Improvement of Aglycone π-Stacking Yields Nanomolar to Sub-nanomolar FimH Antagonists
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Improvement of Aglycone π-Stacking Yields Nanomolar to Sub-nanomolar FimH Antagonists
Authors
Keywords
-
Journal
ChemMedChem
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2019-02-02
DOI
10.1002/cmdc.201900051
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Conformational switch of the bacterial adhesin FimH in the absence of the regulatory domain: Engineering a minimalistic allosteric system
- (2017) Said Rabbani et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Urinary Tract Infection: Which Conformation of the Bacterial Lectin FimH Is Therapeutically Relevant?
- (2017) Katharina Mayer et al. JOURNAL OF MEDICINAL CHEMISTRY
- Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions
- (2017) Vasilios Kalas et al. Science Advances
- The Conformational Variability of FimH: Which Conformation Represents the Therapeutic Target?
- (2016) Deniz Eris et al. CHEMBIOCHEM
- Fluorine Scan of Inhibitors of the Cysteine Protease Human Cathepsin L: Dipolar and Quadrupolar Effects in the π-Stacking of Fluorinated Phenyl Rings on Peptide Amide Bonds
- (2016) Maude Giroud et al. ChemMedChem
- Catch-bond mechanism of the bacterial adhesin FimH
- (2016) Maximilian M. Sauer et al. Nature Communications
- The Tyrosine Gate of the Bacterial Lectin FimH: A Conformational Analysis by NMR Spectroscopy and X-ray Crystallography
- (2015) Brigitte Fiege et al. CHEMBIOCHEM
- Applications of Fluorine in Medicinal Chemistry
- (2015) Eric P. Gillis et al. JOURNAL OF MEDICINAL CHEMISTRY
- FimH Antagonists: Bioisosteres To Improve the in Vitro and in Vivo PK/PD Profile
- (2015) Simon Kleeb et al. JOURNAL OF MEDICINAL CHEMISTRY
- Urinary tract infections: epidemiology, mechanisms of infection and treatment options
- (2015) Ana L. Flores-Mireles et al. NATURE REVIEWS MICROBIOLOGY
- Inhibition and Reversal of Microbial Attachment by an Antibody with Parasteric Activity against the FimH Adhesin of Uropathogenic E. coli
- (2015) Dagmara I. Kisiela et al. PLoS Pathogens
- A neutron-diffraction study of the low-cycle fatigue behaviour of an austenitic stainless steel 316
- (2015) Adelaide Dubreuil et al. ACTA CRYSTALLOGRAPHICA SECTION A
- The system E8, a special class of simple polyhedra and gas hydrate structures
- (2015) Alexander Talis et al. ACTA CRYSTALLOGRAPHICA SECTION A
- Heptyl α-D-Mannosides Grafted on a β-Cyclodextrin Core To Interfere withEscherichia coliAdhesion: An In Vivo Multivalent Effect
- (2013) Julie Bouckaert et al. CHEMISTRY-A EUROPEAN JOURNAL
- Allosteric Coupling in the Bacterial Adhesive Protein FimH
- (2013) Victoria B. Rodriguez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Thiazolylaminomannosides As Potent Antiadhesives of Type 1 Piliated Escherichia coli Isolated from Crohn’s Disease Patients
- (2013) Sami Brument et al. JOURNAL OF MEDICINAL CHEMISTRY
- In VitroAntimicrobial Resistance of Urinary Escherichia coli Isolates among U.S. Outpatients from 2000 to 2010
- (2012) Guillermo V. Sanchez et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The Tyrosine Gate as a Potential Entropic Lever in the Receptor-Binding Site of the Bacterial Adhesin FimH
- (2012) Adinda Wellens et al. BIOCHEMISTRY
- FimH Antagonists: Structure-Activity and Structure-Property Relationships for Biphenyl α-D-Mannopyranosides
- (2012) Lijuan Pang et al. ChemMedChem
- Antiadhesion Therapy for Urinary Tract Infections—A Balanced PK/PD Profile Proved To Be Key for Success
- (2012) Xiaohua Jiang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Lead Optimization Studies on FimH Antagonists: Discovery of Potent and Orally Bioavailable Ortho-Substituted Biphenyl Mannosides
- (2012) Zhenfu Han et al. JOURNAL OF MEDICINAL CHEMISTRY
- Uncomplicated Urinary Tract Infection
- (2012) Thomas M. Hooton NEW ENGLAND JOURNAL OF MEDICINE
- Aromatic Rings in Chemical and Biological Recognition: Energetics and Structures
- (2011) Laura M. Salonen et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Design, synthesis and biological evaluation of mannosyl triazoles as FimH antagonists
- (2011) Oliver Schwardt et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Squaric Acid Monoamide Mannosides as Ligands for the Bacterial Lectin FimH: Covalent Inhibition or Not?
- (2011) Carsten Grabosch et al. CHEMBIOCHEM
- Treatment and Prevention of Urinary Tract Infection with Orally Active FimH Inhibitors
- (2011) C. K. Cusumano et al. Science Translational Medicine
- Dynamical structural science
- (2010) E. Collet ACTA CRYSTALLOGRAPHICA SECTION A
- More examples of the 15-crown-5...H2O—M—OH2...15-crown-5 motif,M= Al3+, Cr3+and Pd2+
- (2010) Maxime A. Siegler et al. ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE
- Expression of the carbohydrate recognition domain of FimH and development of a competitive binding assay
- (2010) Said Rabbani et al. ANALYTICAL BIOCHEMISTRY
- Structural Basis for Mechanical Force Regulation of the Adhesin FimH via Finger Trap-like β Sheet Twisting
- (2010) Isolde Le Trong et al. CELL
- The functional valency of dodecamannosylated fullerenes with Escherichia coli FimH—towards novel bacterial antiadhesives
- (2010) Maxime Durka et al. CHEMICAL COMMUNICATIONS
- Lipophilicity in drug discovery
- (2010) Michael J Waring Expert Opinion on Drug Discovery
- Renal clearance in drug discovery and development: molecular descriptors, drug transporters and disease state
- (2010) Bo Feng et al. Expert Opinion on Drug Metabolism & Toxicology
- Structure-Based Drug Design and Optimization of Mannoside Bacterial FimH Antagonists
- (2010) Zhenfu Han et al. JOURNAL OF MEDICINAL CHEMISTRY
- FimH Antagonists for the Oral Treatment of Urinary Tract Infections: From Design and Synthesis to in Vitro and in Vivo Evaluation
- (2010) Tobias Klein et al. JOURNAL OF MEDICINAL CHEMISTRY
- Origins and virulence mechanisms of uropathogenic Escherichia coli
- (2008) Travis J. Wiles et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- The biology and future prospects of antivirulence therapies
- (2007) Lynette Cegelski et al. NATURE REVIEWS MICROBIOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now