Unique features of human cathelicidin LL-37

Human antimicrobial peptide LL-37 induces glial-mediated neuroinflammation

(2015) Moonhee Lee et al.   BIOCHEMICAL PHARMACOLOGY

Antimicrobial Peptide LL-37 Is Both a Substrate of Cathepsins S and K and a Selective Inhibitor of Cathepsin L

(2015) Pierre-Marie Andrault et al.   BIOCHEMISTRY

Antimicrobial Protein and Peptide Concentrations and Activity in Human Breast Milk Consumed by Preterm Infants at Risk of Late-Onset Neonatal Sepsis

(2015) Stephanie Trend et al.   PLoS One

LL-37 Concentrations and the Relationship to Vitamin D, Immune Status, and Inflammation in HIV-Infected Children and Young Adults

(2014) Vin Tangpricha et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

High-quality 3D structures shine light on antibacterial, anti-biofilm and antiviral activities of human cathelicidin LL-37 and its fragments

(2014) Guangshun Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cathelicidin antimicrobial peptide LL-37 augments interferon-β expression and antiviral activity induced by double-stranded RNA in keratinocytes

(2014) T. Takiguchi et al.   BRITISH JOURNAL OF DERMATOLOGY

Human cathelicidin LL-37 and its derivative IG-19 regulate interleukin-32-induced inflammation

(2014) Ka-Yee G. Choi et al.   IMMUNOLOGY

Role of Urinary Cathelicidin LL-37 and Human β-Defensin 1 in Uncomplicated Escherichia coli Urinary Tract Infections

(2014) Karen L. Nielsen et al.   INFECTION AND IMMUNITY

IL-17A Enhances Vitamin D3-Induced Expression of Cathelicidin Antimicrobial Peptide in Human Keratinocytes

(2014) M. Peric et al.   JOURNAL OF IMMUNOLOGY

Responses of Candida albicans to the human antimicrobial peptide LL-37

(2014) Pei-Wen Tsai et al.   JOURNAL OF MICROBIOLOGY

Regulation of the human cathelicidin antimicrobial peptide gene by 1α,25-dihydroxyvitamin D3 in primary immune cells

(2014) Malcolm B. Lowry et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Antimicrobial Cathelicidin Peptide LL-37 Inhibits the LPS/ATP-Induced Pyroptosis of Macrophages by Dual Mechanism

(2014) Zhongshuang Hu et al.   PLoS One

A Novel Model of Chronic Wounds: Importance of Redox Imbalance and Biofilm-Forming Bacteria for Establishment of Chronicity

(2014) Sandeep Dhall et al.   PLoS One

Treatment with LL-37 is safe and effective in enhancing healing of hard-to-heal venous leg ulcers: a randomized, placebo-controlled clinical trial

(2014) Alvar Grönberg et al.   WOUND REPAIR AND REGENERATION

Cathelicidin LL-37 Induces Angiogenesis via PGE 2 –EP3 Signaling in Endothelial Cells, In Vivo Inhibition by Aspirin

(2013) M. Dolores Salvado et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Structural and Functional Analysis of the Pro-Domain of Human Cathelicidin, LL-37

(2013) Marzena Pazgier et al.   BIOCHEMISTRY

Surface activity and structures of two fragments of the human antimicrobial LL-37

(2013) Claudia Dannehl et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Antimicrobial peptide LL-37 attenuates LTA induced inflammatory effect in macrophages

(2013) Yang Ruan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Human Antimicrobial Peptide LL-37, but Not the Mouse Ortholog, mCRAMP, Can Stimulate Signaling by Poly(I:C) through a FPRL1-dependent Pathway

(2013) Divyendu Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Antimicrobial Peptide LL-37 Alters Human Osteoblast Ca2+Handling and Induces Ca2+-Independent Apoptosis

(2013) Johanna Säll et al.   Journal of Innate Immunity

Molecular biology for formyl peptide receptors in human diseases

(2013) Yongsheng Li et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Cathelicidin LL-37 bloodstream surveillance is down regulated during septic shock

