Positioning of extracellular loop 1 affects pore gating of the cystic fibrosis transmembrane conductance regulator

An Electrostatic Interaction at the Tetrahelix Bundle Promotes Phosphorylation-dependent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channel Opening

(2014) Wei Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metal Bridges Illuminate Transmembrane Domain Movements during Gating of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel

(2014) Yassine El Hiani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Three charged amino acids in extracellular loop 1 are involved in maintaining the outer pore architecture of CFTR

(2014) Guiying Cui et al.   JOURNAL OF GENERAL PHYSIOLOGY

Cysteine Scanning of CFTR’s First Transmembrane Segment Reveals Its Plausible Roles in Gating and Permeation

(2013) Xiaolong Gao et al.   BIOPHYSICAL JOURNAL

Origin and evolution of the cystic fibrosis transmembrane regulator protein R domain

(2013) Aswathy Sebastian et al.   GENE

CFTR: Effect of ICL2 and ICL4 amino acids in close spatial proximity on the current properties of the channel

(2013) Arnaud Billet et al.   Journal of Cystic Fibrosis

Effect of ivacaftor on CFTR forms with missense mutations associated with defects in protein processing or function

(2013) Fredrick Van Goor et al.   Journal of Cystic Fibrosis

Modeling the Conformational Changes Underlying Channel Opening in CFTR

(2013) Kazi S. Rahman et al.   PLoS One

Refined structures of mouse P-glycoprotein

(2013) Jingzhi Li et al.   PROTEIN SCIENCE

Cystic Fibrosis Transmembrane Conductance Regulator (ABCC7) Structure

(2013) J. F. Hunt et al.   Cold Spring Harbor Perspectives in Medicine

The CFTR Ion Channel: Gating, Regulation, and Anion Permeation

(2013) T.-C. Hwang et al.   Cold Spring Harbor Perspectives in Medicine

β-Adrenergic Sweat Secretion as a Diagnostic Test for Cystic Fibrosis

(2012) Paul Quinton et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Relative Movements of Transmembrane Regions at the Outer Mouth of the Cystic Fibrosis Transmembrane Conductance Regulator Channel Pore during Channel Gating

(2012) Wuyang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation

(2012) Michael Hohl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Differential contribution of TM6 and TM12 to the pore of CFTR identified by three sulfonylurea-based blockers

(2011) Guiying Cui et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

β1, β2, and β3 Adrenoceptors and Na+/H+Exchanger Regulatory Factor 1 Expression in Human Bronchi and Their Modifications in Cystic Fibrosis

(2010) Florian Bossard et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation

(2010) Yonghong Bai et al.   JOURNAL OF GENERAL PHYSIOLOGY

Cystic Fibrosis Transmembrane Conductance Regulator: Using Differential Reactivity toward Channel-Permeant and Channel-Impermeant Thiol-Reactive Probes To Test a Molecular Model for the Pore

(2009) Christopher Alexander et al.   BIOCHEMISTRY

Oxidation of a single active site suffices for the functional inactivation of the dimeric Bacillus subtilis OhrR repressor in vitro

(2009) Warawan Eiamphungporn et al.   NUCLEIC ACIDS RESEARCH

Multiple Membrane-Cytoplasmic Domain Contacts in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mediate Regulation of Channel Gating

(2008) Lihua He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Geometric characteristics of hydrogen bonds involving sulfur atoms in proteins

(2008) Peng Zhou et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS