Stromal cell-derived factor-1 (SDF-1) as a target in liver diseases

VEGF-sdf1 recruitment of CXCR7+ bone marrow progenitors of liver sinusoidal endothelial cells promotes rat liver regeneration

(2016) Laurie D. DeLeve et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Role of chemokine pathways in hepatobiliary cancer

(2016) Josef Ehling et al.   CANCER LETTERS

Evidence-Based Diagnosis, Staging, and Treatment of Patients With Hepatocellular Carcinoma

(2016) Jordi Bruix et al.   GASTROENTEROLOGY

Pharmacological Intervention in Hepatic Stellate Cell Activation and Hepatic Fibrosis

(2016) Hans-Theo Schon et al.   Frontiers in Pharmacology

Impact of a CXCL12/CXCR4 Antagonist in Bleomycin (BLM) Induced Pulmonary Fibrosis and Carbon Tetrachloride (CCl4) Induced Hepatic Fibrosis in Mice

(2016) Leola N. Chow et al.   PLoS One

Biliary Epithelial Cells Are Not the Predominant Source of Hepatic CXCL12

(2015) Yedidya Saiman et al.   AMERICAN JOURNAL OF PATHOLOGY

CXC chemokine receptor-4 signaling limits hepatocyte proliferation after hepatic ischemia-reperfusion in mice

(2015) Gregory C. Wilson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Potential molecular, cellular and microenvironmental mechanism of sorafenib resistance in hepatocellular carcinoma

(2015) Jiang Chen et al.   CANCER LETTERS

Matrix metalloproteinase 10 contributes to hepatocarcinogenesis in a novel crosstalk with the stromal derived factor 1/C-X-C chemokine receptor 4 axis

(2015) Oihane García-Irigoyen et al.   HEPATOLOGY

CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice

(2015) Yunching Chen et al.   HEPATOLOGY

The yin and yang of evasion and immune activation in HCC

(2015) Oxana V. Makarova-Rusher et al.   JOURNAL OF HEPATOLOGY

CXCL12/CXCR4: a symbiotic bridge linking cancer cells and their stromal neighbors in oncogenic communication networks

(2015) F Guo et al.   ONCOGENE

A meta-analysis for C-X-C chemokine receptor type 4 as a prognostic marker and potential drug target in hepatocellular carcinoma

(2015) Fei Hu et al.   Drug Design Development and Therapy

Contribution and Mobilization of Mesenchymal Stem Cells in a mouse model of carbon tetrachloride-induced liver fibrosis

(2015) Yan Liu et al.   Scientific Reports

SDF-1/CXCR4 Axis Promotes MSCs to Repair Liver Injury Partially through Trans-Differentiation and Fusion with Hepatocytes

(2015) Ning-Bo Hao et al.   Stem Cells International

CXCR4 expression affects overall survival of HCC patients whereas CXCR7 expression does not

(2014) Maria Neve Polimeno et al.   Cellular & Molecular Immunology

Roles for Chemokines in Liver Disease

(2014) Fabio Marra et al.   GASTROENTEROLOGY

Inhibition of the CXCL12/CXCR4 chemokine axis with AMD3100, a CXCR4 small molecule inhibitor, worsens murine hepatic injury

(2014) Yedidya Saiman et al.   HEPATOLOGY RESEARCH

Blockade of CXCL12/CXCR4 signaling inhibits intrahepatic cholangiocarcinoma progression and metastasis via inactivation of canonical Wnt pathway

(2014) Shengqiang Zhao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer

(2014) Ramona Rudalska et al.   NATURE MEDICINE

Dynamic Expression Patterns of Differential Proteins during Early Invasion of Hepatocellular Carcinoma

(2014) Rong-Xin Chen et al.   PLoS One

CXCR7 stimulates MAPK signaling to regulate hepatocellular carcinoma progression

(2014) L Lin et al.   Cell Death & Disease

Tumor-associated antigen specific CD8+T cells in hepatocellular carcinoma – a promising target for immunotherapy

(2014) Nathalie Schmidt et al.   OncoImmunology

CXCL12 induces hepatic stellate cell contraction through a calcium-independent pathway

(2013) Yedidya Saiman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization

(2013) J. Hoellenriegel et al.   BLOOD

Common structural interactions between the receptors CXCR3, CXCR4 and CXCR7 complexed with their natural ligands, CXCL11 and CXCL12, by a modeling approach

(2013) Susan Costantini et al.   CYTOKINE

Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice

(2013) Yunching Chen et al.   HEPATOLOGY

Regulation of accumulation and function of myeloid derived suppressor cells in different murine models of hepatocellular carcinoma

(2013) Tamar Kapanadze et al.   JOURNAL OF HEPATOLOGY

Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis

(2013) Bi-Sen Ding et al.   NATURE

microRNA-27b suppresses mouse MSC migration to the liver by targeting SDF-1α in vitro

(2012) Mu-Han Lü et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Increased Susceptibility to Severe Chronic Liver Damage in CXCR4 Conditional Knock-Out Mice

(2012) Atsunori Tsuchiya et al.   DIGESTIVE DISEASES AND SCIENCES

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

X4 Human Immunodeficiency Virus Type 1 gp120 Promotes Human Hepatic Stellate Cell Activation and Collagen I Expression through Interactions with CXCR4

(2012) Feng Hong et al.   PLoS One

CXCL12 (SDF1 )-CXCR4/CXCR7 Pathway Inhibition: An Emerging Sensitizer for Anticancer Therapies?

(2011) D. G. Duda et al.   CLINICAL CANCER RESEARCH

CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression

(2010) Xueqing Sun et al.   CANCER AND METASTASIS REVIEWS

Roles of Chemokine Receptor 4 (CXCR4) and Chemokine Ligand 12 (CXCL12) in Metastasis of Hepatocellular Carcinoma Cells

(2010) Hui Liu et al.   Cellular & Molecular Immunology

Phase 2 Trial of Single Agent Ipilimumab (Anti-CTLA-4) for Locally Advanced or Metastatic Pancreatic Adenocarcinoma

(2010) Richard E. Royal et al.   JOURNAL OF IMMUNOTHERAPY

CXCR7 Functions as a Scavenger for CXCL12 and CXCL11

(2010) Ulrike Naumann et al.   PLoS One

Chemokine receptor CXCR4 expression in hepatocellular carcinoma patients increases the risk of bone metastases and poor survival

(2009) Zuo-lin Xiang et al.   BMC CANCER

Increased Expression of Vascular Endothelial Growth Factor-C and Nuclear CXCR4 in Hepatocellular Carcinoma Is Correlated With Lymph Node Metastasis and Poor Outcome

(2009) Zuolin Xiang et al.   CANCER JOURNAL

Hepatic stellate cells express functional CXCR4: Role in stromal cell-derived factor-1α-mediated stellate cell activation

(2009) Feng Hong et al.   HEPATOLOGY

 -arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7

(2009) S. Rajagopal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Abrogation of TGFβ Signaling in Mammary Carcinomas Recruits Gr-1+CD11b+ Myeloid Cells that Promote Metastasis

(2008) Li Yang et al.   CANCER CELL

A New Population of Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Induces CD4+CD25+Foxp3+ T Cells

(2008) Bastian Hoechst et al.   GASTROENTEROLOGY

Early postnatal lethality and cardiovascular defects in CXCR7-deficient mice

(2008) Han Gerrits et al.   GENESIS