(2013) Denise Frediani Barbeiro et al.   MICROBES AND INFECTION

The Human Cathelicidin LL-37 Has Antiviral Activity against Respiratory Syncytial Virus

(2013) Silke M. Currie et al.   PLoS One

Cathelicidin a potential therapeutic peptide for gastrointestinal inflammation and cancer

(2013) Jimmy Yip Chuen Chow   WORLD JOURNAL OF GASTROENTEROLOGY

The Human Cathelicidin Antimicrobial Peptide LL-37 as a Potential Treatment for Polymicrobial Infected Wounds

(2013) Allen J. Duplantier et al.   Frontiers in Immunology

Cathelicidin LL-37: An Antimicrobial Peptide with a Role in Inflammatory Skin Disease

(2012) Markus Reinholz et al.   Annals of Dermatology

The cathelicidins LL-37 and rCRAMP are associated with pathogenic events of arthritis in humans and rats

(2012) Markus H Hoffmann et al.   ANNALS OF THE RHEUMATIC DISEASES

Host Immune Defense Peptide LL-37 Activates Caspase-Independent Apoptosis and Suppresses Colon Cancer

(2012) S. X. Ren et al.   CANCER RESEARCH

A comprehensive summary of LL-37, the factotum human cathelicidin peptide

(2012) Dieter Vandamme et al.   CELLULAR IMMUNOLOGY

Human antimicrobial peptides LL-37 and human β-defensin-2 reduce viral replication in keratinocytes infected with varicella zoster virus

(2012) L. R. Crack et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Effect of antimicrobial peptides derived from human cathelicidin LL-37 on Entamoeba histolytica trophozoites

(2012) Rosa Rico-Mata et al.   EXPERIMENTAL PARASITOLOGY

Microcin Amyloid Fibrils A Are Reservoir of Toxic Oligomeric Species

(2012) Mohammad Shahnawaz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The human cathelicidin LL-37 inhibits influenza A viruses through a mechanism distinct from that of surfactant protein D or defensins

(2012) S. Tripathi et al.   JOURNAL OF GENERAL VIROLOGY

Neutrophil Extracellular Trap-Associated Protein Activation of the NLRP3 Inflammasome Is Enhanced in Lupus Macrophages

(2012) J. M. Kahlenberg et al.   JOURNAL OF IMMUNOLOGY

Doxycycline Indirectly Inhibits Proteolytic Activation of Tryptic Kallikrein-Related Peptidases and Activation of Cathelicidin

(2012) Kimberly N. Kanada et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Age and low levels of circulating vitamin D are associated with impaired innate immune function

(2012) Lorena Alvarez-Rodriguez et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Antimicrobial Peptide Cathelicidin Protects Mice from Escherichia coli O157:H7-Mediated Disease

(2012) Milan Chromek et al.   PLoS One

Natural and synthetic cathelicidin peptides with anti-microbial and anti-biofilm activity against Staphylococcus aureus

(2011) Scott N Dean et al.   BMC MICROBIOLOGY

Cathelicidin is involved in the intracellular killing of mycobacteria in macrophages

(2011) Avinash Sonawane et al.   CELLULAR MICROBIOLOGY

The anti-microbial peptide LL-37 modulates immune responses in the palatine tonsils where it is exclusively expressed by neutrophils and a subset of dendritic cells

(2011) Sigrun L. Sigurdardottir et al.   CLINICAL IMMUNOLOGY

New insights into cathelicidin modulation of adaptive immunity

(2011) Kelli Wuerth et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

LL-37 suppresses sodium nitroprusside-induced apoptosis of systemic sclerosis dermal fibroblasts

(2011) Hee Jung Kim et al.   EXPERIMENTAL DERMATOLOGY

Cathelicidin Signaling via the Toll-like Receptor Protects Against Colitis in Mice

(2011) Hon Wai Koon et al.   GASTROENTEROLOGY

Entamoeba histolytica Induces Intestinal Cathelicidins but Is Resistant to Cathelicidin-Mediated Killing

(2011) Eduardo R. Cobo et al.   INFECTION AND IMMUNITY

Human anti-microbial cathelicidin peptide LL-37 suppresses the LPS-induced apoptosis of endothelial cells

(2011) Kaori Suzuki et al.   INTERNATIONAL IMMUNOLOGY

Regulation of Cathelicidin Antimicrobial Peptide Expression by an Endoplasmic Reticulum (ER) Stress Signaling, Vitamin D Receptor-independent Pathway

(2011) Kyungho Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Human Cathelicidin, LL-37, Induces Granzyme-mediated Apoptosis in Regulatory T Cells

(2011) Jamie S. Mader et al.   JOURNAL OF IMMUNOTHERAPY

Cathelicidin Antimicrobial Peptide LL-37 in Psoriasis Enables Keratinocyte Reactivity against TLR9 Ligands

(2011) Shin Morizane et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The antimicrobial peptide LL-37 is anti-inflammatory and proapoptotic in human periodontal ligament cells

(2011) D. Jönsson et al.   JOURNAL OF PERIODONTAL RESEARCH

Involvement of P2X7 purinergic receptor and MEK1/2 in interleukin-8 up-regulation by LL-37 in human gingival fibroblasts

(2011) P. Montreekachon et al.   JOURNAL OF PERIODONTAL RESEARCH

The bone marrow-expressed antimicrobial cationic peptide LL-37 enhances the responsiveness of hematopoietic stem progenitor cells to an SDF-1 gradient and accelerates their engraftment after transplantation

(2011) W Wu et al.   LEUKEMIA

Cord Blood Vitamin D Deficiency Is Associated With Respiratory Syncytial Virus Bronchiolitis

(2011) M. E. Belderbos et al.   PEDIATRICS

Effects of cathelicidin and its fragments on three key enzymes of HIV-1

(2011) Jack Ho Wong et al.   PEPTIDES

Wound healing activity of the human antimicrobial peptide LL37

(2011) Reinaldo Ramos et al.   PEPTIDES

Antifungal action of human cathelicidin fragment (LL13–37) on Candida albicans

(2011) Jack Ho Wong et al.   PEPTIDES

Phenylbutyrate Counteracts Shigella Mediated Downregulation of Cathelicidin in Rabbit Lung and Intestinal Epithelia: A Potential Therapeutic Strategy

(2011) Protim Sarker et al.   PLoS One

Antiviral Activity and Increased Host Defense against Influenza Infection Elicited by the Human Cathelicidin LL-37

(2011) Peter G. Barlow et al.   PLoS One

LL37 and Cationic Peptides Enhance TLR3 Signaling by Viral Double-stranded RNAs

(2011) Yvonne Lai et al.   PLoS One

Shedding light on the vitamin D-tuberculosis-HIV connection

(2011) S. Realegeno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Susceptibility of Pseudomonas aeruginosa Biofilm to Alpha-Helical Peptides: D-enantiomer of LL-37

(2011) Scott N. Dean et al.   Frontiers in Microbiology

Cathelicidins in inflammation and tissue repair: Potential therapeutic applications for gastrointestinal disorders

(2010) William Ka Kei Wu et al.   ACTA PHARMACOLOGICA SINICA

The Human Cathelicidin LL-37 Preferentially Promotes Apoptosis of Infected Airway Epithelium

(2010) Peter G. Barlow et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

High level expression and purification of antimicrobial human cathelicidin LL-37 in Escherichia coli

(2010) Ján Krahulec et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Antimicrobial and antibiofilm activity of cathelicidins and short, synthetic peptides against Francisella

(2010) Lilian S. Amer et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effect of the antimicrobial peptide LL-37 on Toll-like receptors 2-, 3- and 4-triggered expression of IL-6, IL-8 and CXCL10 in human gingival fibroblasts

(2010) T. Into et al.   CELLULAR IMMUNOLOGY

The Effect of Calcipotriol on the Expression of HumanβDefensin-2 and LL-37 in Cultured Human Keratinocytes

(2010) Beom Joon Kim et al.   Clinical & Developmental Immunology

Antimicrobial Peptides Present in Mammalian Skin and Gut are Multifunctional Defence Molecules

(2010) Marie-Helene Metz-Boutigue et al.   CURRENT PHARMACEUTICAL DESIGN

The antimicrobial peptide LL-37 modulates the inflammatory and host defense response of human neutrophils

(2010) Sadek M. Alalwani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Response of sessile cells to stress: from changes in gene expression to phenotypic adaptation

(2010) Tom Coenye   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Antimicrobial activities of LL-37 and its truncated variants against Burkholderia thailandensis

(2010) Sakawarat Kanthawong et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications

(2010) William K.K. Wu et al.   INTERNATIONAL JOURNAL OF CANCER

Kallikrein-related Peptidase-8 (KLK8) Is an Active Serine Protease in Human Epidermis and Sweat and Is Involved in a Skin Barrier Proteolytic Cascade

(2010) Azza Eissa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antimicrobial Peptides Human  -Defensins and Cathelicidin LL-37 Induce the Secretion of a Pruritogenic Cytokine IL-31 by Human Mast Cells

(2010) F. Niyonsaba et al.   JOURNAL OF IMMUNOLOGY

Kallikrein Expression and Cathelicidin Processing Are Independently Controlled in Keratinocytes by Calcium, Vitamin D3, and Retinoic Acid

(2010) Shin Morizane et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Vitamin D as an inducer of cathelicidin antimicrobial peptide expression: Past, present and future

(2010) John H. White   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The human cathelicidin hCAP18/LL-37: A multifunctional peptide involved in mycobacterial infections

(2010) Patricia Méndez-Samperio   PEPTIDES

Cost-effective expression and purification of antimicrobial and host defense peptides in Escherichia coli

(2010) B. Bommarius et al.   PEPTIDES

Generation of Novel Bone Forming Cells (Monoosteophils) from the Cathelicidin-Derived Peptide LL-37 Treated Monocytes

(2010) Zhifang Zhang et al.   PLoS One

Phenylbutyrate Induces Antimicrobial Peptide Expression

(2009) J. Steinmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Generic and Specific Adaptive Responses of Streptococcus pneumoniae to Challenge with Three Distinct Antimicrobial Peptides, Bacitracin, LL-37, and Nisin

(2009) J. A. Majchrzykiewicz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The vitamin D–antimicrobial peptide pathway and its role in protection against infection

(2009) Adrian F Gombart   Future Microbiology

Treatment with LL-37 Peptide Enhances Antitumor Effects Induced by CpG Oligodeoxynucleotides Against Ovarian Cancer

(2009) Chi-Mu Chuang et al.   HUMAN GENE THERAPY

Differing effects of exogenous or endogenous cathelicidin on macrophage toll-like receptor signaling

(2009) Fabiano Pinheiro da Silva et al.   IMMUNOLOGY AND CELL BIOLOGY

Antibacterial and lipopolysaccharide (LPS)-neutralising activity of human cationic antimicrobial peptides against periodontopathogens

(2009) Sung-Hoon Lee et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Vitamin D3 induces expression of human cathelicidin antimicrobial peptide 18 in newborns

(2009) Yuka Misawa et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

cAMP Stringently Regulates Human Cathelicidin Antimicrobial Peptide Expression in the Mucosal Epithelial Cells by Activating cAMP-response Element-binding Protein, AP-1, and Inducible cAMP Early Repressor

(2009) Krishnendu Chakraborty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8

(2009) Dipyaman Ganguly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Host Defense Peptide Cathelicidin Is Required for NK Cell-Mediated Suppression of Tumor Growth

(2009) Amanda S. Büchau et al.   JOURNAL OF IMMUNOLOGY

Intracellular Receptor for Human Host Defense Peptide LL-37 in Monocytes

(2009) N. Mookherjee et al.   JOURNAL OF IMMUNOLOGY

Antimicrobial Peptides and Suppression of Apoptosis in Human Skin

(2009) Michael Zasloff   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Transmigration across activated endothelium induces transcriptional changes, inhibits apoptosis, and decreases antimicrobial protein expression in human monocytes

(2009) Marcie R. Williams et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Leucine Leucine-37 Uses Formyl Peptide Receptor-Like 1 to Activate Signal Transduction Pathways, Stimulate Oncogenic Gene Expression, and Enhance the Invasiveness of Ovarian Cancer Cells

(2009) S. B. Coffelt et al.   MOLECULAR CANCER RESEARCH

The chemistry and biology of LL-37

(2009) Matthew F. Burton et al.   NATURAL PRODUCT REPORTS

The pro-inflammatory peptide LL-37 promotes ovarian tumor progression through recruitment of multipotent mesenchymal stromal cells

(2009) S. B. Coffelt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Escherichia coli expression and purification of LL37 fused to a family III carbohydrate-binding module from Clostridium thermocellum

(2009) Reinaldo Ramos et al.   PROTEIN EXPRESSION AND PURIFICATION

Effects of the cathelicidin LL-37 on intestinal epithelial barrier integrity

(2009) Jan-Michel Otte et al.   REGULATORY PEPTIDES

Alarmins link neutrophils and dendritic cells

(2009) De Yang et al.   TRENDS IN IMMUNOLOGY

Nitric Oxide Synthesis is Modulated by 1,25-Dihydroxyvitamin D3 and Interferon-γ in Human Macrophages after Mycobacterial Infection

(2009) Ji-Sook Lee et al.   Immune Network

Shiga Toxin-Mediated Disease in MyD88-Deficient Mice Infected with Escherichia coli O157:H7

(2008) Carla Calderon Toledo et al.   AMERICAN JOURNAL OF PATHOLOGY

Anti-Human Immunodeficiency Virus Type 1 Activities of Antimicrobial Peptides Derived from Human and Bovine Cathelicidins

(2008) G. Wang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antimicrobial fragments of the pro-region of cathelicidins and other immune peptides

(2008) Rachel C. Anderson et al.   BIOTECHNOLOGY LETTERS

Bacterial exotoxins downregulate cathelicidin (hCAP-18/LL-37) and human β-defensin 1 (HBD-1) expression in the intestinal epithelial cells

(2008) Krishnendu Chakraborty et al.   CELLULAR MICROBIOLOGY

Recent Insights in Islet Amyloid Polypeptide-Induced Membrane Disruption and Its Role inβ-Cell Death in Type 2 Diabetes Mellitus

(2008) Lucie Khemtémourian et al.   Experimental Diabetes Research

Human Host Defense Peptide LL-37 Prevents Bacterial Biofilm Formation

(2008) J. Overhage et al.   INFECTION AND IMMUNITY

The Human Cathelicidin LL-37 Modulates the Activities of the P2X7Receptor in a Structure-dependent Manner

(2008) Linda Tomasinsig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of Human Host Defense Cathelicidin LL-37 and Its Smallest Antimicrobial Peptide KR-12 in Lipid Micelles

(2008) Guangshun Wang   JOURNAL OF BIOLOGICAL CHEMISTRY

Host Defence Peptide LL-37 Induces IL-6 Expression in Human Bronchial Epithelial Cells by Activation of the NF-κB Signaling Pathway

(2008) Jelena Pistolic et al.   Journal of Innate Immunity

The Human Antimicrobial Peptide LL-37 Suppresses Apoptosis in Keratinocytes

(2008) Clara I. Chamorro et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Neutrophil secondary necrosis is induced by LL-37 derived from cathelicidin

(2008) Zhifang Zhang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

In vitro and In vivo Wound Healing-Promoting Activities of Human Cathelicidin LL-37

(2007) Marta Carretero et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The host defence peptide LL-37/hCAP-18 is a growth factor for lung cancer cells

(2007) Judith von Haussen et al.   LUNG CANCER