Large-scale exploration and analysis of drug combinations

Network predicting drug’s anatomical therapeutic chemical code

(2013) Yong-Cui Wang et al.   BIOINFORMATICS

Binding site comparison for function prediction and pharmaceutical discovery

(2013) Janez Konc et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Deciphering the combination principles of Traditional Chinese Medicine from a systems pharmacology perspective based on Ma-huang Decoction

(2013) Yao Yao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Systems pharmacology strategies for drug discovery and combination with applications to cardiovascular diseases

(2013) Peng Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Combination therapy for hypertension 2013: An update

(2013) Ayesha Salahuddin et al.   Journal of the American Society of Hypertension

Systems-level antimicrobial drug and drug synergy discovery

(2013) Terry Roemer et al.   Nature Chemical Biology

Synergysm of voriconazole or itraconazole with other antifungal agents against species of Fusarium

(2013) Tatiana B. Spader et al.   REVISTA IBEROAMERICANA DE MICOLOGIA

Systems Pharmacology of Adverse Event Mitigation by Drug Combinations

(2013) S. Zhao et al.   Science Translational Medicine

Target Inhibition Networks: Predicting Selective Combinations of Druggable Targets to Block Cancer Survival Pathways

(2013) Jing Tang et al.   PLoS Computational Biology

Systematic Prediction of Pharmacodynamic Drug-Drug Interactions through Protein-Protein-Interaction Network

(2013) Jialiang Huang et al.   PLoS Computational Biology

A Systems Biology Approach to Uncovering Pharmacological Synergy in Herbal Medicines with Applications to Cardiovascular Disease

(2012) Xia Wang et al.   Evidence-based Complementary and Alternative Medicine

INDI: a computational framework for inferring drug interactions and their associated recommendations

(2012) Assaf Gottlieb et al.   Molecular Systems Biology

Systematic identification of synergistic drug pairs targeting HIV

(2012) Xu Tan et al.   NATURE BIOTECHNOLOGY

Combinatorial drug therapy for cancer in the post-genomic era

(2012) Bissan Al-Lazikani et al.   NATURE BIOTECHNOLOGY

Systems-pharmacology dissection of a drug synergy in imatinib-resistant CML

(2012) Georg E Winter et al.   Nature Chemical Biology

Predicting drug side-effect profiles: a chemical fragment-based approach

(2011) Edouard Pauwels et al.   BMC BIOINFORMATICS

Combining Drug and Gene Similarity Measures for Drug-Target Elucidation

(2011) Liat Perlman et al.   JOURNAL OF COMPUTATIONAL BIOLOGY

Systematic exploration of synergistic drug pairs

(2011) M. Cokol et al.   Molecular Systems Biology

Network Neighbors of Drug Targets Contribute to Drug Side-Effect Similarity

(2011) Lucas Brouwers et al.   PLoS One

Prediction of Drug Combinations by Integrating Molecular and Pharmacological Data

(2011) Xing-Ming Zhao et al.   PLoS Computational Biology

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

A side effect resource to capture phenotypic effects of drugs

(2010) Michael Kuhn et al.   Molecular Systems Biology

DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs

(2010) C. Knox et al.   NUCLEIC ACIDS RESEARCH

Predicting Drug–Drug Interactions: An FDA Perspective

(2009) Lei Zhang et al.   AAPS Journal

DCDB: Drug combination database

(2009) Y. Liu et al.   BIOINFORMATICS

Supervised prediction of drug–target interactions using bipartite local models

(2009) Kevin Bleakley et al.   BIOINFORMATICS

Infrastructure for the life sciences: design and implementation of the UniProt website

(2009) Eric Jain et al.   BMC BIOINFORMATICS

Synergistic drug combinations tend to improve therapeutically relevant selectivity

(2009) Joseph Lehár et al.   NATURE BIOTECHNOLOGY

Mechanisms of drug combinations: interaction and network perspectives

(2009) Jia Jia et al.   NATURE REVIEWS DRUG DISCOVERY

Update of TTD: Therapeutic Target Database

(2009) Feng Zhu et al.   NUCLEIC ACIDS RESEARCH

Fast Gene Ontology based clustering for microarray experiments

(2009) Kristian Ovaska et al.   BioData Mining

Balancing early market access to new drugs with the need for benefit/risk data: a mounting dilemma

(2008) Hans-Georg Eichler et al.   NATURE REVIEWS DRUG DISCOVERY