Article
Pharmacology & Pharmacy
Kamil Uney, Duygu Durna Corum, Ertugrul Terzi, Orhan Corum
Summary: This study investigated the pharmacokinetics of carprofen in rainbow trout broodstock via intravenous, intramuscular, and oral routes, showing favorable properties such as good bioavailability and long elimination half-life for the drug when administered via intramuscular and oral routes.
Article
Chemistry, Applied
Orhan Corum, Ertugrul Terzi, Duygu Durna Corum, Yigit Tastan, Ruby C. Gonzales, Osman Nezih Kenanoglu, Dan M. Arriesgado, Victor R. Navarro, Soner Bilen, Adem Yavuz Sonmez, Kamil Uney
Summary: The aim of this study was to investigate the pharmacokinetics of enrofloxacin (ENR) and its active metabolite ciprofloxacin (CIP) in Nile tilapia (Oreochromis niloticus) after intravascular (IV), intraperitoneal (IP), or oral (PO) administration. The results showed that ENR could be detected up to 120 h after treatment, indicating its potential efficacy against infections caused by susceptible bacteria in tilapia.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2022)
Article
Agriculture, Dairy & Animal Science
Kamil Uney, Ertugrul Terzi, Duygu Durna Corum, Rahmi Can Ozdemir, Soner Bilen, Orhan Corum
Summary: The pharmacokinetic/pharmacodynamic studies revealed non-linear and dose-disproportional pharmacokinetics of enrofloxacin in brown trout. Single oral administration of 10 and 20 mg/kg of enrofloxacin provided long duration of action, potentially reducing handling and stress in brown trout. Further research is needed for successful treatment of infections caused by Aeromonas hydrophila and A. sobria in brown trout.
Article
Infectious Diseases
Yuya Futagi, Yuriko Ito, Junya Nakade, Arimi Fujita, Tsutomu Shimada, Misaki Yoshida, Yoshinori Takahashi, Mitsuhiro Kawano, Takumi Taniguchi, Yoshimichi Sai
Summary: We present a case of CRO-induced encephalopathy, where the patient experienced seizures during treatment. The study found significant differences in the patient's pharmacokinetic parameters compared to healthy individuals.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Microbiology
Aaron J. Heffernan, Fekade B. Sime, Nilesh Kumta, Steven C. Wallis, Brett McWhinney, Jacobus Ungerer, Gloria Wong, Gavin M. Joynt, Jeffrey Lipman, Jason A. Roberts
Summary: This study aimed to describe the pharmacokinetics of ceftriaxone in critically ill adult patients and determine the best dosing regimens. It found that the dose should be adjusted based on the patient's renal function, albumin concentration, and isolate MIC.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Manoli Vourvahis, Wonkyung Byon, Cheng Chang, Vu Le, Annette Diehl, Daniela Graham, Sakambari Tripathy, Nancy Raha, Lina Luo, Sumathy Mathialagan, Martin Dowty, A. David Rodrigues, Bimal Malhotra
Summary: Abrocitinib has the potential to inhibit certain drug transporters, leading to increased plasma exposure of certain medications when co-administered. However, not all drug transporters are affected by abrocitinib.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Orhan Corum, Ertugrul Terzi, Duygu Durna Corum, Kamil Uney
Summary: The pharmacokinetics and bioavailability of meloxicam in rainbow trout broodstock were studied after intravascular, intramuscular, and oral administration. Results showed that intramuscular administration had higher bioavailability and shorter elimination half-life compared to oral administration. Therefore, for short-term use in acute conditions, intramuscular administration may be preferred.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2022)
Article
Pediatrics
Mohamed W. Eldougdoug, Doaa M. Youssef, Amal S. El-Shal, Yasmine Ahmed Sharaf, Sridivya Raparla, Bhaskara R. Jasti, Hanan M. Elnahas
Summary: This study aimed to evaluate the pharmacokinetics of ceftriaxone in critically ill children and monitor for drug adverse effects. The results showed that the clearance of ceftriaxone is correlated with renal function and total bilirubin and liver enzymes increased during treatment. It is recommended to monitor total bilirubin and liver enzymes in ceftriaxone treatment, especially in patients with high baseline values.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Pharmacology & Pharmacy
Duygu Durna Corum, Orhan Corum, Ertugrul Terzi, Devran Coskun, Soner Bilen, Gul Cetin, Kamil Uney
Summary: This study investigated the pharmacokinetics and bioavailability of cefquinome in rainbow trout. The results showed that the bioavailability was lower for oral and intraperitoneal administrations compared to intravenous administration. Further studies are needed to determine the antibacterial efficacy of cefquinome against pathogens isolated from rainbow trout.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2022)
Article
Clinical Neurology
Thomas W. Lategan, Laurene Wang, Tiffany N. Sprague, Franck S. Rousseau
Summary: The study confirmed the bioequivalence between two Bafiertam(TM) capsules and one Tecfidera(R) capsule, both of which were found to be safe and generally well tolerated.
Article
Pharmacology & Pharmacy
Lydia de Salazar, Ignacio Segarra, Francisco Javier Lopez-Roman, Antonio Torregrosa-Garcia, Silvia Perez-Pinero, Vicente Avila-Gandia
Summary: The novel controlled-release powder blend shows 100% higher bioavailability of beta-alanine, opening a new paradigm that shifts from chronic to short or mid-term supplementation strategies to increase carnosine stores in sports nutrition.
Article
Pharmacology & Pharmacy
Halley Gora Ravuri, Nana Satake, Alexandra Balmanno, Jazmine Skinner, Samantha Kempster, Paul C. Mills
Summary: This study evaluated the pharmacokinetic parameters of ketoprofen after intravenous and transdermal administration in healthy dogs. The results showed that transdermal administration of ketoprofen in dogs had a longer elimination half-life, higher AUC, and longer residence time compared to intravenous administration. It took 30 minutes to reach effective plasma concentrations after transdermal application.
Article
Agriculture, Multidisciplinary
Alexandre Vinco Pimenta, Thaisa Agrizzi Verediano, Joel Camilo Souza Carneiro, Neuza Maria Brunoro Costa, Andre Gustavo Vasconcelos Costa
Summary: Germination can reduce antinutritional factors in flaxseed varieties, while improving the in vitro bioaccessibility of calcium. However, it did not increase calcium absorption and balance in animals, possibly due to interactions with other compounds in the body.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Food Science & Technology
Mangala Hegde, Aviral Kumar, Sosmitha Girisa, Babu Santha Aswani, Ravichandran Vishwa, Gautam Sethi, Ajaikumar B. Kunnumakkara
Summary: Cancer is a complex disease with diverse characteristics and treatment responses. Overcoming the recurrence and resistance to therapy, as well as minimizing side effects, is crucial for improving the quality of life in cancer patients. This review explores the potential benefits of nanocurcumin, a nanotechnology-based formulation of the natural compound curcumin, in cancer treatment. Various types of curcumin nanoformulations are discussed, along with their anticancer activities and cellular mechanisms. The review also highlights the potential of nanocurcumin as a preventive or adjuvant therapy with conventional drugs.
Article
Microbiology
Adriana M. Rauseo, Patrick Mazi, Phoebe Lewis, Bruce Burnett, Stuart Mudge, Andrej Spec
Summary: The study found that under fasted conditions, SUBA-itraconazole (S-ITZ) capsules had less absorption variability compared to conventional itraconazole (C-ITZ) capsules.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Zeynep Ozdemir Kutahya, Sinan Kandir, Hatice Eser Faki, Kamil Uney, Bunyamin Tras, Mehmet Celik, Osman Torun
Summary: This study aimed to investigate the pharmacokinetics of oxfendazole and oxyclozanide tablet formulation in sheep and whether there is an interaction between these two drugs. The results showed that co-administration of oxfendazole increased the plasma concentration of oxyclozanide, potentially enhancing its antiparasitic activity.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Bunyamin Tras, Kamil Uney, Tugba Melike Parlak, Oznur Tufan
Summary: This study aimed to investigate the effect of different doses of oral vitamins A and E on the concentrations of ivermectin in the plasma and brain of mice. High doses of vitamins A and E, as well as their combination, significantly increased the transportation of ivermectin into the brain.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2023)
Article
Veterinary Sciences
Orhan Corum, Kamil Uney, Ertugrul Terzi, Duygu Durna Corum, Devran Coskun, Feray Altan, Muammer Elmas
Summary: This study compared the pharmacokinetics, tissue residues, and withdrawal times of doxycycline after oral administration in rainbow trout reared at different temperatures. The results showed that temperature significantly affected the metabolism, excretion, tissue residues, and withdrawal times of doxycycline in rainbow trout, suggesting the need for temperature-dependent dosing regimens and withdrawal times.
VETERINARY SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Feray Altan, Sakine Ulkum Cizmeci, Ayse Merve Kose, Orhan Corum, Kamil Uney
Summary: This study investigated temporal changes in hepatic drug-oxidizing capacity using plasma metabolite/caffeine ratios in goats. The results showed that plasma metabolite/caffeine ratios were similar between pregnant and non-pregnant goats, but significantly higher in the third period for pregnant goats. This suggests that pregnancy may not affect the enzymes involved in caffeine metabolism in goats.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Devran Coskun, Orhan Corum, Duygu Durna Corum, Gul Cetin, Mehmet Irmak, Hatice Rumeysa Ceyhan, Kamil Uney
Summary: The pharmacokinetics of meloxicam was studied in sheep at different ages. The concentration of meloxicam in plasma was detected up to 72 h after intravenous administration in all age groups. The volume of distribution at steady state and total body clearance were higher in younger sheep compared to older sheep. The findings suggest that the age of the sheep may affect the pharmacokinetics of meloxicam and dosage adjustments may be needed.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Mehmet Bugra Kivrak, Orhan Corum, Murat Yuksel, Erdinc Turk, Duygu Durna Corum, Ibrahim Ozan Tekeli, Kamil Uney
Summary: This study aimed to investigate the pharmacokinetics of letrozole at different doses and its effect on gonadotropins. The results showed that letrozole exhibited nonlinear kinetic behavior and significantly reduced luteinizing hormone concentration.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2023)
Article
Agriculture, Dairy & Animal Science
Kamil Uney, Murat Yuksel, Duygu Durna Corum, Devran Coskun, Erdinc Turk, Hasan Basri Dingil, Orhan Corum
Summary: This study investigates the pharmacokinetics and physiological efficacy of Carprofen and Xylazine in the castration process of male goats. The results show that Xylazine can affect the distribution and metabolism of Carprofen, and the combined use of Carprofen and Xylazine may be beneficial in reducing the cortisol response after castration.
Article
Veterinary Sciences
R. Yildiz, D. Durna Corum, O. Corum, M. Ider, O. Atik, M. Ok, K. Uney
Summary: The study aimed to investigate the cardiotoxic effect of combining tilmicosin and diclofenac sodium in sheep. Thirty-two sheep were divided into four groups: tilmicosin only, diclofenac sodium only, combination of tilmicosin and diclofenac sodium, and control group. Blood samples were taken at different time points to measure cardiac markers. The results showed that the combination group exhibited significantly higher levels of cardiac biomarkers compared to the other groups, indicating potential cardiac damage.
POLISH JOURNAL OF VETERINARY SCIENCES
(2023)
Article
Veterinary Sciences
Erdem Gulersoy, Mahmut Ok, Kamil Uney, Murat Kaan Durgut, Tugba Melike Parlak, Yusuf Emre Ekici
Summary: This study investigates the diagnostic utility of clinical and laboratory examinations in cats with symptomatic feline infectious peritonitis (FIP) or asymptomatic feline enteric coronavirus (FECV). The results show that pH, HCO3, base excess, lactate, MCV, and magnesium levels are important in the course of the disease, and AGP is useful for evaluating the presence of an inflammatory state. Clinical, laboratory, and serum AGP evaluations can be used to determine the likelihood of FIP and FECV development.
ACTA VETERINARIA-BEOGRAD
(2023)
Article
Pharmacology & Pharmacy
Huseyin Gungor, Orhan Corum, Duygu Durna Corum, Alper Serhat Kumru, Gokhan Yilmaz, Devran Coskun, Alparslan Coskun, Kamil Uney
Summary: The aim of this study was to determine the pharmacokinetic change of meloxicam in sheep after intravenous administration at different doses. The results showed that the duration of meloxicam in plasma, as well as the elimination half-life and area under the concentration-time curve, increased as the dose increased, while the total clearance decreased. Meloxicam exhibited non-linear pharmacokinetics in sheep, and when administered intravenously at a dose of 1 mg/kg or above, plasma concentrations became unpredictable.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Bunyamin Tras, Kamil Uney, Tugba Melike Parlak, Oznur Tufan
Summary: This study aimed to investigate the effect of different doses of oral vitamins A and E on the concentrations of ivermectin in the plasma and brain of mice. The results showed that high doses of vitamins A and E, as well as their combination, significantly increased the passage of ivermectin into the brain.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2023)
Article
Fisheries
Hunter S. Bailey, Ashley N. Fincannon, Lee A. Fuiman
Summary: This study investigated the transfer of fatty acids from broodstock diets to eggs and the time needed for the eggs to equilibrate to the diet in Southern flounder. The findings indicate that different diet treatments significantly affect the fatty acid composition of eggs, and it takes 8-16 weeks for the eggs to adapt to changes in the adult diet. These results are important for improving broodstock diets and feeding protocols in stock-enhancement programs.
Article
Fisheries
Yu Liu, Mingtao Lei, Hector Victor, Yan Wang
Summary: This study confirms the feasibility of replacing raw fish diet with a formulated diet in commercial farming of large yellow croaker, which can increase fish survival and yield, and reduce feed cost and body lipid deposition.
Article
Fisheries
Xiaoyan Zhang, Lize San, Yucong Yang, Yuehong Tao, Jiangong Ren, Yufeng Liu, Zhongwei He, Jiashuo Di, Ziteng Pei, Guixing Wang, Jilun Hou
Summary: Gynogenesis is an effective technique for establishing homogeneous lines and confirming potential chromosomal mechanisms of sex determination in fish. This study successfully induced gynogenetic families in Thamnaconus modestus and established a complete method for gynogenesis induction.
Article
Fisheries
Julieta C. Martinelli, Megan Considine, Helen R. Casendino, Carolyn M. Tarpey, Isadora Jimenez-Hidalgo, Jacqueline L. Padilla-Gamino, Teri L. King, Lorenz Hauser, Steven Rumrill, Chelsea L. Wood
Summary: Shell-boring polychaetes have caused significant damage to mariculture operations worldwide, particularly in the US Pacific region. This study provides a comprehensive dataset on the prevalence, species distribution, and environmental associations of these parasites, highlighting the impact of season, culturing methods, and environmental factors on infestation.
Article
Fisheries
Juan Gao, Xueshan Li, Kangle Lu, Kai Song, Jian Zhang, Ling Wang, Chunxiao Zhang
Summary: This study investigated the effects of dietary protein levels on growth performance, antioxidant capacity, digestive enzyme activity, and metamorphosis rate of bullfrog tadpoles. The optimal dietary protein level for bullfrog tadpoles was estimated to be 42.49%-46.50% of the diet.
Article
Fisheries
Qiang Li, Lijun Duan, Dongsheng Jin, Yuxin Chen, Yirong Lou, Qianjin Zhou, Zhongjie Xu, Fangjie Chen, Hongxian Chen, Guizong Xu, Maocang Yan, Guanjun Yang, Jianfei Lu, Yanjun Zhang, Jiong Chen
Summary: This study developed a centrifugal microfluidic chip with on-chip RPA to detect five pathogenic microorganisms. The chip enabled the parallel analysis of six genetic markers from a single sample and allowed for the highly automated detection of multiple samples. Compared with PCR and DNA sequencing, the on-chip RPA assay showed high sensitivity and specificity for detecting multiple pathogens in shrimp aquaculture.
Article
Fisheries
Xingchen Huo, Pengxu Wang, Fengxia Zhao, Qian Liu, Qingqing Tian, Lingjie Tang, Maolin Lv, Zhaohui Wei, Chunrong Yang, Jianguo Su
Summary: Bacterial diseases in aquaculture ponds have negative effects on sustainable development. The use of composite I20 biotherapy has been shown to effectively treat bacterial diseases in bullfrog ponds, providing a new strategy for controlling bacterial diseases in aquaculture.
Article
Fisheries
Peng Yin, Takaya Saito, Per Gunnar Fjelldal, Bjorn Tharandur Bjornsson, Sofie Charlotte Remo, Sandeep Sharma, Rolf Erik Olsen, Kristin Hamre
Summary: This study aims to investigate the effect of seasonal changes in temperature and photoperiod on the redox metabolism of Atlantic salmon at the molecular level. The research findings suggest that the changing photoperiod and temperature influenced the redox metabolism of Atlantic salmon, highlighting the importance of oxidative status in the ecological implications.
Article
Fisheries
Nicholas Oppong Mensah, Jeffery Kofi Asare, Emmanuel Tetteh-Doku Mensah, Ernest Christlieb Amrago, Frank Osei Tutu, Anthony Donkor
Summary: This study investigates aquaculture farmers' preference for climate-smart aquaculture insurance products, the challenges they face, and their preferred insurance coverage. The results show that farmers prefer Climate-Induced Aquaculture Stock Mortality Insurance and the most significant constraint is the delay in claim settlement.
Article
Fisheries
Qiu-Ping Chai, Pei Wu, Wei-Dan Jiang, Yang Liu, Hong-Mei Ren, Xiao-Wan Jin, Lin Feng, Xiao-Qiu Zhou
Summary: The study found that appropriate levels of potassium diformate (KDF) can enhance the immune defense and mediate the inflammatory process in fish, possibly through the regulation of T cell differentiation via JAK-STAT and NF-kappa B signaling pathways.
Article
Fisheries
Tian Zhu, Haomin Jia, Haopeng Zhang, Yujing Xiao, Cui Han, Jiaxin Yang
Summary: Chicken manure has significant effects on the cultivation of Chlorella and rotifers. The optimal amount of chicken manure extract for continuous cultivation is 10 mLL-1. Chicken manure can promote the growth of Chlorella and improve the fatty acid composition, indirectly enhancing the growth condition and fatty acid content of rotifers.
Article
Fisheries
Zheng Luo, Yang Yu, Zhenning Bao, Fuhua Li
Summary: This study analyzed the heritability and genetic correlation of two growth traits in Pacific white shrimp and evaluated the genomic prediction using different genomic selection models. The results showed that the NeuralNet model had the highest prediction accuracy and better prospects for predicting shrimp growth traits.
Article
Fisheries
Alberto Ruiz, Ignasi Sanahuja, Karl B. Andree, Dolors Furones, Paul G. Holhorea, Josep A. Calduch-Giner, Jose J. Pastor, Marc Vinas, Jaume Perez-Sanchez, Sofia Morais, Enric Gisbert
Summary: Supplementing diets with a combination of spice oleoresins can reduce lipid accumulation and inflammation in farmed fish. The combination of spice oleoresins also has an immunomodulatory effect on the fish's intestinal immune system, potentially offering anti-inflammatory benefits.
Article
Fisheries
Beibei Zhao, Renhui Mei, Le Li, Di Hu, Lei Li
Summary: This study reveals that JfCXCL8_L1a and JfCXCL8_L1b have different immune pathways, and JfCXCL8_L1b plays a significant role in enhancing the adaptive immunity of T cell-dependent antigen.
Article
Fisheries
Yuhang Liu, Danying Cao, Nan Wu, Xuyang Zhao, Qingsong Zhu, Lian Su, Fatima Altaf, Qianqian Zhang, Haokun Liu, Yongming Li, Bruno Hamish Unger, Yingyin Cheng, Wanting Zhang, Aihua Li, Yaping Wang, Xiao-Qin Xia
Summary: Based on previous research, sinomenine has been found to protect mucosal immunity in farmed fish species by preventing intestinal pathological changes and regulating gene expression related to inflammation. It also enhances immune homeostasis and controls the growth of pathogenic bacteria.