Article
Environmental Sciences
Hojat Anbara, Rasoul Shahrooz, Mazdak Razi, Hassan Malekinejad, Gholamreza Najafi, Ali Shalizar-Jalali
Summary: Royal jelly has a protective effect on PHZ-induced anemia, improving reproductive cells and sperm characteristics, promoting embryo development, and restoring normal oxidant/antioxidant status.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xuepeng Chi, Zhenguo Liu, Hongfang Wang, Ying Wang, Wei Wei, Baohua Xu
Summary: Royal jelly can enhance antioxidant activities, modulate gut microbiota, and the appropriate dose of royal jelly has a positive effect on physical health.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Xuepeng Chi, Zhenguo Liu, Wei Wei, Xiyi Hu, Ying Wang, Hongfang Wang, Baohua Xu
Summary: The study demonstrates that selenium-rich royal jelly inhibits tumor growth by inducing apoptosis and inhibiting angiogenesis, while also exhibiting anti-tumor effects through improving immune function and antioxidant activities. These findings suggest that selenium-rich royal jelly could be a potential functional food for the management and prevention of cancer.
Article
Biochemistry & Molecular Biology
Xuepeng Chi, Zhenguo Liu, Hongfang Wang, Ying Wang, Baohua Xu, Wei Wei
Summary: This study demonstrated that selenium-rich royal jelly (SRJ) can enhance antioxidant capacity in the liver and kidney of mice, as well as alter the composition of gut microbiota. SRJ treatment increased the levels of glutathione peroxidase and total antioxidant activity, while also affecting the ratio of different bacterial families in the gut. Additionally, SRJ showed potential in optimizing the functional network of gut microbiota and improving the interactions between gut microbiota and the host.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Food Science & Technology
Simona Sagona, Francesca Coppola, Gino Giannaccini, Laura Betti, Lionella Palego, Elena Tafi, Lucia Casini, Lucia Piana, Raffaele Dall'Olio, Antonio Felicioli
Summary: This study investigated the activity of enzymes in refrigerated and frozen Royal Jelly. The results showed that freezing can better preserve the activities of glucose oxidase and carboxypeptidase A-like, which can be used as markers to determine the freshness of Royal Jelly.
Article
Nutrition & Dietetics
Genki Kobayashi, Takuro Okamura, Saori Majima, Takafumi Senmaru, Hiroshi Okada, Emi Ushigome, Naoko Nakanishi, Yuichiro Nishimoto, Takuji Yamada, Hideto Okamoto, Nobuaki Okumura, Ryoichi Sasano, Masahide Hamaguchi, Michiaki Fukui
Summary: This study focused on the therapeutic efficacy of medium-chain fatty acids (MCFAs), unique to royal jelly (RJ), in treating non-alcoholic fatty liver disease (NAFLD). Results showed that RJ improved NAFLD activity scores and decreased gene expression related to fatty acid metabolism, fibrosis, and inflammation in the liver. RJ also regulated innate immunity-related inflammatory responses in the small intestine and decreased the expression of genes associated with inflammation and nutrient absorption transporters. RJ increased the abundance of certain bacteria that produce short-chain fatty acids and increased the concentrations of RJ-related MCFAs in the serum and liver. These MCFAs decreased saturated fatty acid deposition in liver cells and decreased the gene expression associated with fibrosis and fatty acid metabolism. RJ and RJ-related MCFAs improved dysbiosis and regulated the expression of inflammation-, fibrosis-, and nutrient absorption transporter-related genes, thereby preventing NAFLD.
Article
Multidisciplinary Sciences
Susanna Gevorgyan, Robin Schubert, Sven Falke, Kristina Lorenzen, Karen Trchounian, Christian Betzel
Summary: In recent years, silver nanoparticles have been widely used in various fields such as industry, technology, and medicine. This study focused on the green synthesis of silver nanoparticles using a low-molecular-weight fraction of Royal Jelly and investigated their antibacterial activity. The results showed that the size of the silver nanoparticles increased with the increase in silver ion precursor concentration, and most particles had dimensions in the range of 50-100 nm. Additionally, E. coli was more susceptible to the silver nanoparticles compared to B. subtilis.
SCIENTIFIC REPORTS
(2022)
Review
Pharmacology & Pharmacy
Lilla Bagameri, Gabriela-Maria Baci, Daniel Severus Dezmirean
Summary: Royal jelly is a highly valued natural product known for its health-promoting properties. Recent studies indicate that it acts as a powerful antimicrobial agent with antioxidant and anticancer activities. Its main bioactive compounds include proteins, peptides, phenolic, and fatty acids.
Review
Biology
Lilla Bagameri, Sara Botezan, Otilia Bobis, Victorita Bonta, Daniel Severus Dezmirean
Summary: Royal jelly is a highly nutritious natural product widely used in the pharmaceutical, food, and cosmetic industries. Research has shown that it possesses various therapeutic effects such as anti-inflammatory, antioxidant, antitumor, anti-aging, and antibacterial activities. It contains abundant protein and a diverse array of bioactive substances, making it valuable for human health.
Article
Food Science & Technology
Ashwak Abdel-moeim Hassan, Yasser Essam Elenany, Amr Nassrallah, Weiwei Cheng, Ahmed A. Abd El-Maksoud
Summary: The study showed that supplementation of royal jelly can improve the quality of fermented milk by increasing viscosity, water holding capacity, prolonging shelf life, enhancing antioxidant activity, boosting probiotic content, and improving bioactivity.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Environmental Sciences
Ali Acar
Summary: This study demonstrated that royal jelly exhibited therapeutic effects in reducing the toxic impact of sodium benzoate on physiological, genetic, and biochemical parameters. Additionally, royal jelly showed a positive interaction with antioxidant enzyme residues, highlighting its potential benefits for human health and the environment.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Nutrition & Dietetics
Masayuki Yamaga, Toshihiro Imada, Hiroko Tani, Shigeru Nakamura, Ayanori Yamaki, Kazuo Tsubota
Summary: This study investigates the active components involved in tear secretion capacity, focusing on acetylcholine and fatty acids in royal jelly. The results confirm that acetylcholine along with specific fatty acids are essential for tear secretion efficacy in a stress-induced dry-eye model. The study provides new insights into the active molecules and efficacy mechanisms of royal jelly.
Article
Food Science & Technology
Chuan Ma, Buajiram Ahmat, Jianke Li
Summary: This study investigates the effect of queen cell numbers on the quality of royal jelly produced. It is found that increasing queen cell numbers significantly decrease the quality of royal jelly, primarily through reducing fatty acid levels and the content of 10-hydroxy-2-decenoic acid.
CURRENT RESEARCH IN FOOD SCIENCE
(2022)
Article
Food Science & Technology
Jianying Guo, Zixu Wang, Yaoxing Chen, Jing Cao, Wenli Tian, Baochen Ma, Yulan Dong
Summary: Royal jelly is a bee product widely used in cosmetics, medicine, and other fields. It has various beneficial effects on human health, such as regulating immunity, lifespan, memory, digestive system, blood glucose, obesity, antibacterial and anti-cancer effects. The active ingredients in royal jelly play a key role in maintaining health and can even be used in the treatment of Alzheimer's disease.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Ercument Aksakal, Deniz Ekinci, Claudiu T. Supuran
Summary: The study investigated the effects of different levels of royal jelly on the enzyme activity and gene expression profiles in zebrafish tissues. While mRNA levels of enzymes were generally elevated in fish fed with royal jelly, there was some decrease in enzyme activity as well. The correlation between gene expression and enzyme activity was not significant in all tissues, suggesting that post-translational modifications may play a key role in regulation.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Article
Andrology
Noushin Mahdivand, Gholamreza Najafi, Vahid Nejati, Ali Shalizar-Jalali, Fatemeh Rahmani
Article
Veterinary Sciences
A. Saadi, B. Dalir-Naghadeh, S. M. Hashemi-Asl, A. A. Tehrani, R. Hobbenaghi, S. S. Mahmoudi, A. Shalizar-Jalali
EQUINE VETERINARY EDUCATION
(2020)
Article
Biology
Noushin Mahdivand, Ali Shalizar-Jalali, Vahid Nejati, Gholamreza Najafi, Fatemeh Rahmani
Summary: Royal Jelly was found to ameliorate testicular pathologies induced by experimental heat stress in rats by enhancing the testicular antioxidant defense system and regulating germ cells apoptosis.
