Article
Cardiac & Cardiovascular Systems
Roman Witzel, Annika Block, Solvey Pollmann, Leandra Oetzel, Fenja Fleck, Gabriel A. Bonaterra, Ralf Kinscherf, Anja Schwarz
Summary: This study aimed to investigate the regulatory effects of PACAP and its receptor VPAC1 in different macrophage subtypes in relation to inflammatory processes and lipid homeostasis. The results showed that PACAP played an important role in regulating inflammatory processes in atherosclerotic plaques and lipid homeostasis in different macrophage subtypes, affecting foam cell formation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Elham Abdollahi, Thomas P. Johnston, Zahra Ghaneifar, Parviz Vahedi, Pouya Goleij, Sara Azhdari, Abbas Shapouri Moghaddam
Summary: This review summarizes the impact of curcumin on macrophage polarization in various inflammatory diseases and explores the underlying molecular mechanisms. The findings suggest that curcumin can beneficially influence M1 and M2 macrophages, leading to improved inflammatory conditions such as cancer, autoimmune diseases, renal inflammation, stroke, atherosclerosis, and macrophage-driven pathogenesis.
CURRENT MOLECULAR PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Max Lenz, Christoph Kaun, Konstantin A. Krychtiuk, Patrick Haider, Mira Brekalo, Nadine Maier, Laura Goederle, Christoph J. Binder, Kurt Huber, Christian Hengstenberg, Johann Wojta, Philipp J. Hohensinner, Walter S. Speidl
Summary: The study found that nicorandil has a positive effect on stabilizing atherosclerotic plaque by reducing apoptosis.
Article
Cardiac & Cardiovascular Systems
Andreas Edsfeldt, Maarten Swart, Pratibha Singh, Lea Dib, Jiangming Sun, Jennifer E. Cole, Inhye Park, Dania Al-Sharify, Ana Persson, Mihaela Nitulescu, Patricia Das Neves Borges, Christina Kassiteridi, Michael E. Goddard, Regent Lee, Petr Volkov, Marju Orho-Melander, Lars Maegdefessel, Jan Nilsson, Irina Udalova, Isabel Goncalves, Claudia Monaco
Summary: The study found that IRF5 is associated with plaque vulnerability and symptoms in human carotid endarterectomies. In a murine model of inducible carotid artery plaque rupture, IRF5 drives plaque rupture. IRF5 modulates macrophage phenotype and colocalizes with CD11c(+) macrophages at the plaque shoulder.
EUROPEAN HEART JOURNAL
(2022)
Article
Immunology
Rui Duan, Yan Liu, Dongmei Tang, Sujun Xiao, Run Lin, Ming Zhao
Summary: In this study, the role of a specific subset of macrophages, Lyve1+ M2-like macrophages, in atherosclerosis was investigated using single-cell RNA sequencing analysis. It was found that these macrophages, detected mainly in mice treated with a high-fat diet and collagen VI monoclonal antibodies, showed distinct gene expression patterns and functions related to lipid metabolism. Further experiments demonstrated that transplantation of Lyve1+ M2-like macrophages could reduce plaque areas in mice with atherosclerosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Weiyu Chen, Sergey Tumanov, Christopher P. Stanley, Stephanie M. Y. Kong, James Nadel, Niv Vigder, Darren L. Newington, Xiao Suo Wang, Louise L. Dunn, Roland Stocker
Summary: This study shows that deficiency of bilirubin is associated with increased risk of atherosclerosis and cardiovascular disease. In the experiments, mice deficient in bilirubin showed higher burden of atherosclerotic plaques, increased systemic oxidative stress, endothelial dysfunction, and hyperlipidemia. Furthermore, the study found that bilirubin deficiency selectively enhanced neutrophil-mediated inflammation and destabilization of unstable plaques.
CIRCULATION RESEARCH
(2023)
Article
Hematology
Qingling Liu, Junlu Pan, Linrui Bao, Chunxiang Xu, Yu Qi, Bin Jiang, Dongdong Wang, Xudong Zhu, Xiaoyu Li, Hanwen Zhang, Hui Bai, Qing Yang, Junqing Ma, Erik A. C. Wiemer, Jingjing Ben, Qi Chen
Summary: This study found that MVP can attenuate macrophage-associated plaque instability by inhibiting the production of MMP-9 mediated by the ASK1-JNK signaling pathway. This discovery suggests that suppression of macrophage ASK1-JNK signaling may be an effective strategy against atherosclerotic diseases.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Sathuwarman Raveenthiraraj, Griselda Awanis, Marcello Chieppa, Amy E. O'Connell, Anastasia Sobolewski
Summary: This study demonstrates the different effects of homeostatic and inflammatory macrophages on the colonic epithelium. Inflammatory macrophages reduce the numbers of goblet and tuft cells and increase the numbers of stem cells in the crypt, while homeostatic macrophages promote crypt cell proliferation through physical contact. The findings highlight the importance of understanding cellular interactions and immune cell subtypes in crypt cell biology during inflammation.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Immunology
Hongxia Li, Zhiqiang Cao, Lili Wang, Chang Liu, Hongkun Lin, Yuhan Tang, Ping Yao
Summary: Cardiovascular diseases are mainly caused by atherosclerosis, and macrophages play a crucial role in its progression. The polarization phenotypes and death pathways of macrophages have an impact on plaque formation and cardiovascular vulnerability.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Lia Farahi, Satyesh K. Sinha, Aldons J. Lusis
Summary: Atherosclerosis is a chronic inflammatory disease that involves the recruitment and differentiation of monocytes into macrophages in response to inflammatory insults. Macrophages play critical roles in tissue damage, wound healing, and regression of atherosclerotic lesions, and their phenotypes are influenced by various stimuli. Recent advances in single-cell sequencing have revealed the heterogeneity of macrophages in lesions, shedding light on potential macrophage-based therapies for atherosclerosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Hematology
Marios K. Georgakis, Sander W. van der Laan, Yaw Asare, Joost M. Mekke, Saskia Haitjema, Arjan H. Schoneveld, Saskia C. A. de Jager, Nick S. Nurmohamed, Jeffrey Kroon, Erik S. G. Stroes, Dominique P. de Kleijn, Gert J. de Borst, Lars Maegdefessel, Oliver Soehnlein, Gerard Pasterkamp, Martin Dichgans
Summary: The study revealed that MCP-1 levels in human atherosclerotic plaques are associated with vulnerability features, clinical manifestations, and increased risk of adverse vascular events. Higher levels of MCP-1 are linked to histopathologic and molecular markers of plaque vulnerability, clinical plaque instability, and risks of major adverse vascular events post plaque removal.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Milessa Silva Afonso, Monika Sharma, Martin Schlegel, Coen van Solingen, Graeme J. Koelwyn, Lianne C. Shanley, Lauren Beckett, Daniel Peled, Karishma Rahman, Chiara Giannarelli, Huilin Li, Emily J. Brown, Alireza Khodadadi-Jamayran, Edward A. Fisher, Kathryn J. Moore
Summary: Inhibition of miR-33 shifts the balance of proatherosclerotic and antiatherosclerotic immune cell subsets in atherosclerotic plaques, reducing plaque burden and inflammation. This treatment also affects the expression of specific target genes in different macrophage subsets, ultimately leading to a decrease in aortic CD8+ T cells and CD4+ T-helper 1 cells, and an increase in regulatory T cells within plaques. These findings shed light on the immune mechanisms underlying the atheroprotective effects of anti-miR-33.
CIRCULATION RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Zhengyu Cao, Guotao Yuan, Lingli Zeng, Lu Bai, Xiao Liu, Maoxiong Wu, Runlu Sun, Zhiteng Chen, Yuan Jiang, Qingyuan Gao, Yangxin Chen, Yuling Zhang, Yue Pan, Jingfeng Wang
Summary: Sonodynamic therapy (SDT) and photothermal therapy (PTT) are combined using hyaluronic acid and PEG-modified copper sulfide/titanium oxide heterostructure nanosheets to target and treat early atherosclerotic plaques. The synergistic therapy induces apoptosis of proinflammatory macrophages, reduces heat shock protein 90 expression, and mitigates inflammation, preventing plaque progression.
