Therapeutic Targeting of the IL-6 Trans-Signaling/Mechanistic Target of Rapamycin Complex 1 Axis in Pulmonary Emphysema

Restoration of Corticosteroid Sensitivity in Chronic Obstructive Pulmonary Disease by Inhibition of Mammalian Target of Rapamycin

(2016) Akihisa Mitani et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Transforming Growth Factor β1-induced Apoptosis in Podocytes via the Extracellular Signal-regulated Kinase-Mammalian Target of Rapamycin Complex 1-NADPH Oxidase 4 Axis

(2015) Ranjan Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-6-Dependent Mucosal Protection Prevents Establishment of a Microbial Niche for Attaching/Effacing Lesion-Forming Enteric Bacterial Pathogens

(2014) S. M. Dann et al.   JOURNAL OF IMMUNOLOGY

Therapeutic Targeting of IL-6 Trans Signaling Counteracts STAT3 Control of Experimental Inflammatory Arthritis

(2014) M. A. Nowell et al.   JOURNAL OF IMMUNOLOGY

Blockade of IL-6TransSignaling Attenuates Pulmonary Fibrosis

(2014) Thanh-Thuy T. Le et al.   JOURNAL OF IMMUNOLOGY

mTOR and autophagy in regulation of acute lung injury: a review and perspective

(2014) Yue Hu et al.   MICROBES AND INFECTION

Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR)

(2013) Christoph Garbers et al.   CELL CYCLE

Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant mice

(2012) Saleela M. Ruwanpura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Interleukin-6 Promotes Pulmonary Emphysema Associated with Apoptosis in Mice

(2011) Saleela M. Ruwanpura et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Transsignaling of Interleukin-6 Crucially Contributes to Atherosclerosis in Mice

(2011) Harald Schuett et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

(2011) Marina Lesina et al.   CANCER CELL

mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1–JNK pathway

(2011) H Kato et al.   CELL DEATH AND DIFFERENTIATION

Species Specificity of ADAM10 and ADAM17 Proteins in Interleukin-6 (IL-6) Trans-signaling and Novel Role of ADAM10 in Inducible IL-6 Receptor Shedding

(2011) Christoph Garbers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-6 Contributes to Inflammation and Remodeling in a Model of Adenosine Mediated Lung Injury

(2011) Mesias Pedroza et al.   PLoS One

Role of interleukin-6 in elastase-induced lung inflammatory changes in mice

(2010) Sadatomo Tasaka et al.   EXPERIMENTAL LUNG RESEARCH

The role of interleukin-6 in pulmonary and systemic manifestations in a murine model of chronic obstructive pulmonary disease

(2010) Nele S. Pauwels et al.   EXPERIMENTAL LUNG RESEARCH

IL-6 Trans-Signaling Modulates TLR4-Dependent Inflammatory Responses via STAT3

(2010) C. J. Greenhill et al.   JOURNAL OF IMMUNOLOGY

Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke–induced pulmonary injury and emphysema

(2010) Toshinori Yoshida et al.   NATURE MEDICINE

Rapamycin Prevents Transforming Growth Factor-α–Induced Pulmonary Fibrosis

(2009) Thomas R. Korfhagen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Associations of IL6 polymorphisms with lung function decline and COPD

(2009) J-Q He et al.   THORAX

Serum Amyloid A Is a Biomarker of Acute Exacerbations of Chronic Obstructive Pulmonary Disease

(2007) Steven Bozinovski et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE