Loss of the Osteogenic Differentiation Potential during Senescence Is Limited to Bone Progenitor Cells and Is Dependent on p53

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

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Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Knockdown of p21Cip1/Waf1 enhances proliferation, the expression of stemness markers, and osteogenic potential in human mesenchymal stem cells

(2011) Tu-Lai Yew et al.   AGING CELL

Senescence-associated intrinsic mechanisms of osteoblast dysfunctions

(2011) Moustapha Kassem et al.   AGING CELL

Ionizing radiation-induced expression of INK4a/ARF in murine bone marrow-derived stromal cell populations interferes with bone marrow homeostasis

(2011) C. L. Carbonneau et al.   BLOOD

Telomerase-deficient mice exhibit bone loss owing to defects in osteoblasts and increased osteoclastogenesis by inflammatory microenvironment

(2011) Hamid Saeed et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bone density and structure in long-term survivors of pediatric allogeneic hematopoietic stem cell transplantation

(2011) Sogol Mostoufi-Moab et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Devastation of adult stem cell pools by irradiation precedes collapse of trabecular bone quality and quantity

(2011) Danielle E Green et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

p21cip/WAF is a key regulator of long-term radiation damage in mesenchyme-derived tissues

(2010) Babak J. Mehrara et al.   FASEB JOURNAL

Rb regulates fate choice and lineage commitment in vivo

(2010) Eliezer Calo et al.   NATURE

Secretion of SDF-1α by bone marrow-derived stromal cells enhances skin wound healing of C57BL/6 mice exposed to ionizing radiation

(2009) Yannick Landry et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Total-Body Irradiation of Postpubertal Mice with137Cs Acutely Compromises the Microarchitecture of Cancellous Bone and Increases Osteoclasts

(2009) Hisataka Kondo et al.   RADIATION RESEARCH

Cause-Specific Late Mortality Among 5-Year Survivors of Childhood Cancer: The Childhood Cancer Survivor Study

(2008) A. C. Mertens et al.   JNCI-Journal of the National Cancer Institute

p53 Plays a Role in Mesenchymal Differentiation Programs, in a Cell Fate Dependent Manner

(2008) Alina Molchadsky et al.   PLoS One

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY