Article
Environmental Sciences
Jialu Bao, Yan Zhang, Ran Wen, Linchao Zhang, Xiaodan Wang
Summary: This study investigated the effects of low level MCZ exposure on mouse ovaries. The results showed that MCZ exposure led to damaged ovarian structure and increased apoptosis in mice, which may be achieved by affecting the function of mitochondrial respiratory chain and inducing oxidative stress.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Shamsi Emtenani, Elliot T. Martin, Attila Gyoergy, Julia Bicher, Jakob-Wendelin Genger, Thomas Kocher, Maria Akhmanova, Mariana Guarda, Marko Roblek, Andreas Bergthaler, Thomas R. Hurd, Prashanth Rangan, Daria E. Siekhaus
Summary: A previously uncharacterized nuclear protein, Atossa, controls cellular metabolism to support macrophage invasion into the germband of Drosophila. Atossa increases mRNA levels of proteins and enzymes related to mitochondrial bioenergetics, while Porthos enhances the translational efficiency of specific mRNAs, including those affecting mitochondrial functions. This genetic program powers up OxPhos and energy production to promote the leading of macrophages into tissues.
Review
Medicine, General & Internal
Daniel L. Galvan, Koki Mise, Farhad R. Danesh
Summary: The role and nature of mitochondrial dysfunction in diabetic kidney disease (DKD) have been extensively studied, with a focus on understanding the molecular drivers of mitochondrial remodeling. Despite the lack of complete elucidation on how these changes contribute to DKD progression, there is great excitement for future targeted therapies based on improving mitochondrial function.
FRONTIERS IN MEDICINE
(2021)
Article
Cell Biology
Aida Adlimoghaddam, Benedict C. Albensi
Summary: This study found that ammonia decreased mitochondrial numbers in astroglia through a CaMKII-CREB-PGC1α-Nrf2 pathway, leading to reduced OCR, ATP, COX, and OXPHOS levels. Treatment with NF-kappa B inhibitors reversed the mitochondrial deficits induced by ammonia, suggesting the involvement of the NF-kappa B signaling pathway in ammonia-induced changes in bioenergetics in astroglia.
Article
Critical Care Medicine
Briana K. Shimada, Liron Boyman, Weiliang Huang, Jing Zhu, Yang Yang, Fengqian Chen, Maureen A. Kane, Nagendra Yadava, Lin Zou, W. Jonathan Lederer, Brian M. Polster, Wei Chao
Summary: This study identified a broad mitochondrial protein remodeling, inactivation of pyruvate dehydrogenase (PDH), and impaired pyruvate-fueled oxidative phosphorylation during sepsis-induced cardiomyopathy. These findings provide a molecular framework for further exploration and understanding of the pathogenesis of sepsis-induced cardiomyopathy.
Article
Cell Biology
Silvia Ravera, Maria Grazia Signorello, Isabella Panfoli
Summary: Platelets are cellular elements that play important roles in hemostasis, inflammation, thrombotic events, and human diseases. Their activation is linked to their metabolism, and they possess considerable metabolic flexibility. Although their roles in hemostasis and inflammation are known, there is limited understanding of their metabolism in terms of substrate preference. Platelet activation triggers an increase in oxidative metabolism to meet energy requirements, and they also possess extra-mitochondrial oxidative phosphorylation. Understanding the link between platelet activation and metabolic changes is crucial for improving human health.
Article
Multidisciplinary Sciences
Mahmoud AbuEid, Donna M. McAllister, Laura McOlash, Megan Cleland Harwig, Gang Cheng, Donovan Drouillard, Kathleen A. Boyle, Micael Hardy, Jacek Zielonka, Bryon D. Johnson, R. Blake Hill, Balaraman Kalyanaraman, Michael B. Dwinell
Summary: Targeted inhibition of complex I with Mito-CI has multiple effects that cumulatively inhibit melanoma growth and promote immune remodeling.
Review
Biochemistry & Molecular Biology
Lauren L. Walkon, Jasiel O. Strubbe-Rivera, Jason N. Bazil
Summary: Mitochondrial calcium plays a dual role, with low levels being essential for ATP production and high levels leading to mitochondrial dysfunction. In moderate amounts, calcium inhibits ATP synthesis. The mechanism of mitochondrial dysfunction during calcium overload remains unclear, but it may involve changes in mitochondrial ultrastructure and enzyme activity.
Editorial Material
Hematology
Aaron D. Schimmer
Summary: In this study, it is shown that ZDHHC21-mediated palmitoylation is crucial for regulating oxidative phosphorylation in a subset of acute myeloid leukemia cells.
Article
Pharmacology & Pharmacy
Dan E. E. Vivas-Ruiz, Paola Rosas, Alex Proleon, Daniel Torrejon, Fanny Lazo, Ana Belen Tenorio-Ricca, Francisco Guajardo, Cristopher Almarza, Victor Andrades, Jessica Astorga, Daniel Oropesa, Jorge Toledo, Maria Jesus Vera, Jorge Martinez, Ramiro Araya-Maturana, Karen Dubois-Camacho, Marcela A. A. Hermoso, Valeria G. Alvarenga, Eladio Flores Sanchez, Armando Yarleque, Luciana Souza Oliveira, Felix A. Urra
Summary: We have described toxins derived from the venom of Bothrops pictus snake that inhibit platelet aggregation and cancer cell migration. We characterized a novel P-III class snake venom metalloproteinase called pictolysin-III (Pic-III), which hydrolyzes various proteins and is affected by different ions and inhibitors. Pic-III also affects mitochondrial bioenergetics in cells and increases sensitivity to a cytotoxic drug in cancer cells.
Article
Oncology
Yogesh Rai, Saurabh Singh, Sanjay Pandey, Dhananjay Sah, Raj Kumar Sah, B. G. Roy, Bilikere S. Dwarakanath, Anant Narayan Bhatt
Summary: Cancer cells exhibit altered energy metabolism, with impaired mitochondrial function and increased glycolysis. This study investigated the effect of prolonged exposure to the mitochondrial uncoupler DNP on the energy metabolism of glioma cells and its impact on tumor progression. The results showed that chronic DNP exposure increased glycolysis and OXPHOS in glioma cells, leading to enhanced tumor formation and accelerated tumor growth in an animal model. Furthermore, DNP-treated cells also exhibited increased migration and invasion potential. These findings suggest that prolonged exposure to mitochondrial uncouplers may confer a growth advantage to glioma cells and result in poor clinical outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Sport Sciences
Erik D. Marchant, Nathan D. Marchant, Robert D. Hyldahl, Jayson R. Gifford, Michael W. Smith, Chad R. Hancock
Summary: This study aimed to investigate the effects of ultraendurance exercise on the bioenergetic status of muscle. The findings showed that completing a 100 km ultramarathon led to significant mitochondrial impairment in muscle, which rapidly recovered within two days. Blood markers also showed changes after the run but partially recovered within 48 hours.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Neurosciences
Brendan J. Lujan, Mahendra Singh, Abhyudai Singh, Robert B. Renden
Summary: The study investigated the roles of presynaptic glycolysis and mitochondrial respiration in supporting high-frequency neurotransmission. It was found that both glycolysis and mitochondrial ATP production have impacts on sustained neurotransmission, but transmission in mature synapses relies exclusively on mitochondrial ATP production.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Patrik Palacka, Anna Gvozdjakova, Zuzana Rausova, Jarmila Kucharska, Jan Slopovsky, Jana Obertova, Daniel Furka, Samuel Furka, Keshav K. Singh, Zuzana Sumbalova
Summary: This study found that patients with urothelial carcinoma (UC) have deficient platelet mitochondrial function, decreased antioxidant levels, and increased oxidative stress. These changes are consistent with cell metabolism reprogramming in UC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Melanie Boel, Yann Voituron, Damien Roussel
Summary: In this study, it was found that oxygen consumption and ATP production in vertebrates are dependent on body mass, but the ATP/O value at the maximal phosphorylating state is not. In addition, the study also revealed that the ATP/O value at sub-maximal phosphorylating states is positively correlated with body mass, regardless of metabolic intensity.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Xiaoyu Li, Yingju Qin, Long Kong, Xiliang Yan, Wei Zhang, Christopher J. Martyniuk, Xiaohong Wang, Bing Yan
Summary: The exposure to Cu(OH)(2) nanopesticide led to changes in cell metabolic activity, shifting cells from oxidative phosphorylation to glycolysis and resulting in lipid accumulation. This exposure also decreased the activity of the TCA cycle and increased oxidative stress.
ENVIRONMENTAL SCIENCE-NANO
(2022)
Article
Marine & Freshwater Biology
Shuo Wang, Xiao Zhang, Xiaotian Xu, Limin Su, Yuan H. Zhao, Christopher J. Martyniuk
Summary: This study investigated the modes of toxic action of various chemicals on non-target organisms such as worms and tadpoles. The results showed that tadpoles were more sensitive than worms to these chemicals and there were differences in toxicity values between the two species. Regression analysis revealed linear relationships between the toxicity of certain compounds and hydrophobicity for both tadpoles and worms. The study also identified different classes of compounds and their toxic effects on both species. The findings suggest that worm toxicity data can be used to estimate tadpole toxicity, and these two species can be used as surrogates in the evaluation of organic pollutants.
AQUATIC TOXICOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Christopher J. Martyniuk
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
(2022)
Article
Environmental Sciences
Xiaotian Xu, Chen Wang, Bingxin Gui, Xiangyi Yuan, Chao Li, Yuanhui Zhao, Christopher J. Martyniuk, Limin Su
Summary: With the promotion of carbon neutrality, it is important to simultaneously focus on the assessment and sustainable management of chemicals to protect public health. This study successfully established a predictive model based on compounds derived from cyclic adenosine monophosphate (cAMP) analysis, effectively identifying and predicting chemicals and active compounds that inhibit the thyroid stimulating hormone receptor (TSHR).
ENVIRONMENTAL RESEARCH
(2022)
Article
Engineering, Environmental
Jiye Zhang, Huihui Chen, Tianheng Tong, Ruimin Liu, Saihong Yan, Xuefang Liang, Christopher J. Martyniuk, Jinmiao Zha
Summary: Asian clams (Corbicula fluminea) exposed to different concentrations of Benzotriazole ultraviolet stabilizers (BUVSs) showed varying physiological and molecular toxic effects, including changes in filtration rate, histopathological changes, and induction of apoptosis. This study provides important insights into the toxicity and hazards of BUVSs in benthic organisms.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Emma Ivantsova, Isaac Konig, Christopher L. Souders II, David McNabney, Denina D. B. Simmons, Christopher J. Martyniuk
Summary: Blood pressure medication atenolol, a beta-blocker detected in wastewater systems, has negative effects on early stages of zebrafish development. It affects survival, heart rate, mitochondrial function, lipid and amino acid profiles, and locomotor activity. Atenolol decreases heart rate and alters lipid content in zebrafish at environmentally relevant levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Nazish Iftikhar, Isaac Konig, Cole English, Emma Ivantsova, Christopher L. L. Souders II, Imran Hashmi, Christopher J. J. Martyniuk
Summary: The broad-range bacteriostatic antibiotic sulfamethoxazole (SMX) has been found to have sub-lethal toxicity effects on developing zebrafish embryos and larvae, including decreased survivability, delayed hatch, and induced malformations. It also triggers an inflammatory response and alters the expression of genes related to apoptosis. These findings contribute to the understanding of antibiotic toxicity in aquatic organisms and provide a foundation for environmental risk assessment of SMX and other antibiotics.
Article
Multidisciplinary Sciences
Cole D. English, Kira J. Kazi, Isaac Konig, Emma Ivantsova, Christopher L. Souders Ii, Christopher J. Martyniuk
Summary: Zebrafish larvae were exposed to different concentrations of Ifosfamide, and RNA-seq analysis revealed 21 microRNAs that were associated with Ifosfamide exposure. This study provides valuable insights for the advancement of regulatory toxicology and biomarker discovery in aquatic environments.
Article
Environmental Sciences
Mohamed Hamed, Christopher J. Martyniuk, Rashad E. M. Said, Hamdy A. M. Soliman, Ahmed E. A. Badrey, Elhagag A. Hassan, Hani N. Abdelhamid, Alaa G. M. Osman, Alaa El -Din H. Sayed
Summary: This study reports the presence of pyrogallol in wastewater in Egypt for the first time. Acute and sub-acute toxicity experiments were conducted to evaluate the toxic effects of pyrogallol on catfish. The results showed that pyrogallol exposure caused morphological changes, hematological and biochemical alterations, indicating potential risks to aquatic species.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Wei Chi, Juanjuan Fu, Chris J. Martyniuk, Jiangyong Wang, Libin Zhou
Summary: This study investigates the collaboration of HIF-1 alpha A and HIF-1 alpha B in regulating mitophagy and apoptosis under hypoxic stress in cyprinid fish. The results show that HIF-1 alpha A induces apoptosis by promoting ROS generation and mitochondrial depolarization, while HIF-1 alpha B is primarily responsible for mitophagy induction, promoting ATP production to mitigate apoptosis.
JOURNAL OF MOLECULAR EVOLUTION
(2023)
Article
Endocrinology & Metabolism
Chunyu Lu, Di Peng, W. C. K. Udeesha Erandani, Kimberly Mitchell, Christopher J. Martyniuk, Vance L. Trudeau
Summary: The detection and quantification of hormones are crucial for assessing experimental models and diagnosing diseases. Traditional methods involve separate experiments, while the new approach allows simultaneous measurement of different categories of hormones. This study presents a novel sample processing strategy for the simultaneous extraction and detection of peptides, steroids, and proteins.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Sarah J. Patuel, Cole English, Victoria Lopez-Scarim, Isaac Konig, Christopher L. Souders II, Emma Ivantsova, Christopher J. Martyniuk
Summary: The study investigates the effects of Broflanilide, a novel pesticide, on zebrafish larvae. It reveals that exposure to different concentrations of Broflanilide can impact gene networks associated with various neurological disorders, including axonal injury, depression, neuroinflammation, brain infarction, and excitotoxicity. The study also identifies genes related to MPTP-induced neurotoxicity, which has relevance for Parkinson's disease.
Article
Environmental Sciences
David W. Bertolatus, Larry B. Barber, Christopher J. Martyniuk, Huajun Zhen, Timothy W. Collette, Drew R. Ekman, Aaron Jastrow, Jennifer L. Rapp, Alan M. Vajda
Summary: In order to evaluate the relationships between anthropogenic impacts, contaminant occurrence, and fish health, fish exposures were conducted across different land use sites in the Shenandoah River watershed. The study found adverse reproductive outcomes and increased mortality in fish exposed to wastewater treatment plant effluent and agricultural impacts. Molecular biomarkers and hepatic metabolomic and transcriptomic profiles indicated variations in land use and contaminant profiles. This study demonstrated the linkages between human impacts, contaminant occurrence, and exposure effects, highlighting the increased risk of adverse outcomes in fish exposed to complex mixtures.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Isaac Konig, Nazish Iftikhar, Evelyn Henry, Cole English, Emma Ivantsova, Christopher L. Souders II, Silvana Marcussi, Christopher J. Martyniuk
Summary: This study compared the toxicity of carvacrol, acetylcarvacrol, and fipronil to early staged zebrafish. The results showed that carvacrol and its derivative have lower acute toxicity compared to fipronil.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Environmental Sciences
Sarah J. Patuel, Cole English, Victoria Lopez-Scarim, Isaac Konig, Christopher L. Souders II, Emma Ivantsova, Christopher J. Martyniuk
Summary: This study evaluates the sub-lethal toxicity potential of broflanilide in early staged zebrafish and finds that the insecticide has minimal impact on survival and biochemical parameters of the fish but can induce neurotoxicity and motor dysfunction.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Gabriela Maressa Machado Baesso, Amanda Vitoria Venancio, Livia Costa Varela Barca, Pepita Fernanda Peppi, Caique Aparecido Faria, Joao Pedro Cosmo Machado, Luiz David Solis Murgas, Alvaro Jose de Almeida Bicudo, Eduardo Mauricio Mendes de Lima, Andre Rodrigues da Cunha Barreto-Vianna
Summary: This study evaluated the effects of eugenol, menthol, and lidocaine as anesthetics on glucose levels and recovery times in zebrafish. The results showed that eugenol and menthol did not affect glucose levels, while lidocaine caused non-concentration-dependent hyperglycemia. Recovery times were similar for eugenol and menthol, but concentration-dependent for lidocaine. Eugenol and menthol were deemed safe and satisfactory for glucose analysis in zebrafish research, while lidocaine could introduce biases and safety concerns. Researchers should carefully consider the selection of anesthetics for reliable results in zebrafish assessments.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Xiaoxue Li, Tangsong Feng, Weiqun Lu
Summary: This study reveals that exposure to VPA induces ASD-like phenotypes and behaviors, including gene transcription changes, social interaction deficit, decreased aggression, increased anxiety behavior, and elevated cortisol levels. The aggression behavior assay is a better predictor of neurotoxicology behavior of VPA.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Garam An, Junho Park, Whasun Lim, Gwonhwa Song
Summary: In this study, we investigated the hepatotoxicity and mechanism of action of pyridaben using zebrafish and ZFL cells. Pyridaben caused liver size reduction and apoptosis, and these effects were associated with uncontrolled intracellular calcium flow and downregulation of the PI3K/Akt signaling cascade.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Md Alamgir Kabir, Md. Golam Rabbane, Marco R. Hernandez, Md Aftab Ali Shaikh, Mohammad Moniruzzaman, Xuexiu Chang
Summary: This study investigated the toxicity of high concentrations of cadmium (Cd) on intestinal immunity and microbial diversity in common carp. The results showed that high Cd concentration caused intestinal inflammation, immunosuppression, and changes in the gut microbiome, leading to detrimental effects on the intestinal homeostasis and health status of the fish.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Anuradha Batabyal, Veronica Rivi, Cristina Benatti, Johanna M. C. Blom, Fabio Tascedda, Ken Lukowiak
Summary: This study found that exposure to heat shock stressors and bacterial lipopolysaccharide can induce the Garcia effect in pond snails. Additionally, aspirin can prevent the formation of the Garcia effect. However, unexpectedly, exposure to crushed aspirin and heat shock stressors together leads to long-lasting feeding suppression and molecular changes in the snails' serotoninergic system and neuroplasticity genes.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Li-Yih Lin, Chieh-An Cheng, Sian-Tai Liu, Jiun-Lin Horng
Summary: This study reveals that ammonia exposure impairs ion regulation in zebrafish embryos by inducing oxidative stress, mitochondrial dysfunction, and cell death. The findings suggest that ammonia is toxic to aquatic animals and can lead to the death of embryos.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Antonio Durate Pagano, Natieli Machado Goncalves, William Borges Domingues, Tony Leandro Rezende da Silveira, Mateus Tavares Kutter, Antonio Sergio Varela Jr, Carine Dahl Corcini, Mariana Cavalcanti Nascimento, Luana Ferreira Viana dos Reis, Patricia Gomes Costa, Adalto Bianchini, Matheus Vieira Volcan, Mariana Harter Remia, Vinicius Farias Campos
Summary: This study analyzed the toxic effects of Roundup Transorb (R) on the endangered Neotropical annual killifish Austrolebias charrua by evaluating molecular and biochemical biomarkers. The findings showed that exposure to Roundup significantly increased the production of reactive oxygen species, lipid peroxidation, and DNA damage in the fish's blood cells. It also decreased membrane fluidity. Gene expression analysis revealed alterations in genes associated with oxidative stress and antioxidant defense. This study provides new insights into adaptive mechanisms of A. charrua in response to Roundup, and it has important implications for environmental monitoring and aquatic toxicology assessment.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Xiaochan Gao, Hongtao Ren, Yong Huang, Yimin Li, Jiaqi Shen
Summary: The influence of multi-walled carbon nanotubes (MWCNTs) on the toxicity of zinc oxide nanoparticles (ZnONPs) in the intestine of common carp was investigated. The study found that the concentration and concentration ratio of the mixture played a role in the toxicity of ZnONPs. The presence of MWCNTs significantly decreased intercellular zinc accumulation and altered the microbial community diversity and composition of the gut microbiota.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Guangchao Yang, Qian Yang, Trust Beta, Qin Liu, Zhenzhu Zhu, Fei Shen
Summary: The study found that black garlic MLDs have alleviative effects on ZEN-induced toxicity, and exert their effects through antioxidative, anti-apoptotic, and inhibitory mechanisms on ZEN absorption.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Tuul Sepp, Ciara Baines, Randel Kreitsberg, Joern Peter Scharsack, Pedro Nogueira, Thomas Lang, Jerome Fort, Elin Sild, John T. Clarke, Arvo Tuvikene, Richard Meitern
Summary: Environmental factors can cause cancer in both wild animals and humans. The use of polluted habitats provides opportunities to study cancer defense mechanisms, which can be influenced by genetic variation and natural selection. Flatfish species, specifically flounders, show higher resistance to pollution-induced cancer compared to dabs, with elevated pollutant metabolism and stronger tumor suppression mechanisms in their liver tissue. This suggests a potential hormetic upregulation of tumor suppression or stronger natural selection pressure for cancer resistance in flounders. Wild species offer valuable insights into understanding the nature and evolution of natural cancer defense mechanisms.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Regan A. Moss, Kaitlyn M. Murphy, Steven T. Gardner, Madison M. Watkins, John W. Finger Finger Jr, Meghan D. Kelley, Ruth M. Elsey, Daniel A. Warner, Mary T. Mendonca
Summary: The study explored the impact of environmentally relevant concentrations of E2 on the immune system and hormone levels of hatchling American alligators. Results showed that exposure to environmental estrogen can alter plasma hormone concentrations but have little to no impact on morphology and immune responses.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ye Liang, Zihao Li, Jing Yuan, Yiwen Zhou, Meng Li, Haifeng Gu
Summary: This study investigated the toxicity mechanism of homo-YTX and NH3-N on the survival of abalone. The results showed that homo-YTX and NH3-N enhanced oxidative stress and lipid peroxidation reactions, inhibited energy supply, disrupted metabolic and immune physiological functions, and activated apoptosis in the gills of abalone.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)