Article
Biochemistry & Molecular Biology
Anna Petrova, Mikhail Zakharov, Marina Ageeva, Ryan McKenzie, Tatyana Gorshkova, Michael Deyholos, Liudmila Kozlova
Summary: Intrusive growth is a type of cell growth where a cell exceeds the growth rate of its neighbors and extends longer. Fibers, the most abundant cell type in plant mechanical tissues, play a fundamental role in the production of textiles and other materials. A mutant of flax, known as reduced fiber 1 (rdf), has impaired intrusive growth in both phloem and xylem. This mutant provides insights into the molecular mechanisms and principles of plant mechanical tissue functioning.
Article
Food Science & Technology
Kotaro Matsui, Takamichi Kamigaki, Ryota Wakui, Yuri Nishino, Yoshiko Ito, Atsuo Miyazawa, Koichiro Yoshioka, Makoto Shiota
Summary: The physical properties of butter are influenced by its microstructure, and a novel observation method using AFM without pretreatment process was proposed in this study to observe the fat crystal structure. Measurements of milk fat-crystalline nanoplatelets were conducted using TEM and SAXS, revealing the thickness and structure of the fat crystals. Through this observation method, the relationship between the physical properties of butter and its fat crystal network can be discerned, benefiting the bread and confectionery industries in improving butter processing conditions.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Polymer Science
Shazia Naheed, Muhammad Shahid, Rashida Zahoor, Zumaira Siddique, Nasir Rasool, Sajjad Haider, Shaukat Khan
Summary: This study focused on the synthesis and characterization of polyurethane elastomers based on xanthan gum and titanium dioxide, revealing thermal stability, micro-phase separation, antimicrobial activity, and hydrophilicity. The results demonstrate the potential of these polymers in various applications.
Article
Nanoscience & Nanotechnology
Jonas Weber, Yue Yuan, Fabian Kuehnel, Christoph Metzke, Josef Schaetz, Werner Frammelsberger, Guenther Benstetter, Mario Lanza
Summary: Conductive atomic force microscopy (CAFM) is a powerful technique for studying electrical and mechanical properties at the nanoscale. The reliability of probe tips is a major challenge in CAFM, and solid Pt probes offer a more durable and reliable alternative to metal-coated silicon tips. The use of solid Pt probes can enhance the reliability of CAFM experiments by providing similar performance in terms of lateral resolution and a longer lifetime.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
A. Rodriguez, M. S. Jaman, O. Acikgoz, B. Wang, J. Yu, P. G. Grutzmacher, A. Rosenkranz, M. Z. Baykara
Summary: Ti3C2Tx nano-sheets exhibit solid lubrication properties on the nanoscale, reducing friction on silicon dioxide substrates, although not as effectively as few-layer graphene. This paves the way for further investigations into nanoscale solid lubrication achieved by Ti3C2Tx (MXene) nano-sheets.
APPLIED SURFACE SCIENCE
(2021)
Article
Physics, Multidisciplinary
D. Stryukov, A. Pavlenko, Ya Yu Matyash, A. Nazarenko
Summary: High quality Ba2NdFeNb4O15 epitaxial films with thicknesses ranging from 10 nm to 1 μm have been successfully fabricated by RF cathode sputtering. The films exhibit orientational domains with a 18.4-degree in-plane rotation and tetragonal unit cell. The surface of the films is smooth and the presence of orientational domains does not affect the surface relief. X-ray diffraction, atomic force microscopy and energy dispersive elemental analysis confirm the absence of impurities in the obtained films.
Article
Chemistry, Multidisciplinary
Kaitlin P. McCreery, Xin Xu, Adrienne K. Scott, Apresio K. Fajrial, Sarah Calve, Xiaoyun Ding, Corey P. Neu
Summary: The reciprocal interactions between the cell nucleus and the extracellular matrix influence macroscale tissue phenotype changes. Enzymatic disruption of the tissue matrix is hypothesized to result in softer tissue, impacting the stiffness of embedded cell and nuclear structures. An atomic force microscopy needle-tip probe technique is expanded to measure nuclear and cell membrane stiffness in native tissue without perturbing the tissue structure.
Article
Nanoscience & Nanotechnology
Keivan Asadi, Junghoon Yeom, Hanna Cho
Summary: Investigating internal resonance (IR) mechanisms in micro/nanoresonators reveals that intermodal coupling between second and third flexural modes in asymmetric structures provides an optimal condition for strong IR, with high energy transfer to the resonated mode. This study introduces design strategies that can be easily integrated into typical micro/nanoelectromechanical systems, offering potential for paradigm-shifting applications in micro/nanosystems.
MICROSYSTEMS & NANOENGINEERING
(2021)
Article
Mechanics
Antigoni Barouni, Colin Lupton, Chulin Jiang, Abu Saifullah, Khaled Giasin, Zhongyi Zhang, Hom N. Dhakal
Summary: This study investigates the fatigue behavior of composite laminates with flax and glass fiber hybrid reinforcements. The hybrid configuration shows a great effect on fatigue life, with the alternating layers of flax and glass demonstrating the best performance and significantly lower probability of failure compared to other configurations. Fabrication-induced defects and fiber-matrix interface also play a role in influencing fatigue life and overall performance of the structures.
COMPOSITE STRUCTURES
(2022)
Article
Materials Science, Multidisciplinary
M. Vadivel, R. Ramesh Babu, M. Sridharan
Summary: This study reports the characteristics of Cr3+- and Zn2+-substituted CoFe2O4 thin films prepared by solution-based spray pyrolysis method. The results show that the substitution of transition metal ions significantly affects the surface topography and gas-sensing behavior of the films. Cr3+-substituted CoFe2O4 thin films exhibit excellent sensing behavior towards NH3 gas at room temperature.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2022)
Article
Materials Science, Multidisciplinary
Ya. Yu. Matyash, D. V. Stryukov, A. V. Pavlenko
Summary: This paper presents the study results of barium-neodymium ferroniobate films with thicknesses of 180 and 980 nm obtained by RF cathode sputtering. Through X-ray diffraction and magnetic force microscopy, it was found that the films are single-phase, epitaxial, and free from magnetic impurities. Atomic force microscopy data indicates that the growth of the films follows the Volmer-Weber mechanism.
Editorial Material
Multidisciplinary Sciences
Telmo O. Paiva, Albertus Viljoen, Yves F. Dufrene
Summary: Advancements in atomic force microscopy (AFM) techniques and methodologies in microbiology have enhanced our understanding of microbial cell surfaces. Recent studies have shown that AFM imaging of cells and membranes at or near molecular resolution enables detailed visualization of membrane-drug interactions.
NATURE COMMUNICATIONS
(2022)
Article
Materials Science, Multidisciplinary
Chen Shao, Fenglin Guo, Xiufang Chen, Xiaomeng Li, Wancheng Yu, Xianglong Yang, Xuejian Xie, Xiaobo Hu, Xiangang Xu
Summary: In this paper, atomic force microscopy (AFM) was used to study the atomic steps of the 4H-SiC substrate (0001) surface. The results show that the distributions of the atomic step morphology on the surfaces of wafers obtained from the same crystal are consistent. Based on a comparison of high-resolution X-ray diffraction (HRXRD) results, basal plane bending is the fundamental reason for the change in the atomic step morphology in different regions of the substrate.
Article
Materials Science, Ceramics
Ahlem Bendaoued, Mouna Messaoud, Omar Harzallah, Sophie Bistac, Rached Salhi
Summary: In this paper, TiO2 was prepared by the sol-gel process and reinforced the polypropylene matrix using supercritical drying of ethanol, while maintaining thermal and mechanical properties and ensuring good interface compatibility. The use of 5wt.% TiO2 was found to effectively increase the crystallinity and dynamic and static mechanical properties of the polypropylene matrix.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2022)
Article
Physics, Applied
Shiquan Lin, Zhong Lin Wang
Summary: Inspired by TENG, scanning TENG is proposed for local surface charge density measurement using atomic force microscopy. The technique taps a conductive tip above a charged dielectric surface to induce an AC, with Fourier analysis showing a linear relation to surface charge density. Results demonstrate its power in probing nanoscale charge transfer in contact-electrification.
APPLIED PHYSICS LETTERS
(2021)
Article
Chemistry, Applied
Estelle Bonnin, Maud Joseph-Aime, Luc Fillaudeau, Sylvie Durand, Xavier Falourd, Sophie Le Gall, Luc Saulnier
Summary: Hetemxylans (HX) were isolated from vitreous and floury parts of maize endosperm, with structural analysis revealing differences in side chain content between the two fractions. Xylanase was more effective at solubilizing material from floury endosperm cell walls compared to vitreous endosperm, suggesting varying enzymatic susceptibility based on structural differences between the fractions.
CARBOHYDRATE POLYMERS
(2022)
Article
Materials Science, Paper & Wood
Somia Haouache, Clara Jimenez-Saelices, Fabrice Cousin, Xavier Falourd, Bruno Pontoire, Karine Cahier, Francois Jerome, Isabelle Capron
Summary: This study provides a detailed characterization of two types of cellulose nanofibers, focusing on their morphology, surface chemistry, crystallinity, and molecular weight. The results show a reduction in crystal size after mercerization treatment, while the surface charge density remains the same.
Article
Biophysics
Aurore Delvart, Celine Moreau, Angelina D'Orlando, Xavier Falourd, Bernard Cathala
Summary: The growth process of thin polyelectrolyte films composed of Dextran sulfate with high and low sulfation rate and poly(allylamine hydrochloride) was studied using various monitoring techniques. Different growth behaviors were observed between the two systems, leading to differences in film water content and surface morphology. Charge compensation and neutralization variations likely contribute to the dissimilar growth mechanisms observed.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Janske Nel, David Siniscalco, Cecilia Hognon, Mathilde Bouche, Nadege Touche, Emilie Brunner, Philippe C. Gros, Antonio Monari, Stephanie Grandemange, Gregory Francius
Summary: This study characterized the effects of iron-based complexes on the structural and morphological properties of breast cell lines. The complexes caused cell softening, increased size, and subsequent re-stiffening. They also induced cytoskeletal and mitochondrial reorganization. Molecular dynamic simulation suggested direct internalization of the complexes and demonstrated that their effects were not solely due to physical interaction with the cell membrane.
Article
Engineering, Electrical & Electronic
G. Pellecuer, F. Forest, J-J Huselstein, T. Martire, O. Arnould, A. Chrysochoos
Summary: This paper presents a numerical approach for wire bond ageing in semiconductor power modules, considering the multi-physical coupling mechanisms. The physical interactions and numerical modeling of electro-thermal and thermomechanical processes are described. The calculations show significant viscoplastic strains and quasi-cyclic stabilization of mechanical and thermal states, as well as the preponderance of creep-fatigue damage mechanisms inducing mechanical-electrical couplings.
MICROELECTRONICS RELIABILITY
(2022)
Article
Chemistry, Applied
Maxime Gautreau, Sylvie Durand, Angeline Paturel, Sophie Le Gall, Loic Foucat, Xavier Falourd, Bruno Novales, Marie-Christine Ralet, Sylvie Chevallier, Antoine Kervoelen, Alain Bourmaud, Fabienne Guillon, Johnny Beaugrand
Summary: The relationship between the mechanical properties, chemical composition, and cellulose structure of flax fibre bundles was investigated in this study using sequential biopolymer extraction. The results showed that the oxalate extract mainly consisted of homogalacturonans and type I rhamnogalacturonans, while the LiCl extract was composed mainly of glucomannans and the KOH extract of xyloglucans. The extraction process led to the disappearance of the middle lamella, resulting in a decrease in the tensile Young's modulus and maximum strength of the fibre bundles.
CARBOHYDRATE POLYMERS
(2022)
Article
Agricultural Engineering
Alessia Melellia, Sylvie Durandb, Camille Alvaradob, Antoine Kervoelena, Loic Foucatb, Marie Gregoired, Olivier Arnoulde, Xavier Falourdb, Franck Callebertf, Pierre Ouagned, Audrey Geaironb, Sylviane Danielb, Frederic Jammeg, Caroline Mauveh, Bertrand Gakiereh, Alain Bourmauda, Johnny Beaugrandb
Summary: The effects of global warming on crop yields and fiber quality are important. Cellulosic materials are considered a solution to reduce environmental impact, but their properties depend on environmental conditions. This study examines the impact of seasonal drought on flax plants and fiber quality.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Chemistry, Multidisciplinary
Celine Moreau, Xavier Falourd, Malika Talantikite, Bernard Cathala, Ana Villares
Summary: We have developed a one-pot modified carboxymethylation reaction to prepare multifunctional cellulose fibers. By introducing negative charge and benzophenone moieties on the surface of cellulose, we were able to fabricate papers and 3D networks with unique properties, such as fibrillation and hydrophobization.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Chemistry, Applied
X. Falourd, M. Lahaye, C. Rondeau-Mouro
Summary: Studying and modeling 1H->13C polarization transfer kinetics during NMR spectroscopy allows for a better understanding of cellulose interactions with water, demonstrating the interactions of polysaccharides with structural water and the evolution of proton-proton interactions during hydration through spin diffusion times.
CARBOHYDRATE POLYMERS
(2022)
Article
Polymer Science
Alain Bourmaud, Kolja Konschak, Coralie Buffet, Meline Calatraba, Anton Loic Rudolph, Antoine Kervoelen, Basile Gautherot, Estelle Bonnin, Johnny Beaugrand
Summary: This study focuses on the use of tomato by-product biomass from industrial plants as reinforcement for new degradable and biobased thermoplastic materials. The results show that the tomato by-product-reinforced materials have mechanical performance comparable to existing formulations. Depending on the targeted application, a wide range of biobased and/or degradable products can be designed.
Article
Polymer Science
Emmanuelle Richely, Johnny Beaugrand, Michel Coret, Christophe Binetruy, Pierre Ouagne, Alain Bourmaud, Sofiane Guessasma
Summary: This study aims to understand the damage and fracture kinetics in flax fibre elements at both the unitary and bundle scales. It uses an experimental setup allowing for optical observation during tensile loading, capturing crack initiation, propagation, and damage mechanisms. The study shows different failure scenarios depending on the nature of the fibre element, highlighting the importance of the structural scale. The findings can contribute to the eco-design of flax-based composites for a variety of applications.
Article
Multidisciplinary Sciences
G. Caneva, A. Bourmaud, A. Bellini, A. Melelli
Summary: This paper proposes an interpretation for the plant represented in the iconic painting in Pompeii called "Flora in Ariadne's house", suggesting it is flax. Flax was economically and culturally important and symbolized fertility and the afterlife, associated with the feminine sphere. This interpretation strengthens the proposed identification of the girl in yellow as Persephone, a wife transitioning to the afterlife.
RENDICONTI LINCEI-SCIENZE FISICHE E NATURALI
(2023)
Article
Chemistry, Physical
Rova-Karine Rajaonarivony, Xavier Rouau, Jean-Michel Commandre, Charlene Fabre, Jean-Eudes Maigret, Xavier Falourd, Sophie Le Gall, Bruno Piriou, Camille Goudenhooft, Sylvie Durand, Alain Bourmaud, Johnny Beaugrand, Claire Mayer-Laigle
Summary: Lignocellulosic powders have the potential to be used as fuel in combustion devices, but their production faces challenges of high energy consumption and poor flowability. Thermal pretreatment methods such as torrefaction can modify the chemical and physical properties of biomass, improving the flowability and grindability of the resulting powder.
SUSTAINABLE ENERGY & FUELS
(2023)
Article
Multidisciplinary Sciences
X. Falourd, M. Lahaye, C. Rondeau-Mouro
Summary: Solid-state NMR is a technique for studying macromolecular assemblies in their native state. This study proposes a simplified data acquisition and processing method, achieving reduced acquisition time and shortened processing time while maintaining good signal to noise ratio.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
