Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

eXpression2Kinases (X2K) Web: linking expression signatures to upstream cell signaling networks

(2018) Daniel J B Clarke et al.   NUCLEIC ACIDS RESEARCH

Challenges in diagnosis of pancreatic cancer

(2018) Lulu Zhang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

A data science based standardized Gini index as a Lorenz dominance preserving measure of the inequality of distributions

(2017) Alfred Ultsch et al.   PLoS One

Three-Dimensional Cell Cultures in Drug Discovery and Development

(2017) Ye Fang et al.   SLAS Discovery

A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation

(2016) Jason D. Arroyo et al.   Cell Metabolism

Pancreatic cancer

(2016) Terumi Kamisawa et al.   LANCET

Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes

(2016) David W Morgens et al.   NATURE BIOTECHNOLOGY

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

MYC Is a Major Determinant of Mitotic Cell Fate

(2015) Caroline Topham et al.   CANCER CELL

Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis

(2015) Sidi Chen et al.   CELL

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

(2015) Traver Hart et al.   CELL

MYC in pancreatic cancer: novel mechanistic insights and their translation into therapeutic strategies

(2015) E Hessmann et al.   ONCOGENE

Interdependence of Gemcitabine Treatment, Transporter Expression, and Resistance in Human Pancreatic Carcinoma Cells

(2015) Wolfgang Hagmann et al.   NEOPLASIA

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Bortezomib-induced apoptosis in cultured pancreatic cancer cells is associated with ceramide production

(2013) Lei Gong et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

(2013) Linn Fagerberg et al.   MOLECULAR & CELLULAR PROTEOMICS

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Sequence analysis of  -subunit genes of the 20S proteasome in patients with relapsed multiple myeloma treated with bortezomib or dexamethasone

(2012) D. I. Lichter et al.   BLOOD

Pathology and Molecular Genetics of Pancreatic Neoplasms

(2012) Laura D. Wood et al.   CANCER JOURNAL

Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia

(2012) Mitsuro Kanda et al.   GASTROENTEROLOGY

Molecular evidence for increased antitumor activity of gemcitabine in combination with a cyclin-dependent kinase inhibitor, P276-00 in pancreatic cancers

(2012) Maggie J Rathos et al.   Journal of Translational Medicine

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

(2012) Andrew V. Biankin et al.   NATURE

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Bortezomib: Understanding the Mechanism of Action

(2011) B. Piperdi et al.   MOLECULAR CANCER THERAPEUTICS

Combination effects of bortezomib with gemcitabine and EMAP II in experimental pancreatic cancer

(2010) Niranjan Awasthi et al.   CANCER BIOLOGY & THERAPY

Knockdown of COPA, Identified by Loss-of-Function Screen, Induces Apoptosis and Suppresses Tumor Growth in Mesothelioma Mouse Model

(2010) Hitomi Sudo et al.   GENOMICS

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

(2009) Balazs Györffy et al.   BREAST CANCER RESEARCH AND TREATMENT

Identification of Survival Genes in Human Glioblastoma Cells by Small Interfering RNA Screening

(2009) N. G. Thaker et al.   MOLECULAR PHARMACOLOGY

Point Mutation of the Proteasome  5 Subunit Gene Is an Important Mechanism of Bortezomib Resistance in Bortezomib-Selected Variants of Jurkat T Cell Lymphoblastic Lymphoma/Leukemia Line

(2008) S. Lu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS