The leptin sensitizer celastrol reduces age-associated obesity and modulates behavioral rhythms

Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy

(2017) Mengjie Hu et al.   MOLECULAR CELL

Systems Chronotherapeutics

(2017) Annabelle Ballesta et al.   PHARMACOLOGICAL REVIEWS

Celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1

(2017) Yinliang Zhang et al.   Molecular Metabolism

The biology of the metabolic syndrome and aging

(2016) Ligia J. Dominguez et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Age-related changes in acute central leptin effects on energy balance are promoted by obesity

(2016) I. Rostás et al.   EXPERIMENTAL GERONTOLOGY

Treatment of Obesity with Celastrol

(2015) Junli Liu et al.   CELL

Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis

(2015) Xinran Ma et al.   Cell Metabolism

Hypothalamic Amylin Acts in Concert with Leptin to Regulate Food Intake

(2015) Zhiying Li et al.   Cell Metabolism

Diet/Energy Balance Affect Sleep and Wakefulness Independent of Body Weight

(2015) Isaac J. Perron et al.   SLEEP

Diet/Energy Balance Affect Sleep and Wakefulness Independent of Body Weight

(2015) Isaac J. Perron et al.   SLEEP

Age versus nutritional state in the development of central leptin resistance

(2014) Erika Pétervári et al.   PEPTIDES

Leptin receptor neurons in the dorsomedial hypothalamus are key regulators of energy expenditure and body weight, but not food intake

(2014) Kavon Rezai-Zadeh et al.   Molecular Metabolism

Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice

(2013) Tsutomu Sasaki et al.   DIABETOLOGIA

Aging in Mice Reduces the Ability to Sustain Sleep/Wake States

(2013) Mathieu E. Wimmer et al.   PLoS One

Body composition and its association with cardiometabolic risk factors in the elderly: A focus on sarcopenic obesity

(2012) Ji-Youn Chung et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Challenges and Opportunities of Defining Clinical Leptin Resistance

(2012) Martin G. Myers et al.   Cell Metabolism

Rapamycin Ameliorates Age-Dependent Obesity Associated with Increased mTOR Signaling in Hypothalamic POMC Neurons

(2012) Shi-Bing Yang et al.   NEURON

Prevalence, Pathophysiology, Health Consequences and Treatment Options of Obesity in the Elderly: A Guideline

(2012) Elisabeth M.H. Mathus-Vliegen et al.   Obesity Facts

Alterations in Mouse Hypothalamic Adipokine Gene Expression and Leptin Signaling following Chronic Spinal Cord Injury and with Advanced Age

(2012) Gregory E. Bigford et al.   PLoS One

Leptin reduces food intake via a dopamine D2 receptor-dependent mechanism

(2012) Sonja K. Billes et al.   Molecular Metabolism

Endoplasmic reticulum stress in wake-active neurons progresses with aging

(2011) Nirinjini Naidoo et al.   AGING CELL

Essential role of protein tyrosine phosphatase 1B in obesity-induced inflammation and peripheral insulin resistance during aging

(2011) Águeda González-Rodríguez et al.   AGING CELL

Circadian clocks and drug delivery systems: impact and opportunities in chronotherapeutics

(2011) Francis Lévi et al.   Expert Opinion on Drug Delivery

Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice

(2011) Michael M. Scott et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanistic Modeling of the Effects of Glucocorticoids and Circadian Rhythms on Adipokine Expression

(2011) S. Sukumaran et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The metabolic footprint of aging in mice

(2011) Riekelt H. Houtkooper et al.   Scientific Reports

Age-related changes in total and regional fat distribution

(2009) Jennifer L. Kuk et al.   AGEING RESEARCH REVIEWS

Visceral adipose tissue modulates mammalian longevity

(2008) Radhika Muzumdar et al.   AGING CELL