Combating breast cancer using combination therapy with 3 phytochemicals: Piperine, sulforaphane, and thymoquinone

Hesperidin, piperine and bee venom synergistically potentiate the anticancer effect of tamoxifen against breast cancer cells

(2018) Abeer A.A. Khamis et al.   BIOMEDICINE & PHARMACOTHERAPY

Withaferin A and sulforaphane regulate breast cancer cell cycle progression through epigenetic mechanisms

(2018) Kendra J. Royston et al.   EXPERIMENTAL CELL RESEARCH

Autophagic cell death and premature senescence: New mechanism of 5-fluorouracil and sulforaphane synergistic anticancer effect in MDA-MB-231 triple negative breast cancer cell line

(2018) Małgorzata Milczarek et al.   FOOD AND CHEMICAL TOXICOLOGY

The Effects of Combinatorial Genistein and Sulforaphane in Breast Tumor Inhibition: Role in Epigenetic Regulation

(2018) Bidisha Paul et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model

(2018) Chhanda Bose et al.   PLoS One

The novel strategies for next-generation cancer treatment: miRNA combined with chemotherapeutic agents for the treatment of cancer

(2018) Chiranjib Chakraborty et al.   Oncotarget

Thymoquinone synergizes gemcitabine anti-breast cancer activity via modulating its apoptotic and autophagic activities

(2018) Hanan A. Bashmail et al.   Scientific Reports

A Novel Combination of Withaferin A and Sulforaphane Inhibits Epigenetic Machinery, Cellular Viability and Induces Apoptosis of Breast Cancer Cells

(2017) Kendra Royston et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

(2017) Rajesha Rupaimoole et al.   NATURE REVIEWS DRUG DISCOVERY

Antitumor effect of thymoquinone combined with resveratrol on mice transplanted with breast cancer

(2017) Omar H. Alobaedi et al.   Asian Pacific Journal of Tropical Medicine

Sulforaphane sensitizes human breast cancer cells to paclitaxel-induced apoptosis by downregulating the NF-κB signaling pathway

(2017) Seung-Hyun Kim et al.   Oncology Letters

MicroRNA-34a targets epithelial to mesenchymal transition-inducing transcription factors (EMT-TFs) and inhibits breast cancer cell migration and invasion

(2017) Saber Imani et al.   Oncotarget

Evaluation of the protective effect of Nigella sativa extract and its primary active component thymoquinone against DMBA-induced breast cancer in female rats

(2015) Sabah A. A. Linjawi et al.   Archives of Medical Science

Piperine inhibits the growth and motility of triple-negative breast cancer cells

(2015) Anna L. Greenshields et al.   CANCER LETTERS

Lipopolysaccharide based oral nanocarriers for the improvement of bioavailability and anticancer efficacy of curcumin

(2015) Sundeep Chaurasia et al.   CARBOHYDRATE POLYMERS

Piperine loaded PEG-PLGA nanoparticles: Preparation, characterization and targeted delivery for adjuvant breast cancer chemotherapy

(2015) Manendra Pachauri et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Dual drug-loaded paclitaxel–thymoquinone nanoparticles for effective breast cancer therapy

(2015) Parth Soni et al.   JOURNAL OF NANOPARTICLE RESEARCH

The combination of thymoquinone and paclitaxel shows anti-tumor activity through the interplay with apoptosis network in triple-negative breast cancer

(2015) Çağrı Şakalar et al.   TUMOR BIOLOGY

Thymoquinone Restores Radiation-Induced TGF-β Expression and Abrogates EMT in Chemoradiotherapy of Breast Cancer Cells

(2014) Shashi Rajput et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Thymoquinone, A Bioactive Component of Black Caraway Seeds, Causes G1 Phase Cell Cycle Arrest and Apoptosis in Triple-Negative Breast Cancer Cells with Mutant p53

(2014) Kimberly M. Sutton et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Sulforaphane inhibits growth of phenotypically different breast cancer cells

(2013) Anna Pawlik et al.   EUROPEAN JOURNAL OF NUTRITION

Antitumor efficacy of piperine in the treatment of human HER2-overexpressing breast cancer cells

(2013) Minh Truong Do et al.   FOOD CHEMISTRY

Molecular targeting of Akt by thymoquinone promotes G1 arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells

(2013) Shashi Rajput et al.   LIFE SCIENCES

Targeted Apoptotic Effects of Thymoquinone and Tamoxifen on XIAP Mediated Akt Regulation in Breast Cancer

(2013) Shashi Rajput et al.   PLoS One

Thymoquinone Inhibits Tumor Growth and Induces Apoptosis in a Breast Cancer Xenograft Mouse Model: The Role of p38 MAPK and ROS

(2013) Chern Chiuh Woo et al.   PLoS One

Piperine suppresses tumor growth and metastasis in vitro and in vivo in a 4T1 murine breast cancer model

(2012) Li-hua Lai et al.   ACTA PHARMACOLOGICA SINICA

Anticancer activity of thymoquinone in breast cancer cells: Possible involvement of PPAR-γ pathway

(2011) Chern Chiuh Woo et al.   BIOCHEMICAL PHARMACOLOGY

Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells

(2010) Y. Li et al.   CLINICAL CANCER RESEARCH

Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells

(2010) El-Shaimaa A. Arafa et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Sulforaphane Causes Epigenetic Repression of hTERT Expression in Human Breast Cancer Cell Lines

(2010) Syed M. Meeran et al.   PLoS One

Targeting breast stem cells with the cancer preventive compounds curcumin and piperine

(2009) Madhuri Kakarala et al.   BREAST CANCER RESEARCH AND TREATMENT

Suppression of microtubule dynamic instability and turnover in MCF7 breast cancer cells by sulforaphane

(2008) Olga Azarenko et al.   CARCINOGENESIS

Medicinal Plants and Cancer Chemoprevention

(2008) Avni Desai et al.   CURRENT DRUG METABOLISM

Regulation of estrogen receptor α expression in human breast cancer cells by sulforaphane

(2008) Marcela Cortes Ramirez et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY