The immunomodulatory potential of natural compounds in tumor-bearing mice and humans

T Cell Dysfunction in Cancer

(2018) Daniela S. Thommen et al.   CANCER CELL

TriCurin, a synergistic formulation of curcumin, resveratrol, and epicatechin gallate, repolarizes tumor-associated macrophages and triggers an immune response to cause suppression of HPV+ tumors

(2018) Sumit Mukherjee et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Cancer-associated cachexia, reactive oxygen species, and nutrition therapy

(2018) Geir Bjorklund et al.   CURRENT MEDICINAL CHEMISTRY

Plasticity of myeloid-derived suppressor cells in cancer

(2018) Evgenii Tcyganov et al.   CURRENT OPINION IN IMMUNOLOGY

Unconventional T Cell Targets for Cancer Immunotherapy

(2018) Dale I. Godfrey et al.   IMMUNITY

Liposomal TriCurin, A Synergistic Combination of Curcumin, Epicatechin Gallate and Resveratrol, Repolarizes Tumor-Associated Microglia/Macrophages, and Eliminates Glioblastoma (GBM) and GBM Stem Cells

(2018) Sumit Mukherjee et al.   MOLECULES

Use of Functional Foods and Oral Supplements as Adjuvants in Cancer Treatment

(2018) Guadalupe Serna-Thomé et al.   Revista de Investigacion Clinica-Clinical and Translational Investigation

Colon Cancer

(2018) Pan Pan et al.   Surgical Oncology Clinics of North America

Naturally occurring immunomodulators with antitumor activity: An insight on their mechanisms of action

(2017) Shimaa Ibrahim Abdelmonym Mohamed et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Medicinal Mushrooms in Human Clinical Studies. Part I. Anticancer, Oncoimmunological, and Immunomodulatory Activities: A Review

(2017) Solomon P. Wasser   INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS

The Role of Resveratrol in Cancer Therapy

(2017) Jeong-Hyeon Ko et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lung cancer and β-glucans: review of potential therapeutic applications

(2017) Raheleh Roudi et al.   INVESTIGATIONAL NEW DRUGS

Curcumin converts Foxp3+ regulatory T cells to T helper 1 cells in patients with lung cancer

(2017) Jian Y. Zou et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Dietary flavonoids and modulation of natural killer cells: implications in malignant and viral diseases

(2017) Markus Burkard et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Cancer Chemoprevention by Resveratrol: The p53 Tumor Suppressor Protein as a Promising Molecular Target

(2017) Danielly Ferraz da Costa et al.   MOLECULES

The Repeated Administration of Resveratrol Has Measurable Effects on Circulating T-Cell Subsets in Humans

(2017) J. Luis Espinoza et al.   Oxidative Medicine and Cellular Longevity

A Placebo-Controlled Double-Blinded Randomized Pilot Study of Combination Phytotherapy in Biochemically Recurrent Prostate Cancer

(2017) M. Diana van Die et al.   PROSTATE

Natural killer cell-mediated immunosurveillance of human cancer

(2017) Karl-Johan Malmberg et al.   SEMINARS IN IMMUNOLOGY

Bisdemethoxycurcumin in combination with α-PD-L1 antibody boosts immune response against bladder cancer

(2017) Yiqun Shao et al.   OncoTargets and Therapy

A comprehensive review of the health perspectives of resveratrol

(2017) Abdur Rauf et al.   Food & Function

Resveratrol promotes MICA/B expression and natural killer cell lysis of breast cancer cells by suppressing c-Myc/miR-17 pathway

(2017) Jie Pan et al.   Oncotarget

Myeloid-Derived Suppressor Cells

(2017) Dmitry I. Gabrilovich   Cancer Immunology Research

Black Raspberries Enhance Natural Killer Cell Infiltration into the Colon and Suppress the Progression of Colorectal Cancer

(2017) Pan Pan et al.   Frontiers in Immunology

Berries and other natural products in pancreatic cancer chemoprevention in human clinical trials

(2017) Pan Pan et al.   Journal of Berry Research

Regulatory T-Cell Modulation by Green Tea in Chronic Lymphocytic Leukemia

(2017) G. D'arena et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Carotenoids: biochemistry, pharmacology and treatment

