Comparative Analyses of DHA-Phosphatidylcholine Forage and Liposomes on Alzheimer's Disease in SAMP8 Mice

The present work comparatively evaluates the efficacy of docosahexaenoic acid - phosphatidylcholine (DHA-PC) forage and liposome on Alzheimer's disease (AD) in the senescence-accelerated prone 8 (SAMP8) mice and illustrates the potential mechanism. The dose of DHA-PC in forage group (1% of total diets) is equal to that of liposome group. The results of Morris maze test show that both DHA-PC forage and liposome obviously alleviated cognitive impairment (P<0.05). Moreover, the administration of DHA-PC liposome shows advantage than forage in reducing beta-amyloid (A beta) accumulation (P<0.05). Meanwhile, DHA-PC forage exhibits excellent inhibition on the IL-1 beta protein expression (P<0.05) and improvement in the protein levels of SYN and BDNF (P<0.05). These data are the first to perform comparative analysis of DHA-PC forage and liposome on AD.Practical Applications: The outcomes in the present study might help to understand the bioactivities of DHA-PC forage and liposomes, which might exert potential application value for dietary supplement with neuroprotective effects. Both docosahexaenoic acid - phosphatidylcholine (DHA-PC) forage and liposome shows benefits in alleviating Alzheimer's disease development in senescence-accelerated prone 8 mice by inhibiting beta-amyloid generation, oxidative stress, apoptosis, neural inflammation, and enhancing neurotrophins pathway in different degrees.