Review
Biotechnology & Applied Microbiology
Akram Bardestani, Shiva Ebrahimpour, Ali Esmaeili, Abolghasem Esmaeili
Summary: Iron oxide nanoparticles (IONPs) have been proposed as targeted carriers to deliver therapeutic molecules in the central nervous system (CNS), but they may damage neural tissue. Quercetin (QC) has neuroprotective effects, but poor solubility and low bioavailability have led to the development of QC-involved nanoparticles. Combining quercetin with superparamagnetic iron oxide nanoparticles (QCSPIONs) can improve cognitive dysfunction and promote neurogenesis without toxicity by inhibiting protein aggregation and acting against iron overload.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuan-yuan Fang, Cui-liu Gan, Jian-chao Peng, Yu-han Xie, Han-xiao Song, Ya-qi Mo, Shi-yan Ou, Michael Aschner, Yue-ming Jiang
Summary: The aim of this study was to investigate the effects of manganese and iron on apoptosis of BV2 microglia cells, both individually and in combination. The results showed that exposure to manganese, iron, or their combination induced cell activation, increased ROS production, inflammatory cytokine expression, and apoptosis. Additionally, iron was found to reduce the toxicity of manganese, and there was an antagonistic effect between manganese and iron.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Review
Neurosciences
Tyler Lanman, Scott Letendre, Qing Ma, Anne Bang, Ronald Ellis
Summary: The development of novel antiretroviral treatments has marked a significant turning point in the battle against HIV, but HIV-associated neurocognitive disorder (HAND) remains prevalent. Research has explored the neurotoxic effects of these medications, raising questions about their impact on neurocognitive and neuropsychiatric function in HIV patients, while also discussing the concept of accelerated aging and potential treatments for HAND in HIV-positive individuals.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2021)
Article
Environmental Sciences
Dongying Yan, Liang Gao, Jing Lang, Xianhui Gao, Honglin Ma
Summary: Excessive exposure to manganese can lead to neurological diseases characterized by behavioral and motor impairments. Microglia-mediated neuroinflammation plays a key role in the pathogenesis of neurodegenerative diseases. SIRT1, PGC-1 alpha, NF-kappa B, and STAT3 are important factors in the regulation of neuroinflammatory responses and microglial polarization in mice exposed to manganese.
ENVIRONMENTAL TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Alexey A. Tinkov, Monica M. B. Paoliello, Aksana N. Mazilina, Anatoly V. Skalny, Airton C. Martins, Olga N. Voskresenskaya, Jan Aaseth, Abel Santamaria, Svetlana V. Notova, Aristides Tsatsakis, Eunsook Lee, Aaron B. Bowman, Michael Aschner
Summary: Recent research has uncovered various mechanisms of Mn-induced neurotoxicity, including the role of Mn transporters, metabolic pathways, autophagic flux, synaptic dysfunction, and neuroinflammation, among others. Further studies are needed to fully understand the critical targets and pathways involved in Mn-induced neurotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Jingjing Liu, Xin Zhang, Hui Wang
Summary: Heavy metal pollution, particularly manganese exposure, poses a global health challenge and can lead to neurodegenerative diseases characterized by inflammation and Tau hyperphosphorylation. The cGAS-STING/NLRP3 pathway may play a crucial role in the neurotoxicity of manganese exposure, offering potential insights for future research.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Toxicology
Wenmin Lu, Danni Li, Shengtao Wei, Jie Yang, Chuanqiao Tang, Xiaoli Ma, Yunfeng Zou
Summary: This study reveals the role of lncRNAs in Mn-induced neurotoxicity, identifying lncSh2d3c as a key regulatory factor that is involved in Mn-induced neuronal apoptosis through the mmu-miR-675-5p/Chmp4b/Bax pathway. This finding suggests a novel mechanism of Mn-induced neurotoxicity and highlights the potential of lncSh2d3c as a therapeutic target.
TOXICOLOGY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Yanning Huang, Qiaolin Wen, Jinfeng Huang, Man Luo, Yousheng Xiao, Ruikang Mo, Jin Wang
Summary: The study demonstrated that MnCl2 induces mitophagy and neurotoxicity in dopaminergic SH-SY5Y cells through BNIP3-mediated ROS generation. This suggests that BNIP3 plays a role in manganese-induced neurotoxicity by acting as a mitophagy receptor protein.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Review
Biochemistry & Molecular Biology
Christina A. Porras, Tracey A. Rouault
Summary: This review provides an overview of the role of iron homeostasis disruption in various neurological disorders, discussing the consequences of both iron accumulation and deficiency. It also examines the history of animal models and presents a comparison of patients with a newly discovered neurodegenerative disorder caused by mutations in iron regulatory protein 2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Environmental Sciences
Rachel M. Shaffer, J. Michael Wright, Ila Cote, Thomas F. Bateson
Summary: This study compares the susceptibility to manganese neurotoxicity in children and adults using biomarker data. The results show that children may be more susceptible to neurotoxic effects of manganese compared to adults. However, due to the limited number of studies available, further research is needed to support the comparison between children and adults.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Qian Sun, Run-Run Kang, Kai-Ge Chen, Kuan Liu, Zhuo Ma, Chang Liu, Yu Deng, Wei Liu, Bin Xu
Summary: The study found that resveratrol can alleviate manganese-induced neuronal injury and mitochondrial dysfunction by activating the SIRT1/PGC-1 alpha signaling pathway, with SIRT3 playing a key role in promoting mitochondrial biogenesis and reducing manganese-induced mitochondrial dysfunction.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
David C. Dorman
Summary: This literature review focuses on the evidence implicating oxidative stress in the pathogenesis of manganese neurotoxicity. The review highlights contributions made by Professor Michael Aschner's laboratory in this field of study, which have significantly advanced our understanding of cellular responses to manganese exposure. His research has identified molecular targets of manganese toxicity and explored the role of astrocytes in neurotoxicity, as well as discovered new facets of manganese-induced neurotoxicity using C. elegans.
Review
Biochemistry & Molecular Biology
Alexey A. Tinkov, Airton C. Martins, Daiana Silva Avila, Victor A. Gritsenko, Anatoly Skalny, Abel Santamaria, Eunsook Lee, Aaron B. Bowman, Michael Aschner
Summary: Manganese (Mn) exposure can lead to alterations in gut microbiota diversity and metabolite production, potentially contributing to neurotoxicity. Transplantation of healthy microbiota may alleviate Mn-induced neurotoxicity, highlighting the significant role of gut flora in Mn-mediated effects.
Article
Environmental Sciences
Yongjie Xu, Tao Peng, Yang Xiang, Gengze Liao, Fei Zou, Xiaojing Meng
Summary: This study found that exposure to manganese increases mortality and malformation rates in zebrafish larvae, and significantly reduces swim distance and velocity. Manganese exposure also leads to apoptosis of dopaminergic neurons and decreased expression of tyrosine hydroxylase. Transcriptome sequencing results showed upregulation of genes associated with apoptosis and DNA damage repair.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Biochemistry & Molecular Biology
Megan Chesnut, Thomas Hartung, Helena Hogberg, David Pamies
Summary: Neurodevelopment is highly sensitive to toxic insults, and there is a lack of evaluation on the potential developmental neurotoxicity (DNT) of most commonly used chemicals. Using human cell-based in vitro systems for testing DNT chemicals can aid in prioritizing them based on their effects on neurodevelopment, but there is a limited number of in vitro models for myelination, which is a fundamental process in neurodevelopment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Michael Aschner, Thuy T. Nguyen, Anton I. Sinitskii, Abel Santamaria, Julia Bornhorst, Olga P. Ajsuvakova, Joao Batista Texeira da Rocha, Anatoly V. Skalny, Alexey A. Tinkov
Summary: The study reviews the biological effects of isoLG and isoLG adducts in various diseases, suggesting their potential as targets for the treatment of oxidative stress-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Food Science & Technology
Beatriz Ferrer, Lisa M. Prince, Alexey A. Tinkov, Abel Santamaria, Aaron B. Bowman, Michael Aschner
Summary: MeHg disrupts the physiological functions of ghrelin differently in males and females, enhancing ghrelin-induced body weight gain in males by activating the AMPK/UCP2 signaling pathway and mitigating ghrelin-induced weight gain in females by inhibiting mTOR signaling and decreasing Npy mRNA expression.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Food Science & Technology
Beatriz Ferrer, Lisa M. Prince, Alexey A. Tinkov, Abel Santamaria, Marcelo Farina, Joao Batista Rocha, Aaron B. Bowman, Michael Aschner
Summary: Studies have shown that methylmercury enhances leptin effects in male mice, leading to anorexigenic behavior, with different impacts on the leptin signaling pathway in males and females. Understanding the molecular alterations induced by methylmercury in the hypothalamus advances knowledge of its neurotoxicity and potential for novel therapies.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Airton C. Martins, Silvana Ruella Oliveira, Fernando Barbosa, Alexey A. Tinkov, Anatoly V. Skalny, Abel Santamaria, Eunsook Lee, Aaron B. Bowman, Michael Aschner
Summary: In this critical review, we suggest that additional research is required to safely set Mn levels in PN, and that eliminating Mn as an additive should be considered by physicians and nutritionists on a case by case basis in the meantime to avoid the greater risk of neurotoxicity by its presence. There is a need to better define clinical biomarkers for Mn toxicity by PN, as well as identify new effective agents to treat Mn-neurotoxicity. Moreover, we highlight the importance of the development of new guidelines and practice safeguards to protect patients from excessive Mn exposure and neurotoxicity upon PN administration.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2021)
Article
Neurosciences
Zubeyir Elmazoglu, Marta Soltesova Prnova, Milan Stefek, Asli F. Ceylan, Michael Aschner, Edgar Rangel-Lopez, Abel Santamaria, Cimen Karasu
Summary: This study found that AR inhibitors have potential therapeutic effects in neurodegenerative diseases by preventing ROS generation and reducing cell damage.
NEUROTOXICITY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Beatriz Ferrer, Harshini Suresh, Abel Santamaria, Joao Batista Rocha, Aaron B. Bowman, Michael Aschner
Summary: This study found that exposure to MeHg can induce STAT3 activation in mouse hypothalamic neuronal cells, exacerbating oxidative stress and antioxidant responses. It suggests that the STAT3 signaling pathway plays an important role in responding to MeHg-induced oxidative stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Alexey A. Tinkov, Monica M. B. Paoliello, Aksana N. Mazilina, Anatoly V. Skalny, Airton C. Martins, Olga N. Voskresenskaya, Jan Aaseth, Abel Santamaria, Svetlana V. Notova, Aristides Tsatsakis, Eunsook Lee, Aaron B. Bowman, Michael Aschner
Summary: Recent research has uncovered various mechanisms of Mn-induced neurotoxicity, including the role of Mn transporters, metabolic pathways, autophagic flux, synaptic dysfunction, and neuroinflammation, among others. Further studies are needed to fully understand the critical targets and pathways involved in Mn-induced neurotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Zubeyir Elmazoglu, Sonia Galvan-Arzate, Michael Aschner, Edgar Rangel-Lopez, Oguz Bayraktar, Abel Santamaria, Cimen Karasu
Summary: This study investigated the neuroprotective effects of antioxidant phytoconstituents in a model simulating Alzheimer's disease, finding that SAC showed the highest efficacy in preventing cell viability loss and oxidative damage, while RUT was most effective in mitigating inflammatory endpoints. The results suggest that these compounds act as redox modulators to reduce oxidative stress and neuroinflammation in hippocampal neurons exposed to high glucose and amyloid-β peptide.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Alexey A. Tinkov, Airton C. Martins, Daiana Silva Avila, Victor A. Gritsenko, Anatoly Skalny, Abel Santamaria, Eunsook Lee, Aaron B. Bowman, Michael Aschner
Summary: Manganese (Mn) exposure can lead to alterations in gut microbiota diversity and metabolite production, potentially contributing to neurotoxicity. Transplantation of healthy microbiota may alleviate Mn-induced neurotoxicity, highlighting the significant role of gut flora in Mn-mediated effects.
