Mouse models of colorectal cancer as preclinical models

Targeting ion channels for cancer therapy by repurposing the approved drugs

(2015) Vijay Pralhad Kale et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis

(2015) Sidi Chen et al.   CELL

How informative is the mouse for human gut microbiota research?

(2015) T. L. A. Nguyen et al.   Disease Models & Mechanisms

Whole-exome DNA sequence analysis ofBrca2- andTrp53-deficient mouse mammary gland tumours

(2015) Jeffrey C Francis et al.   JOURNAL OF PATHOLOGY

Integrated Next-Generation Sequencing and Avatar Mouse Models for Personalized Cancer Treatment

(2014) E. Garralda et al.   CLINICAL CANCER RESEARCH

A comprehensive transcriptional portrait of human cancer cell lines

(2014) Christiaan Klijn et al.   NATURE BIOTECHNOLOGY

Primary prevention of colorectal cancer: Myth or reality?

(2014) Marcela Crosara Teixeira   WORLD JOURNAL OF GASTROENTEROLOGY

A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation-Driven Colorectal Tumor Growth

(2013) T. Lau et al.   CANCER RESEARCH

The Ubiquitin Ligase FBXW7 Modulates Leukemia-Initiating Cell Activity by Regulating MYC Stability

(2013) Bryan King et al.   CELL

Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer

(2013) Gabriela Bindea et al.   IMMUNITY

KRAS gene amplification in colorectal cancer and impact on response to EGFR-targeted therapy

(2013) Emanuele Valtorta et al.   INTERNATIONAL JOURNAL OF CANCER

Origin of the vasculature supporting growth of primary patient tumor xenografts

(2013) Bonnie L Hylander et al.   Journal of Translational Medicine

Tumour heterogeneity in the clinic

(2013) Philippe L. Bedard et al.   NATURE

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

The role of KCNQ1 in mouse and human gastrointestinal cancers

(2013) B L N Than et al.   ONCOGENE

DNA–Methylome Analysis of Mouse Intestinal Adenoma Identifies a Tumour-Specific Signature That Is Partly Conserved in Human Colon Cancer

(2013) Christina Grimm et al.   PLoS Genetics

Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation

(2012) Alexandre Calon et al.   CANCER CELL

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

(2012) Joseph Rosenbluh et al.   CELL

Characterization of a Large Panel of Patient-Derived Tumor Xenografts Representing the Clinical Heterogeneity of Human Colorectal Cancer

(2012) S. Julien et al.   CLINICAL CANCER RESEARCH

Proximal Fluid Proteome Profiling of Mouse Colon Tumors Reveals Biomarkers for Early Diagnosis of Human Colorectal Cancer

(2012) R. J. A. Fijneman et al.   CLINICAL CANCER RESEARCH

Cancer gene discovery in the mouse

(2012) Rebecca E McIntyre et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Epithelial to mesenchymal transition and cancer stem cell phenotypes leading to liver metastasis are abrogated by the novel TGFβ1-targeting peptides P17 and P144

(2012) Idoia G. Zubeldia et al.   EXPERIMENTAL CELL RESEARCH

Metronomic oral topotecan prolongs survival and reduces liver metastasis in improved preclinical orthotopic and adjuvant therapy colon cancer models

(2012) Christina Hackl et al.   GUT

Systematic identification of genomic markers of drug sensitivity in cancer cells

(2012) Mathew J. Garnett et al.   NATURE

Recurrent R-spondin fusions in colon cancer

(2012) Somasekar Seshagiri et al.   NATURE

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer

(2012) Clara Montagut et al.   NATURE MEDICINE

A bacterial driver–passenger model for colorectal cancer: beyond the usual suspects

(2012) Harold Tjalsma et al.   NATURE REVIEWS MICROBIOLOGY

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mice Lacking a Myc Enhancer That Includes Human SNP rs6983267 Are Resistant to Intestinal Tumors

(2012) I. K. Sur et al.   SCIENCE

Priceless GEMMs: genetically engineered mouse models for colorectal cancer drug development

(2012) Jatin Roper et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Circumventing Cancer Drug Resistance in the Era of Personalized Medicine

(2012) Levi A. Garraway et al.   Cancer Discovery

Molecular Genetics of Colorectal Cancer

(2011) Eric R. Fearon   Annual Review of Pathology-Mechanisms of Disease

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse

(2011) Anna Merlos-Suárez et al.   Cell Stem Cell

FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation

(2011) Roya Babaei-Jadidi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Colorectal cancer mouse models: Integrating inflammation and the stroma

(2011) Matthias Ernst et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

WAC, a Functional Partner of RNF20/40, Regulates Histone H2B Ubiquitination and Gene Transcription

(2011) Feng Zhang et al.   MOLECULAR CELL

Microenvironmental regulation of stem cells in intestinal homeostasis and cancer

(2011) Jan Paul Medema et al.   NATURE

Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis

(2011) H Nikki March et al.   NATURE GENETICS

Optimized Mouse Model for the Imaging of Tumor Metastasis upon Experimental Therapy

(2011) Sergio Lavilla-Alonso et al.   PLoS One

A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis

(2011) T. K. Starr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Advanced colorectal cancer: ESMO Clinical Practice Guidelines for treatment

(2010) E. Van Cutsem et al.   ANNALS OF ONCOLOGY

A new conditional Apc-mutant mouse model for colorectal cancer

(2010) E. C. Robanus-Maandag et al.   CARCINOGENESIS

Targeting the Cytoprotective Chaperone, Clusterin, for Treatment of Advanced Cancer

(2010) A. Zoubeidi et al.   CLINICAL CANCER RESEARCH

Targeting Wnt Signaling in Colon Cancer Stem Cells

(2010) E. M. F. de Sousa et al.   CLINICAL CANCER RESEARCH

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

(2010) S. A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment

(2010) K. E. Hung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A superficial colon tumor model involving subcutaneous colon translocation and orthotopic transplantation of green fluorescent protein-expressing human colon tumor

(2010) Heiying Jin et al.   TUMOR BIOLOGY

Genetic Dissection of Differential Signaling Threshold Requirements for the Wnt/β-Catenin Pathway In Vivo

(2010) Michael Buchert et al.   PLoS Genetics

Comprehensive Proteome Analysis of an Apc Mouse Model Uncovers Proteins Associated with Intestinal Tumorigenesis

(2009) K. E. Hung et al.   Cancer Prevention Research

Long-lived Min Mice Develop Advanced Intestinal Cancers through a Genetically Conservative Pathway

(2009) R. B. Halberg et al.   CANCER RESEARCH

An Msh2 Conditional Knockout Mouse for Studying Intestinal Cancer and Testing Anticancer Agents

(2009) Melanie H. Kucherlapati et al.   GASTROENTEROLOGY

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Cell-Specific Information Processing in Segregating Populations of Eph Receptor Ephrin-Expressing Cells

(2009) C. Jorgensen et al.   SCIENCE

A Transposon-Based Genetic Screen in Mice Identifies Genes Altered in Colorectal Cancer

(2009) T. K. Starr et al.   SCIENCE

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology

Clonality, Founder Mutations, and Field Cancerization in Human Ulcerative Colitis–Associated Neoplasia

(2008) Simon J. Leedham et al.   GASTROENTEROLOGY

Intestinal adenomagenesis involves core molecular signatures of the epithelial–mesenchymal transition

(2008) Xiaodi Chen et al.   JOURNAL OF MOLECULAR HISTOLOGY

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

(2008) Kevin M Haigis et al.   NATURE GENETICS

Processed Meat and Colorectal Cancer: A Review of Epidemiologic and Experimental Evidence

(2008) Raphaëlle Santarelli et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Comparative lesion sequencing provides insights into tumor evolution

(2008) S. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA