Article
Plant Sciences
Mingyue Guo, Fengjun Yang, Chenxu Liu, Jinping Zou, Zhenyu Qi, Vasileios Fotopoulos, Gang Lu, Jingquan Yu, Jie Zhou
Summary: This study investigates the mechanism of how promoter mutations affect gene expression and crop stress tolerance. The researchers analyze RNA-Seq data and validate their findings through reverse transcription quantitative real-time PCR in tomato plants. They discover that the WRKY33 gene is induced under cold stress in cold-tolerant wild tomato relatives but remains almost unchanged in cold-sensitive cultivated tomato. Overexpression of WRKY33 enhances cold tolerance in tomato plants. The study also uncovers the role of nucleotide polymorphism in cis-regulatory regions in determining cold sensitivity in cultivated and wild tomato plants.
Article
Horticulture
Peiying Li, Dongdong Yu, Bao Gu, Hongjuan Zhang, Qiying Liu, Jianxia Zhang
Summary: The study reveals that the VaERD15 gene contributes to enhancing cold tolerance in grapevines, with transgenic plants showing improved cold resistance and higher antioxidant enzyme activities. The expression of ERD15 gene is regulated by external factors such as low temperature, and proteins interacting with VaERD15 exhibit diverse responses under different conditions.
SCIENTIA HORTICULTURAE
(2022)
Article
Plant Sciences
Lili Li, Lei Yang, Dingyu Fan, Juan Jin, Subina Xiaokelaiti, Yanjun He, Qing Hao
Summary: This study identified and analyzed ALDHs in the jujube genome, and revealed their function in heat stress response. The study found that different heat-sensitive jujube varieties have distinct gene expression patterns in response to high temperatures, and overexpression of a specific ALDH gene can enhance heat tolerance in tobacco plants.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Plant Sciences
Yin Wen, Qing Ye, Cristian Roman-Palacios, Hui Liu, Guilin Wu
Summary: Understanding how plants respond to thermal stress is crucial for predicting plant responses and community dynamics in natural ecosystems under climate change scenarios. This study compared the evolutionary rates of physiological tolerance to extreme temperatures with the corresponding rates of climatic niche in three major vascular plant groups. The results showed that physiological cold tolerance evolves faster than heat tolerance in all three groups. The coldest climatic-niche temperatures also evolve faster than the warmest climatic-niche temperatures. Additionally, the evolutionary rates of physiological cold tolerance were faster than the rates of change in climatic niches.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Plant Sciences
Kora Vyse, Stephanie Schaarschmidt, Alexander Erban, Joachim Kopka, Ellen Zuther
Summary: This study investigates the metabolic and transcriptomic changes in plants during cold priming and triggering. The research findings suggest that genes involved in cell wall remodeling and stress response regulation are induced during triggering, while the expression of late embryogenesis abundant proteins and antifreeze proteins is higher during priming. Moreover, the study indicates that a cold triggering stimulus might be perceived as a milder stress compared to priming in plants.
PHYSIOLOGIA PLANTARUM
(2022)
Article
Plant Sciences
Mei Wang, Lepeng Wang, Xiangxue Yu, Jingyi Zhao, Zhijia Tian, Xiaohong Liu, Guoping Wang, Li Zhang, Xinyong Guo
Summary: This study demonstrated that overexpression of cold-regulated plasma membrane protein COR413PM1 from Saussurea involucrata (SikCOR413PM1) enhanced cotton tolerance to cold and drought stresses. SikCOR413PM1 overexpression minimized cell membrane damage, increased plant stability, and modulated the expression of antioxidant enzyme-related genes and stress-related genes in cotton seedlings. Transgenic cotton plants overexpressing SikCOR413PM1 also showed high yields and increased environmental tolerance in field trials.
Article
Plant Sciences
Natalia Repkina, Anna Ignatenko, Ekaterina Holoptseva, Zbigniew MiszalskI, Pawel Kaszycki, Vera Talanova
Summary: Exogenous Methyl Jasmonate (MJ) can enhance cold tolerance in wheat by promoting the recovery of photosynthesis, increasing antioxidant enzyme activity, and promoting proline accumulation, thus increasing wheat cold tolerance.
Article
Plant Sciences
Zhenqi Tian, Chao Ma, Yan Zhang, Hongsong Chen, Xuyuan Gao, Jianying Guo, Zhongshi Zhou
Summary: Low temperatures affect the establishment of newly introduced species, but increased cold tolerance can promote their adaptability. This study found that cold stress improves the accumulation of cryoprotectants and cold tolerance in Ambrosia artemisiifolia, an invasive alien species. Furthermore, feeding on cold-hardened A. artemisiifolia enhances the cold tolerance of its biological control agent, Ophraella communa.
FRONTIERS IN PLANT SCIENCE
(2023)
Review
Agronomy
Anna L. Casto, Katherine M. Murphy, Malia A. Gehan
Summary: Sorghum is an important crop that is drought tolerant but susceptible to low temperatures. Research has identified concentrated regions of markers associated with chilling tolerance traits on chromosomes 2, 3, and 6. Further studies are needed to confirm and characterize the molecular mechanisms responsible for variation in chilling tolerance in sorghum.
Article
Plant Sciences
Zhensong Li, Xianglin Li, Feng He
Summary: Soil water content only affects the regeneration time of alfalfa, while the content of non-structural carbohydrates (NSCs) is related to the success of regeneration. This study analyzed the dynamic change and allocation of root NSCs under three irrigation frequencies and found that NSCs are the key driver of cold tolerance and regeneration. These findings provide further insight into the mechanism of overwintering and can help improve water management of alfalfa in high latitude areas.
Article
Plant Sciences
Fei Ding, Xizhi Wang, Ziye Li, Meiling Wang
Summary: As a cold-sensitive species, tomatoes increase both jasmonate (JA) and abscisic acid (ABA) levels under cold conditions. The NCED2 gene is associated with JA-mediated ABA biosynthesis in tomato plants in response to cold stress. Silencing NCED2 decreases ABA accumulation and increases cold sensitivity, while inhibiting ABA biosynthesis impairs JA-induced cold tolerance in tomatoes. The MYC2 protein, a core component of the JA signaling pathway, promotes NCED2 transcription, ABA accumulation, and cold tolerance in tomatoes.
Article
Plant Sciences
Chong Ren, Peige Fan, Shaohua Li, Zhenchang Liang
Summary: This review summarizes recent major advances in physiological and molecular analyses of cold tolerance in grapevine and discusses strategies for improving tolerance to cold stress. Understanding grapevine cold tolerance will facilitate the development of grapevines for adaption to global climate change.
Article
Genetics & Heredity
Li Zhang, Xinyong Guo, Zexing Zhang, Aiying Wang, Jianbo Zhu
Summary: The study identified that the expression of LeCOR413PM2 gene increases under cold stress, and its overexpression can enhance cold tolerance in transgenic tomato plants, while suppression of its expression through RNA interference increases plant sensitivity to cold.
Article
Plant Sciences
Zhifu Guo, Haotian Wang, Jialu Yao, Yishan Cheng, Wenzhong Zhang, Zhengjin Xu, Maomao Li, Jing Huang, Minghui Zhao
Summary: In this study, a population of BRILs derived from a cross between a wild rice (DXWR) and a super rice (SN265) was constructed to assess cold tolerance in rice. The LTG, SR, PH, and FLL were used as indices for this assessment. A high-resolution SNP genetic map was constructed using GBS technique. A total of 73 QTLs were detected, with 30 QTLs coinciding under both cold stress and BR-combined cold treatment. 14 candidate genes related to cold tolerance or the BR signaling pathway were located, and the transcript levels of 10 candidate genes were identified under cold stress and BR-combined cold treatment by qRT-PCR.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Yan Yan, Sun Mintao, Ma Si, Feng Qian, Wang Yijia, Di Qinghua, Zhou Mengdi, He Chaoxing, Li Yansu, Gao Lihong, Yu Xianchang
Summary: This study reveals the mechanism of G protein Ga subunit (CsGPA1) in regulating cold tolerance of plants. The results show that CsGPA1 interacts with CsCDL1 and CsCOR413PM2, and positively regulates the expression of brassinolide-related genes. Additionally, CsGPA1 or CsCOR413PM2 inhibition affects Ca (2+) influx at low temperature and subsequently modulates the expression of CsICE-CsCBF.
HORTICULTURE RESEARCH
(2022)
Article
Plant Sciences
Li Xiang, Mei Wang, Junxia Huang, Weitao Jiang, Zhubing Yan, Xuesen Chen, Chengmiao Yin, Zhiquan Mao
Summary: Apple replant disease (ARD) is a common issue worldwide, hindering apple tree growth and reducing yield and quality. The soil-borne pathogen Fusarium solani is the cause of ARD. WrKY transcription factors play a crucial role in plant response to biological stress, and MdWRKY74 was found to be a positive regulator of disease resistance, improving apple plant resistance to F. solani infection.
PLANT GROWTH REGULATION
(2022)
Article
Plant Sciences
Shuo Wang, Li-Xian Li, Zhen Zhang, Yue Fang, Dan Li, Xue-Sen Chen, Shou-Qian Feng
Summary: The study revealed the molecular mechanisms by which ethylene regulates anthocyanin synthesis in apple fruit, including the interactions of MdMYB17, MdMYB1, and MdEIL1, and the formation of a regulatory module.
HORTICULTURE RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Yanan Duan, Shurui Ma, Xuesen Chen, Xiang Shen, Chengmiao Yin, Zhiquan Mao
Summary: RNA-seq profiling was conducted to analyze the response of apple roots to Fpmd MR5 infection, revealing that the activation of resistance genes in apple roots plays a crucial role in defending against the pathogen.
Article
Plant Sciences
Mei Wang, Weixiao Tang, Li Xiang, Xuesen Chen, Xiang Shen, Chengmiao Yin, Zhiquan Mao
Summary: This study investigated the transcriptional response of apple seedlings inoculated with arbuscular mycorrhizal fungi to infection with F. solani. The results showed that mycorrhizal apple plants had less damage to their roots when infected with F. solani, along with enhanced activity of antioxidant enzymes and reduced lipid oxidation. A total of 1839 differentially expressed genes (DEGs) were identified after infection, with most of the DEGs involved in the binding of ADP and calcium ions. Furthermore, a large number of DEGs were found to be involved in the stress response of mycorrhizal plants based on MapMan analysis. Among them, MdWRKY40 transcription factor significantly improved the resistance of apple callus to F. solani by binding the promoter of the resistance gene MdGLU.
Article
Horticulture
Zhenquan Fan, Qun Xia, Zhiqiang Zhao, Yanan Duan, Lei Zhao, Haiyan Wang, Weitao Jiang, Xuesen Chen, Chengmiao Yin, Zhiquan Mao
Summary: XERF-1, an endophytic fungus isolated from healthy roots of apple trees, showed strong competitive antagonism against ARD-related pathogenic Fusarium species. Treatment with XERF-1 fertilizer significantly improved the growth of Malus hupehensis Rehd. seedlings and reduced the abundance of harmful Fusarium species in the soil.
SCIENTIA HORTICULTURAE
(2022)
Article
Plant Sciences
Zhuoxin Mei, Zhiqiang Li, Xia Lu, Shuhui Zhang, Wenjun Liu, Qi Zou, Lei Yu, Hongcheng Fang, Zongying Zhang, Zhiquan Mao, Xuesen Chen, Nan Wang
Summary: This study utilized LED lighting to extend the light duration in an apple orchard and found that this method significantly improved apple fruit quality, including anthocyanins synthesis in the fruit skin and accumulation of soluble sugars in the fruit flesh. The study also identified transcription factors that regulate these processes. These findings provide valuable insights into the effect of regulating the light environment on apple fruit quality.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2023)
Article
Plant Sciences
Yicheng Wang, Yansong Zhu, Huiyan Jiang, Zuolin Mao, Junkang Zhang, Hongcheng Fang, Wenjun Liu, Zongying Zhang, Xuesen Chen, Nan Wang
Summary: The anthocyanin content is a crucial indicator of the nutritional value of fruits, including apple. This study reveals the antagonistic relationship between light and brassinosteroid signaling pathways in apple, controlled by MdBZR1 and MdCOL6. Understanding the molecular basis of light and BR signal integration in anthocyanin biosynthesis has significant implications for fruit quality regulation.
Article
Plant Sciences
Y. N. Duan, S. R. Ma, X. S. Chen, X. Shen, C. M. Yin, Z. Q. Mao
Summary: Apple replant disease (ARD) caused by Fusarium proliferatum f. sp. malus domestica (Fpmd) MR5 is a fungal pathogen that leads to annual losses in apple production in China. In this study, the whole-genome sequence of the highly virulent Fpmd MR5 was obtained, revealing potential pathogenicity-related genes and specific virulence factor genes. These findings will contribute to further research on host-pathogen interactions and the development of disease management strategies.
Article
Plant Sciences
Shuhui Zhang, Hui Wang, Tong Wang, Wenjun Liu, Jing Zhang, Hongcheng Fang, Zongying Zhang, Futian Peng, Xuesen Chen, Nan Wang
Summary: The R2R3-MYB transcription factor MdMYB305 is positively correlated with fruit sugar content but negatively correlated with anthocyanin content in red-fleshed apples. It promotes sugar accumulation and inhibits anthocyanin synthesis through binding with sugar-related and anthocyanin-related genes. MdMYB305 competes with MdMYB10 for the MdbHLH33 binding site to balance sugar and anthocyanin accumulation in fruits.
Article
Plant Sciences
Zhiqiang Li, Wenjun Liu, Qiaojing Chen, Shuhui Zhang, Zhuoxin Mei, Lei Yu, Chen Wang, Zhiquan Mao, Zijing Chen, Xuesen Chen, Nan Wang
Summary: Anthocyanins are important secondary metabolites in plants that have antioxidant activities and can reduce the incidence of cardiovascular and cerebrovascular diseases and tumors. This study focuses on the mechanism of microRNA-mediated post-transcriptional regulation of anthocyanin synthesis in red-fleshed apples. It identifies a specific microRNA that inhibits anthocyanin accumulation and describes a novel regulatory loop involved in anthocyanin biosynthesis.
Article
Agronomy
Xin Xu, Weitao Jiang, Gongshuai Wang, Fengxia Ding, Qianjin Li, Ruolan Wang, Xuesen Chen, Xiang Shen, Chengmiao Yin, Zhiquan Mao
Summary: The Luochuan area is vital for apple production in China, but the occurrence of apple replant disease (ARD) in aged apple orchards has hindered sustainable development. The study examined the soil fungal community in 14 aged apple orchards in Luochuan and found significant differences in fungal diversity. Harmful fungi, such as Gibberella, Fusarium, and Cryptococcus, were present but varied in abundance across different aged apple orchards. Pathogenic fungi were identified, increasing disease risk and affecting fruit tree growth and development. The unbalanced microbial community structure can be addressed during orchard renewal to mitigate the impact of ARD on the apple industry.
Article
Engineering, Civil
Xue-Chun Liu, Kun Meng, Xuesen Chen, Yong-Mei Li, Yue Cui
Summary: A beam-to-column bolted joint with L-stubs was proposed and investigated. Parameter adjustments were found to improve the joint's stiffness and energy dissipation capacity.
ENGINEERING STRUCTURES
(2023)
Article
Plant Sciences
Shuhui Zhang, Hui Wang, Tong Wang, Jing Zhang, Wenjun Liu, Hongcheng Fang, Zongying Zhang, Futian Peng, Xuesen Chen, Nan Wang
Summary: This study investigated sugar accumulation and the underlying mechanisms in the progenies of a hybridization between high-sugar apples and high-flavonoid apple germplasm. The results showed that MdSWEET9b promotes sugar accumulation by transporting sucrose, and MdWRKY9 and MdbZIP23/46 regulate its expression in the ABA signaling pathway, thereby influencing sugar accumulation.
Article
Chemistry, Multidisciplinary
Xin Xu, Yifan Zhou, Xiaoqi Wang, Weitao Jiang, Lei Qin, Jian Wang, Haijun Yu, Xuesen Chen, Xiang Shen, Chengmiao Yin, Zhiquan Mao
Summary: Apple replant disease (ARD) is a common problem in apple production, affecting the growth and development of apples. This study investigated the use of hydrogen peroxide to treat replanted soil and its effects on seedling growth and soil microbiology. The results showed that hydrogen peroxide treatment improved seedling growth and reduced the population of Fusarium, while increasing the abundance of Bacillus, Mortierella, and Guehomyces. The best results were obtained with replanted soil + 4.5% hydrogen peroxide. Therefore, hydrogen peroxide can effectively prevent and control ARD.
Article
Horticulture
Susu Zhang, Sumin Qi, Bin Li, Jing Zhang, Can Cui, Rui Zhang, Zhiquan Mao, Nan Wang, Xuesen Chen, Zongying Zhang
Summary: 'Shannongsu' and 'Xincixiang' are two new late-ripening pear cultivars with high quality bred by our team. The postharvest storage characteristics of mature pears were studied by storing them at room temperature. Various fruit characteristics were evaluated over time, including firmness, ethylene release rate, aroma component content, softening-related enzyme activity, and gene expression. Both 'Shannongsu' and 'Xincixiang' exhibited excellent storage characteristics, remaining crisp and juicy after 60 days at room temperature, which may be attributed to low levels of ethylene production, aroma synthesis, softening-related activities, and gene expression. This research provides scientific guidance for fruit production and marketing by clarifying the storage characteristics of 'Shannongsu' and 'Xincixiang' at room temperature for the first time.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
