Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug-resistance (MDR) modulators

Published 2019 View Full Article

Title

Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug-resistance (MDR) modulators

Authors

Keywords

P-gp modulators, BCRP modulators, MRP1 modulators, MDR reversers, Pirarubicin uptake, Molecular docking, Human plasma stability, Rhodamine-123 efflux, ATPase activity, Apparent permeability

Journal

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Volume -, Issue -, Pages -

Publisher

Elsevier BV

Online

2019-03-28

DOI

10.1016/j.ejmech.2019.03.054

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