Article
Polymer Science
Mohamed Chaala, Fatima Zohra Sebba, Marta G. Fuster, Imane Moulefera, Mercedes G. Montalban, Guzman Carissimi, Gloria Villora
Summary: The development of new biomaterials from natural fibres, especially silk fibroin, has gained significant attention in the field of biomedicine. Hydrogels, which are flexible polymer networks capable of absorbing large amounts of water and accommodating drugs or cells, have emerged as potential candidates for various applications such as scaffolding and cell therapy. In this study, curcumin-hyaluronic acid-silk fibroin hydrogels were prepared using a simple sonication process. The hydrogels were characterized using various techniques and their biological activity was evaluated using fibroblast cell viability assays.
Article
Chemistry, Multidisciplinary
Ziyang Sun, Haoran Liu, Dandan Dai, Hao Lyu, Ruochuan Huang, Wenzhao Wang, Chengchen Guo
Summary: This study presents a promising injectable cell-laden hydrogel system based on silk acid, which exhibits good cytocompatibility and injectability. The hydrogel has potential applications in 3D cell culture, targeted cell delivery, and tissue engineering.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
San Seint Seint Aye, Zhi-Hong Zhang, Xin Yu, Heidi Yu, Wen-Dong Ma, Kai Yang, Xin Liu, Jian Li, Jing-Liang Li
Summary: Functionalization of silk fibroin hydrogel with antimicrobial peptide polymyxin B through electrostatic interaction demonstrates antimicrobial activity against Gram-negative bacterial strains, providing a straightforward approach for the functionalization of inert silk hydrogel with other antimicrobial peptides.
Article
Materials Science, Multidisciplinary
Berkant Yetiskin, Burak Tavsanli, Oguz Okay
Summary: In this study, soft hydrogels with an interconnected protein and glycosaminoglycan network, inspired by the extracellular matrix (ECM), were fabricated. These hydrogels exhibit compressible and stretchable properties, as well as highly frequency-dependent viscoelasticity above a certain frequency. The mechanical and viscoelastic properties of the hydrogels can be easily adjusted by changing the degree of methacrylation of the glycosaminoglycan, as well as the concentration and type of the monomer. This study suggests that the prepared hydrogels have potential applications in tissue engineering.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2022)
Review
Engineering, Biomedical
Yu Zhao, Zhi Shou Zhu, Juan Guan, Su Jun Wu
Summary: Hydrogels are versatile materials in biomedical engineering with applications similar to wet tissues. Silk fibroin (SF) is a natural polymer with biocompatibility and tunable biodegradation, but its poor mechanical performance hinders its structural applications. Researchers are exploring strategies to enhance the strength of SF-based hydrogels for biomedical uses.
ACTA BIOMATERIALIA
(2021)
Article
Materials Science, Biomaterials
Reihane Ziadlou, Stijn Rotman, Andreas Teuschl, Elias Salzer, Andrea Barbero, Ivan Martin, Mauro Alini, David Eglin, Sibylle Grad
Summary: This study aimed to formulate injectable hydrogels for drug delivery and cartilage tissue engineering by combining hyaluronic acid-tyramine (HA-Tyr) with regenerated silk-fibroin (SF) solutions. The HA20/SF80 hydrogel showed superior chondrogenic effects and mechanical properties for cartilage tissue engineering applications, making it a promising biomaterial for osteoarthritis treatment.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Engineering, Biomedical
Xiaohang Qu, Ling Yan, Shuang Liu, Yunfei Tan, Jing Xiao, Yuan Cao, Ke Chen, Wenqian Xiao, Bo Li, Xiaoling Liao
Summary: Silk fibroin (SF) from Bombyx mori is a natural polymer with excellent biocompatibility, but traditional SF hydrogels may have some drawbacks. By inducing the formation of uniform beta-sheet structures through sonication and enzymatic crosslinking, a composite hydrogel with enhanced strength and elasticity was fabricated, showing concentration-dependent stiffness and time-dependent toughness variations. This biocompatible composite hydrogel with unique mechanical properties holds great potential for tissue engineering and regenerative medicine.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)
Review
Materials Science, Biomaterials
Haiyan Zheng, Baoqi Zuo
Summary: Traditional silk protein hydrogels have limitations in terms of structure and functionality, but the development of functional silk protein hydrogels presents opportunities to overcome these limitations, attracting attention from scholars worldwide.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Biochemistry & Molecular Biology
Lu Wang, Yufang Zhang, Yijing Xia, Changzhen Xu, Kejing Meng, Jing Lian, Xinsong Zhang, Jie Xu, Chunfang Wang, Bin Zhao
Summary: An injectable photocrosslinked methacrylylated silk fibroin/hyaluronic acid composite hydrogel has been developed for pulp regeneration in dentistry, with good biocompatibility and mechanical properties. The results indicate that cells in low-concentration RSFMA composite gel exhibit better growth, proliferation, and osteogenic differentiation ability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Pu Qiao, Kaiyuan Shi, Yanlong Wang, Bo Li, Lei Su, Ke Zhang, Katsuyoshi Nishinari, Guoqiang Yang
Summary: For the first time, a rapid and effective method for gel formation from hyaluronic acid (HA) using dynamic pressure has been demonstrated. The hydrogels prepared through the alternate compression-decompression procedure exhibit a layered structure and high yield. Compared to conventional freeze-thawed hydrogels, these gels have enhanced intermolecular interaction and improved mechanical properties. This method is fast, simple, and safe, providing new ideas for obtaining physical gels and contributing to the development of HA-based materials in biomedical and agricultural applications.
FOOD HYDROCOLLOIDS
(2023)
Article
Engineering, Multidisciplinary
Hui Yao, Congcong Wang, Yuchen Zhang, Ying Wan, Qing Min
Summary: A novel bilayered composite hydrogel with multi-network structures and injectability was developed for osteochondral tissue engineering. It exhibited strong mechanical properties and supported the growth of chondrocytes and osteoblasts, making it suitable for osteochondral repair applications.
Article
Chemistry, Multidisciplinary
Xinyu Bian, Chunyan Cui, Ying Qi, Yage Sun, Zhuodan Zhang, Wenguang Liu
Summary: This study proposes a strategy to induce superfast gelation of silk fibroin using the surfactant LAE, creating new possibilities for biomedical applications. LAE can quickly gelate SF and can be applied to prepare injectable antibacterial biodegradable hemostatic hydrogels.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Yuqing Niu, Massimiliano Galluzzi, Fuming Deng, Zhang Zhao, Ming Fu, Liang Su, Weitang Sun, Wei Jia, Huimin Xia
Summary: The study found that the hyaluronic acid-coating silk fibroin nanofiber scaffold can effectively regulate the epithelialization process of urethral regeneration, promoting luminal epithelialization, smooth muscle bundle structural remodeling, and capillary formation.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Min A. Gwak, Bo Min Hong, Ji Min Seok, Su A. Park, Won Ho Park
Summary: In this study, an HA-catechol conjugate (HA-Cat) was synthesized by reacting the HA polymer with dopamine to improve its adhesion to various substrates. The addition of tannic acid (TA) improved both the adhesive and compressive properties of the HA-Cat hydrogels, showing great potential as cost-effective and biocompatible medical adhesives.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Materials Science, Textiles
Zhanao Hu, Shixian Chen, Renchuan You, Xiufang Li, Qiang Zhang, Lu Wang, Shuqin Yan
Summary: A hierarchical porous structure was directly established in silk fibroin/hyaluronic acid scaffold, leading to improved cell adhesion, proliferation, and neotissue formation. The scaffold exhibited desirable microarchitecture and cytocompatibility, surpassing silk fibroin scaffold in compression stress and Young's modulus. This study presents a new strategy for preparing silk-based scaffolds with hierarchical porous structure in tissue engineering.
FIBERS AND POLYMERS
(2021)
Article
Materials Science, Multidisciplinary
Ozge Akca, Oguz Okay
Summary: This study presents a simple strategy for fabricating shape-memory materials using commercial rubbers. The rubbers are dissolved in a monomer called n-octadecyl acrylate (C18A) and then polymerized using UV light to form interconnected interpenetrating polymer networks (c-IPNs) with crystalline domains. The resulting materials exhibit tunable melting and crystallization temperatures, as well as adjustable mechanical properties. The coexistence of chemical cross-links and crystalline domains allows the c-IPNs to efficiently demonstrate shape-memory functionality.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2022)
Article
Polymer Science
Esra Su, Gozde Bayazit, Semra Ide, Oguz Okay
Summary: In this study, a self-healing and shape-memory interpenetrating polymer network (IPN) was synthesized by UV polymerization. It was found that the physical properties of IPNs, including melting temperature, crystallinity, Young's modulus, toughness, and stretchability, could be tuned by varying the amount of isobutylene-isoprene rubber (IIR). The crystalline structure acted as sacrificial bonds to dissipate energy under strain, leading to improved toughness. Furthermore, the IPNs exhibited temperature induced healing behavior and effective shape-memory function.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Polymer Science
Ezgi B. Ceper, Esra Su, Oguz Okay, Orhan Guney
Summary: In this work, graphene oxide (GO) and vinyl modified GO (V-GO)-based nanocomposite hydrogels with improved mechanical property and self-healing ability have been synthesized and characterized. The effects of GO and V-GO content on the gelation process, viscoelastic characteristics, pH-responsive action, swelling behavior, and mechanical performance of the hydrogels were studied.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Materials Science, Multidisciplinary
Berkant Yetiskin, Burak Tavsanli, Oguz Okay
Summary: In this study, soft hydrogels with an interconnected protein and glycosaminoglycan network, inspired by the extracellular matrix (ECM), were fabricated. These hydrogels exhibit compressible and stretchable properties, as well as highly frequency-dependent viscoelasticity above a certain frequency. The mechanical and viscoelastic properties of the hydrogels can be easily adjusted by changing the degree of methacrylation of the glycosaminoglycan, as well as the concentration and type of the monomer. This study suggests that the prepared hydrogels have potential applications in tissue engineering.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2022)
Article
Materials Science, Multidisciplinary
Berkant Yetiskin, Oguz Okay
Summary: In contrast to synthetic gels, biological hydrogels containing both hydrophilic and lyophilic phases, known as organohydrogels (OHGs), have the potential to mimic biological systems and find various applications. This study presents a simple strategy to obtain adaptive OHGs with tunable mechanics and viscoelasticity. By utilizing a hydrophilic cryogel scaffold and reaction loci within the scaffold, mechanically robust OHGs consisting of a silk fibroin (SF) scaffold and organogel microinclusions were successfully prepared. The OHGs exhibited switchable mechanics and viscoelasticity as well as shape-memory function.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Mechanics
Burak Tavsanli, Cigdem Bilici, Pelin Sungur, Semra Ide, Oguz Okay
Summary: A simple strategy for preparing interconnected interpenetrating polymer networks (IPNs) based on butyl rubber (IIR) and poly(n-octadecyl acrylate) (PC18A) has been developed recently. The use of IIR grafted with acrylic acid, methacrylic acid, and 10-undecenoic acid instead of unmodified IIR improves the mechanical properties of IPNs. The type of grafted monomers significantly affects the mechanical performance of IPNs, and the amount of grafted rubbers in IPN can be increased by incorporating toluene into the reaction system, resulting in IPNs with a wide range of tunable thermal and mechanical properties.
JOURNAL OF RHEOLOGY
(2022)
Article
Chemistry, Applied
Gozde Bayazit Sekitmen, Esra Su, Sinem Diken Gur, Semra Ide, Oguz Okay
Summary: This study emphasizes the importance of hydrogel-based therapy in repairing cartilage tissue and discusses the nanoscopic requirements for the physical sterilization of hydrogels. The nanostructured and shape memory hydrogel composites previously designed and synthesized by the researchers were used in the study. The study evaluates physical sterilization methods and biofilm formations in the hydrogel materials and investigates their potential as artificial cartilage or cartilage tissue scaffolds. The study determines the most suitable hydrogel sample, physical sterilization methods, and ability to resist biofilm formation for further in vivo studies.
REACTIVE & FUNCTIONAL POLYMERS
(2022)
Article
Nanoscience & Nanotechnology
Turdimuhammad Abdullah, Oguz Okay
Summary: This study developed 4D-printed hydrogels based on poly(acrylic acid) that can possess shape-memory and self-healing properties. These hydrogels can be magically actuated near the body temperature by adjusting the molar ratio of the monomers and exhibit high mechanical properties. Overall, these 4D printable hydrogels have great potential for biomedical applications.
ACS APPLIED BIO MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Yahya Bas, Oguz Okay
Summary: This study demonstrates the preparation of mechanically strong and shape-memory organohydrogels (OHGs) by incorporating organo-microgels into the pores of silk fibroin (SF) scaffolds. The stiffness of OHGs can be controlled by adjusting the SF concentration and pore size.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Busra Sekizkardes, Esra Su, Oguz Okay
Summary: Polymers based on AMPS have high water absorption capacity when swollen in water. PAMPS hydrogels, synthesized via free-radical cross-linking copolymerization, have poor mechanical properties. Here, we demonstrate that terpolymerization of AMPS, MAAc, and DMAA without a chemical cross-linker produces mechanically strong hydrogen-bonded hydrogels. The water content during gelation affects the microstructure and mechanical properties of the hydrogels.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Cigdem Buse Oral, Berkant Yetiskin, Canan Cil, Fatma Nese Kok, Oguz Okay
Summary: Inspired by nature, we designed organohydrogels (OHGs) consisting of a silk fibroin (SF) hydrogel as the continuous phase and the hydrophobic microinclusions based on semicrystalline poly(n-octadecyl acrylate) (PC18A) as the dispersed phase. SF acts as a self-emulsifier to obtain oil-in-water emulsions, and ethanol is added to induce gelation in the continuous SF phase. In the second step, in situ polymerization of C18A droplets in the emulsion system was conducted under UV light in the presence of a photoinitiator to obtain high-strength OHGs with shape-memory function and good cytocompatibility.
ACS APPLIED BIO MATERIALS
(2023)
Article
Chemistry, Applied
Gamze Doser, Esra Su, Oguz Okay
Summary: We discussed the properties of seven different synthetic and biopolymer cryogels prepared under the same conditions, and how the cryogenic conditions and chemistry affect their properties. The monomers used included acrylamide, N, N-dimethylacrylamide, sodium acrylate, sodium methacrylate, and 2-acrylamido-2-methylpropane sulfonic acid sodium salt. Silk fibroin and double-stranded deoxyribonucleic acid were selected as the biopolymers for cryogel preparation. Nonionic cryogels produced with acrylamide and N, N-dimethylacrylamide had the largest pore volumes and average pore diameters, while ionic cryogels exhibited smaller pore volumes due to pore collapse during drying. The SF cryogel had the most mechanically stable porous structure.
REACTIVE & FUNCTIONAL POLYMERS
(2023)
Article
Nanoscience & Nanotechnology
Cigdem Buse Oral, Berkant Yetiskin, Canan Cil, Fatma Nese Kok, Oguz Okay
Summary: Inspired by nature, the researchers designed organohydrogels (OHGs) using silk fibroin (SF) as the continuous phase and semicrystalline poly(n-octadecyl acrylate) (PC18A) as the dispersed phase. SF acted as a self-emulsifier, making it a versatile and green alternative to chemical emulsifiers. By inducing gelation in the SF phase and polymerization of PC18A droplets, the researchers obtained high-strength OHGs with shape-memory function and good cytocompatibility. The incorporation of hydrophilic and noncrystallizable hydrophobic units further improved the mechanical and shape-memory properties of the OHGs.
ACS APPLIED BIO MATERIALS
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
