Article
Endocrinology & Metabolism
Lars Lind, Samira Salihovic, Johan Sundstrom, Solve Elmstahl, Ulf Hammar, Koen Dekkers, Johan Arnlov, J. Gustav Smith, Gunnar Engstrom, Tove Fall
Summary: This study compared the plasma metabolome in obese subjects with and without metabolic syndrome (MetS) to normal-weight subjects without MetS. The results showed significant differences in metabolite profiles between obese and normal-weight individuals without MetS, with a gradual deterioration in metabolite profile from lean to obese to MetS. The pathways highlighted in this study, such as amino acid synthesis/metabolism and sphingolipid metabolism, may play a role in this metabolic deterioration, with insulin resistance as a potential mediator.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cell Biology
Tatsuo Kawai, Michael Autieri, Rosario Scalia
Summary: Chronic low-grade inflammation of adipose tissue is linked to metabolic disease and organ complications, mainly caused by the secretion of inflammatory substances by adipocytes and infiltration of immune cells. Despite being low-grade, this inflammation negatively impacts remote organ function and is considered a causative factor of obesity-related complications.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Immunology
Hui Zhou, Xiyan Liao, Qin Zeng, Haowei Zhang, Jianfeng Song, Wanyu Hu, Xiaoxiao Sun, Yujin Ding, Dandan Wang, Yalun Xiao, Tuo Deng
Summary: Accumulation and activation of immunocytes in adipose tissues are important in obesity-induced inflammation and insulin resistance. Chemokines, especially CCL5, play a crucial role in recruiting immunocytes to adipose tissue during obesity. CCL5 deficiency exacerbates adipose inflammation and impairs insulin sensitivity in obese mice. This study provides insights into the role of CCL5 in obesity-induced adipose inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Endocrinology & Metabolism
Bashir Ahmad Laway, Mohammad Salem Baba
Summary: Sheehan syndrome caused by postpartum hemorrhage leads to pituitary hormone deficiency, resulting in various abnormalities including lipid and glucose abnormalities, increased body fat, insulin resistance, coagulation abnormalities, increased leptin concentration, low-grade inflammation, and endothelial dysfunction. Replacement with growth hormone in addition to standard hormone replacement improves the cardiometabolic profile of patients with Sheehan syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Pharmacology & Pharmacy
Richa Garg, Sanjana Kumariya, Roshan Katekar, Saurabh Verma, Umesh K. Goand, Jiaur R. Gayen
Summary: Metabolic Syndrome is a multifactorial disease associated with increased risk of cardiovascular disorders, type 2 diabetes mellitus, fatty liver disease, etc., with stress kinase activation potentially playing a crucial role in regulating whole-body metabolism.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ashley Mulcahy Toney, Darius Fox, Virginia Chaidez, Amanda E. Ramer-Tait, Soonkyu Chung
Summary: UroA, a gut metabolite derived from ellagic acid-containing foods, shows promising therapeutic potential for metabolic diseases by attenuating inflammation in various tissues and potentially delaying the onset of diseases. Recent research highlights the anti-inflammatory properties of UroA and how it may help prevent diseases such as Alzheimer's, diabetes, and fatty liver disease.
Article
Pharmacology & Pharmacy
Jiali Yang, Yunhui Ran, Yonghui Yang, Shuyi Song, Yahong Wu, Yuanming Qi, Yanfeng Gao, Guodong Li
Summary: The study found that 4-HIL can inhibit obesity-related insulin resistance by reducing inflammation and regulating the state of macrophages associated with obesity.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Nutrition & Dietetics
Hiroki Nishikawa, Akira Asai, Shinya Fukunishi, Shuhei Nishiguchi, Kazuhide Higuchi
Summary: Skeletal muscle plays a crucial role in insulin-induced glucose metabolism, with muscle loss and intramuscular fat accumulation closely linked. Skeletal muscle loss and fat accumulation are associated with various pathologies through factors such as oxidative stress, inflammatory cytokines, mitochondrial dysfunction, insulin resistance, and inactivity. The relationship between Metabolic Syndrome (Met-S) and sarcopenia is attracting attention, with persistent inflammation, fat deposition, and insulin resistance thought to play important roles in their association.
Article
Agriculture, Multidisciplinary
Juciane de Abreu Ribeiro Pereira, Maria de Fatima Piccolo Barcelos, Eduardo Valerio Villas Boas, Roberta Hilsdorf Piccoli, Janina de Sales Guilarducci, Rafaela Correa Pereira, Jose Rodrigo Pauli, Eric Batista Ferreira, Michel Cardoso de Angelis-Pereira, Dennys Esper Cintra
Summary: This study found that the combination of yacon flour and yogurt with two strains of probiotics had positive effects on metabolic parameters, inflammatory and insulin signaling proteins in diet-induced obese mice. The combination resulted in decreased body weight, fasting glucose, and triacylglycerol levels, as well as reduced fat accumulation. Additionally, it decreased inflammatory markers and improved insulin signaling. These findings suggest that the use of prebiotics and probiotics in food can counteract obesity-associated inflammation and improve insulin resistance in the short term.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Review
Cell Biology
Richa Pant, Priyanka Firmal, Vibhuti Kumar Shah, Aftab Alam, Samit Chattopadhyay
Summary: Obesity is a major public health concern characterized by an increase in adipose tissue mass, which can lead to impaired metabolic health and even influence cancer progression. Dysfunction in adipocyte function is influenced by genetics and environmental factors, affecting gene expression and onset of obesity. Understanding the complexities of adipogenesis is crucial for recognizing disease conditions and identifying therapeutic interventions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Guoqing Zhang, Ran Li, Wu Li, Sijia Yang, Qing Sun, Hongping Yin, Cui Wang, Biyu Hou, Huanhuan Wang, Liping Yu, Rucheng Chen, Liyun Shi, Kezhong Zhang, Chong Wee Liew, Guifen Qiang, Qinghua Sun, Cuiqing Liu
Summary: TLR3 plays a crucial role in obesity and metabolic disorders, as demonstrated by the protective effects of TLR3 deficiency against high-fat diet-induced obesity, glucose intolerance, insulin resistance, and lipid accumulation. These findings provide new mechanistic links between inflammation and obesity-related metabolic abnormalities in lipid/glucose metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Environmental Sciences
Xu Hong, Yi Zhou, Zhiyuan Zhu, Yuting Li, Zuo Li, Yuheng Zhang, Xinxin Hu, Fuhai Zhu, Yong Wang, Mingliang Fang, Yichao Huang, Tong Shen
Summary: This study demonstrates a significant association between BPA exposure and risk of obesity, as well as elevated levels of IL-17A in human adipose tissue. Animal experiments further confirm that BPA exposure exacerbates weight gain, insulin resistance, and inflammation in adipose tissue. Genetically modified mice with altered IL-17A gene show reversed inflammatory response and improved insulin sensitivity. Mediation analysis in humans suggests that IL-17A plays a mediating role in the association between BPA exposure and obesity risk.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Immunology
Yan Hao, Ya-juan Zhu, Song Zou, Pei Zhou, Ya-wen Hu, Qi-xiang Zhao, Lin-na Gu, Hao-zhou Zhang, Zhen Wang, Jiong Li
Summary: The association between psoriasis and metabolic syndrome involves various mechanisms including endoplasmic reticulum stress, pro-inflammatory cytokine releases, excess production of reactive oxygen species, alterations in adipocytokine levels, and gut microbiota dysbiosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Jose E. Galgani, Rodrigo Fernandez-Verdejo
Summary: Glucose, fatty acids, and amino acids are oxidized to produce ATP for energy, and the complex adaptive systems in the body adjust fuel oxidation rates based on fuel availability. Metabolic flexibility refers to the ability of cells, tissues, or organisms to adapt fuel oxidation to fuel availability, which can be impaired in conditions like insulin resistance, diabetes, and obesity. Mitochondrial dysfunction in these conditions has been linked to metabolic inflexibility and overall metabolic health.
Article
Genetics & Heredity
Aecio A. Braga, Raul H. Bortolin, Magda E. Graciano-Saldarriaga, Thiago D. C. Hirata, Alvaro Cerda, Renata C. C. de Freitas, Hui T. Lin-Wang, Jessica B. Borges, Joao I. D. Franca, Laureane N. Masi, Rui Curi, Tania C. Pithon-Curi, Marcelo F. Sampaio, Lara R. Castro, Gisele M. Bastos, Rosario D. C. Hirata, Mario H. Hirata
Summary: This study aimed to explore the association of circulating miRNAs with obesity, metabolic alterations, and inflammation in patients with MetS. Seven miRNAs were found to be dysregulated in MetS patients, with miR-421 being associated with a high risk of MetS, insulin resistance, and hypertension. Circulating miR-421 may serve as a potential biomarker for insulin resistance, metabolic dysregulation, and inflammatory status in MetS patients.
Article
Obstetrics & Gynecology
T. L. B. Bretas, M. C. A. Issa, S. C. A. V. Fialho, E. A. G. Villar, L. G. C. Velarde, F. R. Perez-Lopez
Summary: The study found that CO2 laser treatment could improve the Vaginal Health Index and Female Sexual Function Index scores in postmenopausal women, while reducing the International Consultation on Incontinence Questionnaire Short Form score. Histological analysis showed an increase in total and superficial epithelial cell layers and type III collagen fibers in the vaginal wall after treatment.
Review
Endocrinology & Metabolism
Kumar Vivek, E. Prabhakar Reddy, Balachandar Thangappazham, Hemanth Raj, Faustino R. Perez-Lopez, Seshadri Reddy Varikasuvu
Summary: The meta-analysis showed that maternal serum/plasma adropin levels were significantly higher in GDM patients compared to non-GDM controls. Sensitivity analysis revealed that no individual study significantly influenced the overall outcome.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Kumar Vivek, Balachandar Thangappazham, Alekya Vykunta, Paresh P. Kulkarni, Faustino R. Perez-Lopez, Seshadri Reddy Varikasuvu
Summary: This meta-analysis found significantly decreased maternal serum irisin level in preeclampsia patients compared to normotensive pregnant women. The study highlights the importance of future evaluations of the diagnostic utility and associations of irisin with fetal and neonatal outcomes in preeclampsia.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Seshadri Reddy Varikasuvu, Faustino R. Perez-Lopez, Balachandar Thangappazham, Hemanth Raj, Alekya Vykunta
Summary: This meta-analysis found a significant decrease in circulating irisin levels after metformin intervention in PCOS patients, which was validated through sensitivity analysis. The higher pretreatment levels of irisin in PCOS patients may return to normal upon metformin treatment, suggesting a potential restoration of altered metabolic states.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Editorial Material
Obstetrics & Gynecology
F. R. Perez-Lopez, S. R. Varikasuvu
Summary: Postmenopausal vulvovaginal pain and atrophy require appropriate outcomes that correlate with symptoms and expected changes. In some studies, hormone and laser treatments did not show benefits due to inadequate measuring tools. It is important to follow the Core Outcomes in Menopause global initiative.
Article
Obstetrics & Gynecology
P. Garcia-Alfaro, I Rodriguez, F. R. Perez-Lopez
Summary: Handgrip strength (HGS) and dynapenia were not associated with hyperhomocysteinemia. Plasma homocysteine levels were significantly correlated with age, GFR, and creatinine.
Review
Obstetrics & Gynecology
Faustino R. Perez-Lopez, Ricardo Saviron-Cornudella, Peter Chedraui, Maria T. Lopez-Baena, Gonzalo Perez-Roncero, Ana Sanz-Arenal, Marta Narvaez-Salazar, Pena Dieste-Perez, Mauricio Tajada
Summary: This meta-analysis compared obstetric and perinatal outcomes in pregnant women with laboratory-tested SARS-CoV-2 infection before delivery. The results showed that pregnant women with a positive PCR test had a higher risk of delivering at an earlier gestational age, preeclampsia, NICU admissions, stillbirths, and perinatal mortality.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Faustino R. R. Perez-Lopez, Junhua Yuan, Manuel Sanchez-Prieto, Maria T. Lopez-Baena, Gonzalo R. R. Perez-Roncero, Seshadri Reddy Varikasuvu
Summary: This systematic review and meta-analysis explored the levels of maternal and cord blood betatrophin in pregnant women with gestational diabetes mellitus (GDM) and normoglycemic controls. The results showed that women with GDM had higher levels of betatrophin in the second half of pregnancy compared to the normoglycemic controls. Additionally, women with GDM also had increased levels of insulin, glucose, glycosylated hemoglobin, HOMA-IR, LDL-cholesterol, HDL-cholesterol, triglycerides, and body mass index.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Review
Endocrinology & Metabolism
Faustino R. Perez-Lopez, Maria T. Lopez-Baena, Gonzalo R. Perez-Roncero, Peter Chedraui, Seshadri Reddy Varikasuvu, Pascual Garcia-Alfaro
Summary: This systematic review and meta-analysis aimed to summarize the evidence on circulating asprosin and related hormones and metabolites in women with and without PCOS. Eight studies were evaluated, and the results showed that women with PCOS had significantly higher levels of circulating asprosin compared to those without PCOS.
GYNECOLOGICAL ENDOCRINOLOGY
(2023)
Review
Obstetrics & Gynecology
F. R. Perez-Lopez, A. M. Fernandez-Alonso, E. Mezones-Holguin, P. Vieira-Baptista
Summary: This review examines the clinical associations between specific low genitourinary tract clinical conditions in perimenopausal and postmenopausal women living with HIV. Despite appropriate antiretroviral therapy, these women may experience menstrual dysfunction, vaginal microbiome alterations, vaginal dryness, low sexual function, and increased risks of certain cancers and infections. Furthermore, menstrual dysfunction and early menopause could contribute to a higher risk of vascular atherosclerosis and osteoporosis. It is important to manage these risks and complications related to hormone dysfunction and early menopause in WLHIV.
Article
Endocrinology & Metabolism
Sandra C. Sanchez-Zarza, Anastasia K. Armeni, Peter Chedraui, Faustino R. Perez-Lopez, Antonio W. D. Gavilanes
Summary: This study aimed to determine the prevalence of menopausal symptoms and factors related to severity in mid-aged women. The results showed that menopausal symptoms were related to hormonal, sexual and other female aspects.
GYNECOLOGICAL ENDOCRINOLOGY
(2023)
Review
Obstetrics & Gynecology
Faustino R. Perez-Lopez, Maria T. Lopez-Baena, Juan R. Ulloque-Badaracco, Vicente A. Benites-Zapata
Summary: This study conducted a systematic review and meta-analysis to assess telomere length in women with gestational diabetes mellitus (GDM) and normoglycemic pregnant women (NPW) and their infants. The findings showed no significant differences in maternal and offspring telomere length between pregnancies with and without GDM.
REPRODUCTIVE SCIENCES
(2023)
Review
Medicine, General & Internal
Giovanna Santos Cavalcanti, Katia Candido Carvalho, Cecilia da Silva Ferreira, Peter Andre Chedraui Alvarez, Pedro Augusto Araujo Monteleone, Edmund Chada Baracat, Jose Maria Soares Jr
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2023)
