Upregulation of the p53-p21 pathway by G2019S LRRK2 contributes to the cellular senescence and accumulation of α-synuclein

Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease

(2018) Shankar J. Chinta et al.   Cell Reports

LRRK2 Kinase Activity Induces Mitochondrial Fission in Microglia via Drp1 and Modulates Neuroinflammation

(2018) Dong Hwan Ho et al.   Experimental Neurobiology

LRRK2 impairs autophagy by mediating phosphorylation of leucyl-tRNA synthetase

(2018) Dong Hwan Ho et al.   CELL BIOCHEMISTRY AND FUNCTION

Lysosomal cathepsins and their regulation in aging and neurodegeneration

(2016) Veronika Stoka et al.   AGEING RESEARCH REVIEWS

Anti-aging treatments slow propagation of synucleinopathy by restoring lysosomal function

(2016) Dong-Kyu Kim et al.   Autophagy

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Anti-TNF-α treatment modulates SASP and SASP-related microRNAs in endothelial cells and in circulating angiogenic cells

(2016) Francesco Prattichizzo et al.   Oncotarget

Cellular senescence and the aging brain

(2015) Shankar J. Chinta et al.   EXPERIMENTAL GERONTOLOGY

Lowering Endogenous Cathepsin D Abundance Results in Reactive Oxygen Species Accumulation and Cell Senescence

(2015) Siyuan Su et al.   MOLECULAR & CELLULAR PROTEOMICS

Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21WAF1/CIP1 expression

(2015) Dong Hwan Ho et al.   Molecular Brain

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

(2012) Diana Jurk et al.   AGING CELL

CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, “fueling” tumor growth via paracrine interactions, without an increase in neo-angiogenesis

(2012) Claudia Capparelli et al.   CELL CYCLE

LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

(2012) X. Wang et al.   HUMAN MOLECULAR GENETICS

Astrocyte Senescence as a Component of Alzheimer’s Disease

(2012) Rekha Bhat et al.   PLoS One

Cellular senescence induced by cathepsin X downregulation

(2011) Steffen Kraus et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Protein homeostasis and aging: The importance of exquisite quality control

(2010) Hiroshi Koga et al.   AGEING RESEARCH REVIEWS

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Protein homeostasis and aging in neurodegeneration

(2010) Peter M. Douglas et al.   JOURNAL OF CELL BIOLOGY

DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

(2010) F. Rodier et al.   JOURNAL OF CELL SCIENCE

Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

(2010) B. Winner et al.   NEUROBIOLOGY OF DISEASE

Cathepsin D Is the Main Lysosomal Enzyme Involved in the Degradation of α-Synuclein and Generation of Its Carboxy-Terminally Truncated Species†

(2008) Daniel Sevlever et al.   BIOCHEMISTRY

The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease

(2008) T. Pan et al.   BRAIN

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

(2008) Yuzuru Imai et al.   EMBO JOURNAL

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

(2008) Daniel G Healy et al.   LANCET NEUROLOGY