation-based random forest method

(2016) Jing Li et al.   BioData Mining

A cautionary note on the impact of protocol changes for genome-wide association SNP × SNP interaction studies: an example on ankylosing spondylitis

(2015) Kyrylo Bessonov et al.   HUMAN GENETICS

Model-Based Multifactor Dimensionality Reduction for Rare Variant Association Analysis

(2015) Ramouna Fouladi et al.   HUMAN HEREDITY

Parallelizing Epistasis Detection in GWAS on FPGA and GPU-Accelerated Computing Systems

(2015) Jorge Gonzalez-Dominguez et al.   IEEE-ACM Transactions on Computational Biology and Bioinformatics

The population genetics of drug resistance evolution in natural populations of viral, bacterial and eukaryotic pathogens

(2015) Benjamin A. Wilson et al.   MOLECULAR ECOLOGY

IMP 2.0: a multi-species functional genomics portal for integration, visualization and prediction of protein functions and networks

(2015) Aaron K. Wong et al.   NUCLEIC ACIDS RESEARCH

Highlighting nonlinear patterns in population genetics datasets

(2015) Gregorio Alanis-Lobato et al.   Scientific Reports

Discovering Genetic Interactions in Large-Scale Association Studies by Stage-wise Likelihood Ratio Tests

(2015) Mattias Frånberg et al.   PLoS Genetics

gammaMAXT: a fast multiple-testing correction algorithm

(2015) François Van Lishout et al.   BioData Mining

Bridging the Gap between Statistical and Biological Epistasis in Alzheimer’s Disease

(2015) Mark T. W. Ebbert et al.   Biomed Research International

Associating rare genetic variants with human diseases

(2015) Qunyuan Zhang   Frontiers in Genetics

Heuristic Identification of Biological Architectures for Simulating Complex Hierarchical Genetic Interactions

(2014) Jason H. Moore et al.   GENETIC EPIDEMIOLOGY

Epistasis analysis for quantitative traits by functional regression model

(2014) F. Zhang et al.   GENOME RESEARCH

Practical aspects of genome-wide association interaction analysis

(2014) Elena S. Gusareva et al.   HUMAN GENETICS

Detecting epistasis in human complex traits

(2014) Wen-Hua Wei et al.   NATURE REVIEWS GENETICS

Genome-wide association interaction analysis for Alzheimer's disease

(2014) Elena S. Gusareva et al.   NEUROBIOLOGY OF AGING

Multiple hypothesis testing in genomics

(2014) Jelle J. Goeman et al.   STATISTICS IN MEDICINE

A comprehensive evaluation of collapsing methods using simulated and real data: excellent annotation of functionality and large sample sizes required

(2014) Carmen Dering et al.   Frontiers in Genetics

An efficient algorithm to perform multiple testing in epistasis screening

(2013) François Van Lishout et al.   BMC BIOINFORMATICS

ViSEN: Methodology and Software for Visualization of Statistical Epistasis Networks

(2013) Ting Hu et al.   GENETIC EPIDEMIOLOGY

Multifactor dimensionality reduction reveals a three-locus epistatic interaction associated with susceptibility to pulmonary tuberculosis

(2013) Ryan L Collins et al.   BioData Mining

SNP interaction detection with Random Forests in high-dimensional genetic data

(2012) Stacey J Winham et al.   BMC BIOINFORMATICS

iLOCi: a SNP interaction prioritization technique for detecting epistasis in genome-wide association studies

(2012) Jittima Piriyapongsa et al.   BMC GENOMICS

Gene interaction enrichment and network analysis to identify dysregulated pathways and their interactions in complex diseases

(2012) Yu Liu et al.   BMC Systems Biology

GLIDE: GPU-Based Linear Regression for Detection of Epistasis

(2012) Tony Kam-Thong et al.   HUMAN HEREDITY

Recommendations for presenting analyses of effect modification and interaction

(2012) Mirjam J Knol et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Cost-effective GPU-Grid for Genome-wide Epistasis Calculations

(2012) B. Pütz et al.   METHODS OF INFORMATION IN MEDICINE

Evaluation of removable statistical interaction for binary traits

(2012) Jaya M. Satagopan et al.   STATISTICS IN MEDICINE

Improved Statistics for Genome-Wide Interaction Analysis

(2012) Masao Ueki et al.   PLoS Genetics

GAMETES: a fast, direct algorithm for generating pure, strict, epistatic models with random architectures

(2012) Ryan J Urbanowicz et al.   BioData Mining

Predicting the difficulty of pure, strict, epistatic models: metrics for simulated model selection

(2012) Ryan J Urbanowicz et al.   BioData Mining

eCEO: an efficient Cloud Epistasis cOmputing model in genome-wide association study

(2011) Z. Wang et al.   BIOINFORMATICS

Travelling the world of gene-gene interactions

(2011) K. Van Steen   BRIEFINGS IN BIOINFORMATICS

Model-Based Multifactor Dimensionality Reduction to detect epistasis for quantitative traits in the presence of error-free and noisy data

(2011) Jestinah M Mahachie John et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

Molecular mechanisms of epistasis within and between genes

(2011) Ben Lehner   TRENDS IN GENETICS

BioGraph: unsupervised biomedical knowledge discovery via automated hypothesis generation

(2011) Anthony ML Liekens et al.   GENOME BIOLOGY

BOOST: A Fast Approach to Detecting Gene-Gene Interactions in Genome-wide Case-Control Studies

(2010) Xiang Wan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Tests for Compositional Epistasis under Single Interaction-Parameter Models

(2010) Tyler J. VanderWeele et al.   ANNALS OF HUMAN GENETICS

Model-Based Multifactor Dimensionality Reduction for detecting epistasis in case-control data in the presence of noise

(2010) Tom Cattaert et al.   ANNALS OF HUMAN GENETICS

Using Biological Knowledge to Uncover the Mystery in the Search for Epistasis in Genome-Wide Association Studies

(2010) Marylyn D. Ritchie   ANNALS OF HUMAN GENETICS

Multifactor dimensionality reduction for graphics processing units enables genome-wide testing of epistasis in sporadic ALS

(2010) Casey S. Greene et al.   BIOINFORMATICS

SHEsisEpi, a GPU-enhanced genome-wide SNP-SNP interaction scanning algorithm, efficiently reveals the risk genetic epistasis in bipolar disorder

(2010) Xiaohan Hu et al.   CELL RESEARCH

On the Distinction Between Interaction and Effect Modification

(2010) Tyler J. VanderWeele   EPIDEMIOLOGY

EPIBLASTER-fast exhaustive two-locus epistasis detection strategy using graphical processing units

(2010) Tony Kam-Thong et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The Meaning of Interaction

(2010) Xuefeng Wang et al.   HUMAN HEREDITY

Evidence for epistatic interactions in antiepileptic drug resistance

(2010) Myeong-Kyu Kim et al.   JOURNAL OF HUMAN GENETICS

On model selection and model misspecification in causal inference

(2010) Stijn Vansteelandt et al.   STATISTICAL METHODS IN MEDICAL RESEARCH

Epistasis and Its Implications for Personal Genetics

(2009) Jason H. Moore et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Multiply Robust Inference for Statistical Interactions

(2009) Stijn Vansteelandt et al.   JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION

Detecting gene–gene interactions that underlie human diseases

(2009) Heather J Cordell   NATURE REVIEWS GENETICS

Failure to Replicate a Genetic Association May Provide Important Clues About Genetic Architecture

(2009) Casey S. Greene et al.   PLoS One

Spatially Uniform ReliefF (SURF) for computationally-efficient filtering of gene-gene interactions

(2009) Casey S Greene et al.   BioData Mining

On multiple-testing correction in genome-wide association studies

(2008) Valentina Moskvina et al.   GENETIC EPIDEMIOLOGY

Large-scale multiple testing under dependence

(2008) Wenguang Sun et al.   JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY

Epistasis — the essential role of gene interactions in the structure and evolution of genetic systems

(2008) Patrick C. Phillips   NATURE REVIEWS GENETICS