(2016) Alireza Milani et al.   BRITISH JOURNAL OF PHARMACOLOGY

Phase I study of topical epigallocatechin-3-gallate (EGCG) in patients with breast cancer receiving adjuvant radiotherapy

(2016) Hanxi Zhao et al.   BRITISH JOURNAL OF RADIOLOGY

Loss of free fatty acid receptor 2 enhances colonic adenoma development and reduces the chemopreventive effects of black raspberries in ApcMin/+mice

(2016) Pan Pan et al.   CARCINOGENESIS

The Basis of Oncoimmunology

(2016) A. Karolina Palucka et al.   CELL

Immunosurveillance and immunotherapy of tumors by innate immune cells

(2016) Alexandre Iannello et al.   CURRENT OPINION IN IMMUNOLOGY

Inhibition of curcumin on myeloid-derived suppressor cells is requisite for controlling lung cancer

(2016) Dan Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Prevention and treatment of cancers by immune modulating nutrients

(2016) Naveena B. Janakiram et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Curcumin Micelles Remodel Tumor Microenvironment and Enhance Vaccine Activity in an Advanced Melanoma Model

(2016) Yao Lu et al.   MOLECULAR THERAPY

Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled Study

(2016) Jalal Hejazi et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

The New Combination Docetaxel, Prednisone and Curcumin in Patients with Castration-Resistant Prostate Cancer: A Pilot Phase II Study

(2016) Hakim Mahammedi et al.   ONCOLOGY

Food-based natural products for cancer management: Is the whole greater than the sum of the parts?

(2016) Suleman S. Hussain et al.   SEMINARS IN CANCER BIOLOGY

Neutrophils in the Tumor Microenvironment

(2016) Davalyn R. Powell et al.   TRENDS IN IMMUNOLOGY

The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

(2016) Vinit Kumar et al.   TRENDS IN IMMUNOLOGY

The effects of curcumin (diferuloylmethane) on body composition of patients with advanced pancreatic cancer

(2016) Henrique A. Parsons et al.   Oncotarget

Laricitrin ameliorates lung cancer-mediated dendritic cell suppression by inhibiting signal transducer and activator of transcription 3

(2016) Wei-An Chang et al.   Oncotarget

Innate Immune Recognition of Cancer

(2015) Seng-Ryong Woo et al.   Annual Review of Immunology

Dendrosomal Curcumin Suppresses Metastatic Breast Cancer in Mice by Changing M1/M2 Macrophage Balance in the Tumor Microenvironment

(2015) Sadaf Shiri et al.   Asian Pacific Journal of Cancer Prevention

Macrophages and Therapeutic Resistance in Cancer

(2015) Brian Ruffell et al.   CANCER CELL

Beneficial Regulation of Metabolic Profiles by Black Raspberries in Human Colorectal Cancer Patients

(2015) P. Pan et al.   Cancer Prevention Research

Modification of Antitumor Immunity and Tumor Microenvironment by Resveratrol in Mouse Renal Tumor Model

(2015) Liang Chen et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Tea and Its Consumption: Benefits and Risks

(2015) Khizar Hayat et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

The Role of Systemic Retinoids in the Treatment of Cutaneous T-Cell Lymphoma

(2015) Auris O. Huen et al.   DERMATOLOGIC CLINICS

Seeing through the dark: New insights into the immune regulatory functions of vitamin A

(2015) Chrysothemis C. Brown et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected

(2015) Douglas Marvel et al.   JOURNAL OF CLINICAL INVESTIGATION

Impact of dietary components on NK and Treg cell function for cancer prevention

(2015) Young S. Kim et al.   MOLECULAR CARCINOGENESIS

Nutritional immunology: function of natural killer cells and their modulation by resveratrol for cancer prevention and treatment

(2015) Christian Leischner et al.   Nutrition Journal

A phase I study of muscadine grape skin extract in men with biochemically recurrent prostate cancer: Safety, tolerability, and dose determination

(2015) Channing J. Paller et al.   PROSTATE

Cancer prevention and therapy through the modulation of the tumor microenvironment

(2015) Stephanie C. Casey et al.   SEMINARS IN CANCER BIOLOGY

Macrophages and cancer: from mechanisms to therapeutic implications

(2015) Renato Ostuni et al.   TRENDS IN IMMUNOLOGY

Curcumin and tumor immune-editing: resurrecting the immune system

(2015) Sayantan Bose et al.   Cell Division

Adaptive Immune Resistance: How Cancer Protects from Immune Attack

(2015) A. Ribas   Cancer Discovery

Curcumin: A Promising Agent Targeting Cancer Stem Cells

(2014) Shufei Zang et al.   Anti-Cancer Agents in Medicinal Chemistry

Regulation of Dendritic Cell Function by Dietary Polyphenols

(2014) Manuela del Cornò et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Adjuvant Therapy with Bioavailability-Boosted Curcuminoids Suppresses Systemic Inflammation and Improves Quality of Life in Patients with Solid Tumors: A Randomized Double-Blind Placebo-Controlled Trial

(2014) Yunes Panahi et al.   PHYTOTHERAPY RESEARCH

A phase I study of concurrent chemotherapy and thoracic radiotherapy with oral epigallocatechin-3-gallate protection in patients with locally advanced stage III non-small-cell lung cancer

(2014) Hanxi Zhao et al.   RADIOTHERAPY AND ONCOLOGY

The Use of Lentinan for Treating Gastric Cancer

(2013) Kenji Ina et al.   Anti-Cancer Agents in Medicinal Chemistry

β -Glucans and their Applications in Cancer Therapy: Focus on human studies

(2013) Eiman Aleem   Anti-Cancer Agents in Medicinal Chemistry

The Effects of β -Glucans on Dendritic Cells and Implications for Cancer Therapy

(2013) Sabrin H. Albeituni et al.   Anti-Cancer Agents in Medicinal Chemistry

A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin®) in cancer patients

(2013) Masashi Kanai et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Polyphenol E Enhances the Antitumor Immune Response in Neuroblastoma by Inactivating Myeloid Suppressor Cells

(2013) G. Santilli et al.   CLINICAL CANCER RESEARCH

Immunity: Plants as Effective Mediators

(2013) M. Tauseef Sultan et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Inhibition of Breast Cancer Metastasis by Resveratrol-Mediated Inactivation of Tumor-Evoked Regulatory B Cells

(2013) C. Lee-Chang et al.   JOURNAL OF IMMUNOLOGY

Evaluation of host quality of life and immune function in breast cancer patients treated with combination of adjuvant chemotherapy and oral administration of Lentinula edodes mycelia extract

(2013) Yukiko Nagashima et al.   OncoTargets and Therapy

Curcumin improves the therapeutic efficacy of Listeriaat-Mage-b vaccine in correlation with improved T-cell responses in blood of a triple-negative breast cancer model 4T1

(2013) Manisha Singh et al.   Cancer Medicine

A global clinical view on vitamin A and carotenoids

(2012) Alfred Sommer et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Immunomodulation and Anti-inflammatory Roles of Polyphenols as Anticancer Agents

(2012) Francois Ghiringhelli et al.   Anti-Cancer Agents in Medicinal Chemistry

Retinoids: novel immunomodulators and tumour-suppressive agents?

(2012) MR Carratù et al.   BRITISH JOURNAL OF PHARMACOLOGY

Phase 2 trial of daily, oral polyphenon E in patients with asymptomatic, Rai stage 0 to II chronic lymphocytic leukemia

(2012) Tait D. Shanafelt et al.   CANCER

Phase IB Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Women with Hormone Receptor-Negative Breast Cancer

(2012) K. D. Crew et al.   Cancer Prevention Research

Cancer Chemoprevention with Green Tea Catechins: From Bench to Bed

(2012) Yohei Shirakami et al.   CURRENT DRUG TARGETS

Plant phytochemicals as new potential drugs for immune disorders and cancer therapy: really a promising path?

(2012) Salvatore Chirumbolo   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Dietary Agents in Cancer Prevention: An Immunological Perspective†

(2012) Ya Ying Zheng et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Resveratrol Prevents Endothelial Cells Injury in High-Dose Interleukin-2 Therapy against Melanoma

(2012) Hongbing Guan et al.   PLoS One

The role of edible mushrooms in health: Evaluation of the evidence

(2012) Peter Roupas et al.   Journal of Functional Foods

Efficacy and Safety of Orally Administered Lentinula edodes Mycelia Extract for Patients Undergoing Cancer Chemotherapy: A Pilot Study

(2011) Yoshiyuki Yamaguchi et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

The treatment of bladder cancer in a mouse model by epigallocatechin-3-gallate-gold nanoparticles

(2011) Dar-Shih Hsieh et al.   BIOMATERIALS

Immunomodulation of Curcumin on Adoptive Therapy with T Cell Functional Imaging in Mice

(2011) Y.-F. Chang et al.   Cancer Prevention Research

Phase I Randomized, Double-Blind Pilot Study of Micronized Resveratrol (SRT501) in Patients with Hepatic Metastases--Safety, Pharmacokinetics, and Pharmacodynamics

(2011) L. M. Howells et al.   Cancer Prevention Research

The effects of dietary supplementation with Agaricales mushrooms and other medicinal fungi on breast cancer: evidence-based medicine

(2011) Maria Rita Carvalho Garbi Novaes et al.   Clinics

Anti-tumor and immunomodulatory activity of resveratrol in vitro and its potential for combining with cancer immunotherapy

(2011) Brenda L. Soto et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Low-dose curcumin leads to the inhibition of tumor growth via enhancing CTL-mediated antitumor immunity

(2011) Feifei Luo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Immunomodulatory and Antitumor Activities of Grape Seed Proanthocyanidins

(2011) Haibin Tong et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Subtype and pathway specific responses to anticancer compounds in breast cancer

(2011) L. M. Heiser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resveratrol Modulates Drug- and Carcinogen-Metabolizing Enzymes in a Healthy Volunteer Study

(2010) H.-H. S. Chow et al.   Cancer Prevention Research

Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics, and Effect on the Insulin-like Growth Factor Axis

(2010) V. A. Brown et al.   CANCER RESEARCH

Clinical Pharmacology of Resveratrol and Its Metabolites in Colorectal Cancer Patients

(2010) K. R. Patel et al.   CANCER RESEARCH

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Curcumin reverses T cell-mediated adaptive immune dysfunctions in tumor-bearing hosts

(2010) Sankar Bhattacharyya et al.   Cellular & Molecular Immunology

Immune modulating effects of β-glucan

(2010) E Angela Murphy et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Immunomodulatory and therapeutic activity of curcumin

(2010) Raghvendra M. Srivastava et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Curcumin and Gemcitabine in Patients With Advanced Pancreatic Cancer

(2010) Ron Epelbaum et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Immunomodulatory dietary polysaccharides: a systematic review of the literature

(2010) Jane E Ramberg et al.   Nutrition Journal

DNA vaccination with all-trans retinoic acid treatment induces long-term survival and elicits specific immune responses requiring CD4+ and CD8+ T-cell activation in an acute promyelocytic leukemia mouse model

(2009) K. Furugaki et al.   BLOOD

Green Tea: Nature's Defense against Malignancies

(2009) Masood Sadiq Butt et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Phase I Trial of Daily Oral Polyphenon E in Patients With Asymptomatic Rai Stage 0 to II Chronic Lymphocytic Leukemia

(2009) Tait D. Shanafelt et al.   JOURNAL OF CLINICAL ONCOLOGY

The effects of β-glucan on human immune and cancer cells

(2009) Godfrey Chan et al.   Journal of Hematology & Oncology

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Retinoids as Critical Modulators of Immune Functions: New Therapeutic Perspectives for Old Compounds

(2009) Michele Montrone et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer

(2008) N. Dhillon et al.   CLINICAL CANCER RESEARCH

Resveratrol induces the suppression of tumor-derived CD4+CD25+ regulatory T cells

(2008) Yoolhee Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Grape seed proanthocyanidines and skin cancer prevention: Inhibition of oxidative stress and protection of immune system

(2008) Santosh K. Katiyar   MOLECULAR NUTRITION & FOOD RESEARCH

Potential of resveratrol in anticancer and anti-inflammatory therapy

(2008) Chibuike C Udenigwe et al.   NUTRITION REVIEWS