Chemical modification of neuropeptide Y for human Y1 receptor targeting in health and disease

Different mode of arrestin-3 binding at the human Y 1 and Y 2 receptor

(2018) Lizzy Wanka et al.   CELLULAR SIGNALLING

Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor

(2018) Zhenlin Yang et al.   NATURE

Carbaboranylation of Truncated C-Terminal Neuropeptide Y Analogue Leads to Full hY1 Receptor Agonism

(2018) Sven Hofmann et al.   CHEMBIOCHEM

Brain-derived neurotrophic factor and epilepsy: a systematic review

(2018) Lorenzo Iughetti et al.   NEUROPEPTIDES

The Role of Neuropeptide Y in Cardiovascular Health and Disease

(2018) Cheryl M. J. Tan et al.   Frontiers in Physiology

Neuropeptide Y and its involvement in chronic pain

(2017) Marta Diaz-delCastillo et al.   NEUROSCIENCE

Spinal activation of the NPY Y1 receptor reduces mechanical and cold allodynia in rats with chronic constriction injury

(2017) Mariana Malet et al.   PEPTIDES

The role of neuropeptide Y in the pathophysiology of atherosclerotic cardiovascular disease

(2016) Ping Zhu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Neuropeptide Y (NPY) in tumor growth and progression: Lessons learned from pediatric oncology

(2016) Jason Tilan et al.   NEUROPEPTIDES

The role of Neuropeptide Y in fear conditioning and extinction

(2016) R.O. Tasan et al.   NEUROPEPTIDES

Osteoblastic Actions of the Neuropeptide Y System to Regulate Bone and Energy Homeostasis

(2016) Harry Horsnell et al.   Current Osteoporosis Reports

Ablation of Y1 receptor impairs osteoclast bone-resorbing activity

(2016) Daniela M. Sousa et al.   Scientific Reports

The homeostatic role of neuropeptide Y in immune function and its impact on mood and behaviour

(2015) A. Farzi et al.   Acta Physiologica

Unwinding of the C-Terminal Residues of Neuropeptide Y is critical for Y2Receptor Binding and Activation

(2015) Anette Kaiser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Controlling Toxicity of Peptide-Drug Conjugates by Different Chemical Linker Structures

(2015) David Böhme et al.   ChemMedChem

Novel lipidized analogs of prolactin-releasing peptide have prolonged half-lives and exert anti-obesity effects after peripheral administration

(2015) L Maletínská et al.   INTERNATIONAL JOURNAL OF OBESITY

A cleavable cytolysin–neuropeptide Y bioconjugate enables specific drug delivery and demonstrates intracellular mode of action

(2015) Verena M. Ahrens et al.   JOURNAL OF CONTROLLED RELEASE

Carbohydrate-based materials for targeted delivery of drugs and genes to the liver

(2015) Marya Ahmed et al.   Nanomedicine

Regulation of energy homeostasis by the NPY system

(2015) Kim Loh et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Strategic Approaches to Optimizing Peptide ADME Properties

(2014) Li Di   AAPS Journal

Peptide Modifications Differentially Alter G Protein-Coupled Receptor Internalization and Signaling Bias

(2014) Veronika Mäde et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Blood–brain barrier (BBB) toxicity and permeability assessment after L-(4-10Boronophenyl)alanine, a conventional B-containing drug for boron neutron capture therapy, using an in vitro BBB model

(2014) E. Roda et al.   BRAIN RESEARCH

Receptor-Mediated Uptake of Boron-Rich Neuropeptide Y Analogues for Boron Neutron Capture Therapy

(2014) Verena M. Ahrens et al.   ChemMedChem

Position and Length of Fatty Acids Strongly Affect Receptor Selectivity Pattern of Human Pancreatic Polypeptide Analogues

(2014) Veronika Mäde et al.   ChemMedChem

Comparison of Somatostatin Receptor Agonist and Antagonist for Peptide Receptor Radionuclide Therapy: A Pilot Study

(2014) D. Wild et al.   JOURNAL OF NUCLEAR MEDICINE

Biased ligands at G-protein-coupled receptors: promise and progress

(2014) Jonathan D. Violin et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Pancreatic Polypeptide Is Recognized by Two Hydrophobic Domains of the Human Y4Receptor Binding Pocket

(2013) Xavier Pedragosa-Badia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extolling the benefits of molecular therapeutic lipidation

(2013) Miriam Avadisian et al.   Molecular BioSystems

Neuropeptide Y Is Produced by Adipose Tissue Macrophages and Regulates Obesity-Induced Inflammation

(2013) Kanakadurga Singer et al.   PLoS One

NPY and Stress 30 Years Later: The Peripheral View

(2012) Dalay Hirsch et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Converting Peptides into Drug Leads by Lipidation

(2012) L. Zhang et al.   CURRENT MEDICINAL CHEMISTRY

Peptides and peptide conjugates: therapeutics on the upward path

(2012) Verena M Ahrens et al.   Future Medicinal Chemistry

Carboranes Increase the Potency of Small Molecule Inhibitors of Nicotinamide Phosphoribosyltranferase

(2012) Mark W. Lee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut–brain axis

(2012) Peter Holzer et al.   NEUROPEPTIDES

Re-exposure and environmental enrichment reveal NPY-Y1 as a possible target for post-traumatic stress disorder

(2012) Hendrikus Hendriksen et al.   NEUROPHARMACOLOGY

From ortho-carbaborane-9-thiol towards new building blocks

(2012) René Frank et al.   POLYHEDRON

Imitation and modification of bioactive lead structures via integration of boron clusters

(2012) Sven Stadlbauer et al.   PURE AND APPLIED CHEMISTRY

Monosaccharide derivatives as central scaffolds in the synthesis of glycosylated drugs

(2012) Marco Filice et al.   RSC Advances

A unique and rapid approach toward the efficient development of novel protein tyrosine phosphatase (PTP) inhibitors based on ‘clicked’ pseudo-glycopeptides

(2011) Jin-Wei Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbaboranes as Pharmacophores: Properties, Synthesis, and Application Strategies

(2011) Matthias Scholz et al.   CHEMICAL REVIEWS

The role of NPY in hypothalamic mediated food intake

(2011) Rebecca E. Mercer et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Long-Acting Lipidated Analogue of Human Pancreatic Polypeptide Is Slowly Released into Circulation

(2011) Kathrin Bellmann-Sickert et al.   JOURNAL OF MEDICINAL CHEMISTRY

Incorporation ofortho-Carbaboranyl-Nε-Modifiedl-Lysine into Neuropeptide Y Receptor Y1- and Y2-Selective Analogues

(2011) Verena M. Ahrens et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neuropeptide Y receptors: ligand binding and trafficking suggest novel approaches in drug development

(2011) Cornelia Walther et al.   JOURNAL OF PEPTIDE SCIENCE

The Role of Conformational Ensembles in Ligand Recognition in G-Protein Coupled Receptors

(2011) Michiel J. M. Niesen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Role of neuropeptide Y Y1 and Y2 receptors on behavioral despair in a rat model of depression with co-morbid anxiety

(2011) Julio César Morales-Medina et al.   NEUROPHARMACOLOGY

Breast-Cancer Diagnosis by Neuropeptide Y Analogues: From Synthesis to Clinical Application

(2010) Irfan U. Khan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Glyco-Scan: Varying Glycosylation in the Sequence of the Peptide Hormone PYY3-36 and Its Effect on Receptor Selectivity

(2010) Søren L. Pedersen  et al.   CHEMBIOCHEM

Therapeutic potential of neuropeptide Y (NPY) receptor ligands

(2010) Shaun P. Brothers et al.   EMBO Molecular Medicine

Beyond Desensitization: Physiological Relevance of Arrestin-Dependent Signaling

(2010) L. M. Luttrell et al.   PHARMACOLOGICAL REVIEWS

Neuropeptide Y and sleep

(2010) Michal Dyzma et al.   SLEEP MEDICINE REVIEWS

Receptor Mediated Tumor Targeting: An Emerging Approach for Cancer Therapy

(2010) Chandana Mohanty et al.   Current Drug Delivery

Labeling and Glycosylation of Peptides Using Click Chemistry: A General Approach to 18F-Glycopeptides as Effective Imaging Probes for Positron Emission Tomography

(2009) Simone Maschauer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

[Lys(DOTA)4]BVD15, a novel and potent neuropeptide Y analog designed for Y1 receptor-targeted breast tumor imaging

(2009) Brigitte Guérin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

First selective agonist of the neuropeptide Y1-receptor with reduced size

(2009) Denise Zwanziger et al.   JOURNAL OF PEPTIDE SCIENCE

Neuropeptide Y stimulates proliferation, migration and differentiation of neural precursors from the subventricular zone in adult mice

(2009) Mickaël Decressac et al.   NEUROBIOLOGY OF DISEASE

Recent departures in the synthesis of peptides and glycopeptides

(2009) Cindy Kan et al.   TETRAHEDRON

GPC Receptors and Not Ligands Decide the Binding Mode in Neuropeptide Y Multireceptor/Multiligand System†

(2008) Diana Lindner et al.   BIOCHEMISTRY

Novel Chemically Modified Analogues of Neuropeptide Y for Tumor Targeting§

(2008) Denise Zwanziger et al.   BIOCONJUGATE CHEMISTRY

Effects of glycosylation on the stability of protein pharmaceuticals

(2008) Ricardo J. Solá et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Hungry for life: How the arcuate nucleus and neuropeptide Y may play a critical role in mediating the benefits of calorie restriction

(2008) Robin K. Minor et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY