Article
Oncology
Jinxiang Huang, Fenglin Zhang, Guohan Hu, Yuan Pan, Wei Sun, Lei Jiang, Peng Wang, Jiting Qiu, Xuehua Ding
Summary: The role of SIRT1 in pituitary tumors was investigated, and it was found that the SIRT1/H3K9ac/PTTG1 axis plays a crucial role in the formation of pituitary tumors. This discovery may provide a new therapeutic strategy for the treatment of pituitary tumors.
Article
Biochemistry & Molecular Biology
Yue Wang, Guilin Yu, Yiyang Liu, Longfei Xie, Jinnian Ge, Guohua Zhao, Jie Lin
Summary: PTTG3P plays a critical role in CRC by affecting cell proliferation, glycolysis, and macrophage polarization. Overexpression of PTTG3P accelerates tumor growth, while silencing PTTG3P reduces the release of inflammatory cytokines and impacts immune cell infiltration. Additionally, hypoxia-induced PTTG3P contributes to glycolysis and M2 macrophage polarization, providing a novel approach for clinical treatment.
BIOSCIENCE REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Linhang Mei
Summary: This study elucidated the relationship between PTTG1 and miRNAs in breast cancer, successfully identified several potential upstream ncRNAs, and found that the PTTG1-miR-186-5p/miR-655-3p axis is associated with TGF-beta and MAPK signaling pathways, further revealing the importance of AURKA.
Article
Medicine, Research & Experimental
Zhengting Chen, Ke Cao, Yu Hou, Fei Lu, Lan Li, Li Wang, Yaoxiong Xia, Lan Zhang, Haixia Chen, Rong Li, Li Chang, Wenhui Li
Summary: Ionizing radiation (IR) exerts dual effects on the invasive ability and immune response of LAC cells, targeting PTTG1 and the TGF-beta 1/SMAD3 pathway may ameliorate the immunosuppressive TME and enhance the antitumour immune response.
Article
Oncology
Qi Zhou, Leijia Li, Feifei Sha, Yiming Lei, Xuan Tian, Lingjun Chen, Yan Chen, Huiling Liu, Yunwei Guo
Summary: PTTG1 is highly expressed in hepatocellular carcinoma and plays a crucial role in its development. PTTG1 promotes asparagine synthetase transcription, leading to increased levels of asparagine and activation of the mTOR pathway, facilitating HCC progression.
Article
Biochemistry & Molecular Biology
Sang Shin Lee, Jong Ho Choi, Seung Mook Lim, Gi Jin Kim, Suk Keun Lee, Yoon Kyung Jeon
Summary: The study found that by regulating the expression of PTTG1, newly identified microRNA-186 and -655 can impact the invasion activity of oral squamous cell carcinoma cells, providing further insights into the role of PTTG1 in oral SCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Gang Yang, Yongfu Xiog, Guan Wang, Weinan Li, Tao Tang, Ji Sun, Jingdong Li
Summary: The study reveals the important role of miR-374c-5p in hepatocellular carcinoma (HCC), showing its potential as a biological indicator for predicting poor prognosis. It regulates the malignant behavior of HCC through targeting PTTG1 and affecting epithelial-mesenchymal transition.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Haibo Zhang, Ziqing He, Li Qiu, Jinfen Wei, Xiaocheng Gong, Mingjian Xian, Zixi Chen, Ying Cui, Shuying Fu, Zihao Zhang, Bowen Hu, Xiquan Zhang, Shudai Lin, Hongli Du
Summary: The upregulated PRR11 in various cancers is associated with poor prognosis and can promote cell proliferation and migration by regulating the expression of PTTG1, thus influencing cell cycle progression.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Shao-Ying Yang, Yi-Fan Xie, Tai-Mei Zhang, Ling Deng, Li Liao, Shu-Yuan Hu, Yin-Ling Zhang, Fang-Lin Zhang, Da-Qiang Li
Summary: This study reports the upregulation of IMPA1 in TNBC and its role in proliferation, metastasis and tumor formation in TNBC cells. Transcriptome sequencing analysis reveals that IMPA1 induces mTOR activity and epithelial-mesenchymal transition (EMT) process, thus promoting TNBC progression.
Review
Pharmacology & Pharmacy
Abdul Basit Baba, Bilal Rah, Gh Rasool Bhat, Ifra Mushtaq, Sabra Parveen, Rukhsana Hassan, Mahrukh Hameed Zargar, Dil Afroze
Summary: The ubiquitously expressed cytokine transforming growth factor-beta (TGF-beta) plays a significant role in cellular mechanisms. It functions as a tumor suppressor at the early onset of malignancy but promotes tumorigenesis at an advanced stage. Moreover, TGF-beta regulates cell fate through immune and stroma components.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Urszula Forys, Alon Nahshony, Moran Elishmereni
Summary: This paper presents a new mathematical model describing androgen deprivation therapy for hormone sensitive prostate cancer patients. The model is able to reflect the clinical scenario where the level of testosterone rises leading to the failure of ADT.
Review
Plant Sciences
Siqi Wu, Zhe Sun, Zehuai Guo, Peiqin Li, Qianqian Mao, Yang Tang, Hongyu Chen, Huiting Peng, Sisi Wang, Yang Cao
Summary: Blood-activating and stasis-transforming traditional Chinese medicines (BAST) have been proven to improve hemodynamics and micro-flow, prevent thrombosis, and inhibit the invasion and metastasis of lung cancer. This review summarizes the research progress of BAST on lung cancer and explores the underlying molecular mechanisms.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Anita Rogic, Ila Pant, Luca Grumolato, Ruben Fernandez-Rodriguez, Andrew Edwards, Suvendu Das, Aaron Sun, Shen Yao, Rui Qiao, Shabnam Jaffer, Ravi Sachidanandam, Guray Akturk, Rosa Karlic, Mihaela Skobe, Stuart A. Aaronson
Summary: Inflammatory breast cancer (IBC) is an aggressive form of breast cancer with a poor prognosis. The characterization of a human IBC cell line in this study suggests that the high level of CCL2 is implicated in macrophage infiltration and tumor progression.
NATURE COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Jinlian Li, Shuting Zheng, Ting Cheng, Yuanyuan Li, Xiaobin Mai, Guangchun Jiang, Yongxia Yang, Qianqian Zhang, Jiangchao Li, Lingyun Zheng, Lijing Wang, Cuiling Qi
Summary: The study found that Decylubiquinone (DUb) can inhibit the growth and metastasis of colorectal cancer (CRC), and it suppresses CRC progression by upregulating SIRT2.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Teng Tu, Ye Yuan, Xiaoxue Liu, Xin Liang, Xiaofan Yang, Yue Yang
Summary: This article elucidates the role and regulatory mechanisms of the SLFN5 gene in tumors, as well as its potential as a new biomarker for tumor diagnosis and prognosis.
FRONTIERS IN ONCOLOGY
(2023)