JOURNAL OF THERMAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Tayebe Azizi, Mohsen Daneshyar, Manoochehr Allymehr, Ali Shalizar Jalali, Hamed Khalilvandi Behroozyar, Amir Tukmechi
Summary: The study aimed to investigate the impact of deoxynivalenol (DON) contaminated diet on broiler chickens. While DON did not significantly affect performance-related indicators, it did have adverse effects on immune response, muc-2 gene expression in the jejunum, gut morphology, liver enzyme levels, and blood protein contents.
Article
Medicine, Research & Experimental
Fereshteh Radmanesh, Mazdak Razi, Ali Shalizar-Jalali
Summary: The study revealed that curcumin nano-micelle (NCMN) has an impact on testicular antioxidant status, leading to increased expression of heat shock proteins (Hsp) 70-2a and Hsp90, as well as cell DNA and mRNA damage, reduced sperm count, motility, and DNA integrity.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Environmental Sciences
Hojat Anbara, Rasoul Shahrooz, Mazdak Razi, Hassan Malekinejad, Gholamreza Najafi, Ali Shalizar-Jalali
Summary: Royal jelly has a protective effect on PHZ-induced anemia, improving reproductive cells and sperm characteristics, promoting embryo development, and restoring normal oxidant/antioxidant status.
ENVIRONMENTAL TOXICOLOGY
(2022)
Review
Reproductive Biology
Mobina Fathi, Kimia Vakili, Abbas Aliaghaei, Shahrzad Nematollahi, Tahmineh Peirouvi, Ali Shalizar-Jalali
Summary: It is recommended to evaluate gonadal function in males infected with COVID-19 to determine the presence of the virus in seminal fluid, assess its impact on the reproductive system, and sexual transmissibility. Further research is needed to fully understand the effects of SARS-CoV-2 on the male reproductive system and viral transmission risk.
MIDDLE EAST FERTILITY SOCIETY JOURNAL
(2021)
Article
Veterinary Sciences
Mohammad-Ali Maadi, Mehdi Behfar, Amir Rasaei, Ali Shalizar-Jalali, Gholamreza Najafi, Vahid Mohammadi
Summary: The study demonstrated that intra-testicular injection of mannitol in rats significantly decreased testosterone levels, resulting in reduced sperm count, increased morphological abnormalities, ultimately leading to testicular degeneration and infertility.
TURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES
(2021)
Article
Veterinary Sciences
Amineh Beyrami, Farhad Soltanalinejad, Ali Shalizar-Jalali
Summary: The study aimed to describe the course and branches of the arteries supplying the eye in adult river buffaloes. The results showed that the eye blood supply in buffaloes originates from various arteries and is similar to that of other related animals such as yak, with minor differences from oxen, sheep, and goat, and obvious differences from camel and giraffe.
VETERINARY RESEARCH FORUM
(2021)
Article
Agriculture, Dairy & Animal Science
Tayebe Azizi, Mohsen Daneshyar, Manoochehr Allymehr, Amir Tukmechi, Hamed Khalilvandi Behroozyar, Ali Shalizar Jalali
Summary: This study showed that the inclusion of Lactobacillus species and yeast in DON-contaminated diets improved immune parameters, gut morphology, and gene expressions in broiler chickens. The highest levels of Lactobacillus and yeast led to enhanced spleen weight, immune responses, villus height, and gene expressions in broilers challenged with DON.
ITALIAN JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Veterinary Sciences
Abbas Sadeghi, Farah Farokhi, Ali Shalizar-Jalali, Gholamreza Najafi
VETERINARY RESEARCH FORUM
(2020)
Article
Medicine, Research & Experimental
Alireza Nourian, Ali Soleimanzadeh, Ali Shalizar Jalali, Gholamreza Najafi
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2020)
Article
Veterinary Sciences
Ramin Jahangirfard, Ali Shalizar-Jalali, Rasoul Shahrooz, Gholamreza Najafi, Aram Minas
VETERINARY RESEARCH FORUM
(2019)