Article
Physics, Multidisciplinary
Iris N. Serratos, Hugo J. Avila-Paredes, Ileana Hernandez-Resendiz, Abel Santamaria, Victoria Bustos-Terrones, Patricia Ruiz Sanchez, Gerardo Saucedo-Castaneda, Juan Marcos Esparza Shulz, Alma Arrieta, Rebeca Sosa
Summary: This study presents the preparation, absorption, and emission characterizations of chlorophyll samples from green microalgae, mainly chlorophyll a with a small amount of beta-carotene. The unique absorption and emission spectra of the microalgal chlorophyll samples were identified, showing a radiative energy transfer mechanism between the silica matrix and the chlorophyll.
JOURNAL OF PHYSICS COMMUNICATIONS
(2021)
Article
Neurosciences
Iris N. Serratos, Elizabeth Hernandez-Perez, Carolina Campos, Michael Aschner, Abel Santamaria
Summary: The aggregation of alpha-synuclein plays a critical role in the development of Parkinson's disease and other synucleinopathies. Changes in protein conformation due to mutations and post-translational modifications lead to the abnormal aggregation of alpha-synuclein, which contributes to the progression of these diseases.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Neurosciences
Karen Jaqueline Paredes-Ruiz, Karla Chavira-Ramos, Mario Orozco-Morales, Cimen Karasu, Alexey A. Tinkov, Michael Aschner, Abel Santamaria, Ana Laura Colin-Gonzalez
Summary: The endocannabinoid system is a complex physiological system composed of endogenous cannabinoids, components involved in their synthesis and degradation, as well as a variety of cannabinoid receptors. Dysregulation of this system has been linked to pathological conditions, highlighting the potential therapeutic value of enhancing endocannabinoid levels and regulating their metabolism. Inhibitors of degradation/reuptake have been suggested as important strategies for modulating the endocannabinoid system, potentially offering new avenues for treating various disorders.
NEUROTOXICITY RESEARCH
(2021)
Article
Oncology
Mario Orozco-Morales, Norma Yanet Hernandez-Pedro, Pedro Barrios-Bernal, Oscar Arrieta, Luz Maria Ruiz-Godoy, Michael Aschner, Abel Santamaria, Ana Laura Colin-Gonzalez
Summary: The study found that the garlic-derived compound S-allylcysteine (SAC) exerts cytotoxic effects on lung cancer cells, reducing malignant growth and proliferation by inducing oxidative damage and downregulating the expression of Nrf2 and NF-κB.
Article
Neurosciences
Karla Chavira-Ramos, Mario Orozco-Morales, Cimen Karasu, Alexey A. Tinkov, Michael Aschner, Abel Santamaria, Ana Laura Colin-Gonzalez
Summary: Endocannabinoid-based therapies show potential as a tool for treating neurodegenerative disorders, with experimental studies demonstrating the neuroprotective properties of the FAAH inhibitor URB597 in preventing early toxic effects induced by QUIN in rat cortical tissue. The protective effects of URB597 were found to be mediated by the activation of CB1 receptors and were similar to those observed with AEA, suggesting a potential link between FAAH inhibition and the protective effects of endocannabinoids.
NEUROTOXICITY RESEARCH
(2021)
Article
Neurosciences
Zubeyir Elmazoglu, Marta Soltesova Prnova, Abel Santamaria, Milan Stefek, Cimen Karasu
Summary: Cellular redox dysregulation caused by aldose reductase in the presence of high blood sugar is a key mechanism in the neurodegeneration of diabetes mellitus and Parkinson's disease. Various compounds were tested for their neuroprotective properties in different neurotoxic models, showing that some compounds can improve cell viability while antioxidants have a protective effect on cell survival. These findings offer potential therapeutic strategies for the treatment of neurodegeneration related to diabetes and Parkinson's disease.
NEUROTOXICITY RESEARCH
(2021)