Opioidergic effects on enteric and sensory nerves in the lower GI tract: basic mechanisms and clinical implications

Evidence for nociceptin/orphanin FQ (NOP) but not µ (MOP), δ (DOP) or κ (KOP) opioid receptor mRNA in whole human blood

(2016) M. Al-Hashimi et al.   BRITISH JOURNAL OF ANAESTHESIA

Efficacy and Safety of Methylnaltrexone for Opioid-Induced Constipation in Patients With Chronic Noncancer Pain

(2016) Eugene R. Viscusi et al.   REGIONAL ANESTHESIA AND PAIN MEDICINE

Animal models of gastrointestinal and liver diseases. Animal models of visceral pain: pathophysiology, translational relevance, and challenges

(2015) Beverley Greenwood-Van Meerveld et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Cognitive-behavioural therapy has no effect on disease activity but improves quality of life in subgroups of patients with inflammatory bowel disease: a pilot randomised controlled trial

(2015) Antonina Mikocka-Walus et al.   BMC GASTROENTEROLOGY

Opioid and chemokine receptor crosstalk: a promising target for pain therapy?

(2015) Stéphane Mélik Parsadaniantz et al.   NATURE REVIEWS NEUROSCIENCE

Stress and opioids: Role of opioids in modulating stress-related behavior and effect of stress on morphine conditioned place preference

(2015) Anjana Bali et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Neurochemical features of endomorphin-2-containing neurons in the submucosal plexus of the rat colon

(2015) Jun-Ping Li   WORLD JOURNAL OF GASTROENTEROLOGY

Site and mechanism of morphine tolerance in the gastrointestinal tract

(2015) H. I. Akbarali et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Emerging treatments in neurogastroenterology: a multidisciplinary working group consensus statement on opioid-induced constipation

(2015) M. Camilleri et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Immune derived opioidergic inhibition of viscerosensory afferents is decreased in Irritable Bowel Syndrome patients

(2014) Patrick A. Hughes et al.   BRAIN BEHAVIOR AND IMMUNITY

In vivoopioid receptor heteromerization: where do we stand?

(2014) D Massotte   BRITISH JOURNAL OF PHARMACOLOGY

Revolution in GPCR signalling: opioid receptor heteromers as novel therapeutic targets: IUPHAR Review 10

(2014) Wakako Fujita et al.   BRITISH JOURNAL OF PHARMACOLOGY

Neuroplasticity and dysfunction after gastrointestinal inflammation

(2014) Stuart M. Brierley et al.   Nature Reviews Gastroenterology & Hepatology

Activation of the endogenous nociceptin system by selective nociceptin receptor agonist SCH 221510 produces antitransit and antinociceptive effect: a novel strategy for treatment of diarrhea-predominant IBS

(2014) J. Fichna et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Circular muscle contraction in the mice rectum plays a key role in morphine-induced constipation

(2014) H. Ono et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Specific Localization of β-Arrestin2 in Myenteric Plexus of Mouse Gastrointestinal Tract

(2014) Hercules T. Maguma et al.   PLoS One

Side effects of analgesia may significantly reduce quality of life in symptomatic multiple myeloma: a cross-sectional prevalence study

(2014) Sarah Sloot et al.   SUPPORTIVE CARE IN CANCER

Immune Activation in Irritable Bowel Syndrome: Can Neuroimmune Interactions Explain Symptoms?

(2013) Patrick A Hughes et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Eluxadoline Benefits Patients With Irritable Bowel Syndrome With Diarrhea in a Phase 2 Study

(2013) Leonard S. Dove et al.   GASTROENTEROLOGY

Endogenous Regulation of Visceral Pain via Production of Opioids by Colitogenic CD4+ T Cells in Mice

(2013) Jérôme Boué et al.   GASTROENTEROLOGY

Increased κ-opioid receptor expression and function during chronic visceral hypersensitivity

(2013) Patrick A Hughes et al.   GUT

Extrinsic primary afferent signalling in the gut

(2013) Simon J. H. Brookes et al.   Nature Reviews Gastroenterology & Hepatology

Morphine Induces Bacterial Translocation in Mice by Compromising Intestinal Barrier Function in a TLR-Dependent Manner

(2013) Jingjing Meng et al.   PLoS One

Diagnosis, Characterization and 3-Month Outcome After Detoxification of 39 Patients With Narcotic Bowel Syndrome

(2012) Douglas A Drossman et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Modulation of gastrointestinal function by MuDelta, a mixed µ opioid receptor agonist/ µ opioid receptor antagonist

(2012) PR Wade et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sensory neuro-immune interactions differ between Irritable Bowel Syndrome subtypes

(2012) Patrick A Hughes et al.   GUT

Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC

(2012) Augusto Caraceni et al.   LANCET ONCOLOGY

The enteric nervous system and neurogastroenterology

(2012) John B. Furness   Nature Reviews Gastroenterology & Hepatology

Release of endogenous opioids during a chronic IBD model suppresses the excitability of colonic DRG neurons

(2012) E. Valdez-Morales et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Opioid receptor subtypes: fact or artifact?

(2011) N. Dietis et al.   BRITISH JOURNAL OF ANAESTHESIA

Localization and Regulation of Fluorescently Labeled Delta Opioid Receptor, Expressed in Enteric Neurons of Mice

(2011) Daniel P. Poole et al.   GASTROENTEROLOGY

Endogenous Opioid-Mediated Analgesia Is Dependent on Adaptive T Cell Response in Mice

(2011) J. Boue et al.   JOURNAL OF IMMUNOLOGY

Gastrointestinal side effects in chronic opioid users: results from a population-based survey

(2010) S. F. COOK et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Efficacy and Safety of Prucalopride in Patients with Chronic Noncancer Pain Suffering from Opioid-Induced Constipation

(2010) Cornelius E. J. Sloots et al.   DIGESTIVE DISEASES AND SCIENCES

Evidence of Central and Peripheral Sensitization in a Rat Model of Narcotic Bowel-Like Syndrome

(2010) Simona Agostini et al.   GASTROENTEROLOGY

Opioid receptors and opioid peptide-producing leukocytes in inflammatory pain – Basic and therapeutic aspects

(2009) Melanie Busch-Dienstfertig et al.   BRAIN BEHAVIOR AND IMMUNITY

Post-inflammatory modification of colonic afferent mechanosensitivity

(2009) PA Hughes et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

The Ion Channel TRPA1 Is Required for Normal Mechanosensation and Is Modulated by Algesic Stimuli

(2009) Stuart M. Brierley et al.   GASTROENTEROLOGY

Identification of Medium/High-Threshold Extrinsic Mechanosensitive Afferent Nerves to the Gastrointestinal Tract

(2009) Xingyun Song et al.   GASTROENTEROLOGY

Post-inflammatory colonic afferent sensitisation: different subtypes, different pathways and different time courses

(2009) P A Hughes et al.   GUT

Influence of naloxone on rectal sensorimotor function in health

(2009) b. geeraerts et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Clinical trial: asimadoline in the treatment of patients with irritable bowel syndrome

(2008) A. W. MANGEL et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Selective Role for TRPV4 Ion Channels in Visceral Sensory Pathways

(2008) Stuart M. Brierley et al.   GASTROENTEROLOGY

Adverse Effects of Transdermal Opiates Treating Moderate-Severe Cancer Pain in Comparison to Long-Acting Morphine: A Meta-Analysis and Systematic Review of the Literature

(2008) Davide Tassinari et al.   JOURNAL OF PALLIATIVE MEDICINE

Morphine Tolerance in the Mouse Ileum and Colon

(2008) G. R. Ross et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Involvement of κ-opioid receptors in visceral nociception in mice

(2008) m. h. larsson et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Central and peripheral role of the nociceptinorphaninFQ system on normal and disturbed colonic motor function and faecal pellet output in the rat

(2008) m. broccardo et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The Prevalence, Severity, and Impact of Opioid-Induced Bowel Dysfunction: Results of a US and European Patient Survey (PROBE 1)

(2008) Timothy J. Bell et al.   PAIN MEDICINE