Article
Biochemistry & Molecular Biology
Anna Kiepura, Kamila Stachyra, Anna Wisniewska, Katarzyna Kus, Klaudia Czepiel, Maciej Suski, Magdalena Ulatowska-Bialas, Marcin Surmiak, Rafal Olszanecki
Summary: Prolonged administration of TUG-891 leads to significant reduction in atherosclerotic plaque size and necrotic cores in apoE-knockout mice. The FFAR4 agonist reduces pro-inflammatory M1-like macrophages content and increases smooth muscle cell population in atherosclerotic plaques. These findings suggest that targeting FFAR4 receptor for macrophage phenotype switching holds promise for a new approach in atherosclerosis prevention or treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Lana Fani, Dianne H. K. Van Dam-Nolen, Meike Vernooij, Maryam Kavousi, Aad van der Lugt, Daniel Bos
Summary: The study suggests that innate immunity is linked to larger carotid atherosclerotic plaques, while adaptive immunity seems to be associated with smaller plaques and a lower frequency of intraplaque hemorrhage. This imbalance in innate and adaptive immunity may play a role in the vulnerability of carotid atherosclerotic plaques.
Article
Biochemistry & Molecular Biology
Sara Hashemi, Kazem Karami, Zeinab Saberi Dehkordi, Amir Abbas Momtazi-Borojeni, Seyed Alireza Esmaeili
Summary: Novel Pd(II) complexes were prepared and characterized. The stability of the complexes in biological media was confirmed, and their interaction with DNA and BSA was investigated. The complexes showed selectivity against cancer cells and binding to specific sites of BSA.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Endocrinology & Metabolism
Abbas Samadi-Khouzani, Payam Kheirmand Parizi, Fatemeh Ghafari, Seyed-Alireza Esmaeili, Maryam Peymani, Amir Abbas Momtazi-Borojeni
Summary: The study did not find an association between the rs619586 (A/G) polymorphism in the gene encoding lncRNA-MALAT1 and susceptibility to T2DM in the Isfahan population.
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
(2022)
Article
Pharmacology & Pharmacy
Amir Abbas Momtazi-Borojeni, Elham Abdollahi, Mahmoud R. Jaafari, Maciej Banach, Gerald F. Watts, Amirhossein Sahebkar
Summary: This study investigated the impact of negatively charged nanoliposomes on dyslipidaemia and progression of atherosclerosis in a rabbit model. The results showed that nanoliposome formulations improved dyslipidaemia and reduced the severity of atherosclerotic lesions.
CURRENT VASCULAR PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Amir Abbas Momtazi-Borojeni, Matteo Pirro, Suowen Xu, Amirhossein Sahebkar
Summary: PCSK9 inhibitors are novel therapeutic tools that can decrease cardiovascular risk. Currently approved and investigational drugs mainly work by blocking PCSK9 activity or suppressing its expression or secretion. Antibodies and vaccines are the most widely studied methods, but other approaches are also being investigated. Vaccination against PCSK9 may be a more feasible and cost-effective option for treating high cholesterol.
CURRENT MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Elham Abdollahi, Thomas P. Johnston, Zahra Ghaneifar, Parviz Vahedi, Pouya Goleij, Sara Azhdari, Abbas Shapouri Moghaddam
Summary: This review summarizes the impact of curcumin on macrophage polarization in various inflammatory diseases and explores the underlying molecular mechanisms. The findings suggest that curcumin can beneficially influence M1 and M2 macrophages, leading to improved inflammatory conditions such as cancer, autoimmune diseases, renal inflammation, stroke, atherosclerosis, and macrophage-driven pathogenesis.
CURRENT MOLECULAR PHARMACOLOGY
(2023)
Article
Obstetrics & Gynecology
Abolfazl Mehdizadeh, Shahla Chaichian, Shahla Mirgaloybayat, Samaneh Rokhgireh, Kobra Tahermanesh, Maryam Kadivar, Farahnaz Farzaneh
Summary: Inguinal endometriosis is a rare disease that manifests as painful inguinal masses during menstrual cycles. It is more commonly found on the right side and is often associated with a history of surgery.
INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE
(2022)
Review
Medicine, Research & Experimental
Nastaran Barati, Seyedmousa Motavallihaghi, Banafsheh Nikfar, Shahla Chaichian, Amir Abbas Momtazi-Borojeni
Summary: Ivermectin shows therapeutic potential for treating COVID-19 infection by inhibiting virus adhesion and replication, and clinical evidence suggests its effectiveness in all phases.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Sarina Ataei, Amir Abbas Momtazi-Borojeni, Shiva Ganjali, Maciej Banach, Amirhossein Sahebkar
Summary: This study evaluated the immunogenic potential of a carrier-free peptide-based anti-PCSK9 vaccine in albino mice. The results showed that the vaccine induced a significant production of IgG antibodies and inhibited PCSK9 concentrations and its interaction with LDLR in the blood plasma.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Cell Biology
Mandana Sattari, Mina Masoudnia, Kazem Mashayekhi, Seyed Mahmoud Hashemi, Nikoo Khannazer, Sepanta Sattari, Saeed Mohammadian Haftcheshmeh, Amir Abbas Momtazi-Borojeni
Summary: The molecular mechanisms of senescence in dental pulp stem cells (hDPSCs) stimulated with lipopolysaccharide (LPS) from oral pathogenic bacteria were investigated in this study. The mRNA and protein expression of four senescence-related genes were significantly upregulated in a time-dependent manner following stimulation with different LPSs. Furthermore, the highest expression of certain genes was observed at different time points depending on the type of LPS.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Amir Abbas Momtazi-Borojeni, Maciej Banach, Massimiliano Ruscica, Amirhossein Sahebkar
Summary: “There are conflicting findings regarding the effect of PCSK9 and PCSK9 inhibitors (PCSK9-i) on NAFLD. Preclinical studies show that PCSK9 is associated with NAFLD and NASH progression in opposite directions. In humans, the severity of hepatic steatosis affects the correlation between circulating PCSK9 and liver fat content, with a possible impact in the early stages of NAFLD. However, clinical trials with PCSK9-i suggest their safety, although long-term evidence is needed.”
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Amir Abbas Momtazi-Borojeni, Maciej Banach, Sayed Abbas Tabatabaei, Amirhossein Sahebkar
Summary: The antiPCSK9 vaccine is safe and does not have adverse effects on the function of different organs and blood levels of cellular and biochemical biomarkers in healthy mice.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Chenoor Poorshamohammad, Luguang Liu, Xurui Cheng, Amir Abbas Momtazi-Borojeni, Jie Chai
Summary: In this study, gold nanoparticles (AuNPs) were synthesized using plant extract and characterized by physical and chemical techniques. The quasi-spherical nanoparticles of mean diameter 20-50 nm were observed through SEM imaging. The XRD pattern confirmed the metallic gold composition of the nanoparticles. The biologically synthesized AuNPs showed cytotoxic and anti-gastric carcinoma effects against cancer cell lines, indicating their potential in cancer treatment.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
A. A. Momtazi-Borojeni, S. Ataei, M. R. Sarborji, M. R. Hatamipour, S. A. Tabatabaei, M. Banach, A. Sahebkar
EUROPEAN HEART JOURNAL
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
S. Ataei, A. A. Momtazi-Borojeni, M. R. Jaafari, M. Banach, A. A. Sahebkar
EUROPEAN HEART JOURNAL
(2022)
Correction
Oncology
Zi Yin, Min Yu, Tingting Ma, Chuanzhao Zhang, Shanzhou Huang, Mohammad Reza Karimzadeh, Amir Abaas Momtazi-Borojeni, Sheng Chen
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)